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Gencode Genes

XPO1 (ENST00000401558.7) at chr2:61477849-61538356 - Homo sapiens exportin 1 (XPO1), mRNA. (from RefSeq NM_003400)
XPO1 (ENST00000495003.1) at chr2:61526151-61533968 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000494468.1) at chr2:61485584-61488663 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000492182.5) at chr2:61482625-61485958 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000489954.1) at chr2:61499717-61502608 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000481214.1) at chr2:61526067-61537694 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000481073.5) at chr2:61477935-61494743 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000476585.5) at chr2:61502146-61526523 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000475744.1) at chr2:61496961-61498874 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000469337.1) at chr2:61492342-61492994 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000468259.1) at chr2:61502290-61525775 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000461407.5) at chr2:61482625-61488663 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000460037.1) at chr2:61493638-61495573 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000457483.5) at chr2:61522630-61537640 - exportin 1 (from HGNC XPO1)
XPO1 (ENST00000451765.5) at chr2:61499765-61537117 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9JKM9)
XPO1 (ENST00000449444.5) at chr2:61526462-61536588 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9IYM2)
XPO1 (ENST00000443240.5) at chr2:61502006-61538626 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9J673)
XPO1 (ENST00000437159.5) at chr2:61496994-61526518 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H7BZC5)
XPO1 (ENST00000436018.1) at chr2:61526471-61538626 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9JF49)
XPO1 (ENST00000428210.5) at chr2:61477934-61538231 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt F8WF71)
XPO1 (ENST00000422552.5) at chr2:61522626-61534512 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9JQ02)
XPO1 (ENST00000420673.5) at chr2:61522611-61534278 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9JV99)
XPO1 (ENST00000406957.5) at chr2:61478700-61538248 - Mediates the nuclear export of cellular proteins  (cargos) bearing a leucine-rich nuclear export signal (NES) and of  RNAs. In the nucleus, in association with RANBP3, binds  cooperatively to the NES on its target protein and to the GTPase  RAN in its active GTP-bound form (Ran-GTP). Docking of this  complex to the nuclear pore complex (NPC) is mediated through  binding to nucleoporins. Upon transit of an nuclear export complex  into the cytoplasm, disassembling of the complex and hydrolysis of  Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)  cause release of the cargo from the export receptor. The  directionality of nuclear export is thought to be conferred by an  asymmetric distribution of the GTP- and GDP-bound forms of Ran  between the cytoplasm and nucleus. Involved in U3 snoRNA transport  from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA  bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and  influenza A use it to export their unspliced or incompletely  spliced RNAs out of the nucleus. Interacts with, and mediates the  nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in  HTLV-1 Rex multimerization. (from UniProt O14980)
XPO1 (ENST00000404992.6) at chr2:61478338-61537110 - Mediates the nuclear export of cellular proteins  (cargos) bearing a leucine-rich nuclear export signal (NES) and of  RNAs. In the nucleus, in association with RANBP3, binds  cooperatively to the NES on its target protein and to the GTPase  RAN in its active GTP-bound form (Ran-GTP). Docking of this  complex to the nuclear pore complex (NPC) is mediated through  binding to nucleoporins. Upon transit of an nuclear export complex  into the cytoplasm, disassembling of the complex and hydrolysis of  Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively)  cause release of the cargo from the export receptor. The  directionality of nuclear export is thought to be conferred by an  asymmetric distribution of the GTP- and GDP-bound forms of Ran  between the cytoplasm and nucleus. Involved in U3 snoRNA transport  from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA  bearing a TMG cap. Several viruses, among them HIV-1, HTLV-1 and  influenza A use it to export their unspliced or incompletely  spliced RNAs out of the nucleus. Interacts with, and mediates the  nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in  HTLV-1 Rex multimerization. (from UniProt O14980)
