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Your search resulted in multiple matches. Please select a position:
SYK (ENST00000375754.9) at chr9:90801819-90898549 - <b>SYK</b> ENST00000375754.9 Homo sapiens spleen associated tyrosine kinase SYK transcript KARS1 (ENST00000302445.8) at chr16:75627724-75647665 - ... ENST00000302445.5 ENST00000302445.6 ENST00000302445.7 KARS KIAA0070 NM_005548 O14946 Q15046 Q96J25 Q9HB23 <b>SYK_HUMAN</b> uc002feq.1 uc002feq.2 uc002feq.3 uc002feq.4 uc002feq.5 Aminoacyl-tRNA synthetases are a LAT (ENST00000395456.7) at chr16:28985052-28990784 - ... The protein encoded by this gene is phosphorylated by ZAP-70 <b>Syk</b> protein tyrosine kinases following activation of the T-cell antigen SH3BP2 (ENST00000503393.8) at chr4:2793085-2841096 - ... the SH3 domains of several proteins including the ABL1 and <b>SYK</b> protein tyrosine kinases and functions as a cytoplasmic adaptor TYROBP (ENST00000262629.9) at chr19:35904403-35908295 - ... TCR associated protein kinase 70kDa ZAP-70 and spleen tyrosine kinase <b>SYK</b> and play a role in signal transduction bone modeling SIRPB1 (ENST00000381605.9) at chr20:1561385-1620009 - ... also reported to participate in the recruitment of tyrosine kinase <b>SYK</b> Multiple transcript variants encoding different isoforms have been found LAX1 (ENST00000442561.7) at chr1:203765183-203776372 - ... Up-regulated in T-cells following TCR engagement Phosphorylated on tyrosines by <b>Syk</b> Lck or ZAP70 upon TCR or BCR activation which SLA (ENST00000338087.10) at chr8:133036728-133102602 - ... via its C-terminal domain Interacts with phosphorylated proteins ZAP70 CD3Z <b>SYK</b> and LAT via its SH2 domain Cytoplasm By similarity CLEC1B (ENST00000298527.11) at chr12:9993075-9999121 - ... phosphorylation and this promotes the binding of spleen tyrosine kinase <b>Syk</b> and initiation of downstream tyrosine phosphorylation events and activation CD37 (ENST00000323906.9) at chr19:49335406-49340606 - ... EBI-6139068 EBI-79452 P29350 PTPN6 NbExp 4 IntAct EBI-6139068 EBI-78260 P43405 <b>SYK</b> NbExp 3 IntAct EBI-6139068 EBI-78302 Membrane Multi-pass membrane protein CD79A (ENST00000221972.8) at chr19:41877279-41881372 - ... expression and for efficient differentiation of pro and pre-B-cells Stimulates <b>SYK</b> autophosphorylation and activation Binds to BLNK bringing BLNK into NFAM1 (ENST00000329021.10) at chr22:42380407-42432403 - ... direct interaction with the B-cell antigen receptor BCR Interacts with <b>SYK</b> probably involved in BCR signaling Interacts with ZAP70 By BLNK (ENST00000224337.10) at chr10:96189171-96271569 - ... linker protein downstream of the B-cell receptor BCR bridging the <b>SYK</b> kinase to a multitude of signaling pathways and regulating CLEC9A (ENST00000355819.6) at chr12:10030682-10066031 - ... and mediate the cross-presentation of dead-cell associated antigens in a <b>Syk-dependent</b> manner Homodimer Membrane Single-pass type II membrane protein In VAV3 (ENST00000370056.9) at chr1:107571161-107965180 - ... at least in some cell types In osteoclasts along with <b>SYK</b> tyrosine kinase required for signaling through integrin alpha-v beta-1 CLEC6A (ENST00000382073.4) at chr12:8455962-8478330 - ... Transduces signals through an Fc receptor gamma chain FCER1G and <b>Syk-CARD9-NF-kappa-B-dependent</b> pathway By similarity Associated with FCER1G By similarity Membrane FCRL3 (ENST00000368184.8) at