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Gencode Genes

TPX2 (ENST00000300403.11) at chr20:31739290-31801800 - Homo sapiens TPX2 microtubule nucleation factor (TPX2), mRNA. (from RefSeq NM_012112)
TPX2 (ENST00000340513.4) at chr20:31739271-31801805 - Spindle assembly factor. Required for normal assembly of  mitotic spindles. Required for normal assembly of microtubules  during apoptosis. Required for chromatin and/or kinetochore  dependent microtubule nucleation. Mediates AURKA localization to  spindle microtubules. Activates AURKA by promoting its  autophosphorylation at 'Thr-288' and protects this residue against  dephosphorylation. (from UniProt Q9ULW0)
KIF15 (ENST00000627272.3) at chr3_KN196475v1_fix:287144-378606 - Homo sapiens kinesin family member 15 (KIF15), mRNA. (from RefSeq NM_020242)
KIF15 (ENST00000326047.9) at chr3:44761794-44853256 - Homo sapiens kinesin family member 15 (KIF15), mRNA. (from RefSeq NM_020242)
RAN (ENST00000392369.6) at chr12:130872070-130876281 - GTP-binding protein involved in nucleocytoplasmic  transport. Required for the import of protein into the nucleus and  also for RNA export. Involved in chromatin condensation and  control of cell cycle (By similarity). The complex with BIRC5/  survivin plays a role in mitotic spindle formation by serving as a  physical scaffold to help deliver the RAN effector molecule TPX2  to microtubules. Acts as a negative regulator of the kinase  activity of VRK1 and VRK2. (from UniProt P62826)
AURKA (ENST00000371356.6) at chr20:56369390-56392196 - Mitotic serine/threonine kinases that contributes to the  regulation of cell cycle progression. Associates with the  centrosome and the spindle microtubules during mitosis and plays a  critical role in various mitotic events including the  establishment of mitotic spindle, centrosome duplication,  centrosome separation as well as maturation, chromosomal  alignment, spindle assembly checkpoint, and cytokinesis. Required  for initial activation of CDK1 at centrosomes. Phosphorylates  numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B,  DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1,  TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase  activity. Required for normal axon formation. Plays a role in  microtubule remodeling during neurite extension. Important for  microtubule formation and/or stabilization. Also acts as a key  regulatory component of the p53/TP53 pathway, and particularly the  checkpoint-response pathways critical for oncogenic transformation  of cells, by phosphorylating and stabilizating p53/TP53.  Phosphorylates its own inhibitors, the protein phosphatase type 1  (PP1) isoforms, to inhibit their activity. Necessary for proper  cilia disassembly prior to mitosis. (from UniProt O14965)
BIRC5 (ENST00000592734.5) at chr17:78214317-78222992 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
BIRC5 (ENST00000590925.6) at chr17:78214263-78223554 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
BIRC5 (ENST00000590449.1) at chr17:78214280-78215099 - Multitasking protein that has dual roles in promoting  cell proliferation and preventing apoptosis. Component of a  chromosome passage protein complex (CPC) which is essential for  chromosome alignment and segregation during mitosis and  cytokinesis. Acts as an important regulator of the localization of  this complex; directs CPC movement to different locations from the  inner centromere during prometaphase to midbody during cytokinesis  and participates in the organization of the center spindle by  associating with polymerized microtubules. The complex with RAN  plays a role in mitotic spindle formation by serving as a physical  scaffold to help deliver the RAN effector molecule TPX2 to  microtubules. May counteract a default induction of apoptosis in  G2/M phase. The acetylated form represses STAT3 transactivation of  target gene promoters. May play a role in neoplasia. Inhibitor of  CASP3 and CASP7. Isoform 2 and isoform 3 do not appear to play  vital roles in mitosis. Isoform 3 shows a marked reduction in its  anti-apoptotic effects when compared with the displayed wild-type  isoform. (from UniProt O15392)