NMD3 (ENST00000460469.1) at chr3:161221559-161252004 - Acts as an adapter for the XPO1/CRM1-mediated export of  the 60S ribosomal subunit. (from UniProt Q96D46)
PHAX (ENST00000297540.5) at chr5:126600947-126627252 - Homo sapiens phosphorylated adaptor for RNA export (PHAX), mRNA. (from RefSeq NM_032177)
DDX3Y (ENST00000360160.8) at chrY:12904108-12918539 - Probable ATP-dependent RNA helicase. May play a role in  spermatogenesis. (from UniProt O15523)
DDX3Y (ENST00000336079.8) at chrY:12904868-12920478 - Probable ATP-dependent RNA helicase. May play a role in  spermatogenesis. (from UniProt O15523)
SYNPO2 (ENST00000627783.2) at chr4:119027335-119044009 - Has an actin-binding and actin-bundling activity (By  similarity). (from UniProt Q9UMS6)
SYNPO2 (ENST00000610556.4) at chr4:118850688-119057934 - Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 4, mRNA. (from RefSeq NM_001286754)
SYNPO2 (ENST00000307142.9) at chr4:118888854-119061247 - Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 1, mRNA. (from RefSeq NM_133477)
SYNPO2 (ENST00000434046.6) at chr4:118889037-119037447 - Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 3, mRNA. (from RefSeq NM_001128934)
SYNPO2 (ENST00000429713.7) at chr4:118888855-119044009 - Homo sapiens synaptopodin 2 (SYNPO2), transcript variant 2, mRNA. (from RefSeq NM_001128933)
RANBP3 (ENST00000340578.10) at chr19:5916139-5978140 - Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-d, mRNA. (from RefSeq NM_007322)
RANBP3 (ENST00000439268.6) at chr19:5916139-5978108 - Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-a, mRNA. (from RefSeq NM_003624)
RANBP3 (ENST00000034275.12) at chr19:5917352-5978086 - Homo sapiens RAN binding protein 3 (RANBP3), transcript variant RANBP3-b, mRNA. (from RefSeq NM_007320)
NEMF (ENST00000298310.10) at chr14:49782083-49852788 - Homo sapiens nuclear export mediator factor (NEMF), transcript variant 1, mRNA. (from RefSeq NM_004713)
NMD3 (ENST00000351193.6) at chr3:161221290-161252307 - Homo sapiens NMD3 ribosome export adaptor (NMD3), transcript variant 2, mRNA. (from RefSeq NM_015938)
SNUPN (ENST00000564675.5) at chr15:75598122-75625693 - Functions as an U snRNP-specific nuclear import adapter.  Involved in the trimethylguanosine (m3G)-cap-dependent nuclear  import of U snRNPs. Binds specifically to the terminal m3G-cap U  snRNAs. (from UniProt O95149)
SNUPN (ENST00000564644.5) at chr15:75598089-75625688 - Functions as an U snRNP-specific nuclear import adapter.  Involved in the trimethylguanosine (m3G)-cap-dependent nuclear  import of U snRNPs. Binds specifically to the terminal m3G-cap U  snRNAs. (from UniProt O95149)
SNUPN (ENST00000567134.5) at chr15:75598083-75625794 - Functions as an U snRNP-specific nuclear import adapter.  Involved in the trimethylguanosine (m3G)-cap-dependent nuclear  import of U snRNPs. Binds specifically to the terminal m3G-cap U  snRNAs. (from UniProt O95149)
PHB (ENST00000511832.5) at chr17:49404049-49414905 - Homo sapiens prohibitin (PHB), transcript variant 3, mRNA. (from RefSeq NM_001281497)
PHB (ENST00000614445.4) at chr17:49404049-49414905 - Homo sapiens prohibitin (PHB), transcript variant 4, mRNA. (from RefSeq NM_001281715)
PHB (ENST00000617874.4) at chr17:49404049-49414858 - Homo sapiens prohibitin (PHB), transcript variant 1, mRNA. (from RefSeq NM_001281496)
PHB (ENST00000300408.7) at chr17:49404052-49414880 - Homo sapiens prohibitin (PHB), transcript variant 2, mRNA. (from RefSeq NM_002634)
LSG1 (ENST00000265245.10) at chr3:194640791-194672191 - Homo sapiens large 60S subunit nuclear export GTPase 1 (LSG1), mRNA. (from RefSeq NM_018385)
SNUPN (ENST00000308588.10) at chr15:75598086-75625725 - Homo sapiens snurportin 1 (SNUPN), transcript variant 1, mRNA. (from RefSeq NM_005701)
NUP214 (ENST00000411637.6) at chr9:131125586-131234663 - Homo sapiens nucleoporin 214 (NUP214), transcript variant 3, mRNA. (from RefSeq NM_001318324)
NUP214 (ENST00000359428.10) at chr9:131125586-131234663 - Homo sapiens nucleoporin 214 (NUP214), transcript variant 2, mRNA. (from RefSeq NM_005085)
MYBBP1A (ENST00000254718.8) at chr17:4538902-4555631 - Homo sapiens MYB binding protein 1a (MYBBP1A), transcript variant 2, mRNA. (from RefSeq NM_014520)
MYBBP1A (ENST00000381556.6) at chr17:4538897-4555386 - Homo sapiens MYB binding protein 1a (MYBBP1A), transcript variant 1, mRNA. (from RefSeq NM_001105538)
