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Gencode Genes

TIRAP (ENST00000392679.5) at chr11:126283087-126294933 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 5, mRNA. (from RefSeq NM_001318777)
TIRAP (ENST00000488598.5) at chr11:126283073-126292687 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt F5H2K1)
TIRAP (ENST00000479770.1) at chr11:126290856-126298845 - Adapter involved in TLR2 and TLR4 signaling pathways in  the innate immune response. Acts via IRAK2 and TRAF-6, leading to  the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting  in cytokine secretion and the inflammatory response. Positively  regulates the production of TNF-alpha and interleukin-6. (from UniProt P58753)
TIRAP (ENST00000467006.6) at chr11:126283106-126290897 - TIR domain containing adaptor protein (from HGNC TIRAP)
TIRAP (ENST00000462401.1) at chr11:126283065-126291569 - TIR domain containing adaptor protein (from HGNC TIRAP)
TIRAP (ENST00000392680.6) at chr11:126283118-126294684 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 3, mRNA. (from RefSeq NM_001039661)
TIRAP (ENST00000392678.7) at chr11:126283110-126293244 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 2, mRNA. (from RefSeq NM_148910)
TICAM2 (ENST00000427199.2) at chr5:115578650-115602479 - Homo sapiens toll like receptor adaptor molecule 2 (TICAM2), mRNA. (from RefSeq NM_021649)
CCDC47 (ENST00000582252.1) at chr17:63751770-63773570 -   Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117042;  Q92985:IRF7; NbExp=2; IntAct=EBI-720151, EBI-968267;  Q6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117196;  P58753:TIRAP; NbExp=2; IntAct=EBI-720151, EBI-528644;  Q86WV6:TMEM173; NbExp=2; IntAct=EBI-720151, EBI-2800345; (from UniProt Q96A33)
CCDC47 (ENST00000403162.7) at chr17:63746403-63773570 -   Q99J34:Irak1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117042;  Q92985:IRF7; NbExp=2; IntAct=EBI-720151, EBI-968267;  Q6PDS3:Sarm1 (xeno); NbExp=2; IntAct=EBI-720151, EBI-6117196;  P58753:TIRAP; NbExp=2; IntAct=EBI-720151, EBI-528644;  Q86WV6:TMEM173; NbExp=2; IntAct=EBI-720151, EBI-2800345; (from UniProt Q96A33)
CCDC47 (ENST00000225726.10) at chr17:63745255-63773597 - Homo sapiens coiled-coil domain containing 47 (CCDC47), mRNA. (from RefSeq NM_020198)
SAMHD1 (ENST00000646869.1) at chr20:36890904-36951714 - Putative nuclease involved in innate immune response by  acting as a negative regulator of the cell-intrinsic antiviral  response. May play a role in mediating proinflammatory responses  to TNF-alpha signaling. (from UniProt Q9Y3Z3)
SAMHD1 (ENST00000646066.1) at chr20:36892932-36951643 - Putative nuclease involved in innate immune response by  acting as a negative regulator of the cell-intrinsic antiviral  response. May play a role in mediating proinflammatory responses  to TNF-alpha signaling. (from UniProt Q9Y3Z3)
CD14 (ENST00000401743.6) at chr5:140631728-140633701 - Homo sapiens CD14 molecule (CD14), transcript variant 4, mRNA. (from RefSeq NM_001174105)
CD14 (ENST00000302014.11) at chr5:140631732-140633175 - Homo sapiens CD14 molecule (CD14), transcript variant 1, mRNA. (from RefSeq NM_000591)
LTN1 (ENST00000614971.4) at chr21:28928144-28992956 - E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept  ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a  thioester and then directly transfer the ubiquitin to targeted  substrates (By similarity). (from UniProt O94822)
LTN1 (ENST00000389194.7) at chr21:28928144-28992949 - E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept  ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a  thioester and then directly transfer the ubiquitin to targeted  substrates (By similarity). (from UniProt O94822)
LTN1 (ENST00000361371.10) at chr21:28928144-28992877 - Homo sapiens listerin E3 ubiquitin protein ligase 1 (LTN1), transcript variant 1, mRNA. (from RefSeq NM_015565)
