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Gencode Genes

UBC (ENST00000339647.6) at chr12:124911646-124914650 - <b>UBC</b> ENST00000339647.6 Homo sapiens ubiquitin C UBC mRNA from RefSeq 
UBE2R2 (ENST00000263228.4) at chr9:33817160-33920399 -  ... NM_017811 CDC34B D3DRL5 ENST00000263228.1 ENST00000263228.2 ENST00000263228.3 NM_017811 Q712K3 Q9NX64 UB2R2_HUMAN <b>UBC3B</b> uc003ztm.1 uc003ztm.2 uc003ztm.3 uc003ztm.4 uc003ztm.5 Protein kinase CK2 is 
UBE2M (ENST00000253023.8) at chr19:58555712-58558611 -  ... ENST00000253023.2 ENST00000253023.3 ENST00000253023.4 ENST00000253023.5 ENST00000253023.6 ENST00000253023.7 NM_003969 O76069 P61081 Q8VC50 <b>UBC12</b> UBC12_HUMAN uc002qtl.1 uc002qtl.2 uc002qtl.3 uc002qtl.4 uc002qtl.5 uc002qtl.6 The modification 
UBE2W (ENST00000602593.6) at chr8:73786219-73878862 -  ... ENST00000602593.2 ENST00000602593.3 ENST00000602593.4 ENST00000602593.5 NM_018299 Q1XBE0 Q96B02 Q9H823 Q9HAG6 Q9NV07 <b>UBC16</b> UBE2W_HUMAN uc064nta.1 uc064nta.2 This gene encodes a nuclear-localized ubiquitin-conjugating 
UBE2D2 (ENST00000398733.8) at chr5:139561339-139628434 -  ... ENST00000398733.3 ENST00000398733.4 ENST00000398733.5 ENST00000398733.6 ENST00000398733.7 NM_003339 P51669 P62837 Q3MN78 UB2D2_HUMAN <b>UBC4</b> UBC5B UBCH4 UBCH5B uc003ler.1 uc003ler.2 uc003ler.3 uc003ler.4 Regulated degradation 
UBE2D1 (ENST00000373910.9) at chr10:58335006-58370748 -  ... ENST00000373910.3 ENST00000373910.4 ENST00000373910.5 ENST00000373910.6 ENST00000373910.7 ENST00000373910.8 NM_003338 P51668 SFT UB2D1_HUMAN <b>UBC5A</b> UBCH5 UBCH5A uc001jke.1 uc001jke.2 uc001jke.3 uc001jke.4 The modification of 
UBE2I (ENST00000397514.8) at chr16:1309636-1327017 -  ... ENST00000397514.4 ENST00000397514.5 ENST00000397514.6 ENST00000397514.7 NM_003345 P50550 P63279 Q15698 Q59GX1 Q86VB3 <b>UBC9</b> UBC9_HUMAN UBCE9 uc002clg.1 uc002clg.2 uc002clg.3 uc002clg.4 The modification of 
UBE2D3 (ENST00000453744.7) at chr4:102794383-102827551 -  ... ENST00000453744.4 ENST00000453744.5 ENST00000453744.6 NM_181891 P47986 P61077 Q6IB88 Q6NXS4 Q8N924 UB2D3_HUMAN <b>UBC5C</b> UBCH5C uc003hwl.1 uc003hwl.2 uc003hwl.3 uc003hwl.4 uc003hwl.5 uc003hwl.6 The modification 
ZNF146 (ENST00000443387.3) at chr19:36215106-36238768 -  ... uc002odq.4 uc002odq.5 uc002odq.6 Binds DNA Interacts with SUMO conjugating enzyme <b>UBC9</b> UBE2I Interacts with the telomeric protein TERF2IP Nucleus Liver 
RWDD3 (ENST00000370202.5) at chr1:95234210-95247225 -  ... proteins including HIF1A PIAS and I-kappa-B through direct interaction with <b>UBC9</b> Has no effect on ubiquitination P63165 SUMO1 NbExp 2 
NFATC2IP (ENST00000320805.9) at chr16:28950937-28967092 -  ... expression By similarity Down-regulates formation of poly-SUMO chains by UBE2I <b>UBC9</b> By similarity from UniProt Q8NCF5 B7Z4G5 ENST00000320805.1 ENST00000320805.2 ENST00000320805.3 
SYVN1 (ENST00000377190.8) at chr11:65127279-65134519 -  ... E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated <b>UBC7</b> E2 ligase and transfers it to substrates promoting their 