STAU2 (ENST00000521451.5) at chr8:73550547-73746884 - RNA-binding protein required for the microtubule-  dependent transport of neuronal RNA from the cell body to the  dendrite. As protein synthesis occurs within the dendrite, the  localization of specific mRNAs to dendrites may be a prerequisite  for neurite outgrowth and plasticity at sites distant from the  cell body (By similarity). (from UniProt Q9NUL3)
STAU2 (ENST00000524104.5) at chr8:73652257-73746840 - RNA-binding protein required for the microtubule-  dependent transport of neuronal RNA from the cell body to the  dendrite. As protein synthesis occurs within the dendrite, the  localization of specific mRNAs to dendrites may be a prerequisite  for neurite outgrowth and plasticity at sites distant from the  cell body (By similarity). (from UniProt Q9NUL3)
NFATC2 (ENST00000396009.7) at chr20:51386957-51542719 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 2, mRNA. (from RefSeq NM_173091)
NFATC2 (ENST00000610033.5) at chr20:51391228-51542719 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 7, mRNA. (from RefSeq NM_001258296)
NFATC2 (ENST00000609507.1) at chr20:51391228-51562831 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 5, mRNA. (from RefSeq NM_001258294)
NFATC2 (ENST00000414705.5) at chr20:51391228-51562629 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 3, mRNA. (from RefSeq NM_001136021)
NFATC2 (ENST00000609943.5) at chr20:51388626-51562831 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 6, mRNA. (from RefSeq NM_001258295)
NFATC2 (ENST00000371564.8) at chr20:51386963-51542719 - Homo sapiens nuclear factor of activated T cells 2 (NFATC2), transcript variant 1, mRNA. (from RefSeq NM_012340)
PYM1 (ENST00000408946.7) at chr12:55901413-55927894 - Homo sapiens PYM homolog 1, exon junction complex associated factor (PYM1), transcript variant 1, mRNA. (from RefSeq NM_032345)
PYM1 (ENST00000398213.4) at chr12:55901414-55927112 - Homo sapiens PYM homolog 1, exon junction complex associated factor (PYM1), transcript variant 2, mRNA. (from RefSeq NM_001143853)
RAN (ENST00000392369.6) at chr12:130872070-130876281 - GTP-binding protein involved in nucleocytoplasmic  transport. Required for the import of protein into the nucleus and  also for RNA export. Involved in chromatin condensation and  control of cell cycle (By similarity). The complex with BIRC5/  survivin plays a role in mitotic spindle formation by serving as a  physical scaffold to help deliver the RAN effector molecule TPX2  to microtubules. Acts as a negative regulator of the kinase  activity of VRK1 and VRK2. (from UniProt P62826)
PSMD10 (ENST00000361815.9) at chrX:108084830-108091542 - Homo sapiens proteasome 26S subunit, non-ATPase 10 (PSMD10), transcript variant 2, mRNA. (from RefSeq NM_170750)
PSMD10 (ENST00000217958.8) at chrX:108084207-108091542 - Homo sapiens proteasome 26S subunit, non-ATPase 10 (PSMD10), transcript variant 1, mRNA. (from RefSeq NM_002814)
STAU2 (ENST00000522695.5) at chr8:73420369-73738327 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 2, mRNA. (from RefSeq NM_001164381)
STAU2 (ENST00000523558.5) at chr8:73421130-73746840 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 4, mRNA. (from RefSeq NM_001164383)
STAU2 (ENST00000521210.5) at chr8:73421212-73746840 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 3, mRNA. (from RefSeq NM_001164382)
STAU2 (ENST00000517542.5) at chr8:73551830-73746879 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 7, mRNA. (from RefSeq NM_001164385)
STAU2 (ENST00000522509.5) at chr8:73551643-73747708 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 6, mRNA. (from RefSeq NM_001164384)
STAU2 (ENST00000355780.9) at chr8:73549604-73746840 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 5, mRNA. (from RefSeq NM_014393)
STAU2 (ENST00000524300.6) at chr8:73420369-73746840 - Homo sapiens staufen double-stranded RNA binding protein 2 (STAU2), transcript variant 1, mRNA. (from RefSeq NM_001164380)
DDX3X (ENST00000630255.2) at chrX:41333348-41364472 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
DDX3X (ENST00000629785.2) at chrX:41333348-41364472 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
DDX3X (ENST00000629496.3) at chrX:41333348-41350287 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
RAN (ENST00000543796.6) at chr12:130872066-130877678 - Homo sapiens RAN, member RAS oncogene family (RAN), transcript variant 1, mRNA. (from RefSeq NM_006325)