AURKA (ENST00000395914.5) at chr20:56369389-56392295 - Homo sapiens aurora kinase A (AURKA), transcript variant 3, mRNA. (from RefSeq NM_198434)
AURKA (ENST00000395911.5) at chr20:56369390-56392215 - Homo sapiens aurora kinase A (AURKA), transcript variant 1, mRNA. (from RefSeq NM_198433)
AURKA (ENST00000395913.7) at chr20:56369390-56392337 - Homo sapiens aurora kinase A (AURKA), transcript variant 4, mRNA. (from RefSeq NM_198435)
AURKA (ENST00000395915.7) at chr20:56369390-56392296 - Homo sapiens aurora kinase A (AURKA), transcript variant 6, mRNA. (from RefSeq NM_198437)
AURKA (ENST00000347343.6) at chr20:56369390-56392205 - Homo sapiens aurora kinase A (AURKA), transcript variant 2, mRNA. (from RefSeq NM_003600)
AURKA (ENST00000312783.10) at chr20:56369390-56392295 - Homo sapiens aurora kinase A (AURKA), transcript variant 5, mRNA. (from RefSeq NM_198436)
BIRC5 (ENST00000374948.6) at chr17:78214264-78225636 - Homo sapiens baculoviral IAP repeat containing 5 (BIRC5), transcript variant 2, mRNA. (from RefSeq NM_001012270)
RAN (ENST00000543796.6) at chr12:130872066-130877678 - Homo sapiens RAN, member RAS oncogene family (RAN), transcript variant 1, mRNA. (from RefSeq NM_006325)
PIK3R1 (ENST00000521657.5) at chr5:68215776-68298753 - Binds to activated (phosphorylated) protein-Tyr kinases,  through its SH2 domain, and acts as an adapter, mediating the  association of the p110 catalytic unit to the plasma membrane.  Necessary for the insulin-stimulated increase in glucose uptake  and glycogen synthesis in insulin-sensitive tissues. Plays an  important role in signaling in response to FGFR1, FGFR2, FGFR3,  FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role  in ITGB2 signaling. (from UniProt P27986)
PIK3R1 (ENST00000523872.1) at chr5:68292568-68298756 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 4, mRNA. (from RefSeq NM_001242466)
PIK3R1 (ENST00000336483.9) at chr5:68290637-68298583 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 2, mRNA. (from RefSeq NM_181504)
PIK3R1 (ENST00000320694.12) at chr5:68288368-68298583 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 3, mRNA. (from RefSeq NM_181524)
PIK3R1 (ENST00000521381.6) at chr5:68215756-68301821 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 1, mRNA. (from RefSeq NM_181523)
GRB2 (ENST00000648046.1) at chr17:75319479-75405699 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392564.5) at chr17:75318076-75393864 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392563.5) at chr17:75318076-75393656 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392562.5) at chr17:75318076-75405486 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
NCK1 (ENST00000288986.6) at chr3:136862208-136949126 - Adapter protein which associates with tyrosine-  phosphorylated growth factor receptors, such as KDR and PDGFRB, or  their cellular substrates. Maintains low levels of EIF2S1  phosphorylation by promoting its dephosphorylation by PP1. Plays a  role in the DNA damage response, not in the detection of the  damage by ATM/ATR, but for efficient activation of downstream  effectors, such as that of CHEK2. Plays a role in ELK1-dependent  transcriptional activation in response to activated Ras signaling. (from UniProt P16333)
NCK1 (ENST00000481752.6) at chr3:136862208-136951606 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA. (from RefSeq NM_006153)
NCK1 (ENST00000469404.1) at chr3:136930470-136949823 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 2, mRNA. (from RefSeq NM_001190796)
GRB2 (ENST00000316615.9) at chr17:75318076-75405709 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 2, mRNA. (from RefSeq NM_203506)
GRB2 (ENST00000316804.10) at chr17:75318076-75405678 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1, mRNA. (from RefSeq NM_002086)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_012112.5 at chr20:31739290-31801800

