Consensus CDS Gene CCDS34910.1

Descriptionelongin-C isoform a
SequencesCDS,  protein,  genomic
CCDS database CCDS34910.1

Associated Sequences

UCSC Genesuc003xzx.2 
RefSeqNM_001204857.1 NP_001191786.1
NM_001204858.1 NP_001191787.1
NM_001204859.1 NP_001191788.1
NM_001204860.1 NP_001191789.1
NM_001204861.1 NP_001191790.1
NM_001204862.1 NP_001191791.1
NM_005648.3 NP_005639.1
XM_005251290.1 XP_005251347.1
VegaOTTHUMT00000379014 OTTHUMP00000226846
OTTHUMT00000379017 OTTHUMP00000226848
OTTHUMT00000379018 OTTHUMP00000226849
OTTHUMT00000379019 OTTHUMP00000226850
OTTHUMT00000379020 OTTHUMP00000226851
OTTHUMT00000379021 OTTHUMP00000227658
EnsemblENST00000284811 ENSP00000284811
ENST00000518127 ENSP00000428334
ENST00000519487 ENSP00000429596
ENST00000520242 ENSP00000428171
ENST00000522337 ENSP00000429906
ENST00000523815 ENSP00000428074

Note: mRNA and protein sequences in other gene collections may differ from the CCDS sequences.

RefSeq summary of CCDS34910.1

This gene encodes the protein elongin C, which is a subunit of the transcription factor B (SIII) complex. The SIII complex is composed of elongins A/A2, B and C. It activates elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites within transcription units. Elongin A functions as the transcriptionally active component of the SIII complex, whereas elongins B and C are regulatory subunits. Elongin A2 is specifically expressed in the testis, and capable of forming a stable complex with elongins B and C. The von Hippel-Lindau tumor suppressor protein binds to elongins B and C, and thereby inhibits transcription elongation. Multiple alternatively spliced transcript variants encoding two distinct isoforms have been identified. [provided by RefSeq, Mar 2011].

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Data last updated: 2019-10-03


This track shows human genome high-confidence gene annotations from the Consensus Coding Sequence (CCDS) project. This project is a collaborative effort to identify a core set of human protein-coding regions that are consistently annotated and of high quality. The long-term goal is to support convergence towards a standard set of gene annotations on the human genome.

Collaborators include:

For more information on the different gene tracks, see our Genes FAQ.


CDS annotations of the human genome were obtained from two sources: NCBI RefSeq and a union of the gene annotations from Ensembl and Vega, collectively known as Hinxton.

Genes with identical CDS genomic coordinates in both sets become CCDS candidates. The genes undergo a quality evaluation, which must be approved by all collaborators. The following criteria are currently used to assess each gene:

  • an initiating ATG (Exception: a non-ATG translation start codon is annotated if it has sufficient experimental support), a valid stop codon, and no in-frame stop codons (Exception: selenoproteins, which contain a TGA codon that is known to be translated to a selenocysteine instead of functioning as a stop codon)
  • ability to be translated from the genome reference sequence without frameshifts
  • recognizable splicing sites
  • no intersection with putative pseudogene predictions
  • supporting transcripts and protein homology
  • conservation evidence with other species

A unique CCDS ID is assigned to the CCDS, which links together all gene annotations with the same CDS. CCDS gene annotations are under continuous review, with periodic updates to this track.


This track was produced at UCSC from data downloaded from the CCDS project web site.


Hubbard T, Barker D, Birney E, Cameron G, Chen Y, Clark L, Cox T, Cuff J, Curwen V, Down T et al. The Ensembl genome database project. Nucleic Acids Res. 2002 Jan 1;30(1):38-41. PMID: 11752248; PMC: PMC99161

Pruitt KD, Harrow J, Harte RA, Wallin C, Diekhans M, Maglott DR, Searle S, Farrell CM, Loveland JE, Ruef BJ et al. The consensus coding sequence (CCDS) project: Identifying a common protein-coding gene set for the human and mouse genomes. Genome Res. 2009 Jul;19(7):1316-23. PMID: 19498102; PMC: PMC2704439

Pruitt KD, Tatusova T, Maglott DR. NCBI Reference Sequence (RefSeq): a curated non-redundant sequence database of genomes, transcripts and proteins. Nucleic Acids Res. 2005 Jan 1;33(Database issue):D501-4. PMID: 15608248; PMC: PMC539979