ZC3HAV1 (ENST00000471652.1) at chr7:139060338-139109719 - Homo sapiens zinc finger CCCH-type containing, antiviral 1 (ZC3HAV1), transcript variant 2, mRNA. (from RefSeq NM_024625)
ZC3HAV1 (ENST00000242351.10) at chr7:139043515-139109720 - Homo sapiens zinc finger CCCH-type containing, antiviral 1 (ZC3HAV1), transcript variant 1, mRNA. (from RefSeq NM_020119)
PRKD1 (ENST00000616995.4) at chr14:29576479-29927512 - Serine/threonine-protein kinase that converts transient  diacylglycerol (DAG) signals into prolonged physiological effects  downstream of PKC, and is involved in the regulation of MAPK8/JNK1  and Ras signaling, Golgi membrane integrity and trafficking, cell  survival through NF-kappa-B activation, cell migration, cell  differentiation by mediating HDAC7 nuclear export, cell  proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in  cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced  apoptosis and flagellin-stimulated inflammatory response.  Phosphorylates the epidermal growth factor receptor (EGFR) on dual  threonine residues, which leads to the suppression of epidermal  growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent  JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to  14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition  with RAF1 for binding to GTP-bound form of Ras proteins (NRAS,  HRAS and KRAS). Acts downstream of the heterotrimeric G-protein  beta/gamma-subunit complex to maintain the structural integrity of  the Golgi membranes, and is required for protein transport along  the secretory pathway. In the trans-Golgi network (TGN), regulates  the fission of transport vesicles that are on their way to the  plasma membrane. May act by activating the lipid kinase  phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the  local synthesis of phosphorylated inositol lipids, which induces a  sequential production of DAG, phosphatidic acid (PA) and lyso-PA  (LPA) that are necessary for membrane fission and generation of  specific transport carriers to the cell surface. Under oxidative  stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes  to cell survival by activating IKK complex and subsequent nuclear  translocation and activation of NFKB1. Involved in cell migration  by regulating integrin alpha-5/beta-3 recycling and promoting its  recruitment in newly forming focal adhesion. In osteoblast  differentiation, mediates the bone morphogenic protein 2 (BMP2)-  induced nuclear export of HDAC7, which results in the inhibition  of HDAC7 transcriptional repression of RUNX2. In neurons, plays an  important role in neuronal polarity by regulating the biogenesis  of TGN-derived dendritic vesicles, and is involved in the  maintenance of dendritic arborization and Golgi structure in  hippocampal cells. May potentiate mitogenesis induced by the  neuropeptide bombesin or vasopressin by mediating an increase in  the duration of MAPK1/3 (ERK1/2) signaling, which leads to  accumulation of immediate-early gene products including FOS that  stimulate cell cycle progression. Plays an important role in the  proliferative response induced by low calcium in keratinocytes,  through sustained activation of MAPK1/3 (ERK1/2) pathway.  Downstream of novel PKC signaling, plays a role in cardiac  hypertrophy by phosphorylating HDAC5, which in turn triggers  XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional  activation and induction of downstream target genes that promote  myocyte hypertrophy and pathological cardiac remodeling. Mediates  cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which  results in reduced myofilament calcium sensitivity, and  accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway  is also involved in angiogenesis by mediating VEGFA-induced  specific subset of gene expression, cell migration, and tube  formation. In response to VEGFA, is necessary and required for  HDAC7 phosphorylation which induces HDAC7 nuclear export and  endothelial cell proliferation and migration. During apoptosis  induced by cytarabine and other genotoxic agents, PRKD1 is cleaved  by caspase-3 at Asp-378, resulting in activation of its kinase  function and increased sensitivity of cells to the cytotoxic  effects of genotoxic agents. In epithelial cells, is required for  transducing flagellin-stimulated inflammatory responses by binding  and phosphorylating TLR5, which contributes to MAPK14/p38  activation and production of inflammatory cytokines. May play a  role in inflammatory response by mediating activation of NF-kappa-  B. May be involved in pain transmission by directly modulating  TRPV1 receptor. (from UniProt Q15139)
