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Gencode Genes

WNK2 (ENST00000297954.8) at chr9:93184930-93318271 - Homo sapiens WNK lysine deficient protein kinase 2 (WNK2), transcript variant 1, mRNA. (from RefSeq NM_001282394)
WNK2 (ENST00000479696.1) at chr9:93293133-93300326 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000478583.1) at chr9:93263266-93268040 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000474009.5) at chr9:93293089-93308588 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000471076.1) at chr9:93315488-93320566 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000467401.1) at chr9:93306637-93320564 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000464625.1) at chr9:93256726-93259251 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000462595.1) at chr9:93267020-93267815 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000460335.1) at chr9:93308501-93309195 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000453718.2) at chr9:93289187-93308584 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0Y7J9)
WNK2 (ENST00000448251.5) at chr9:93263948-93320572 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0Y493)
WNK2 (ENST00000448039.5) at chr9:93184916-93259075 - WNK lysine deficient protein kinase 2 (from HGNC WNK2)
WNK2 (ENST00000432730.5) at chr9:93184943-93319204 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0Y7T5)
WNK2 (ENST00000427277.6) at chr9:93184930-93299156 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PCD1)
WNK2 (ENST00000411624.5) at chr9:93234923-93319208 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0Y7R3)
WNK2 (ENST00000395477.6) at chr9:93184930-93320572 - Homo sapiens WNK lysine deficient protein kinase 2 (WNK2), transcript variant 2, mRNA. (from RefSeq NM_006648)
SCNN1B (ENST00000307331.9) at chr16:23303973-23380801 - Sodium permeable non-voltage-sensitive ion channel  inhibited by the diuretic amiloride. Mediates the electrodiffusion  of the luminal sodium (and water, which follows osmotically)  through the apical membrane of epithelial cells. Controls the  reabsorption of sodium in kidney, colon, lung and sweat glands.  Also plays a role in taste perception. (from UniProt P51168)
SCNN1A (ENST00000543768.1) at chr12:6347684-6377359 - Homo sapiens sodium channel epithelial 1 alpha subunit (SCNN1A), transcript variant 3, mRNA. (from RefSeq NM_001159575)
SCNN1A (ENST00000360168.7) at chr12:6346843-6375224 - Homo sapiens sodium channel epithelial 1 alpha subunit (SCNN1A), transcript variant 2, mRNA. (from RefSeq NM_001159576)
SCNN1A (ENST00000228916.7) at chr12:6346847-6375563 - Homo sapiens sodium channel epithelial 1 alpha subunit (SCNN1A), transcript variant 1, mRNA. (from RefSeq NM_001038)
STK39 (ENST00000355999.5) at chr2:167954022-168247595 - Homo sapiens serine/threonine kinase 39 (STK39), mRNA. (from RefSeq NM_013233)
SCNN1G (ENST00000300061.3) at chr16:23182745-23216883 - Homo sapiens sodium channel epithelial 1 gamma subunit (SCNN1G), mRNA. (from RefSeq NM_001039)
SCNN1B (ENST00000343070.7) at chr16:23302302-23381294 - Homo sapiens sodium channel epithelial 1 beta subunit (SCNN1B), mRNA. (from RefSeq NM_000336)
SGK1 (ENST00000528577.5) at chr6:134169881-134177905 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 3, mRNA. (from RefSeq NM_001143677)
SGK1 (ENST00000413996.7) at chr6:134169250-134175991 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 4, mRNA. (from RefSeq NM_001143678)
SGK1 (ENST00000367858.9) at chr6:134169246-134318058 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2, mRNA. (from RefSeq NM_001143676)
SGK1 (ENST00000237305.11) at chr6:134169252-134174896 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 1, mRNA. (from RefSeq NM_005627)
SGK1 (ENST00000367857.9) at chr6:134169353-134174865 - Serine/threonine-protein kinase which is involved in the  regulation of a wide variety of ion channels, membrane  transporters, cellular enzymes, transcription factors, neuronal  excitability, cell growth, proliferation, survival, migration and  apoptosis. Plays an important role in cellular stress response.  Contributes to regulation of renal Na(+) retention, renal K(+)  elimination, salt appetite, gastric acid secretion, intestinal  Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt  sensitivity of blood pressure, salt sensitivity of peripheral  glucose uptake, cardiac repolarization and memory consolidation.  Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2,  K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial  Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2  and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2,  SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid  transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine  transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:  SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter:  SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates  carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT,  SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes:  GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors:  CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport  into epithelial cells by enhancing the stability and expression of  SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L  ubiquitin E3 ligase, promoting its interaction with 14-3-3  proteins, thereby preventing it from binding to SCNN1A/ENAC and  targeting it for degradation. Regulates store-operated Ca(+2)  entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1  directly via its phosphorylation or indirectly via increased  interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and  activates MDM2-dependent ubiquitination of p53/TP53.  Phosphorylates MAPT/TAU and mediates microtubule depolymerization  and neurite formation in hippocampal neurons. Phosphorylates  SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates  APBB1/FE65 and promotes its localization to the nucleus.  Phosphorylates MAPK1/ERK2 and activates it by enhancing its  interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7  and plays an inhibitory role in the NOTCH1 signaling.  Phosphorylates FOXO1 resulting in its relocalization from the  nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit  from the nucleus and interference with FOXO3-dependent  transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits  their activity. Phosphorylates SLC9A3/NHE3 in response to  dexamethasone, resulting in its activation and increased  localization at the cell membrane. Phosphorylates CREB1. Necessary  for vascular remodeling during angiogenesis. Sustained high levels  and activity may contribute to conditions such as hypertension and  diabetic nephropathy. Isoform 2 exhibited a greater effect on cell  plasma membrane expression of SCNN1A/ENAC and Na(+) transport than  isoform 1. (from UniProt O00141)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001282394.1 at chr9:93184930-93319373
NM_006648.3 at chr9:93184930-93320572

