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Gencode Genes

TOPORS (ENST00000360538.7) at chr9:32540544-32552586 - Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 1, mRNA. (from RefSeq NM_005802)
TOPORS (ENST00000379858.1) at chr9:32540826-32552553 - Homo sapiens TOP1 binding arginine/serine rich protein (TOPORS), transcript variant 2, mRNA. (from RefSeq NM_001195622)
NKX3-1 (ENST00000523261.1) at chr8:23680988-23682889 - Homo sapiens NK3 homeobox 1 (NKX3-1), transcript variant 2, mRNA. (from RefSeq NM_001256339)
SIN3A (ENST00000394949.8) at chr15:75371130-75451585 - Acts as a transcriptional repressor. Corepressor for  REST. Interacts with MXI1 to repress MYC responsive genes and  antagonize MYC oncogenic activities. Also interacts with MXD1-MAX  heterodimers to repress transcription by tethering SIN3A to DNA  (By similarity). Acts cooperatively with OGT to repress  transcription in parallel with histone deacetylation. (from UniProt Q96ST3)
SIN3A (ENST00000360439.8) at chr15:75370933-75455783 - Homo sapiens SIN3 transcription regulator family member A (SIN3A), transcript variant 3, mRNA. (from RefSeq NM_001145357)
NKX3-1 (ENST00000380871.5) at chr8:23678697-23682938 - Homo sapiens NK3 homeobox 1 (NKX3-1), transcript variant 1, mRNA. (from RefSeq NM_006167)
SIN3A (ENST00000394947.8) at chr15:75369379-75451690 - Homo sapiens SIN3 transcription regulator family member A (SIN3A), transcript variant 2, mRNA. (from RefSeq NM_015477)
IKBKE (ENST00000584998.5) at chr1:206470495-206496274 - Homo sapiens inhibitor of nuclear factor kappa B kinase subunit epsilon (IKBKE), transcript variant 3, mRNA. (from RefSeq NM_001193321)
IKBKE (ENST00000581977.7) at chr1:206470476-206496889 - Homo sapiens inhibitor of nuclear factor kappa B kinase subunit epsilon (IKBKE), transcript variant 1, mRNA. (from RefSeq NM_014002)
UBE2D3 (ENST00000349311.12) at chr4:102797264-102827849 - Accepts ubiquitin from the E1 complex and catalyzes its  covalent attachment to other proteins. In vitro catalyzes 'Lys-  11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates  with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the  polyubiquitination of NFKBIA leading to its subsequent proteasomal  degradation. Acts as an initiator E2, priming the phosphorylated  NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a  monoubiquitin. Ubiquitin chain elongation is then performed by  CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-  linked ubiquitin. Acts also as an initiator E2, in conjunction  with RNF8, for the priming of PCNA. Monoubiquitination of PCNA,  and its subsequent polyubiquitination, are essential events in the  operation of the DNA damage tolerance (DDT) pathway that is  activated after DNA damage caused by UV or chemical agents during  S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to  perform ubiquitination at DNA damage sites following ionizing  radiation leading to DNA repair. Targets DAPK3 for ubiquitination  which influences promyelocytic leukemia protein nuclear body (PML-  NB) formation in the nucleus. In conjunction with the MDM2 and  TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports  NRDP1-mediated ubiquitination and degradation of ERBB3 and of  BRUCE which triggers apoptosis. In conjunction with the CBL E3  ligase, targets EGFR for polyubiquitination at the plasma membrane  as well as during its internalization and transport on endosomes.  In conjunction with the STUB1 E3 quality control E3 ligase,  ubiquitinates unfolded proteins to catalyze their immediate  destruction (By similarity). (from UniProt P61077)
