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Gencode Genes

SLC12A3 (ENST00000438926.6) at chr16:56865207-56915850 - Homo sapiens solute carrier family 12 member 3 (SLC12A3), transcript variant 1, mRNA. (from RefSeq NM_000339)
SLC12A3 (ENST00000569002.1) at chr16:56902222-56904852 - solute carrier family 12 member 3 (from HGNC SLC12A3)
SLC12A3 (ENST00000566786.5) at chr16:56865207-56913405 - Homo sapiens solute carrier family 12 member 3 (SLC12A3), transcript variant 2, mRNA. (from RefSeq NM_001126107)
SLC12A3 (ENST00000563352.1) at chr16:56907026-56913978 - solute carrier family 12 member 3 (from HGNC SLC12A3)
SLC12A3 (ENST00000563236.5) at chr16:56865211-56914522 - Homo sapiens solute carrier family 12 member 3 (SLC12A3), transcript variant 3, mRNA. (from RefSeq NM_001126108)
SLC12A3 (ENST00000262502.5) at chr16:56865211-56914525 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt J3QSS1)
KLHL3 (ENST00000508657.5) at chr5:137617500-137721310 - Homo sapiens kelch like family member 3 (KLHL3), transcript variant 2, mRNA. (from RefSeq NM_001257194)
KLHL3 (ENST00000309755.9) at chr5:137617500-137736089 - Homo sapiens kelch like family member 3 (KLHL3), transcript variant 1, mRNA. (from RefSeq NM_017415)
KLHL3 (ENST00000506491.5) at chr5:137617500-137706436 - Homo sapiens kelch like family member 3 (KLHL3), transcript variant 3, mRNA. (from RefSeq NM_001257195)
SGK1 (ENST00000367857.9) at chr6:134169353-134174865 - Serine/threonine-protein kinase which is involved in the  regulation of a wide variety of ion channels, membrane  transporters, cellular enzymes, transcription factors, neuronal  excitability, cell growth, proliferation, survival, migration and  apoptosis. Plays an important role in cellular stress response.  Contributes to regulation of renal Na(+) retention, renal K(+)  elimination, salt appetite, gastric acid secretion, intestinal  Na(+)/H(+) exchange and nutrient transport, insulin-dependent salt  sensitivity of blood pressure, salt sensitivity of peripheral  glucose uptake, cardiac repolarization and memory consolidation.  Up-regulates Na(+) channels: SCNN1A/ENAC, SCN5A and ASIC1/ACCN2,  K(+) channels: KCNJ1/ROMK1, KCNA1-5, KCNQ1-5 and KCNE1, epithelial  Ca(2+) channels: TRPV5 and TRPV6, chloride channels: BSND, CLCN2  and CFTR, glutamate transporters: SLC1A3/EAAT1, SLC1A2 /EAAT2,  SLC1A1/EAAT3, SLC1A6/EAAT4 and SLC1A7/EAAT5, amino acid  transporters: SLC1A5/ASCT2, SLC38A1/SN1 and SLC6A19, creatine  transporter: SLC6A8, Na(+)/dicarboxylate cotransporter:  SLC13A2/NADC1, Na(+)-dependent phosphate cotransporter:  SLC34A2/NAPI-2B, glutamate receptor: GRIK2/GLUR6. Up-regulates  carriers: SLC9A3/NHE3, SLC12A1/NKCC2, SLC12A3/NCC, SLC5A3/SMIT,  SLC2A1/GLUT1, SLC5A1/SGLT1 and SLC15A2/PEPT2. Regulates enzymes:  GSK3A/B, PMM2 and Na(+)/K(+) ATPase, and transcription factors:  CTNNB1 and nuclear factor NF-kappa-B. Stimulates sodium transport  into epithelial cells by enhancing the stability and expression of  SCNN1A/ENAC. This is achieved by phosphorylating the NEDD4L  ubiquitin E3 ligase, promoting its interaction with 14-3-3  proteins, thereby preventing it from binding to SCNN1A/ENAC and  targeting it for degradation. Regulates store-operated Ca(+2)  entry (SOCE) by stimulating ORAI1 and STIM1. Regulates KCNJ1/ROMK1  directly via its phosphorylation or indirectly via increased  interaction with SLC9A3R2/NHERF2. Phosphorylates MDM2 and  activates MDM2-dependent ubiquitination of p53/TP53.  Phosphorylates MAPT/TAU and mediates microtubule depolymerization  and neurite formation in hippocampal neurons. Phosphorylates  SLC2A4/GLUT4 and up-regulates its activity. Phosphorylates  APBB1/FE65 and promotes its localization to the nucleus.  Phosphorylates MAPK1/ERK2 and activates it by enhancing its  interaction with MAP2K1/MEK1 and MAP2K2/MEK2. Phosphorylates FBXW7  and plays an inhibitory role in the NOTCH1 signaling.  Phosphorylates FOXO1 resulting in its relocalization from the  nucleus to the cytoplasm. Phosphorylates FOXO3, promoting its exit  from the nucleus and interference with FOXO3-dependent  transcription. Phosphorylates BRAF and MAP3K3/MEKK3 and inhibits  their activity. Phosphorylates SLC9A3/NHE3 in response to  dexamethasone, resulting in its activation and increased  localization at the cell membrane. Phosphorylates CREB1. Necessary  for vascular remodeling during angiogenesis. Sustained high levels  and activity may contribute to conditions such as hypertension and  diabetic nephropathy. Isoform 2 exhibited a greater effect on cell  plasma membrane expression of SCNN1A/ENAC and Na(+) transport than  isoform 1. (from UniProt O00141)
