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Gencode Genes

VCP (ENST00000358901.11) at chr9:35056064-35072625 - <b>VCP</b> ENST00000358901.11 Homo sapiens valosin containing protein VCP transcript variant 
NVL (ENST00000281701.11) at chr1:224227345-224330172 - NVL ENST00000281701.11 Homo sapiens nuclear <b>VCP</b> like NVL transcript variant 1 mRNA from RefSeq NM_002533 
SVIP (ENST00000354193.5) at chr11:22818927-22829801 - SVIP ENST00000354193.5 Homo sapiens small <b>VCP</b> interacting protein SVIP transcript variant 3 mRNA from RefSeq 
UBXN8 (ENST00000265616.10) at chr8:30744164-30767006 -  ... ENST00000265616.6 ENST00000265616.7 ENST00000265616.8 ENST00000265616.9 NM_005671 uc033bgh.1 uc033bgh.2 uc033bgh.3 p97 or <b>VCP</b> valosin-containing protein is a versatile ATPase complex and many 
UBXN6 (ENST00000301281.11) at chr19:4445006-4457794 -  ... UBXN6_HUMAN uc002man.1 uc002man.2 uc002man.3 uc002man.4 Acts in a complex with <b>VCP</b> and cooperates with USP7 in promoting MDM2 deubiquitination and 
NPLOC4 (ENST00000331134.11) at chr17:81556887-81637112 -  ... uc002kat.2 uc002kat.3 uc002kat.4 uc002kat.5 uc002kat.6 The ternary complex containing UFD1L <b>VCP</b> and NPLOC4 binds ubiquitinated proteins and is necessary for 
PLAA (ENST00000397292.8) at chr9:26903372-26947242 -  ... of ubiquitin levels By similarity Interacts with ubiquitin Interacts with <b>VCP</b> Q76353 xeno NbExp 3 IntAct EBI-1994037 EBI-6248077 The PUL 
UBXN4 (ENST00000272638.14) at chr2:135741855-135785056 -  ... protein of the endoplasmic reticulum ER that binds valosin-containing protein <b>VCP</b> MIM 601023 and promotes ER-associated protein degradation ERAD Liang 
UBXN2B (ENST00000399598.7) at chr8:58411361-58451501 -  ... reassembly at the end of mitosis The complex formed with <b>VCP</b> has membrane fusion activity membrane fusion activity requires USO1-GOLGA2 
FCHSD2 (ENST00000409418.9) at chr11:72836745-73142318 -  ... EBI-1215612 EBI-704635 Q96QZ7 MAGI1 NbExp 5 IntAct EBI-1215612 EBI-924464 P55072 <b>VCP</b> NbExp 2 IntAct EBI-1215612 EBI-355164 Event Alternative splicing Named 
UBXN7 (ENST00000296328.9) at chr3:196347662-196432427 -  ... cytosol transcription factor binding nuclear body ubiquitin protein ligase binding <b>VCP-NPL4-UFD1</b> AAA ATPase complex ubiquitin binding post-translational protein modification uc003fwm.1 
UBXN1 (ENST00000301935.10) at chr11:62676500-62679073 -  ... couple retrotranslocation ubiquitination and deglycosylation composed of NGLY1 SAKS1 AMFR <b>VCP</b> and RAD23B Interacts with HOMER2 By similarity Interacts directly 
NSFL1C (ENST00000216879.9) at chr20:1442166-1466849 -  ... provided by RefSeq May 2011 Reduces the ATPase activity of <b>VCP</b> Necessary for the fragmentation of Golgi stacks during mitosis 
DERL2 (ENST00000158771.9) at chr17:5471254-5486178 -  ... and degraded by the proteasome May mediate the interaction between <b>VCP</b> and the degradation substrate In contrast to DERL1 it 
STX5 (ENST00000294179.8) at chr11:62806860-62832051 -  ... similarity Part of a ternary complex containing STX5A NSFL1C and <b>VCP</b> Identified in a unique SNARE complex composed of the 
YOD1 (ENST00000315927.9) at chr1:207043849-207051208 -  ... on the associated substrate to facilitate their threading through the <b>VCP</b> p97 pore Ubiquitin moieties on substrates may present a 
DERL3 (ENST00000620697.3) at chr22_KI270879v1_alt:70865-75368 -  ... and degraded by the proteasome May mediate the interaction between <b>VCP</b> and the degradation substrate Forms homo and heterooligomers with 
UBE4B (ENST00000343090.11) at chr1:10032958-10181239 -  ... conjunction with E1 E2 and E3 By similarity Interacts with <b>VCP</b> By similarity Cytoplasm By similarity Event Alternative splicing Named 
UFD1 (ENST00000263202.15) at chr22:19449911-19479193 -  ... which degrades ubiquitin fusion proteins The ternary complex containing UFD1L <b>VCP</b> and NPLOC4 binds ubiquitinated proteins and is necessary for 
DERL3 (ENST00000318109.12) at chr22:23834503-23839006 -  ... and degraded by the proteasome May mediate the interaction between <b>VCP</b> and the degradation substrate Forms homo and heterooligomers with 
ASPSCR1 (ENST00000306739.9) at chr17:81977629-82017406 -  ... cell surface By similarity Interacts with GLUT4 By similarity P55072 <b>VCP</b> NbExp 2 IntAct EBI-1993677 EBI-355164 Endomembrane system Peripheral membrane 
RNF103 (ENST00000237455.5) at chr2:86603398-86623865 -  ... degradation pathway Protein modification protein ubiquitination Interacts with DERL1 and <b>VCP</b> Endoplasmic reticulum membrane Multi-pass membrane protein Highly expressed in 
