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Gencode Genes

SOCS1 (ENST00000644787.1) at chr16:11254417-11256200 - Protein modification; protein ubiquitination. (from UniProt Q4JHT5)
SOCS1 (ENST00000332029.2) at chr16:11254405-11256179 - Homo sapiens suppressor of cytokine signaling 1 (SOCS1), mRNA. (from RefSeq NM_003745)
CIDEC (ENST00000430427.5) at chr3:9867029-9878511 - May act as a CEBPB coactivator in white adipose tissue  to control the expression of a subset of CEBPB downstream target  genes, including SOCS1, SOCS3, TGFB1, TGFBR1, ID2 and XDH (By  similarity). Binds to lipid droplets and regulates their  enlargement, thereby restricting lipolysis and favoring storage.  At focal contact sites between lipid droplets, promotes  directional net neutral lipid transfer from the smaller to larger  lipid droplets. The transfer direction may be driven by the  internal pressure difference between the contacting lipid droplet  pair. When overexpressed in preadipocytes, induces apoptosis or  increases cell susceptibility to apoptosis induced by serum  deprivation or TGFB treatment. As mature adipocytes, that express  high CIDEC levels, are quite resistant to apoptotic stimuli, the  physiological significance of its role in apoptosis is unclear. (from UniProt Q96AQ7)
GFI1B (ENST00000372122.3) at chr9:132978695-132991687 - Essential proto-oncogenic transcriptional regulator  necessary for development and differentiation of erythroid and  megakaryocytic lineages. Component of a RCOR-GFI-KDM1A-HDAC  complex that suppresses, via histone deacetylase (HDAC)  recruitment, a number of genes implicated in multilineage blood  cell development and controls hematopoietic differentiation.  Transcriptional repressor or activator depending on both promoter  and cell type context; represses promoter activity of SOCS1 and  SOCS3 and thus, may regulate cytokine signaling pathways.  Cooperates with GATA1 to repress target gene transcription, such  as the apoptosis regulator BCL2L1; GFI1B silencing in leukemic  cell lines markedly increase apoptosis rate. Inhibits down-  regulation of MYC and MYB as well as the cyclin-dependent kinase  inhibitor CDKN1A/P21WAF1 in IL6-treated myelomonocytic cells.  Represses expression of GATA3 in T-cell lymphomas and inhibits  GATA1-mediated transcription; as GATA1 also mediates erythroid  GFI1B transcription, both GATA1 and GFI1B participate in a  feedback regulatory pathway controlling the expression of GFI1B  gene in erythroid cells. Suppresses GATA1-mediated stimulation of  GFI1B promoter through protein interaction. Binds to gamma-  satellite DNA and to its own promoter, auto-repressing its own  expression. Alters histone methylation by recruiting histone  methyltransferase to target genes promoters. Plays a role in  heterochromatin formation. (from UniProt Q5VTD9)
CUL5 (ENST00000531427.5) at chr11:108009260-108106852 - Core component of multiple SCF-like ECS (Elongin-Cullin  2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which  mediate the ubiquitination and subsequent proteasomal degradation  of target proteins. As a scaffold protein may contribute to  catalysis through positioning of the substrate and the ubiquitin-  conjugating enzyme. The functional specificity of the E3  ubiquitin-protein ligase complex depends on the variable substrate  recognition component. ECS(SOCS1) seems to direct ubiquitination  of JAk2. Seems to be involved poteosomal degradation of p53/TP53  stimulated by adenovirus E1B-55 kDa protein. May form a cell  surface vasopressin receptor. (from UniProt Q93034)
CUL5 (ENST00000393094.7) at chr11:108008898-108107761 - Homo sapiens cullin 5 (CUL5), mRNA. (from RefSeq NM_003478)
TRIM8 (ENST00000643721.1) at chr10:102642310-102660680 - Homo sapiens tripartite motif containing 8 (TRIM8), transcript variant 1, mRNA. (from RefSeq NM_030912)
CIDEC (ENST00000618572.4) at chr3:9866711-9880254 - Homo sapiens cell death inducing DFFA like effector c (CIDEC), transcript variant 2, mRNA. (from RefSeq NM_001199551)
CIDEC (ENST00000336832.6) at chr3:9866714-9879056 - Homo sapiens cell death inducing DFFA like effector c (CIDEC), transcript variant 3, mRNA. (from RefSeq NM_022094)