UBE2D3 (ENST00000321805.11) at chr4:102797235-102827553 - Accepts ubiquitin from the E1 complex and catalyzes its  covalent attachment to other proteins. In vitro catalyzes 'Lys-  11'-, as well as 'Lys-48'-linked polyubiquitination. Cooperates  with the E2 CDC34 and the SCF(FBXW11) E3 ligase complex for the  polyubiquitination of NFKBIA leading to its subsequent proteasomal  degradation. Acts as an initiator E2, priming the phosphorylated  NFKBIA target at positions 'Lys-21' and/or 'Lys-22' with a  monoubiquitin. Ubiquitin chain elongation is then performed by  CDC34, building ubiquitin chains from the UBE2D3-primed NFKBIA-  linked ubiquitin. Acts also as an initiator E2, in conjunction  with RNF8, for the priming of PCNA. Monoubiquitination of PCNA,  and its subsequent polyubiquitination, are essential events in the  operation of the DNA damage tolerance (DDT) pathway that is  activated after DNA damage caused by UV or chemical agents during  S-phase. Associates with the BRCA1/BARD1 E3 ligase complex to  perform ubiquitination at DNA damage sites following ionizing  radiation leading to DNA repair. Targets DAPK3 for ubiquitination  which influences promyelocytic leukemia protein nuclear body (PML-  NB) formation in the nucleus. In conjunction with the MDM2 and  TOPORS E3 ligases, functions ubiquitination of p53/TP53. Supports  NRDP1-mediated ubiquitination and degradation of ERBB3 and of  BRUCE which triggers apoptosis. In conjunction with the CBL E3  ligase, targets EGFR for polyubiquitination at the plasma membrane  as well as during its internalization and transport on endosomes.  In conjunction with the STUB1 E3 quality control E3 ligase,  ubiquitinates unfolded proteins to catalyze their immediate  destruction (By similarity). (from UniProt P61077)
PLK1 (ENST00000300093.9) at chr16:23678889-23690367 - Homo sapiens polo like kinase 1 (PLK1), mRNA. (from RefSeq NM_005030)
UBE2D3 (ENST00000394804.6) at chr4:102794386-102827948 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 2, mRNA. (from RefSeq NM_181886)
UBE2D3 (ENST00000394801.8) at chr4:102795976-102827948 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 4, mRNA. (from RefSeq NM_181888)
UBE2D3 (ENST00000343106.9) at chr4:102796134-102827122 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 8, mRNA. (from RefSeq NM_181892)
UBE2D3 (ENST00000394803.9) at chr4:102795976-102828159 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 5, mRNA. (from RefSeq NM_181889)
UBE2D3 (ENST00000357194.10) at chr4:102797357-102868896 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 9, mRNA. (from RefSeq NM_181893)
UBE2D3 (ENST00000338145.7) at chr4:102797252-102868875 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 6, mRNA. (from RefSeq NM_181890)
UBE2D3 (ENST00000453744.7) at chr4:102794383-102827551 - Homo sapiens ubiquitin conjugating enzyme E2 D3 (UBE2D3), transcript variant 7, mRNA. (from RefSeq NM_181891)
TP53 (ENST00000269305.8) at chr17:7668402-7687538 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001126112)
TP53 (ENST00000622645.4) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001276696)
TP53 (ENST00000510385.5) at chr17:7668402-7675493 - Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. (from RefSeq NM_001276698)
TP53 (ENST00000455263.6) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. (from RefSeq NM_001276695)
TP53 (ENST00000445888.6) at chr17:7668421-7687487 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001276761)
TP53 (ENST00000610292.4) at chr17:7668402-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. (from RefSeq NM_001126118)
TP53 (ENST00000617185.4) at chr17:7668402-7687550 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001126114)
TP53 (ENST00000504937.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000504290.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000420246.6) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000620739.4) at chr17:7668402-7687538 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000610538.4) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000619485.4) at chr17:7668421-7687487 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TOPORSLP (ENST00000469756.1) at chr9:104270250-104286955 - Homo sapiens uncharacterized LOC105376194 (LOC105376194), long non-coding RNA. (from RefSeq NR_135141)
TOPORSLP (ENST00000493279.1) at chr9:104270228-104277826 - topoisomerase I binding, arginine and serine rich like, pseudogene (from HGNC TOPORSLP)
TOPORSLP (ENST00000467693.1) at chr9:104275298-104277399 - topoisomerase I binding, arginine and serine rich like, pseudogene (from HGNC TOPORSLP)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_005802.4 at chr9:32540544-32552628
NM_001195622.1 at chr9:32540544-32552628