KPNB1 (ENST00000540627.5) at chr17:47651196-47682680 - Homo sapiens karyopherin subunit beta 1 (KPNB1), transcript variant 2, mRNA. (from RefSeq NM_001276453)
KPNB1 (ENST00000290158.9) at chr17:47649919-47685505 - Homo sapiens karyopherin subunit beta 1 (KPNB1), transcript variant 1, mRNA. (from RefSeq NM_002265)
BIRC5 (ENST00000374948.6) at chr17:78214264-78225636 - Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2, mRNA. (from RefSeq NM_001012270)
CAMK1 (ENST00000256460.8) at chr3:9757347-9769947 - Homo sapiens calcium/calmodulin dependent protein kinase I (CAMK1), mRNA. (from RefSeq NM_003656)
KPNB1 (ENST00000535458.6) at chr17:47649476-47682633 - Functions in nuclear protein import, either in  association with an adapter protein, like an importin-alpha  subunit, which binds to nuclear localization signals (NLS) in  cargo substrates, or by acting as autonomous nuclear transport  receptor. Acting autonomously, serves itself as NLS receptor.  Docking of the importin/substrate complex to the nuclear pore  complex (NPC) is mediated by KPNB1 through binding to nucleoporin  FxFG repeats and the complex is subsequently translocated through  the pore by an energy requiring, Ran-dependent mechanism. At the  nucleoplasmic side of the NPC, Ran binds to importin-beta and the  three components separate and importin-alpha and -beta are re-  exported from the nucleus to the cytoplasm where GTP hydrolysis  releases Ran from importin. The directionality of nuclear import  is thought to be conferred by an asymmetric distribution of the  GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus.  Mediates autonomously the nuclear import of ribosomal proteins  RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor  binding (BIB) domain of RPL23A. In association with IPO7 mediates  the nuclear import of H1 histone. In vitro, mediates nuclear  import of H2A, H2B, H3 and H4 histones. In case of HIV-1  infection, binds and mediates the nuclear import of HIV-1 Rev.  Imports PRKCI into the nucleus. (from UniProt Q14974)
TERT (ENST00000310581.9) at chr5:1253167-1295047 - Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 1, mRNA. (from RefSeq NM_198253)
IPO7 (ENST00000379719.8) at chr11:9384652-9448127 - Homo sapiens importin 7 (IPO7), mRNA. (from RefSeq NM_006391)
TERT (ENST00000334602.10) at chr5:1253728-1294989 - Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 2, mRNA. (from RefSeq NM_001193376)
NCBP2 (ENST00000452404.6) at chr3:196936777-196942440 - Homo sapiens nuclear cap binding protein subunit 2 (NCBP2), transcript variant 3, mRNA. (from RefSeq NM_001308036)
NCBP2 (ENST00000427641.2) at chr3:196935434-196942560 - Homo sapiens nuclear cap binding protein subunit 2 (NCBP2), transcript variant 2, mRNA. (from RefSeq NM_001042540)
NCBP2 (ENST00000321256.10) at chr3:196935406-196942528 - Homo sapiens nuclear cap binding protein subunit 2 (NCBP2), transcript variant 1, mRNA. (from RefSeq NM_007362)
BIRC5 (ENST00000592734.5) at chr17:78214317-78222992 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
BIRC5 (ENST00000590925.6) at chr17:78214263-78223554 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
BIRC5 (ENST00000590449.1) at chr17:78214280-78215099 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
PRKD1 (ENST00000331968.10) at chr14:29576479-29927847 - Homo sapiens protein kinase D1 (PRKD1), transcript variant 2, mRNA. (from RefSeq NM_002742)
DDX3X (ENST00000457138.7) at chrX:41333913-41350224 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 3, mRNA. (from RefSeq NM_001193417)
DDX3X (ENST00000644876.1) at chrX:41333284-41351668 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 1, mRNA. (from RefSeq NM_001356)
DDX3X (ENST00000478993.5) at chrX:41333398-41364472 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 4, non-coding RNA. (from RefSeq NR_126093)
NCBP1 (ENST00000375147.8) at chr9:97633821-97673748 - Homo sapiens nuclear cap binding protein subunit 1 (NCBP1), transcript variant 1, mRNA. (from RefSeq NM_002486)
TERT (ENST00000460137.6) at chr5:1253728-1294989 - Homo sapiens telomerase reverse transcriptase (TERT), transcript variant 4, non-coding RNA. (from RefSeq NR_149163)