chr1:157676481-157700769 - ... criteria based on conservation expression RefSeq-Attributes-END Interacts with PTPN6 PTPN11 <b>SYK</b> and ZAP70 Cell membrane Single-pass type I membrane protein PIK3AP1 (ENST00000339364.10) at chr10:96593315-96720514 - ... on tyrosine residues within the YXXM motifs by BTK and <b>SYK</b> By similarity Isoform 1 and isoform 2 are phosphorylated GAB2 (ENST00000361507.5) at chr11:78215293-78417820 - ... SHC1 may mediate interaction with receptors By similarity Interacts with <b>SYK</b> By similarity Interacts with PI-3 kinase Interacts with GRB2 FCGR2A (ENST00000271450.12) at chr1:161505457-161519829 - ... by SRC-type Tyr-kinases such as LYN BLK FYN HCK and <b>SYK</b> Contains 2 Ig-like C2-type immunoglobulin-like domains Sequence AAA35932.1 Type LILRB3 (ENST00000613698.4) at chr19_GL949752v1_alt:191678-198156 - ... SHP-1 resulting in the dephosphorylation of the downstream protein kinases <b>SYK</b> and BTK By similarity Phosphorylated on tyrosine residues by LILRB3 (ENST00000611086.4) at chr19_KI270938v1_alt:191848-198042 - ... SHP-1 resulting in the dephosphorylation of the downstream protein kinases <b>SYK</b> and BTK By similarity Phosphorylated on tyrosine residues by IL15RA (ENST00000379977.8) at chr10:5952384-5977543 - ... Signal transduction involves STAT3 STAT5 STAT6 JAK2 By similarity and <b>SYK</b> The interleukin-15 receptor IL15R is a heterotrimer of IL15RA FCER1G (ENST00000289902.2) at chr1:161215295-161219245 - ... Associated with CLEC6A By similarity Interacts via ITAM domain with <b>SYK</b> via SH2 domains activates SYK enabling integrin-mediated activation of HCLS1 (ENST00000314583.8) at chr3:121631399-121660903 - ... Phosphorylation by LYN FYN and FGR requires prior phosphorylation by <b>SYK</b> or FES Contains 4 cortactin repeats Contains 1 SH3 UBASH3B (ENST00000284273.6) at chr11:122655722-122814473 - ... Exhibits tyrosine phosphatase activity toward several substrates including EGFR FAK <b>SYK</b> and ZAP70 Down-regulates proteins that are dually modified by FGR (ENST00000374005.8) at chr1:27612064-27635185 - ... responses Functions as negative regulator of ITGB2 signaling phagocytosis and <b>SYK</b> activity in monocytes Required for normal ITGB1 and ITGB2 S100A9 (ENST00000368738.4) at chr1:153357854-153361023 - ... bactericidal activity of neutrophils by promoting phagocytosis via activation of <b>SYK</b> PI3K AKT and ERK1 2 and can induce degranulation VAV1 (ENST00000602142.6) at chr19:6772708-6857361 - ... ITK Interacts with PTK2B PYK2 Interacts via SH2 domain with <b>SYK</b> Interacts with ANKRD54 By similarity P62993 GRB2 NbExp 2 CLEC7A (ENST00000304084.13) at chr12:10116777-10130199 - ... Stimulates T-cell proliferation By similarity Homodimer By similarity Interacts with <b>SYK</b> participates in leukocyte activation in presence of fungal pathogens USP25 (ENST00000400183.7) at chr21:15729982-15880064 - ... with SUMO1 the interaction only weakly sumoylates USP25 Interacts with <b>SYK</b> phosphorylates USP25 and regulates USP25 intracellular levels Cytoplasm Isoform CD79B (ENST00000006750.8) at chr17:63928740-63932331 - ... B-cell activation by SRC-type Tyr-kinases such as BLK LYN and <b>SYK</b> Defects in CD79B are the cause of agammaglobulinemia type PTPRE (ENST00000254667.8) at chr10:127907103-128085855 - ... and degranulation most likely by acting at the level of <b>SYK</b> to affect downstream events such as phosphorylation of SLP76 