MYD88 (ENST00000396334.8) at chr3:38138478-38143022 - Adapter protein involved in the Toll-like receptor and  IL-1 receptor signaling pathway in the innate immune response.  Acts via IRAK1, IRAK2, IRF7 and TRAF6, leading to NF-kappa-B  activation, cytokine secretion and the inflammatory response.  Increases IL-8 transcription. Involved in IL-18-mediated signaling  pathway. Activates IRF1 resulting in its rapid migration into the  nucleus to mediate an efficient induction of IFN-beta, NOS2/INOS,  and IL12A genes (By similarity). (from UniProt Q99836)
TLR4 (ENST00000355622.8) at chr9:117704403-117724735 - Homo sapiens toll like receptor 4 (TLR4), transcript variant 4, mRNA. (from RefSeq NM_138557)
TLR4 (ENST00000394487.5) at chr9:117704192-117715775 - Homo sapiens toll like receptor 4 (TLR4), transcript variant 3, mRNA. (from RefSeq NM_003266)
SAMHD1 (ENST00000646673.1) at chr20:36889773-36951901 - Homo sapiens SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1), transcript variant 1, mRNA. (from RefSeq NM_015474)
MYD88 (ENST00000650905.1) at chr3:38138661-38143022 - Homo sapiens MYD88 innate immune signal transduction adaptor (MYD88), transcript variant 2, mRNA. (from RefSeq NM_002468)
MYD88 (ENST00000495303.6) at chr3:38138657-38141643 - Homo sapiens MYD88 innate immune signal transduction adaptor (MYD88), transcript variant 5, mRNA. (from RefSeq NM_001172566)
MYD88 (ENST00000424893.6) at chr3:38138552-38141660 - Homo sapiens MYD88 innate immune signal transduction adaptor (MYD88), transcript variant 3, mRNA. (from RefSeq NM_001172568)
MYD88 (ENST00000421516.3) at chr3:38138661-38143022 - Homo sapiens MYD88 innate immune signal transduction adaptor (MYD88), transcript variant 1, mRNA. (from RefSeq NM_001172567)
MYD88 (ENST00000443433.7) at chr3:38138661-38141450 - Homo sapiens MYD88 innate immune signal transduction adaptor (MYD88), transcript variant 4, mRNA. (from RefSeq NM_001172569)
IRAK1 (ENST00000393687.6) at chrX:154011859-154019812 - Homo sapiens interleukin 1 receptor associated kinase 1 (IRAK1), transcript variant 2, mRNA. (from RefSeq NM_001025242)
IRAK1 (ENST00000369974.6) at chrX:154010506-154019876 - Homo sapiens interleukin 1 receptor associated kinase 1 (IRAK1), transcript variant 3, mRNA. (from RefSeq NM_001025243)
IRAK1 (ENST00000369980.8) at chrX:154010507-154019902 - Homo sapiens interleukin 1 receptor associated kinase 1 (IRAK1), transcript variant 1, mRNA. (from RefSeq NM_001569)
IRAK4 (ENST00000440781.6) at chr12:43758944-43786975 - Homo sapiens interleukin 1 receptor associated kinase 4 (IRAK4), transcript variant 5, mRNA. (from RefSeq NM_001145258)
IRAK4 (ENST00000431837.5) at chr12:43758944-43789543 - Homo sapiens interleukin 1 receptor associated kinase 4 (IRAK4), transcript variant 12, mRNA. (from RefSeq NM_001351344)
SAMHD1 (ENST00000262878.5) at chr20:36890574-36951843 - Homo sapiens SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1 (SAMHD1), transcript variant 2, mRNA. (from RefSeq NM_001363729)
IRAK4 (ENST00000613694.4) at chr12:43758955-43789541 - Homo sapiens interleukin 1 receptor associated kinase 4 (IRAK4), transcript variant 2, mRNA. (from RefSeq NM_016123)
IRAK4 (ENST00000551736.5) at chr12:43758961-43786903 - Homo sapiens interleukin 1 receptor associated kinase 4 (IRAK4), transcript variant 13, mRNA. (from RefSeq NM_001351345)
ARAF (ENST00000377045.9) at chrX:47561205-47571908 - Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 1, mRNA. (from RefSeq NM_001654)
ARAF (ENST00000377039.2) at chrX:47561222-47565975 - Homo sapiens A-Raf proto-oncogene, serine/threonine kinase (ARAF), transcript variant 3, mRNA. (from RefSeq NM_001256197)
IRAK2 (ENST00000256458.5) at chr3:10164919-10243745 - Homo sapiens interleukin 1 receptor associated kinase 2 (IRAK2), mRNA. (from RefSeq NM_001570)