RANBP2 (ENST00000283195.11) at chr2:108719482-108785809 -  ... cycle The encoded protein directly interacts with the E2 enzyme <b>UBC9</b> and strongly enhances SUMO1 transfer from UBC9 to the 
RANGAP1 (ENST00000356244.8) at chr22:41244779-41286187 -  ... a tight complex in association with RANBP2 NUP358 and UBE2I <b>UBC9</b> the ubiquitin-conjugating enzyme E2 Interacts with UBE2I the interaction 
PPM1J (ENST00000309276.11) at chr1:112709998-112715332 -  ... phosphoprotein H 2 O a protein phosphate Interacts with UBE2I <b>UBC9</b> By similarity Event Alternative splicing Named isoforms 2 Name 
MUL1 (ENST00000264198.5) at chr1:20499448-20508151 -  ... modification protein sumoylation Homooligomer Interacts with MAP3K7 TAK1 Interacts with <b>UBC9</b> Interacts with and sumoylates DNM1L Q92624 APPBP2 NbExp 3 
EGR2 (ENST00000242480.4) at chr10:62811996-62816366 -  ... protein sumoylation Interacts with HCFC1 Interacts with WWP2 Interacts with <b>UBC9</b> Nucleus Event Alternative splicing Named isoforms 2 Name Long 
TRAF6 (ENST00000526995.6) at chr11:36483769-36510272 -  ... to proinflammatory cytokines The interaction of this protein with UBE2N <b>UBC13</b> and UBE2V1 UEV1A which are ubiquitin conjugating enzymes catalyzing 
FAF2 (ENST00000261942.7) at chr5:176448385-176510074 -  ... in a complex that contains SEL1L OS9 FAF2 UBXD8 UBE2J1 <b>UBC6E</b> and AUP1 Interacts with YOD1 Cytoplasm Lipid droplet Endoplasmic 
AUP1 (ENST00000377526.4) at chr2:74526652-74529706 -  ... in a complex that contains SEL1L OS9 FAF2 UBXD8 UBE2J1 <b>UBC6E</b> and AUP1 Interacts with the cytoplasmic tail of ITGA2B 
RNF168 (ENST00000318037.3) at chr3:196468783-196503768 -  ... repair proteins to sites of DNA damage Acts with UBE2N <b>UBC13</b> to amplify the RNF8-dependent histone ubiquitination Recruited to sites 
GGA3 (ENST00000537686.6) at chr17:75236599-75261606 -  ... EPN4 NECAP1 NECAP2 and AFTPH aftiphilin Interacts with TSG101 and <b>UBC</b> Q15276 RABEP1 NbExp 4 IntAct EBI-447404 EBI-447043 P0CG47 UBB 
GGA1 (ENST00000343632.9) at chr22:37608834-37633564 -  ... SYNRG EPN4 NECAP2 and AFTPH aftiphilin Interacts with TSG101 and <b>UBC</b> Interacts with RNF11 Q15276 RABEP1 NbExp 8 IntAct EBI-447141 
RABGEF1 (ENST00000284957.9) at chr7:66740733-66811464 -  ... EBI-913954 EBI-739657 P0CG47 UBB NbExp 6 IntAct EBI-913954 EBI-413034 P62990 <b>UBC</b> xeno NbExp 2 IntAct EBI-913954 EBI-413053 Cytoplasm Early endosome 
ZBTB17 (ENST00000375743.9) at chr1:15941869-15976101 -  ... of transcription Interacts with TRAF2 interfering with the binding of <b>UBC13</b> to TRAF2 and inhibiting TRAF2 E3 ligase activity By 
GGA2 (ENST00000309859.8) at chr16:23463542-23510494 -  ... cytosolic acidic cluster-dileucine AC-LL motif Monomer Interacts with NECAP1 TSG101 <b>UBC</b> and AFTPH aftiphilin Interacts with CNST By similarity Interacts 
IPO13 (ENST00000372343.8) at chr1:43946950-43968022 -  ... cytoplasm and nucleus By similarity Mediates the nuclear import of <b>UBC9</b> the RBM8A MAGOH complex PAX6 and probably other members 