MERTK (ENST00000421804.6) at chr2:111898608-112029366 - Receptor tyrosine kinase that transduces signals from  the extracellular matrix into the cytoplasm by binding to several  ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many  physiological processes including cell survival, migration,  differentiation, and phagocytosis of apoptotic cells  (efferocytosis). Ligand binding at the cell surface induces  autophosphorylation of MERTK on its intracellular domain that  provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with GRB2 or PLCG2 and  induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK  signaling plays a role in various processes such as macrophage  clearance of apoptotic cells, platelet aggregation, cytoskeleton  reorganization and engulfment. Functions in the retinal pigment  epithelium (RPE) as a regulator of rod outer segments fragments  phagocytosis. Plays also an important role in inhibition of Toll-  like receptors (TLRs)-mediated innate immune response by  activating STAT1, which selectively induces production of  suppressors of cytokine signaling SOCS1 and SOCS3. (from UniProt Q12866)
CIDEA (ENST00000320477.10) at chr18:12254361-12277595 - Homo sapiens cell death inducing DFFA like effector a (CIDEA), transcript variant 2, mRNA. (from RefSeq NM_001318383)
GFI1B (ENST00000339463.7) at chr9:132945551-132991687 - Homo sapiens growth factor independent 1B transcriptional repressor (GFI1B), transcript variant 1, mRNA. (from RefSeq NM_004188)
GFI1B (ENST00000372123.5) at chr9:132978711-132991687 - Homo sapiens growth factor independent 1B transcriptional repressor (GFI1B), transcript variant 2, mRNA. (from RefSeq NM_001135031)
COMMD1 (ENST00000311832.5) at chr2:61905647-62136247 - Homo sapiens copper metabolism domain containing 1 (COMMD1), transcript variant 1, mRNA. (from RefSeq NM_152516)
CIDEC (ENST00000455015.5) at chr3:9866714-9879056 - Homo sapiens cell death inducing DFFA like effector c (CIDEC), transcript variant 6, mRNA. (from RefSeq NM_001321143)
CIDEC (ENST00000423850.5) at chr3:9866714-9880251 - Homo sapiens cell death inducing DFFA like effector c (CIDEC), transcript variant 7, mRNA. (from RefSeq NM_001321144)
AXL (ENST00000359092.7) at chr19:41219235-41260294 - Homo sapiens AXL receptor tyrosine kinase (AXL), transcript variant 2, mRNA. (from RefSeq NM_001699)
AXL (ENST00000301178.9) at chr19:41219223-41261766 - Homo sapiens AXL receptor tyrosine kinase (AXL), transcript variant 1, mRNA. (from RefSeq NM_021913)
ELOC (ENST00000522337.5) at chr8:73946473-73972232 - SIII, also known as elongin, is a general transcription  elongation factor that increases the RNA polymerase II  transcription elongation past template-encoded arresting sites.  Subunit A is transcriptionally active and its transcription  activity is strongly enhanced by binding to the dimeric complex of  the SIII regulatory subunits B and C (elongin BC complex). (from UniProt Q15369)
ELOC (ENST00000519487.5) at chr8:73946264-73970637 - SIII, also known as elongin, is a general transcription  elongation factor that increases the RNA polymerase II  transcription elongation past template-encoded arresting sites.  Subunit A is transcriptionally active and its transcription  activity is strongly enhanced by binding to the dimeric complex of  the SIII regulatory subunits B and C (elongin BC complex). (from UniProt Q15369)
ELOC (ENST00000284811.12) at chr8:73946401-73972106 - SIII, also known as elongin, is a general transcription  elongation factor that increases the RNA polymerase II  transcription elongation past template-encoded arresting sites.  Subunit A is transcriptionally active and its transcription  activity is strongly enhanced by binding to the dimeric complex of  the SIII regulatory subunits B and C (elongin BC complex). (from UniProt Q15369)
TYRO3 (ENST00000263798.8) at chr15:41559212-41583589 - Homo sapiens TYRO3 protein tyrosine kinase (TYRO3), transcript variant 1, mRNA. (from RefSeq NM_006293)
MERTK (ENST00000295408.9) at chr2:111898607-112029561 - Homo sapiens MER proto-oncogene, tyrosine kinase (MERTK), mRNA. (from RefSeq NM_006343)