BTK (ENST00000308731.7) at chrX:101349450-101386195 - Homo sapiens Bruton tyrosine kinase (BTK), transcript variant 1, mRNA. (from RefSeq NM_000061)
BTK (ENST00000621635.4) at chrX:101349447-101390796 - Homo sapiens Bruton tyrosine kinase (BTK), transcript variant 3, mRNA. (from RefSeq NM_001287344)
TBK1 (ENST00000331710.10) at chr12:64452120-64502114 - Homo sapiens TANK binding kinase 1 (TBK1), mRNA. (from RefSeq NM_013254)
BMX (ENST00000342014.6) at chrX:15507318-15556517 - Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript variant 2, mRNA. (from RefSeq NM_001721)
BMX (ENST00000348343.11) at chrX:15500807-15556519 - Homo sapiens BMX non-receptor tyrosine kinase (BMX), transcript variant 1, mRNA. (from RefSeq NM_203281)
TBK1 (ENST00000650790.1) at chr12:64452101-64502055 - Serine/threonine kinase that plays an essential role in  regulating inflammatory responses to foreign agents. Following  activation of toll-like receptors by viral or bacterial  components, associates with TRAF3 and TANK and phosphorylates  interferon regulatory factors (IRFs) IRF3 and IRF7 as well as  DDX3X. This activity allows subsequent homodimerization and  nuclear translocation of the IRFs leading to transcriptional  activation of pro-inflammatory and antiviral genes including IFN-  alpha and IFN-beta. In order to establish such an antiviral state,  TBK1 form several different complexes whose composition depends on  the type of cell and cellular stimuli. Thus, several scaffolding  molecules including FADD, TRADD, MAVS or SINTBAD can be recruited  to the TBK1-containing-complexes. Under particular conditions,  functions as a NF-kappa-B effector by phosphorylating NF-kappa-B  inhibitor alpha/NFKBIA, IKBKB or RELA to translocate NF-Kappa-B to  the nucleus. Restricts bacterial proliferation by phosphorylating  the autophagy receptor OPTN/Optineurin on 'Ser-177', thus  enhancing LC3 binding affinity and antibacterial autophagy.  Attenuates retroviral budding by phosphorylating the endosomal  sorting complex required for transport-I (ESCRT-I) subunit VPS37C.  Phosphorylates and activates AKT1. Phosphorylates Borna disease  virus (BDV) P protein. (from UniProt Q9UHD2)
BMX (ENST00000357607.6) at chrX:15464246-15556529 - Non-receptor tyrosine kinase that plays central but  diverse modulatory roles in various signaling processes involved  in the regulation of actin reorganization, cell migration, cell  proliferation and survival, cell adhesion, and apoptosis.  Participates in signal transduction stimulated by growth factor  receptors, cytokine receptors, G-protein coupled receptors,  antigen receptors and integrins. Induces tyrosine phosphorylation  of BCAR1 in response to integrin regulation. Activation of BMX by  integrins is mediated by PTK2/FAK1, a key mediator of integrin  signaling events leading to the regulation of actin cytoskeleton  and cell motility. Plays a critical role in TNF-induced  angiogenesis, and implicated in the signaling of TEK and FLT1  receptors, 2 important receptor families essential for  angiogenesis. Required for the phosphorylation and activation of  STAT3, a transcription factor involved in cell differentiation.  Also involved in interleukin-6 (IL6) induced differentiation.  Plays also a role in programming adaptive cytoprotection against  extracellular stress in different cell systems, salivary  epithelial cells, brain endothelial cells, and dermal fibroblasts.  May be involved in regulation of endocytosis through its  interaction with an endosomal protein RUFY1. May also play a role  in the growth and differentiation of hematopoietic cells; as well  as in signal transduction in endocardial and arterial endothelial  cells. (from UniProt P51813)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001318776.1 at chr11:126283087-126293176
NM_148910.2 at chr11:126283087-126293176
NM_001318777.1 at chr11:126283087-126294933
NM_001039661.1 at chr11:126283087-126294933