WNK3 (ENST00000375159.6) at chrX:54198324-54333673 - Serine/threonine kinase which plays an important role in  the regulation of electrolyte homeostasis, cell signaling,  survival and proliferation. Acts as an activator and inhibitor of  sodium-coupled chloride cotransporters and potassium-coupled  chloride cotransporters respectively. Phosphorylates WNK4.  Regulates the phosphorylation of SLC12A1 and SLC12A2. Increases  Ca(2+) influx mediated by TRPV5 and TRPV6 by enhancing their  membrane expression level via a kinase-dependent pathway. Inhibits  the activity of KCNJ1 by decreasing its expression at the cell  membrane in a non-catalytic manner. (from UniProt Q9BYP7)
CUL3 (ENST00000409777.5) at chr2:224473939-224563299 - Core component of multiple cullin-RING-based BCR (BTB-  CUL3-RBX1) E3 ubiquitin-protein ligase complexes which mediate the  ubiquitination and subsequent proteasomal degradation of target  proteins. As a scaffold protein may contribute to catalysis  through positioning of the substrate and the ubiquitin-conjugating  enzyme. The E3 ubiquitin-protein ligase activity of the complex is  dependent on the neddylation of the cullin subunit and is  inhibited by the association of the deneddylated cullin subunit  with TIP120A/CAND1 (By similarity). The functional specificity of  the BCR complex depends on the BTB domain-containing protein as  the susbstrate recognition component. BCR(SPOP) is involved in  ubiquitination of BMI1/PCGF4, H2AFY and DAXX, and probably GLI2 or  GLI3. BCR(KLHL9-KLHL13) controls the dynamic behavior of AURKB on  mitotic chromosomes and thereby coordinates faithful mitotic  progression and completion of cytokinesis. BCR(KLHL12) is involved  in ER-Golgi transport by regulating the size of COPII coats,  thereby playing a key role in collagen export, which is required  for embryonic stem (ES) cells division: BCR(KLHL12) acts by  mediating monoubiquitination of SEC31 (SEC31A or SEC31B).  BCR(KLHL3) acts as a regulator of ion transport in the distal  nephron; possibly by mediating ubiquitination of SLC12A3/NCC.  Involved in ubiquitination of cyclin E and of cyclin D1 (in vitro)  thus involved in regulation of G1/S transition. (from UniProt Q13618)
WNK1 (ENST00000315939.11) at chr12:752579-911452 - Homo sapiens WNK lysine deficient protein kinase 1 (WNK1), transcript variant 1, mRNA. (from RefSeq NM_018979)
WNK3 (ENST00000354646.6) at chrX:54192825-54358005 - Homo sapiens WNK lysine deficient protein kinase 3 (WNK3), transcript variant 1, mRNA. (from RefSeq NM_020922)
WNK4 (ENST00000246914.10) at chr17:42780610-42797066 - Homo sapiens WNK lysine deficient protein kinase 4 (WNK4), transcript variant 1, mRNA. (from RefSeq NM_032387)
SGK1 (ENST00000528577.5) at chr6:134169881-134177905 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 3, mRNA. (from RefSeq NM_001143677)
SGK1 (ENST00000413996.7) at chr6:134169250-134175991 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 4, mRNA. (from RefSeq NM_001143678)
SGK1 (ENST00000367858.9) at chr6:134169246-134318058 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 2, mRNA. (from RefSeq NM_001143676)
SGK1 (ENST00000237305.11) at chr6:134169252-134174896 - Homo sapiens serum/glucocorticoid regulated kinase 1 (SGK1), transcript variant 1, mRNA. (from RefSeq NM_005627)
CUL3 (ENST00000409096.5) at chr2:224473922-224569825 - Homo sapiens cullin 3 (CUL3), transcript variant 3, mRNA. (from RefSeq NM_001257198)
CUL3 (ENST00000344951.8) at chr2:224470150-224585397 - Homo sapiens cullin 3 (CUL3), transcript variant 2, mRNA. (from RefSeq NM_001257197)
CUL3 (ENST00000264414.9) at chr2:224470150-224585363 - Homo sapiens cullin 3 (CUL3), transcript variant 1, mRNA. (from RefSeq NM_003590)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001126107.1 at chr16:56865207-56915850
NM_001126108.1 at chr16:56865207-56915850
NM_000339.2 at chr16:56865207-56915850