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

TOPORS at chr9:32540544-32552586

RefSeq Genes

TOPORS at chr9:32540544-32552586 - (NM_005802) E3 ubiquitin-protein ligase Topors isoform 1
TOPORS at chr9:32540544-32552628 - (NM_001195622) E3 ubiquitin-protein ligase Topors isoform 2

NCBI RefSeq other annotations (not NM_*, NR_*, XM_*, XR_*, NP_* or YP_*)

TOPORSLP at chr9:104275322-104276931

Non-Human RefSeq Genes

Toporsl at chr9:104275118-104276973 - (NM_026652) topoisomerase I binding, arginine/serine-rich like
Toporsl at chr9:104275118-104276973 - (NM_001356293) topoisomerase I binding, arginine/serine-rich like
TOPORS at chr9:32540774-32552481 - (NM_001192578) E3 ubiquitin-protein ligase Topors
Topors at chr9:32540806-32550969 - (NM_134097) E3 ubiquitin-protein ligase Topors
Topors at chr9:32540812-32550969 - (NM_001108658) E3 ubiquitin-protein ligase Topors
TOPORS at chr9:32540801-32552603 - (NM_001266141) E3 ubiquitin-protein ligase Topors
LOC102122352 at chr9:104270228-104277430 - (NM_001319472) E3 ubiquitin-protein ligase Topors-like

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TOPORS at chr9:32540544-32552586
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TOPORS at chr9:32540544-32552586
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TOPORS at chr9:32540544-32552553
TOPORS at chr9:32540826-32552553

International Knockout Mouse Consortium Genes Mapped to Human Genome

Topors_46676 at chr9:32540544-32552624
Topors_82406 at chr9:32540544-32552624
Topors_92588 at chr9:32540544-32552624

Human Aligned mRNA Search Results

AF098300 - Homo sapiens topoisomerase I-binding RS protein (TOPORS) mRNA, complete cds.
BC060884 - Homo sapiens topoisomerase I binding, arginine/serine-rich, mRNA (cDNA clone MGC:71856 IMAGE:30344728), complete cds.

Non-Human Aligned mRNA Search Results

CR855605 - Xenopus tropicalis finished cDNA, clone TEgg124o06.
JU332447 - TSA: Macaca mulatta Mamu_516363 mRNA sequence.
JU473914 - TSA: Macaca mulatta Mamu_374035 mRNA sequence.
JL638485 - TSA: Equus caballus contig24025.EqcaPBMC mRNA sequence.
BC019421 - Mus musculus topoisomerase I binding, arginine/serine-rich, mRNA (cDNA clone IMAGE:3497935), partial cds.
BC037141 - Mus musculus topoisomerase I binding, arginine/serine-rich, mRNA (cDNA clone IMAGE:5026960), partial cds.
AB104865 - Mus musculus Topors mRNA for topoisomerase 1-binding RING finger protein, complete cds.
BC040797 - Mus musculus topoisomerase I binding, arginine/serine-rich, mRNA (cDNA clone MGC:49530 IMAGE:3492178), complete cds.
AF122902 - Rattus norvegicus beta actin mRNA, partial cds.
AF122903 - Rattus norvegicus preproendothelin-1 mRNA, partial cds.
AF085195 - Rattus norvegicus endothelial nitric oxide synthase (NOSIII) mRNA, partial cds.
AB173009 - Macaca fascicularis brain cDNA clone: QflA-20580, similar to human topoisomerase I binding, arginine/serine-rich (TOPORS), mRNA, RefSeq: NM_005802.2.
AB171977 - Macaca fascicularis brain cDNA clone: QflA-16154, similar to human topoisomerase I binding, arginine/serine-rich (TOPORS), mRNA, RefSeq: NM_005802.2.

GeneReviews

TOPORS at chr9:32540544-32552586