RefSeq Genes

TIRAP at chr11:126283087-126293176 - (NM_001318776) toll/interleukin-1 receptor domain-containing adapter protein isoform b
TIRAP at chr11:126283087-126294933 - (NM_001318777) toll/interleukin-1 receptor domain-containing adapter protein isoform a
TIRAP at chr11:126283087-126293176 - (NM_148910) toll/interleukin-1 receptor domain-containing adapter protein isoform b
TIRAP at chr11:126283087-126294933 - (NM_001039661) toll/interleukin-1 receptor domain-containing adapter protein isoform a

Non-Human RefSeq Genes

TIRAP at chr11:126290895-126293068 - (NM_001130435) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126290895-126293068 - (NM_001287700) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126290895-126293068 - (NM_001279203) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126290895-126293068 - (NM_001130461) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126290895-126293068 - (NM_001279568) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126290856-126293054 - (NM_001039962) toll/interleukin-1 receptor domain-containing adapter protein
TIRAP at chr11:126292632-126292997 - (NM_001024829) toll/interleukin-1 receptor domain-containing adapter protein

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TIRAP at chr11:126283065-126291569
TIRAP at chr11:126283073-126292687
TIRAP at chr11:126283087-126294933
TIRAP at chr11:126283106-126290897
TIRAP at chr11:126283110-126293244
TIRAP at chr11:126283118-126294684
TIRAP at chr11:126290856-126298845

International Knockout Mouse Consortium Genes Mapped to Human Genome

Tirap_35308 at chr11:126283087-126294933
Tirap_77380 at chr11:126283087-126294933
Tirap_92573 at chr11:126283087-126294933

Human Aligned mRNA Search Results

BC032474 - Homo sapiens toll-interleukin 1 receptor (TIR) domain containing adaptor protein, mRNA (cDNA clone MGC:40573 IMAGE:5216171), complete cds.
AY304584 - Homo sapiens TIRAP3b (TIRAP3) mRNA, complete cds.
AY304583 - Homo sapiens TIRAP3a (TIRAP3) mRNA, complete cds.
AY304582 - Homo sapiens TIRAP3a short form (TIRAP3) mRNA, complete cds.
AY304581 - Homo sapiens TIRAP3b long form (TIRAP3) mRNA, complete cds.
AF378129 - Homo sapiens TIR domain containing adaptor protein TIRAP mRNA, complete cds.
AY576785 - Homo sapiens MyD88 adapter-like protein variant a (TIRAP) mRNA, complete cds, alternatively spliced.
AY576786 - Homo sapiens MyD88 adapter-like protein variant a (TIRAP) mRNA, complete cds, alternatively spliced.
AY576787 - Homo sapiens MyD88 adapter-like protein variant b (TIRAP) mRNA, complete cds, alternatively spliced.
AB446477 - Homo sapiens TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AK313147 - Homo sapiens cDNA, FLJ93639, Homo sapiens toll-interleukin 1 receptor (TIR) domain containingadaptor protein (TIRAP), transcript variant 2, mRNA.

Non-Human Aligned mRNA Search Results

AF378130 - Mus musculus TIR domain containing adaptor protein TIRAP mRNA, complete cds.
BC005584 - Mus musculus toll-interleukin 1 receptor (TIR) domain-containing adaptor protein, mRNA (cDNA clone MGC:7116 IMAGE:3157913), complete cds.
DQ319072 - Bos taurus toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP) mRNA, complete cds.
AB446478 - Pan troglodytes TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AB446479 - Pan paniscus TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AB446480 - Gorilla gorilla TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AB446481 - Pongo pygmaeus TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AB446482 - Macaca fascicularis TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
AB446483 - Macaca mulatta TIRAP mRNA for TIR domain-containing adaptor protein, complete cds.
JU332796 - TSA: Macaca mulatta Mamu_522818 mRNA sequence.
JU474211 - TSA: Macaca mulatta Mamu_377058 mRNA sequence.
JU474212 - TSA: Macaca mulatta Mamu_377059 mRNA sequence.
DQ019929 - Gallus gallus toll-interleukin 1 receptor domain-containing adaptor protein (TIRAP) mRNA, complete cds.