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005256119.2 at chr16:56865207-56913702

RefSeq Genes

SLC12A3 at chr16:56865207-56915850 - (NM_001126107) solute carrier family 12 member 3 isoform 2
SLC12A3 at chr16:56865207-56915850 - (NM_000339) solute carrier family 12 member 3 isoform 1
SLC12A3 at chr16:56865207-56915850 - (NM_001126108) solute carrier family 12 member 3 isoform 3

Non-Human RefSeq Genes

SLC12A3 at chr16:56865236-56913405 - (NM_001082649) solute carrier family 12 member 3
slc12a3 at chr16:56868297-56913415 - (NM_001309001) solute carrier family 12 member 3
SLC12A3 at chr16:56865211-56914295 - (NM_001132018) solute carrier family 12 member 3
SLC12A3 at chr16:56865236-56913636 - (NM_001206178) solute carrier family 12 member 3
Slc12a3 at chr16:56865276-56913413 - (NM_019415) solute carrier family 12 member 3 isoform 2
Slc12a3 at chr16:56865276-56913413 - (NM_001205311) solute carrier family 12 member 3 isoform 1
Slc12a3 at chr16:56865278-56913734 - (NM_019345) solute carrier family 12 member 3
slc12a3 at chr16:56868297-56913405 - (NM_001045080) solute carrier family 12 member 3

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

SLC12A3 at chr16:56865207-56913405
SLC12A3 at chr16:56865207-56915850
SLC12A3 at chr16:56865211-56914522
SLC12A3 at chr16:56865211-56914525
SLC12A3 at chr16:56902222-56904852
SLC12A3 at chr16:56907026-56913978

International Knockout Mouse Consortium Genes Mapped to Human Genome

Slc12a3_44018 at chr16:56865207-56915850

Non-Human Aligned mRNA Search Results

BC155803 - Danio rerio solute carrier family 12 (sodium/chloride transporters), member 3, mRNA (cDNA clone MGC:174979 IMAGE:6961497), complete cds.
JT416899 - TSA: Ictalurus punctatus vet_k63:56251 mRNA sequence.
MK256760 - Squalus acanthias NCC (SLC12A3) mRNA, complete cds.
BC038612 - Mus musculus solute carrier family 12, member 3, mRNA (cDNA clone MGC:46751 IMAGE:4237274), complete cds.
AB563729 - Takifugu obscurus Slc12a3 mRNA for NaCl cotransporter NCC splicing isoform, partial cds.
AJ564606 - Anguilla anguilla mRNA for putative Na/Cl cotransporter (nccbeta gene), isoform SLC12a3.
AJ564605 - Anguilla anguilla mRNA for putative Na/Cl cotransporter (nccalpha truncate gene), isoform SLC12a3.
AJ564604 - Anguilla anguilla mRNA for putative Na/Cl cotransporter (nccalpha gene), isoform SLC12a3.
AB479211 - Takifugu obscurus mRNA for NaCl cotransporter NCC, solute carrier family 12 member 3 (slc12a3), complete cds.