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Gencode Genes

SMURF2 (ENST00000262435.14) at chr17:64542282-64662307 - <b>SMURF2</b> ENST00000262435.14 Homo sapiens SMAD specific E3 ubiquitin protein ligase 
NDFIP2 (ENST00000218652.12) at chr13:79481155-79556077 -  ... Activates HECT domain-containing E3 ubiquitin-protein ligases including ITCH NEDD4 NEDD4L <b>SMURF2</b> WWP1 and WWP2 and consequently modulates the stability of 
SMAD7 (ENST00000262158.8) at chr18:48919853-48950965 -  ... is a nuclear protein that binds the E3 ubiquitin ligase <b>SMURF2</b> Upon binding this complex translocates to the cytoplasm where 
FBXL15 (ENST00000369956.8) at chr10:102420836-102423136 -  ... pattern formation and bone mass maintenance Also mediates ubiquitination of <b>SMURF2</b> and WWP2 Protein modification protein ubiquitination Part of the 
SMAD1 (ENST00000302085.9) at chr4:145481853-145559176 -  ... target for SMAD-specific E3 ubiquitin ligases such as SMURF1 and <b>SMURF2</b> and undergoes ubiquitination and proteasome-mediated degradation Alternatively spliced transcript 
AIMP1 (ENST00000672341.1) at chr4:106316550-106349456 -  ... inflammatory cytokine activity Negatively regulates TGF-beta signaling through stabilization of <b>SMURF2</b> by binding to SMURF2 and inhibiting its SMAD7-mediated degradation 
RNF11 (ENST00000242719.4) at chr1:51236273-51273447 -  ... LPS-mediated activation of NF-kappa-B Recruits STAMBP to the E3 ubiquitin-ligase <b>SMURF2</b> for ubiquitination leading to its degradation by the 26S 
DAZAP2 (ENST00000412716.8) at chr12:51238826-51243933 -  ... intestine colon and leukocytes Down-regulated in multiple myeloma Ubiquitinated by <b>SMURF2</b> leading to proteasomal degradation Sequence BAA06545.2 Type Erroneous initiation 
DVL2 (ENST00000005340.10) at chr17:7225342-7234517 -  ... EBI-3951744 Q9Z101 Pard6a xeno NbExp 6 IntAct EBI-740850 EBI-81732 A2A5Z6 <b>Smurf2</b> xeno NbExp 8 IntAct EBI-740850 EBI-2348309 Q14134 TRIM29 NbExp 
STAMBP (ENST00000394070.7) at chr2:73828961-73867168 -  ... interaction appears to relieve the autoinhibition of CHMP3 Interacts with <b>SMURF2</b> and RNF11 this interaction promotes ubiquitination Q9HD42 CHMP1A NbExp 
SMAD3 (ENST00000327367.9) at chr15:67065602-67195169 -  ... VDR TGIF and TGIF2 RUNX3 CREBBP SKOR1 SKOR2 SNON ATF2 <b>SMURF2</b> and TGFB1I1 Interacts with DACH1 the interaction inhibits the 
USP15 (ENST00000280377.10) at chr12:62260404-62416389 -  ... and SMAD3 the interaction is direct Forms a complex with <b>SMURF2</b> and SMAD7 Interacts with TGFBR1 Interacts with human papillomavirus