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_011528699.2 at chr20:31739248-31801800
XM_011528697.2 at chr20:31739269-31801800
XM_011528700.3 at chr20:31739280-31801802

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

TPX2 at chr20:31739290-31801800

RefSeq Genes

TPX2 at chr20:31739290-31801800 - (NM_012112) targeting protein for Xklp2

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

TPX2 microtubule nucleation factor at chr20:31739290-31801800 - (NM_012112.5)

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

TPX2 microtubule nucleation factor, transcript variant X2 at chr20:31739248-31801800 - (XM_011528699.2)
TPX2 microtubule nucleation factor, transcript variant X1 at chr20:31739269-31801800 - (XM_011528697.2)
TPX2 microtubule nucleation factor, transcript variant X3 at chr20:31739280-31801802 - (XM_011528700.3)

Non-Human RefSeq Genes

Tpx2 at chr20:31757477-31801071 - (NM_001107790) targeting protein for Xklp2
TPX2 at chr20:31775877-31801080 - (NM_204437) targeting protein for Xklp2
tpx2 at chr20:31782293-31798555 - (NM_001102763) targeting protein for Xklp2
Tpx2 at chr20:31757477-31801073 - (NM_001141976) targeting protein for Xklp2
Tpx2 at chr20:31757477-31801073 - (NM_001141978) targeting protein for Xklp2
Tpx2 at chr20:31757477-31801073 - (NM_001141977) targeting protein for Xklp2
Tpx2 at chr20:31757477-31801073 - (NM_001141975) targeting protein for Xklp2
Tpx2 at chr20:31757477-31801073 - (NM_028109) targeting protein for Xklp2
TPX2 at chr20:31757468-31801194 - (NM_001098898) targeting protein for Xklp2
TPX2 at chr20:31739503-31801801 - (NM_001132272) targeting protein for Xklp2
tpx2.L at chr20:31782293-31797499 - (NM_001088537) targeting protein for Xklp2-A
tpx2.S at chr20:31782293-31797499 - (NM_001093282) targeting protein for Xklp2-B

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739290-31801800

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739290-31801800

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739290-31801800

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739290-31801800

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TPX2 at chr20:31739271-31801805
TPX2 at chr20:31739271-31801805

International Knockout Mouse Consortium Genes Mapped to Human Genome

Tpx2_101575 at chr20:31739101-31801800
Tpx2_71545 at chr20:31739101-31801800

Human Aligned mRNA Search Results

BC004136 - Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis), mRNA (cDNA clone MGC:1537 IMAGE:3509275), complete cds.
BC020207 - Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis), mRNA (cDNA clone MGC:31820 IMAGE:5015279), complete cds.
BC011357 - Homo sapiens TPX2, microtubule-associated, homolog (Xenopus laevis), mRNA (cDNA clone IMAGE:4179581), partial cds.
AF244547 - Homo sapiens targeting protein for Xklp2 (TPX2) mRNA, partial cds.
AK093379 - Homo sapiens cDNA FLJ36060 fis, clone TESTI2018521, moderately similar to Targeting protein for Xklp2; TPX2.

Non-Human Aligned mRNA Search Results

JP020080 - TSA: Mustela putorius furo MPF81015329contig1/1 mRNA sequence.
BC060619 - Mus musculus TPX2, microtubule-associated protein homolog (Xenopus laevis), mRNA (cDNA clone MGC:79188 IMAGE:6812536), complete cds.
BC146057 - Bos taurus TPX2, microtubule-associated, homolog (Xenopus laevis), mRNA (cDNA clone MGC:152526 IMAGE:8458150), complete cds.
BC068637 - Xenopus laevis targeting protein for Xklp2, mRNA (cDNA clone MGC:79885 IMAGE:6636542), complete cds.
KF218349 - Corbicula fluminea thioredoxin peroxidase 2 (TPX2) mRNA, partial cds.
JU331321 - TSA: Macaca mulatta Mamu_518298 mRNA sequence.
JU474761 - TSA: Macaca mulatta Mamu_374875 mRNA sequence.
MK257743 - Haliotis discus hannai thioredoxin peroxidase 2 (TPX2) mRNA, complete cds.
AB168417 - Macaca fascicularis testis cDNA clone: QtsA-11969, similar to human TPX2, microtubule-associated protein homolog (Xenopuslaevis) (TPX2), mRNA, RefSeq: NM_012112.4.

Pfam Domains in UCSC Genes

TPX2 at chr20:31798403-31800990