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Gencode Genes

TDP2 (ENST00000378198.9) at chr6:24649979-24666899 - Homo sapiens tyrosyl-DNA phosphodiesterase 2 (TDP2), mRNA. (from RefSeq NM_016614)
TDP2 (ENST00000480495.1) at chr6:24665987-24666786 - tyrosyl-DNA phosphodiesterase 2 (from HGNC TDP2)
TDP2 (ENST00000478507.1) at chr6:24650987-24666930 - tyrosyl-DNA phosphodiesterase 2 (from HGNC TDP2)
TDP2 (ENST00000478285.1) at chr6:24654378-24659172 - tyrosyl-DNA phosphodiesterase 2 (from HGNC TDP2)
TDP2 (ENST00000341060.3) at chr6:24649979-24666591 - tyrosyl-DNA phosphodiesterase 2 (from HGNC TDP2)
TRAF5 (ENST00000336184.6) at chr1:211326615-211374940 - Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript variant 1, mRNA. (from RefSeq NM_004619)
TRAF5 (ENST00000367004.3) at chr1:211346364-211372795 - Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript variant 2, mRNA. (from RefSeq NM_145759)
TRAF5 (ENST00000261464.10) at chr1:211326833-211374946 - Homo sapiens TNF receptor associated factor 5 (TRAF5), transcript variant 4, mRNA. (from RefSeq NM_001319207)
ACVR1B (ENST00000426655.6) at chr12:51951702-51992341 - Transmembrane serine/threonine kinase activin type-1  receptor forming an activin receptor complex with activin receptor  type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the  cell surface to the cytoplasm and is thus regulating a many  physiological and pathological processes including neuronal  differentiation and neuronal survival, hair follicle development  and cycling, FSH production by the pituitary gland, wound healing,  extracellular matrix production, immunosuppression and  carcinogenesis. Activin is also thought to have a paracrine or  autocrine role in follicular development in the ovary. Within the  receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a  primary activin receptors whereas the type-1 receptors like ACVR1B  act as downstream transducers of activin signals. Activin binds to  type-2 receptor at the plasma membrane and activates its serine-  threonine kinase. The activated receptor type-2 then  phosphorylates and activates the type-1 receptor such as ACVR1B.  Once activated, the type-1 receptor binds and phosphorylates the  SMAD proteins SMAD2 and SMAD3, on serine residues of the C-  terminal tail. Soon after their association with the activin  receptor and subsequent phosphorylation, SMAD2 and SMAD3 are  released into the cytoplasm where they interact with the common  partner SMAD4. This SMAD complex translocates into the nucleus  where it mediates activin-induced transcription. Inhibitory SMAD7,  which is recruited to ACVR1B through FKBP1A, can prevent the  association of SMAD2 and SMAD3 with the activin receptor complex,  thereby blocking the activin signal. Activin signal transduction  is also antagonized by the binding to the receptor of inhibin-B  via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. (from UniProt P36896)
ACVR1B (ENST00000415850.6) at chr12:51951744-51987346 - Transmembrane serine/threonine kinase activin type-1  receptor forming an activin receptor complex with activin receptor  type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the  cell surface to the cytoplasm and is thus regulating a many  physiological and pathological processes including neuronal  differentiation and neuronal survival, hair follicle development  and cycling, FSH production by the pituitary gland, wound healing,  extracellular matrix production, immunosuppression and  carcinogenesis. Activin is also thought to have a paracrine or  autocrine role in follicular development in the ovary. Within the  receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a  primary activin receptors whereas the type-1 receptors like ACVR1B  act as downstream transducers of activin signals. Activin binds to  type-2 receptor at the plasma membrane and activates its serine-  threonine kinase. The activated receptor type-2 then  phosphorylates and activates the type-1 receptor such as ACVR1B.  Once activated, the type-1 receptor binds and phosphorylates the  SMAD proteins SMAD2 and SMAD3, on serine residues of the C-  terminal tail. Soon after their association with the activin  receptor and subsequent phosphorylation, SMAD2 and SMAD3 are  released into the cytoplasm where they interact with the common  partner SMAD4. This SMAD complex translocates into the nucleus  where it mediates activin-induced transcription. Inhibitory SMAD7,  which is recruited to ACVR1B through FKBP1A, can prevent the  association of SMAD2 and SMAD3 with the activin receptor complex,  thereby blocking the activin signal. Activin signal transduction  is also antagonized by the binding to the receptor of inhibin-B  via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2. (from UniProt P36896)
TRAF3 (ENST00000392745.6) at chr14:102777557-102906261 - Regulates pathways leading to the activation of NF-  kappa-B and MAP kinases, and plays a central role in the  regulation of B-cell survival. Part of signaling pathways leading  to the production of cytokines and interferon. Required for normal  antibody isotype switching from IgM to IgG. Plays a role T-cell  dependent immune responses. Plays a role in the regulation of  antiviral responses. Is an essential constituent of several E3  ubiquitin-protein ligase complexes. May have E3 ubiquitin-protein  ligase activity and promote 'Lys-63'-linked ubiquitination of  target proteins. Inhibits activation of NF-kappa-B in response to  LTBR stimulation. Inhibits TRAF2-mediated activation of NF-kappa-  B. Down-regulates proteolytic processing of NFKB2, and thereby  inhibits non-canonical activation of NF-kappa-B. Promotes  ubiquitination and proteasomal degradation of MAP3K14. (from UniProt Q13114)
TRAF3 (ENST00000560371.5) at chr14:102777476-102911500 - Homo sapiens TNF receptor associated factor 3 (TRAF3), transcript variant 1, mRNA. (from RefSeq NM_145725)
TRAF3 (ENST00000539721.5) at chr14:102777602-102906021 - Homo sapiens TNF receptor associated factor 3 (TRAF3), transcript variant 4, mRNA. (from RefSeq NM_001199427)
ACVR1B (ENST00000542485.1) at chr12:51953380-51994925 - Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 2, mRNA. (from RefSeq NM_020327)
ACVR1B (ENST00000541224.5) at chr12:51951701-51994217 - Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 3, mRNA. (from RefSeq NM_020328)
ACVR1B (ENST00000257963.9) at chr12:51951699-51997078 - Homo sapiens activin A receptor type 1B (ACVR1B), transcript variant 1, mRNA. (from RefSeq NM_004302)
TRAF6 (ENST00000348124.5) at chr11:36489173-36510256 - Homo sapiens TNF receptor associated factor 6 (TRAF6), transcript variant 1, mRNA. (from RefSeq NM_145803)
TRAF6 (ENST00000526995.6) at chr11:36483769-36510272 - Homo sapiens TNF receptor associated factor 6 (TRAF6), transcript variant 2, mRNA. (from RefSeq NM_004620)
TRAF2 (ENST00000247668.7) at chr9:136886516-136926607 - Homo sapiens TNF receptor associated factor 2 (TRAF2), mRNA. (from RefSeq NM_021138)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_016614.2 at chr6:24649977-24666887