UBE2V2 (ENST00000523111.7) at chr8:48008431-48064708 -  ... cells after DNA damage Heterodimer with UBE2N Binds CHFR Q94A97 <b>UBC35</b> xeno NbExp 3 IntAct EBI-714329 EBI-994120 P61088 UBE2N NbExp 
FANCL (ENST00000233741.9) at chr2:58159247-58241325 -  ... Q9NW38-1 Sequence Displayed Name 2 IsoId Q9NW38-2 Sequence VSP_041727 The <b>UBC-RWD</b> region URD region mediates interaction with FANCI and FANCD2 
DNMT1 (ENST00000359526.9) at chr19:10133346-10194953 -  ... and DNMT3B Interacts with the PRC2 EED-EZH2 complex Interacts with <b>UBC9</b> and BAZ2A TIP5 Interacts with UHRF1 promoting its recruitment 
CHFR (ENST00000450056.7) at chr12:132832356-132887605 -  ... Lys-63 linked polyubiquitin chains and functions with the specific ubiquitin-conjugating <b>UBC13-MMS2</b> UBE2N-UBE2V2 heterodimer Substrates that are polyubiquitinated at Lys-63 are 
OTUB1 (ENST00000538426.6) at chr11:63986438-63998412 -  ... independently of ubiquitin thioesterase activity by binding and inhibiting UBE2N <b>UBC13</b> the E2 partner of RNF168 thereby limiting spreading of 
DNMT3A (ENST00000321117.10) at chr2:25227874-25341925 -  ... 1 DNMT3A homodimer and 2 DNMT3L subunits DNMT3L-DNMT3A-DNMT3A-DNMT3L Interacts with <b>UBC9</b> PIAS1 and PIAS2 By similarity Binds the ZNF238 transcriptional 
DHX9 (ENST00000367549.4) at chr1:182839347-182887982 -  ... interactions may be indirect Interaction with TOP2A is promoted by <b>UBC9</b> Interacts with histone H2AFX and this requires phosphorylation of 
AMFR (ENST00000290649.10) at chr16:56361452-56425545 -  ... through a region distinct from the RING finger with UBE2G2 <b>UBC7</b> Component of the VCP p97-AMFR gp78 complex that enhances 
CDKN2A (ENST00000579755.2) at chr9:21967752-21994392 -  ... COMMD1 and promotes its Lys63 linked polyubiquitination Interacts with UBE2I <b>UBC9</b> and enhances sumoylation of a number of its binding 
UBE2V1 (ENST00000371674.8) at chr20:50081124-50113150 -  ... JNK cascade cell differentiation ubiquitin conjugating enzyme complex macromolecular complex <b>UBC13-UEV1A</b> complex positive regulation of I-kappaB kinase NF-kappaB signaling positive 
UBE2E2 (ENST00000396703.6) at chr3:23203327-23591794 -  ... RefSeq NM_152653 ENST00000396703.1 ENST00000396703.2 ENST00000396703.3 ENST00000396703.4 ENST00000396703.5 NM_152653 Q96LR5 UB2E2_HUMAN <b>UBCH8</b> uc003ccg.1 uc003ccg.2 uc003ccg.3 uc003ccg.4 Accepts ubiquitin from the E1 
UBE2D4 (ENST00000222402.8) at chr7:43926436-43956136 -  ... ENST00000222402.1 ENST00000222402.2 ENST00000222402.3 ENST00000222402.4 ENST00000222402.5 ENST00000222402.6 ENST00000222402.7 NM_015983 Q9Y2X8 UB2D4_HUMAN <b>UBCH5D</b> uc003tja.1 uc003tja.2 uc003tja.3 uc003tja.4 Accepts ubiquitin from the E1 
UBLCP1 (ENST00000296786.8) at chr5:159263290-159286036 -  ... ENST00000296786.1 ENST00000296786.2 ENST00000296786.3 ENST00000296786.4 ENST00000296786.5 ENST00000296786.6 ENST00000296786.7 NM_145049 Q8WVY7 Q96DK5 <b>UBCP1_HUMAN</b> uc003lxq.1 uc003lxq.2 uc003lxq.3 Dephosphorylates 26S nuclear proteasomes thereby decreasing 