ELOC (ENST00000622804.1) at chr8:73945138-73971908 - Homo sapiens elongin C (ELOC), transcript variant 7, mRNA. (from RefSeq NM_001204862)
ELOC (ENST00000523815.5) at chr8:73946534-73971908 - Homo sapiens elongin C (ELOC), transcript variant 6, mRNA. (from RefSeq NM_001204861)
ELOC (ENST00000518127.5) at chr8:73945119-73972287 - Homo sapiens elongin C (ELOC), transcript variant 5, mRNA. (from RefSeq NM_001204860)
ELOC (ENST00000520242.5) at chr8:73945617-73972247 - Homo sapiens elongin C (ELOC), transcript variant 1, mRNA. (from RefSeq NM_005648)
ELOC (ENST00000520210.1) at chr8:73945608-73972170 - Homo sapiens elongin C (ELOC), transcript variant 9, mRNA. (from RefSeq NM_001204864)
ELOB (ENST00000409906.8) at chr16:2771414-2777297 - Homo sapiens elongin B (ELOB), transcript variant 1, mRNA. (from RefSeq NM_007108)
ELOB (ENST00000262306.11) at chr16:2771414-2777277 - Homo sapiens elongin B (ELOB), transcript variant 2, mRNA. (from RefSeq NM_207013)
RBX1 (ENST00000216225.9) at chr22:40951378-40973309 - Homo sapiens ring-box 1 (RBX1), mRNA. (from RefSeq NM_014248)
FGFR3 (ENST00000340107.8) at chr4:1793312-1808872 - Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 3, mRNA. (from RefSeq NM_001163213)
FGFR3 (ENST00000412135.6) at chr4:1793312-1808872 - Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 2, mRNA. (from RefSeq NM_022965)
FGFR3 (ENST00000440486.7) at chr4:1793293-1808872 - Homo sapiens fibroblast growth factor receptor 3 (FGFR3), transcript variant 4, mRNA. (from RefSeq NM_001354809)
IL27 (ENST00000356897.1) at chr16:28499362-28506834 - Homo sapiens interleukin 27 (IL27), mRNA. (from RefSeq NM_145659)
FGFR3 (ENST00000352904.6) at chr4:1793896-1807322 - Tyrosine-protein kinase that acts as cell-surface  receptor for fibroblast growth factors and plays an essential role  in the regulation of cell proliferation, differentiation and  apoptosis. Plays an essential role in the regulation of  chondrocyte differentiation, proliferation and apoptosis, and is  required for normal skeleton development. Regulates both  osteogenesis and postnatal bone mineralization by osteoblasts.  Promotes apoptosis in chondrocytes, but can also promote cancer  cell proliferation. Required for normal development of the inner  ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to  the activation of several signaling cascades. Activation of PLCG1  leads to the production of the cellular signaling molecules  diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation  of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and  mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP  kinase signaling pathway, as well as of the AKT1 signaling  pathway. Plays a role in the regulation of vitamin D metabolism.  Mutations that lead to constitutive kinase activation or impair  normal FGFR3 maturation, internalization and degradation lead to  aberrant signaling. Over-expressed or constitutively activated  FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and  STAT5B. (from UniProt P22607)
TEC (ENST00000381501.8) at chr4:48135783-48269838 - Homo sapiens tec protein tyrosine kinase (TEC), mRNA. (from RefSeq NM_003215)
RELA (ENST00000308639.13) at chr11:65653602-65663090 - Homo sapiens RELA proto-oncogene, NF-kB subunit (RELA), transcript variant 2, mRNA. (from RefSeq NM_001145138)
RELA (ENST00000406246.8) at chr11:65653601-65662916 - Homo sapiens RELA proto-oncogene, NF-kB subunit (RELA), transcript variant 1, mRNA. (from RefSeq NM_021975)
MAP3K5 (ENST00000359015.5) at chr6:136557046-136792477 - Homo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5), mRNA. (from RefSeq NM_005923)
INSR (ENST00000341500.9) at chr19:7112255-7293931 - Homo sapiens insulin receptor (INSR), transcript variant 2, mRNA. (from RefSeq NM_001079817)
INSR (ENST00000302850.10) at chr19:7112265-7294414 - Homo sapiens insulin receptor (INSR), transcript variant 1, mRNA. (from RefSeq NM_000208)
IGF1R (ENST00000650285.1) at chr15:98648539-98964530 - Homo sapiens insulin like growth factor 1 receptor (IGF1R), transcript variant 1, mRNA. (from RefSeq NM_000875)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_003745.1 at chr16:11254417-11256182