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

TDP2 at chr6:24649979-24666899

RefSeq Genes

TDP2 at chr6:24649979-24666899 - (NM_016614) tyrosyl-DNA phosphodiesterase 2

Non-Human RefSeq Genes

TDP2 at chr6:24650069-24666862 - (NM_001243686) tyrosyl-DNA phosphodiesterase 2
TDP2 at chr6:24650445-24666887 - (NM_001253765) tyrosyl-DNA phosphodiesterase 2
TDP2 at chr6:24650788-24658667 - (NM_001276384) tyrosyl-DNA phosphodiesterase 2
Tdp2 at chr6:24650766-24658739 - (NM_019551) tyrosyl-DNA phosphodiesterase 2
Tdp2 at chr6:24650775-24658733 - (NM_001034947) tyrosyl-DNA phosphodiesterase 2
TDP2 at chr6:24649270-24666864 - (NM_001105341) tyrosyl-DNA phosphodiesterase 2
tdp2 at chr6:24650788-24666769 - (NM_001016944) tyrosyl-DNA phosphodiesterase 2
tdp2.S at chr6:24650788-24666769 - (NM_001098686) tyrosyl-DNA phosphodiesterase 2

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TDP2 at chr6:24649979-24666591
TDP2 at chr6:24649979-24666899

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

TDP2 at chr6:24649979-24666591
TDP2 at chr6:24649979-24666899
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

TDP2 at chr6:24649977-24667033
TDP2 at chr6:24649979-24666591
TDP2 at chr6:24650987-24666930
TDP2 at chr6:24654378-24659172
TDP2 at chr6:24665987-24666786

International Knockout Mouse Consortium Genes Mapped to Human Genome

Tdp2_116639 at chr6:24649977-24666887
Tdp2_37660 at chr6:24649977-24666887
Tdp2_37661 at chr6:24649977-24666887
Tdp2_75761 at chr6:24649977-24666887
Tdp2_82077 at chr6:24649977-24666887

JN104587 Alignments in Human Aligned mRNAs

This aligns in multiple positions. Click on a hyperlink to go to tracks display at a particular alignment.
 SIZE IDENTITY CHROMOSOME STRAND  START     END       cDNA   START  END  TOTAL
------------------------------------------------------------------------------
  334  100.0%          6     -  24666558  24666977  JN104587     6   339   339

Non-Human Aligned mRNA Search Results

JU334929 - TSA: Macaca mulatta Mamu_517920 mRNA sequence.
JU475932 - TSA: Macaca mulatta Mamu_364021 mRNA sequence.
JV047326 - TSA: Macaca mulatta Mamu_407028 mRNA sequence.
JX889415 - UNVERIFIED: Gyps fulvus tyrosil DNA phospodiesterasa 2 TDP2-like mRNA, partial sequence.

GeneReviews

TDP2 at chr6:24649979-24666899