ERBB2 (ENST00000406381.6) at chr17:39694931-39728662 - Protein tyrosine kinase that is part of several cell  surface receptor complexes, but that apparently needs a coreceptor  for ligand binding. Essential component of a neuregulin-receptor  complex, although neuregulins do not interact with it alone. GP30  is a potential ligand for this receptor. Regulates outgrowth and  stabilization of peripheral microtubules (MTs). Upon ERBB2  activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the  phosphorylation and thus the inhibition of GSK3B at cell membrane.  This prevents the phosphorylation of APC and CLASP2, allowing its  association with the cell membrane. In turn, membrane-bound APC  allows the localization of MACF1 to the cell membrane, which is  required for microtubule capture and stabilization. (from UniProt P04626)
ERBB2 (ENST00000584601.5) at chr17:39687914-39728361 - Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 2, mRNA. (from RefSeq NM_001005862)
ERBB2 (ENST00000541774.5) at chr17:39699560-39728662 - Homo sapiens erb-b2 receptor tyrosine kinase 2 (ERBB2), transcript variant 3, mRNA. (from RefSeq NM_001289936)
CHEK1 (ENST00000428830.6) at chr11:125625974-125676255 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 2, mRNA. (from RefSeq NM_001114121)
CHEK1 (ENST00000534070.5) at chr11:125626341-125657147 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 3, mRNA. (from RefSeq NM_001274)
CHEK1 (ENST00000532449.6) at chr11:125626229-125656845 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 6, non-coding RNA. (from RefSeq NR_045205)
CHEK1 (ENST00000438015.6) at chr11:125625976-125657147 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 1, mRNA. (from RefSeq NM_001114122)
CHEK1 (ENST00000544373.5) at chr11:125625977-125655710 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 8, mRNA. (from RefSeq NM_001330428)
CHEK1 (ENST00000524737.6) at chr11:125626558-125676041 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest and activation of DNA repair  in response to the presence of DNA damage or unreplicated DNA. May  also negatively regulate cell cycle progression during unperturbed  cell cycles. This regulation is achieved by a number of mechanisms  that together help to preserve the integrity of the genome.  Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to  and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of  CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at  'Ser-216' creates binding sites for 14-3-3 proteins which inhibit  CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-  124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of  CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein  for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88'  by NEK11, which is required for polyubiquitination and degradation  of CDCD25A. Inhibition of CDC25 leads to increased inhibitory  tyrosine phosphorylation of CDK-cyclin complexes and blocks cell  cycle progression. Also phosphorylates NEK6. Binds to and  phosphorylates RAD51 at 'Thr-309', which promotes the release of  RAD51 from BRCA2 and enhances the association of RAD51 with  chromatin, thereby promoting DNA repair by homologous  recombination. Phosphorylates multiple sites within the C-terminus  of TP53, which promotes activation of TP53 by acetylation and  promotes cell cycle arrest and suppression of cellular  proliferation. Also promotes repair of DNA cross-links through  phosphorylation of FANCE. Binds to and phosphorylates TLK1 at  'Ser-743', which prevents the TLK1-dependent phosphorylation of  the chromatin assembly factor ASF1A. This may enhance chromatin  assembly both in the presence or absence of DNA damage. May also  play a role in replication fork maintenance through regulation of  PCNA. May regulate the transcription of genes that regulate cell-  cycle progression through the phosphorylation of histones.  Phosphorylates histone H3.1 (to form H3T11ph), which leads to  epigenetic inhibition of a subset of genes. May also phosphorylate  RB1 to promote its interaction with the E2F family of  transcription factors and subsequent cell cycle arrest. (from UniProt O14757)
IGF2BP1 (ENST00000431824.2) at chr17:48997746-49049444 - Homo sapiens insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1), transcript variant 2, mRNA. (from RefSeq NM_001160423)
IGF2BP1 (ENST00000290341.8) at chr17:48997385-49056145 - Homo sapiens insulin like growth factor 2 mRNA binding protein 1 (IGF2BP1), transcript variant 1, mRNA. (from RefSeq NM_006546)
CDK9 (ENST00000373264.5) at chr9:127786034-127790792 - Homo sapiens cyclin dependent kinase 9 (CDK9), mRNA. (from RefSeq NM_001261)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_003400.3 at chr2:61477934-61538283