UBE2E1 (ENST00000306627.8) at chr3:23805955-23891640 -  ... ENST00000306627.1 ENST00000306627.2 ENST00000306627.3 ENST00000306627.4 ENST00000306627.5 ENST00000306627.6 ENST00000306627.7 NM_003341 P51965 UB2E1_HUMAN <b>UBCH6</b> uc003cch.1 uc003cch.2 uc003cch.3 uc003cch.4 uc003cch.5 The modification of proteins 
CDC34 (ENST00000215574.9) at chr19:531760-542087 -  ... ENST00000215574.2 ENST00000215574.3 ENST00000215574.4 ENST00000215574.5 ENST00000215574.6 ENST00000215574.7 ENST00000215574.8 NM_004359 P49427 UB2R1_HUMAN <b>UBCH3</b> UBE2R1 uc002lov.1 uc002lov.2 uc002lov.3 uc002lov.4 uc002lov.5 uc002lov.6 The protein 
UBOX5 (ENST00000217173.7) at chr20:3107573-3159865 -  ... ENST00000217173.5 ENST00000217173.6 KIAA0860 NM_014948 O94941 Q6IAR5 Q86X87 Q9H4J2 RNF37 RNF37_HUMAN <b>UBCE7IP5</b> uc002whw.1 uc002whw.2 uc002whw.3 uc002whw.4 uc002whw.5 uc002whw.6 This gene encodes 
UBE2E3 (ENST00000410062.9) at chr2:180980605-181063425 -  ... ENST00000410062.4 ENST00000410062.5 ENST00000410062.6 ENST00000410062.7 ENST00000410062.8 NM_006357 Q5U0R7 Q7Z4W4 Q969T4 UB2E3_HUMAN <b>UBCE4</b> UBCH9 uc002unr.1 uc002unr.2 uc002unr.3 uc002unr.4 The modification of proteins 
UBE2L6 (ENST00000287156.9) at chr11:57551662-57567672 -  ... ENST00000287156.4 ENST00000287156.5 ENST00000287156.6 ENST00000287156.7 ENST00000287156.8 NM_004223 O14933 Q8N5D8 Q9UEZ0 UB2L6_HUMAN <b>UBCH8</b> uc001nkn.1 uc001nkn.2 uc001nkn.3 uc001nkn.4 The modification of proteins with 
UBE2L3 (ENST00000342192.9) at chr22:21567714-21624034 -  ... ENST00000342192.5 ENST00000342192.6 ENST00000342192.7 ENST00000342192.8 NM_003347 P51966 P68036 P70653 Q9HAV1 UB2L3_HUMAN <b>UBCE7</b> UBCH7 uc002zva.1 uc002zva.2 uc002zva.3 The modification of proteins with 
RNF144A (ENST00000320892.11) at chr2:6917412-7044179 -  ... ENST00000320892.6 ENST00000320892.7 ENST00000320892.8 ENST00000320892.9 KIAA0161 NM_014746 P50876 Q585H5 R144A_HUMAN RNF144 <b>UBCE7IP4</b> uc002qys.1 uc002qys.2 uc002qys.3 uc002qys.4 uc002qys.5 This gene encodes a 
RNF216 (ENST00000389902.8) at chr7:5620047-5781663 -  ... NM_207111 Q6Y691 Q75ML7 Q7Z2H7 Q7Z7C1 Q8NHW7 Q9NWF9 Q9NYT1 RN216_HUMAN TRIAD3 <b>UBCE7IP1</b> ZIN uc003sox.1 uc003sox.2 uc003sox.3 uc003sox.4 This gene encodes a 
ARIH1 (ENST00000379887.9) at chr15:72474330-72602987 -  ... ENST00000379887.7 ENST00000379887.8 HUSSY-27 MOP6 NM_005744 O76026 Q9H3T6 Q9UEN0 Q9UP39 Q9Y4X5 <b>UBCH7BP</b> uc002aut.1 uc002aut.2 uc002aut.3 uc002aut.4 uc002aut.5 uc002aut.6 E3 ubiquitin-protein ligase 
RBCK1 (ENST00000356286.10) at chr20:408299-432139 -  ... ENST00000356286.8 ENST00000356286.9 HOIL1_HUMAN NR_136659 O95623 Q86SL2 Q96BS3 Q9BYM8 Q9BYM9 RNF54 <b>UBCE7IP3</b> XAP3 XAP4 uc002wdp.1 uc002wdp.2 uc002wdp.3 uc002wdp.4 uc002wdp.5 uc002wdp.6 The 
BIRC6 (ENST00000421745.7) at chr2:32357023-32618878 -  ... BIR baculoviral inhibition of apoptosis protein repeat domain and a <b>UBCc</b> ubiquitin-conjugating enzyme E2 catalytic domain This protein inhibits apoptosis 