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005252144.2 at chr9:93184156-93309196
XM_017015046.1 at chr9:93184156-93319210
XM_017015051.1 at chr9:93184156-93319210
XM_011518930.2 at chr9:93184156-93319210
XM_017015053.1 at chr9:93184156-93319210
XM_017015048.1 at chr9:93184156-93319210
XM_017015055.1 at chr9:93184156-93319210
XM_017015050.1 at chr9:93184156-93319210
XM_017015045.1 at chr9:93184156-93319210
XM_011518927.2 at chr9:93184156-93319210
XM_017015052.1 at chr9:93184156-93319210
XM_017015047.1 at chr9:93184156-93319210
XM_011518928.2 at chr9:93184156-93319210
XM_011518936.2 at chr9:93184156-93319210
XM_017015054.1 at chr9:93184156-93319210
XM_011518935.2 at chr9:93184156-93319210
XM_011518931.2 at chr9:93184156-93319210
XM_017015049.1 at chr9:93184156-93319210
XM_011518929.2 at chr9:93184156-93319210
XM_005252140.2 at chr9:93184156-93319210
XM_005252137.3 at chr9:93184156-93319210
XM_011518932.2 at chr9:93184156-93319210
XM_011518926.2 at chr9:93184156-93319210
XM_005252141.2 at chr9:93184156-93320572
XR_002956803.1 at chr9:93184156-93327581
XR_001746367.1 at chr9:93184156-93327581
XR_002956804.1 at chr9:93184156-93327581
XM_011518937.3 at chr9:93201880-93319210
XM_011518940.2 at chr9:93202740-93319210
XM_011518939.2 at chr9:93209281-93319210

RefSeq Genes

WNK2 at chr9:93184930-93319373 - (NM_001282394) serine/threonine-protein kinase WNK2 isoform 1
WNK2 at chr9:93184930-93320572 - (NM_006648) serine/threonine-protein kinase WNK2 isoform 2

Non-Human RefSeq Genes

Wnk2 at chr9:93184029-93320567 - (NM_001290313) serine/threonine-protein kinase WNK2 isoform b
Wnk2 at chr9:93184029-93319195 - (NM_001290311) serine/threonine-protein kinase WNK2 isoform a
Wnk2 at chr9:93184029-93320567 - (NM_029361) serine/threonine-protein kinase WNK2 isoform c
Wnk2 at chr9:93184851-93320567 - (NM_001191556) serine/threonine-protein kinase WNK2

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93299156
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93319373
WNK2 at chr9:93184930-93320572

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

WNK2 at chr9:93184916-93259075
WNK2 at chr9:93184930-93318271
WNK2 at chr9:93184930-93319373
WNK2 at chr9:93184930-93320572
WNK2 at chr9:93184943-93319204
WNK2 at chr9:93234923-93319208
WNK2 at chr9:93256726-93259251
WNK2 at chr9:93263266-93268040
WNK2 at chr9:93263948-93320572
WNK2 at chr9:93267020-93267815
WNK2 at chr9:93289187-93308584
WNK2 at chr9:93293089-93308588
WNK2 at chr9:93293133-93300326
WNK2 at chr9:93306637-93320564
WNK2 at chr9:93308501-93309195
WNK2 at chr9:93315488-93320566

Retroposed Genes V9, Including Pseudogenes

WNK2_HUMAN at chr2:240452775-240453787 - (AB463351.1-23)
WNK2 at chr2:240452775-240453787 - (AB463351.1-23)
WNK2 at chr2:240452775-240453787 - (AB463351.1-23)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Wnk2_35730 at chr9:93184930-93320572
Wnk2_72448 at chr9:93184930-93320572

BC037965 Alignments in Human Aligned mRNAs

This aligns in multiple positions. Click on a hyperlink to go to tracks display at a particular alignment.
 SIZE IDENTITY CHROMOSOME STRAND  START     END       cDNA   START  END  TOTAL
------------------------------------------------------------------------------
 2115  100.0%          9     +  93289467  93320565  BC037965    12  2126  2172

Non-Human Aligned mRNA Search Results

JW867843 - TSA: Callorhinchus milii ov.comp37484_c0_seq2 mRNA sequence.
BC046464 - Mus musculus WNK lysine deficient protein kinase 2, mRNA (cDNA clone IMAGE:4193361), partial cds.
BC055795 - Mus musculus WNK lysine deficient protein kinase 2, mRNA (cDNA clone IMAGE:6412459), complete cds.
BC060187 - Mus musculus WNK lysine deficient protein kinase 2, mRNA (cDNA clone IMAGE:6832934), partial cds.
BC126602 - Bos taurus WNK lysine deficient protein kinase 2, mRNA (cDNA clone IMAGE:8134703), partial cds.
AK147550 - Mus musculus cDNA, RIKEN full-length enriched library, clone:M5C1074A18 product:similar to Serine/threonine kinase WNK2 (EC 2.7.1.37) (Protein kinase with no lysine 2) (Protein kinase, lysine-deficient 2) [Homo sapiens], full insert sequence.