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005264546.2 at chr2:61477934-61525506
XM_024453127.1 at chr2:61477934-61533839
XM_024453126.1 at chr2:61477934-61534512
XM_024453125.1 at chr2:61477934-61537206
XM_006712094.3 at chr2:61477934-61537640
XM_011533099.3 at chr2:61477934-61538039
XM_011533098.2 at chr2:61477934-61538039
XM_005264544.2 at chr2:61477934-61538039
XM_011533097.1 at chr2:61477934-61538522

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

XPO1 at chr2:61477849-61538356

RefSeq Genes

XPO1 at chr2:61477849-61538356 - (NM_003400) exportin-1

Non-Human RefSeq Genes

XPO1 at chr2:61478016-61538195 - (NM_001266844) exportin-1
XPO1 at chr2:61477913-61538280 - (NM_001290134) exportin-1
Xpo1 at chr2:61481185-61499894 - (NM_001247253) exportin 1
Xpo1 at chr2:61477916-61538195 - (NM_134014) exportin-1
Xpo1 at chr2:61477916-61538195 - (NM_001035226) exportin-1
Xpo1 at chr2:61478820-61533897 - (NM_053490) exportin-1
XPO1 at chr2:61477715-61536299 - (NM_001192261) exportin-1
xpo1.S at chr2:61477934-61533903 - (NM_001090265) exportin 1 S homeolog
XPO1B at chr2:61490735-61499894 - (NM_111181) exportin 1B

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

XPO1 at chr2:61477849-61538283
XPO1 at chr2:61477934-61538231
XPO1 at chr2:61477935-61494743
XPO1 at chr2:61478338-61537110
XPO1 at chr2:61478700-61538248
XPO1 at chr2:61482625-61485958
XPO1 at chr2:61482625-61488663
XPO1 at chr2:61485584-61488663
XPO1 at chr2:61492342-61492994
XPO1 at chr2:61493638-61495573
XPO1 at chr2:61496961-61498874
XPO1 at chr2:61496994-61526518
XPO1 at chr2:61499717-61502608
XPO1 at chr2:61499765-61537117
XPO1 at chr2:61502006-61538626
XPO1 at chr2:61502146-61526523
XPO1 at chr2:61502290-61525775
XPO1 at chr2:61522611-61534278
XPO1 at chr2:61522626-61534512
XPO1 at chr2:61522630-61537640
XPO1 at chr2:61526067-61537694
XPO1 at chr2:61526151-61533968
XPO1 at chr2:61526462-61536588
XPO1 at chr2:61526471-61538626

International Knockout Mouse Consortium Genes Mapped to Human Genome

Xpo1_42286 at chr2:61477934-61538283
Xpo1_44142 at chr2:61477934-61538283
Xpo1_82242 at chr2:61477934-61538283
Xpo1_VG15595 at chr2:61477934-61538283