RNF167 (ENST00000262482.11) at chr17:4940268-4945222 -  ... that interacts with TSSC5 SLC22A18 MIM 602631 and together with <b>UBCH6</b> UBE2E1 MIM 602916 facilitates TSSC5 polyubiquitylation Yamada and Gorbsky 
RNF8 (ENST00000373479.9) at chr6:37353983-37394734 -  ... interact with several class II ubiquitin-conjugating enzymes E2 including UBE2E1 <b>UBCH6</b> UBE2E2 and UBE2E3 and may act as an ubiquitin 
UBE3D (ENST00000369747.8) at chr6:82892390-83065841 -  ... by the proteasome Protein modification protein ubiquitination Interacts with UBE2C <b>UbcH10</b> E2 ubiquitin-conjugating enzyme In vitro interacts with cyclin-B Cytoplasm 
PJA1 (ENST00000374571.5) at chrX:69160861-69165453 -  ... motif and it can interact with the E2 ubiquitin-conjugating enzyme <b>UbcH5B</b> This gene is located in an area of chromosome 
CUL9 (ENST00000252050.9) at chr6:43182196-43224587 -  ... p53 TP53 in the cytoplasm of unstressed cells Interacts with <b>UBCH7</b> and UBCH8 Interacts with CUL7 and RBX1 The CUL7-CUL9 
RNF5 (ENST00000449794.2) at chr6_GL000250v2_alt:3510956-3513395 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000456167.2) at chr6_GL000251v2_alt:3616712-3619145 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000453473.2) at chr6_GL000253v2_alt:3483335-3485774 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000413786.2) at chr6_GL000254v2_alt:3520375-3522812 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000432616.2) at chr6_GL000255v2_alt:3401555-3403994 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000445885.6) at chr6_GL000256v2_alt:3494561-3497000 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
RNF5 (ENST00000375094.4) at chr6:32178405-32180793 -  ... ligase activity May function together with E2 ubiquitin-conjugating enzymes UBE2D1 <b>UBCH5A</b> and UBE2D2 UBC4 Mediates ubiquitination of PXN paxillin and 
UBE2S (ENST00000264552.14) at chr19:55399745-55407788 -  ... Lys-11 linked polyubiquitin chains initiated by the E2 enzyme UBE2C <b>UBCH10</b> on APC C substrates enhancing the degradation of APC 
RNF40 (ENST00000324685.11) at chr16:30762322-30776307 -  ... enzyme UBE2A or UBE2B reports about the cooperation with UBE2E1 <b>UBCH</b> are contradictory Required for transcriptional activation of Hox genes 
RNF20 (ENST00000389120.8) at chr9:101533853-101563344 -  ... enzyme UBE2A or UBE2B reports about the cooperation with UBE2E1 <b>UBCH</b> are contradictory Required for transcriptional activation of Hox genes 
ANAPC2 (ENST00000323927.3) at chr9:137174784-137188560 -  ... subunits Interacts through the cullin domain with ANAPC11 and with <b>UBCH10</b> Event Alternative splicing Named isoforms 2 Name 1 IsoId 
RAG1 (ENST00000299440.6) at chr11:36568007-36579762 -  ... 23 bp By similarity Autoubiquitinated in the presence of CDC34 <b>UBCH3</b> By similarity Defects in RAG1 are a cause of 
RPS27A (ENST00000272317.11) at chr2:55232688-55235853 -  ... Q91888 Q9BQ77 Q9BWD6 Q9BX98 Q9UEF2 Q9UEG1 Q9UEK8 Q9UPK7 RS27A_HUMAN UBA80 <b>UBCEP1</b> uc002ryk.1 uc002ryk.2 uc002ryk.3 uc002ryk.4 uc002ryk.5 Ubiquitin a highly conserved