TRIM13 (ENST00000378182.4) at chr13:49997042-50018467 -  ... suppressor Protein modification protein ubiquitination Interacts via C-terminal domain with <b>VCP</b> Interacts with AKT1 the interaction ubiquitinates AKT1 and leads 
RNF19A (ENST00000341084.7) at chr8:100257067-100309953 -  ... UBE2L3 and UBE2L6 Interacts with transcription factor Sp1 Interacts with <b>VCP</b> CASR SNCAIP and with some SOD1 variants which cause 
AMFR (ENST00000290649.10) at chr16:56361452-56425545 -  ... CYP3A4 CFTR and APOB for proteasomal degradation Component of a <b>VCP</b> p97 AMFR gp78 complex that participates in the final 
RHBDD1 (ENST00000392062.7) at chr2:226836054-226999210 -  ... transmembrane domains Inhibited by aprotinin Interacts via C-terminus domain with <b>VCP</b> Interacts with ubiquitin and ubiquitinated proteins By similarity Interacts 
SYVN1 (ENST00000377190.8) at chr11:65127279-65134519 -  ... ubiquitination Homodimer Interacts with p53 TP53 and HTT Interacts with <b>VCP</b> HERPUD1 and DERL1 Part of a complex containing SYVN1 
TOMM34 (ENST00000372813.4) at chr20:44942130-44960397 -  ... precursors in an unfolded import compatible state Interacts with HSP90A <b>VCP</b> ATP6M KIAA0665 AMPK and DMAP1 through its TPR repeat 
DERL1 (ENST00000259512.9) at chr8:123013170-123042302 -  ... and degraded by the proteasome May mediate the interaction between <b>VCP</b> and the degradation substrate In case of infection by 
CASR (ENST00000639785.2) at chr3:122183668-122291629 -  ... protein that activates a phosphatidylinositol-calcium second messenger system Interacts with <b>VCP</b> and RNF19A Interacts with ARRB1 By similarity Q15363 TMED2 
SELENOS (ENST00000526049.6) at chr15:101272191-101277485 -  ... of misfolded proteins into the cytosol and the ATPase complex <b>VCP</b> which mediates the translocation and ubiquitination Interacts with DERL1 
RNF125 (ENST00000217740.4) at chr18:32018825-32073219 -  ... conjugating enzyme binding negative regulation of type I interferon production <b>VCP-NPL4-UFD1</b> AAA ATPase complex negative regulation of RIG-I signaling pathway 
NGLY1 (ENST00000280700.10) at chr3:25718944-25783443 -  ... couple retrotranslocation ubiquitination and deglycosylation composed of NGLY1 SAKS1 AMFR <b>VCP</b> and RAD23B Interacts with the proteasome components RAD23B and 
FAF2 (ENST00000261942.7) at chr5:176448385-176510074 -  ... retrograde protein transport ER to cytosol ubiquitin protein ligase binding <b>VCP-NPL4-UFD1</b> AAA ATPase complex lipid particle organization lipase binding azurophil 
ATXN3 (ENST00000644486.2) at chr14:92058552-92106582 -  ... and RAD23B Q9BSU1 C16orf70 NbExp 2 IntAct EBI-946046 EBI-946080 P55072 <b>VCP</b> NbExp 5 IntAct EBI-946046 EBI-355164 Nucleus matrix Note Predominantly 
FAF1 (ENST00000396153.7) at chr1:50437028-50960267 -  ... positive regulation of protein complex assembly ubiquitin protein ligase binding <b>VCP-NPL4-UFD1</b> AAA ATPase complex regulation of protein catabolic process positive 
TRIM21 (ENST00000254436.8) at chr11:4384897-4393702 -  ... degradation of IgG1 heavy chain which is linked to the <b>VCP-mediated</b> ER-associated degradation ERAD pathway Promotes IRF8 ubiquitination which enhanced 
USP15 (ENST00000280377.10) at chr12:62260404-62416389 -  ... by mediating deubiquitination of NFKBIA and deubiquitinates substrates bound to <b>VCP</b> Protects APC and human papillomavirus type 16 protein E6 
FBXO6 (ENST00000376753.9) at chr1:11664200-11674354 -  ... during normal DNA replication Protein modification protein ubiquitination Interacts with <b>VCP</b> By similarity Part of a SCF SKP1 cullin-F-box protein 
HMGCR (ENST00000287936.9) at chr5:75337220-75362101 -  ... by a mechanism probably mediated by the ATPase Valosin-containing protein <b>VCP</b> p97 Lys-248 is the main site of ubiquitination Ubiquitination 
RAD23B (ENST00000358015.8) at chr9:107283279-107332189 -  ... Interacts with PSMD4 and PSMC5 Interacts with AMFR Interacts with <b>VCP</b> the interaction is indirect and mediated by NGLY1 By 
CHEK2 (ENST00000404276.6) at chr22:28687743-28741820 -  ... EBI-1180783 EBI-1266176 Q16537 PPP2R5E NbExp 3 IntAct EBI-1180783 EBI-968374 P55072 <b>VCP</b> NbExp 2 IntAct EBI-1180783 EBI-355164 Isoform 2 Nucleus Note 
VCPIP1 (ENST00000310421.5) at chr8:66628487-66667231 - <b>VCPIP1</b> ENST00000310421.5 Homo sapiens valosin containing protein interacting protein 1 
MATR3 (ENST00000394805.8) at chr5:139293740-139331677 -  ... also called vocal cord and pharyngeal dysfunction with distal myopathy <b>VCPDM</b> MPD2 is a muscular disorder characterized by distal weakness 
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