Human Aligned mRNA Search Results

BC032847 - Homo sapiens exportin 1 (CRM1 homolog, yeast), mRNA (cDNA clone MGC:33022 IMAGE:5267242), complete cds.
BC064026 - Homo sapiens host cell factor C1 regulator 1 (XPO1 dependent), mRNA (cDNA clone MGC:70711 IMAGE:6201972), complete cds.
BC080178 - Homo sapiens host cell factor C1 regulator 1 (XPO1 dependent), mRNA (cDNA clone MGC:99622 IMAGE:6651554), complete cds.
KX404983 - Homo sapiens isolate XPO1_exon_inclusion_R circular RNA circRNA, complete sequence.
KX404982 - Homo sapiens isolate XPO1_exon_exclusion_F circular RNA circRNA, complete sequence.
CR457245 - Homo sapiens full open reading frame cDNA clone RZPDo834C079D for gene HCFC1R1, host cell factor C1 regulator 1 (XPO1 dependant); complete cds, incl. stopcodon.
AK293768 - Homo sapiens cDNA FLJ51801 complete cds, highly similar to Homo sapiens host cell factor C1 regulator 1 (XPO1 dependant) (HCFC1R1), transcript variant 2, mRNA.
AK289920 - Homo sapiens cDNA FLJ78427 complete cds, highly similar to Homo sapiens exportin 1 (CRM1 homolog, yeast) (XPO1), mRNA.
BC065514 - Homo sapiens host cell factor C1 regulator 1 (XPO1 dependent), mRNA (cDNA clone IMAGE:5748501), with apparent retained intron.

Non-Human Aligned mRNA Search Results

AF158021 - Xenopus laevis CRM1/XPO1 protein mRNA, complete cds.
BC079865 - Mus musculus host cell factor C1 regulator 1 (XPO1-dependent), mRNA (cDNA clone MGC:99867 IMAGE:6818222), complete cds.
BC012276 - Mus musculus exportin 1, CRM1 homolog (yeast), mRNA (cDNA clone MGC:7051 IMAGE:3156478), complete cds.
BC025628 - Mus musculus exportin 1, CRM1 homolog (yeast), mRNA (cDNA clone MGC:38171 IMAGE:5321933), complete cds.
BC070550 - Xenopus laevis CRM1/XPO1 protein, mRNA (cDNA clone MGC:79902 IMAGE:6635969), complete cds.
AY096633 - Arabidopsis thaliana putative Exportin1 (XPO1) protein (At5g17020) mRNA, complete cds.
BC111671 - Bos taurus host cell factor C1 regulator 1 (XPO1 dependent), mRNA (cDNA clone MGC:137730 IMAGE:8175312), complete cds.
GU126514 - Solanum lycopersicum exportin-1 (Xpo1) mRNA, complete cds.
BC062912 - Mus musculus exportin 1, CRM1 homolog (yeast), mRNA (cDNA clone MGC:86161 IMAGE:6821729), complete cds.
JT415951 - TSA: Ictalurus punctatus aby_k55:1032655 mRNA sequence.
AJ277542 - Arabidopsis thaliana mRNA for exportin 1b (xpo1b gene).
LC309010 - Sus scrofa domesticus XPO1 mRNA for exportin 1, complete cds.
JT409771 - TSA: Ictalurus punctatus clc_366574 mRNA sequence.
JU319856 - TSA: Macaca mulatta Mamu_503192 mRNA sequence.
JU472665 - TSA: Macaca mulatta Mamu_378167 mRNA sequence.
JV044253 - TSA: Macaca mulatta Mamu_415012 mRNA sequence.
BT072425 - Salmo salar clone ssal-rgf-525-088 Exportin-1 putative mRNA, partial cds.
BT074767 - Osmerus mordax clone omor-eva-502-324 Exportin-1 putative mRNA, complete cds.
AJ608267 - Chironomus tentans xpo1 mRNA for Exportin 1.
AB179024 - Macaca fascicularis testis cDNA clone: QtsA-11616, similar to human exportin 1 (CRM1 homolog, yeast) (XPO1), mRNA, RefSeq: NM_003400.2.

Pfam Domains in UCSC Genes

Xpo1 at chr1:43949681-43950118
Xpo1 at chr12:64418900-64420419
Xpo1 at chr16:28156340-28175996
Xpo1 at chr2:61496963-61502034
Xpo1 at chr6:43567190-43570967
Xpo1 at chr7:129001187-129017974