RefSeq Genes

SOCS1 at chr16:11254417-11256182 - (NM_003745) suppressor of cytokine signaling 1

Non-Human RefSeq Genes

socs1 at chr16:11254423-11255325 - (NM_001011327) suppressor of cytokine signaling 1
socs1 at chr16:11254933-11255250 - (NM_001310091) suppressor of cytokine signaling 1
Socs1 at chr16:11254410-11256179 - (NM_145879) suppressor of cytokine signaling 1
Socs1 at chr16:11254410-11256201 - (NM_009896) suppressor of cytokine signaling 1
Socs1 at chr16:11254410-11256201 - (NM_001271603) suppressor of cytokine signaling 1
SOCS1 at chr16:11254763-11255531 - (NM_001204768) suppressor of cytokine signaling 1
SOCS1 at chr16:11254843-11255511 - (NM_001137648) suppressor of cytokine signaling 1
socs1.L at chr16:11254414-11255517 - (NM_001159688) suppressor of cytokine signaling 1 L homeolog
socs1.S at chr16:11254843-11255517 - (NM_001092026) suppressor of cytokine signaling 1 S homeolog
SOCS1L at chr16:11255068-11255259 - (NM_001318450) uncharacterized protein LOC417978

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

SOCS1 at chr16:11254405-11256179
SOCS1 at chr16:11254417-11256200

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

SOCS1 at chr16:11254405-11256179

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

SOCS1 at chr16:11254405-11256179

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

SOCS1 at chr16:11254405-11256179

International Knockout Mouse Consortium Genes Mapped to Human Genome

Socs1_113930 at chr16:11254417-11256182
Socs1_VG14550 at chr16:11254417-11256182

Non-Human Aligned mRNA Search Results

BC165912 - Danio rerio suppressor of cytokine signaling 1, mRNA (cDNA clone MGC:193000 IMAGE:100061495), complete cds.
HQ917699 - Gallus gallus suppressor of cytokine signalling 1-like protein (SOCS1b) mRNA, complete cds.
AF120490 - Mus musculus suppressor of cytokine signalling-1 (Socs1) mRNA, complete cds.
AF180302 - Mus musculus suppressor of cytokine signalling-1 (Socs1) mRNA, complete cds.
BC132366 - Mus musculus suppressor of cytokine signaling 1, mRNA (cDNA clone MGC:163997 IMAGE:40130643), complete cds.
BC132368 - Mus musculus suppressor of cytokine signaling 1, mRNA (cDNA clone MGC:163999 IMAGE:40130645), complete cds.
HM462248 - Sus scrofa suppressor of cytokine signaling 1 (socs1) mRNA, complete cds.
BC088083 - Xenopus tropicalis suppressor of cytokine signaling 1, mRNA (cDNA clone MGC:108459 IMAGE:7025480), complete cds.
EU836048 - Mustela putorius furo suppressor of cytokine signaling 1 (SOCS1) mRNA, partial cds.
GQ421919 - Sus scrofa suppressor of cytokine signaling 1 (SOCS1) mRNA, partial cds.
FJ696649 - Xenopus laevis suppressor of cytokine signaling (SOCS1) mRNA, complete cds.
KF699315 - Salmo salar suppressor of cytokine signaling 1 (SOCS1) mRNA, complete cds.
KP238280 - Anser cygnoides Suppressor of cytokine signaling 1 (SOCS1) mRNA, partial cds.
KR149237 - Oreochromis niloticus suppressor of cytokine signaling 1 (SOCS1) mRNA, complete cds.
MH410161 - Tachysurus fulvidraco suppressor of cytokine signaling 1 (SOCS1) mRNA, partial cds.