SELPLG (ENST00000550948.2) at chr12:108621895-108633894 - ... selectin SELP binding Interacts with SNX20 Interacts with MSN and <b>SYK</b> mediates the activation of SYK by SELPLG Q7Z614 SNX20 PLCG2 (ENST00000564138.6) at chr16:81779291-81962685 - ... CSF1R By similarity Phosphorylated on tyrosine residues by BTK and <b>SYK</b> upon ligand induced activation of a variety of growth CBLB (ENST00000394030.8) at chr3:105655461-105869012 - ... upon restimulation and promotes anergy In B-cells acts by ubiquitinating <b>SYK</b> and promoting its proteasomal degradation May also be involved CLEC4E (ENST00000299663.8) at chr12:8533305-8540905 - ... secretion of inflammatory cytokines through a pathway that depends on <b>SYK</b> CARD9 and NF-kappa-B Monomer Homodimer Membrane Single-pass type II ITGB3 (ENST00000559488.7) at chr17:47253827-47313743 - ... HIV-1 Tat Interacts with PDIA6 following platelet stimulation Interacts with <b>SYK</b> upon activation by ITGB3 promotes platelet adhesion Interacts with LCP2 (ENST00000046794.10) at chr5:170246233-170297777 - ... which leads to the up-regulation of Th1 preferred cytokine IL-2 <b>SYK-dependent</b> phosphorylation is required for recruitment of PI3K signaling components LYN (ENST00000519728.6) at chr8:55879835-56014169 - ... CD79B CSF2RB DOK1 HCLS1 LILRB3 PIR-B MS4A2 FCER1B PTK2B PYK2 <b>SYK</b> and TEC Promotes phosphorylation of SIRPA PTPN6 SHP-1 PTPN11 FCGR2B (ENST00000358671.10) at chr1:161663143-161678654 - ... Phosphorylated by SRC-type Tyr-kinases such as LYN BLK FYN and <b>SYK</b> Note FCGR2B polymorphisms can influence susceptibility or resistance to PLCG1 (ENST00000685551.1) at chr20:41137543-41177626 - ... Interacts with NTRK1 and NTRK2 phosphorylated upon ligand-binding Interacts with <b>SYK</b> activates PLCG1 Interacts with GRB2 LAT and THEMIS upon MAPK3 (ENST00000263025.9) at chr16:30114105-30123220 - ... as RAF1 RPS6KA1 RSK1 RPS6KA3 RSK2 RPS6KA2 RSK3 RPS6KA6 RSK4 <b>SYK</b> MKNK1 MNK1 MKNK2 MNK2 RPS6KA5 MSK1 RPS6KA4 MSK2 MAPKAPK3 CBL (ENST00000264033.6) at chr11:119206339-119308149 - ... and with the phosphorylated C-terminus of SH2B2 Interacts with EGFR <b>SYK</b> and ZAP70 via the highly conserved Cbl-N region Also LCK (ENST00000336890.10) at chr1:32251265-32286165 - ... and to other protein kinases including CDK1 RAF1 ZAP70 and <b>SYK</b> Binds to phosphatidylinositol 3 kinase PI3K from T-lymphocytes through SLC4A1 (ENST00000262418.12) at chr17:44248390-44268135 - ... protein Erythrocytes Phosphorylated on Tyr-8 and Tyr-21 most likely by <b>SYK</b> PP1 resistant phosphorylation that precedes Tyr-359 and Tyr-904 phosphorylation PIP5K1C (ENST00000335312.8) at chr19:3630183-3700468 - ... Phosphorylation on Ser-650 and Tyr-649 are mutually exclusive Phosphorylated by <b>SYK</b> and CSK By similarity Tyrosine phosphorylation is enhanced by BTK (ENST00000308731.8) at chrX:101349450-101386191 - ... membrane where it gets phosphorylated at Tyr-551 by LYN and <b>SYK</b> Phosphorylation at Tyr-551 is followed by autophosphorylation of Tyr-223 PRKCB (ENST00000643927.1) at chr16:23835983-24220611 - ... have no effect on enzyme activity Phosphorylation at Tyr-662 by <b>SYK</b> induces binding with GRB2 and contributes to the activation ZAP70 (ENST00000264972.10) at chr2:97713576-97739860 - ... Belongs to the protein kinase superfamily Tyr protein kinase family <b>SYK</b> ZAP-70 subfamily Contains 1 protein kinase domain Contains 2More results...