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Gencode Genes

SMO (ENST00000249373.8) at chr7:129188633-129213545 - <b>SMO</b> ENST00000249373.8 Homo sapiens smoothened frizzled class receptor SMO mRNA 
KIF7 (ENST00000394412.8) at chr15:89627977-89655467 -  ... positive regulator of sonic hedgehog Shh pathway acting downstream of <b>SMO</b> Negatively regulates the pathway by preventing inappropriate activation of 
PTCH1 (ENST00000437951.6) at chr9:95442980-95516971 -  ... IHH and desert hedgehog DHH Associates with the smoothened protein <b>SMO</b> to transduce the hedgehog s proteins signal Seems to 
IHH (ENST00000295731.7) at chr2:219054424-219060921 -  ... the patched PTC receptor which functions in association with smoothened <b>SMO</b> to activate the transcription of target genes Implicated in 
TCTN1 (ENST00000397659.9) at chr12:110614129-110649430 -  ... absence of Hh signals Modulates Hh signal transduction downstream of <b>SMO</b> and RAB23 By similarity Part of the tectonic-like complex 
SHH (ENST00000297261.7) at chr7:155799980-155812463 -  ... the patched PTC receptor which functions in association with smoothened <b>SMO</b> to activate the transcription of target genes In the 
FZD3 (ENST00000240093.8) at chr8:28494212-28574258 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain establishment of planar 
FZD5 (ENST00000295417.4) at chr2:207762598-207769906 -  ... by the proteasome Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain Golgi membrane embryonic 
FZD9 (ENST00000344575.5) at chr7:73433778-73436120 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain Has been first 
FZD1 (ENST00000287934.4) at chr7:91264433-91271326 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain positive regulation of 
FZD7 (ENST00000286201.3) at chr2:202033855-202038441 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain transmembrane signaling receptor 
FZD10 (ENST00000229030.5) at chr12:130162464-130165740 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain transmembrane signaling receptor 
FZD2 (ENST00000315323.5) at chr17:44557484-44561262 -  ... proteasome By similarity Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain membranous septum morphogenesis 
GLI3 (ENST00000395925.8) at chr7:41960949-42237209 -  ... the nucleus Ciliary accumulation requires the presence of KIF7 and <b>SMO</b> Translocation to the nucleus is promoted by interaction with 
FZD6 (ENST00000358755.5) at chr8:103298898-103332866 -  ... trimester of pregnancy Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain establishment of planar 
FZD8 (ENST00000374694.3) at chr10:35638247-35642296 -  ... by the proteasome Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain angiogenesis positive regulation 
FZD4 (ENST00000531380.2) at chr11:86945679-86955395 -  ... extreme temporal periphery Belongs to the G-protein coupled receptor Fz <b>Smo</b> family Contains 1 FZ frizzled domain Name GeneReviews URL 
ARRB2 (ENST00000269260.7) at chr17:4710632-4721497 -  ... low-density lipoprotein receptor LDLR Involved in endocytosis of smoothened homolog <b>Smo</b> which also requires ADRBK1 Involved in endocytosis of SLC9A5 
SMOC2 (ENST00000356284.7) at chr6:168441184-168667992 - <b>SMOC2</b> ENST00000356284.7 Homo sapiens SPARC related modular calcium binding 2 
SMOC1 (ENST00000361956.8) at chr14:69879416-70032366 - <b>SMOC1</b> ENST00000361956.8 Homo sapiens SPARC related modular calcium binding 1 
SMOX (ENST00000305958.9) at chr20:4148828-4187727 - <b>SMOX</b> ENST00000305958.9 Homo sapiens spermine oxidase SMOX transcript variant 1 
CYP1A2 (ENST00000343932.5) at chr15:74748845-74756607 -  ... aromatic hydrocarbons PAHs some of which are found in cigarette <b>smoke</b> The enzyme s endogenous substrate is unknown however it 
CYP1A1 (ENST00000379727.8) at chr15:74719542-74725528 -  ... aromatic hydrocarbons PAHs some of which are found in cigarette <b>smoke</b> The enzyme s endogenous substrate is unknown however it 
SLC39A8 (ENST00000356736.5) at chr4:102261666-102345482 -  ... of the toxic cation cadmium which is found in cigarette <b>smoke</b> Multiple transcript variants encoding different isoforms have been found 
CYP2E1 (ENST00000252945.8) at chr10:133527363-133539123 -  ... ethylene glycol and nitrosamines which are premutagens found in cigarette <b>smoke</b> Due to its many substrates this enzyme may be 
PIR (ENST00000380420.10) at chrX:15384799-15493333 -  ... leukemias Up-regulated in primary bronchial epithelial cells exposed to cigarette <b>smoke</b> extract Genetic variations in PIR might have a sex-specific 
PRKG1 (ENST00000373980.11) at chr10:51074487-52298350 -  ... axon guidance hippocampal and cerebellar learning circadian rhythm and nociception <b>Smoth</b> muscle relaxation is mediated through lowering of intracellular free 
ACTA2 (ENST00000224784.10) at chr10:88935074-88952773 -  ... the basal ganglia The abnormal vessels resemble a puff of <b>smoke</b> moyamoya on cerebral angiogram Affected individuals can develop transient