Description: Homo sapiens chemokine (C-C motif) ligand 28 (CCL28), mRNA. RefSeq Summary (NM_148672): This antimicrobial gene belongs to the subfamily of small cytokine CC genes. Cytokines are a family of secreted proteins involved in immunoregulatory and inflammatory processes. The CC cytokines are proteins characterized by two adjacent cysteines. The cytokine encoded by this gene displays chemotactic activity for resting CD4 or CD8 T cells and eosinophils. The product of this gene binds to chemokine receptors CCR3 and CCR10. This chemokine may play a role in the physiology of extracutaneous epithelial tissues, including diverse mucosal organs. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]. Transcript (Including UTRs) Position: hg19 chr5:43,381,600-43,412,488 Size: 30,889 Total Exon Count: 3 Strand: - Coding Region Position: hg19 chr5:43,381,962-43,412,418 Size: 30,457 Coding Exon Count: 3
ID:CCL28_HUMAN DESCRIPTION: RecName: Full=C-C motif chemokine 28; AltName: Full=Mucosae-associated epithelial chemokine; Short=MEC; AltName: Full=Protein CCK1; AltName: Full=Small-inducible cytokine A28; Flags: Precursor; FUNCTION: Chemotactic activity for resting CD4, CD8 T-cells and eosinophils. Binds to CCR3 and CCR10 and induces calcium mobilization in a dose-dependent manner. SUBCELLULAR LOCATION: Secreted. TISSUE SPECIFICITY: Preferentially expressed by epithelial cells of diverse tissues including normal and pathological colon, salivary gland, mammary gland, trachea and rectum. Also found in prostate, spleen, thyroid, psoriasis skin and in lower levels in peripheral blood leukocytes, small intestine, Peyer patches, stomach and normal skin. SIMILARITY: Belongs to the intercrine beta (chemokine CC) family. WEB RESOURCE: Name=Wikipedia; Note=CCL28 entry; URL="http://en.wikipedia.org/wiki/CCL28";
The RNAfold program from the Vienna RNA Package is used to perform the secondary structure predictions and folding calculations. The estimated folding energy is in kcal/mol. The more negative the energy, the more secondary structure the RNA is likely to have.
ModBase Predicted Comparative 3D Structure on Q9NRJ3
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Orthologous Genes in Other Species
Orthologies between human, mouse, and rat are computed by taking the best BLASTP hit, and filtering out non-syntenic hits. For more distant species reciprocal-best BLASTP hits are used. Note that the absence of an ortholog in the table below may reflect incomplete annotations in the other species rather than a true absence of the orthologous gene.
Biological Process: GO:0001954 positive regulation of cell-matrix adhesion GO:0006935 chemotaxis GO:0006955 immune response GO:0007186 G-protein coupled receptor signaling pathway GO:0007204 positive regulation of cytosolic calcium ion concentration GO:0007584 response to nutrient GO:0010469 regulation of receptor activity GO:0031640 killing of cells of other organism GO:0051715 cytolysis in other organism GO:0060326 cell chemotaxis GO:1903237 negative regulation of leukocyte tethering or rolling
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Sequence and Links to Tools and Databases 
Common Gene Haplotype Alleles 
