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Gencode Genes

RIN1 (ENST00000311320.9) at chr11:66330241-66336434 - Homo sapiens Ras and Rab interactor 1 (RIN1), transcript variant 1, mRNA. (from RefSeq NM_004292)
RIN1 (ENST00000627248.1) at chr11:66335641-66336402 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PMB8)
RIN1 (ENST00000534824.5) at chr11:66332210-66335691 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YCG8)
RIN1 (ENST00000530745.3) at chr11:66332609-66336436 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PMB8)
RIN1 (ENST00000530056.1) at chr11:66332223-66336840 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PNR2)
RIN1 (ENST00000528006.1) at chr11:66334999-66335700 - Ras and Rab interactor 1 (from HGNC RIN1)
RIN1 (ENST00000526246.5) at chr11:66330242-66336008 - Ras and Rab interactor 1 (from HGNC RIN1)
RIN1 (ENST00000524804.1) at chr11:66332590-66333553 - Ras and Rab interactor 1 (from HGNC RIN1)
RAB5A (ENST00000422242.1) at chr3:19947405-19984450 - Homo sapiens RAB5A, member RAS oncogene family (RAB5A), transcript variant 2, mRNA. (from RefSeq NM_001292048)
RAB5A (ENST00000273047.9) at chr3:19947097-19985175 - Homo sapiens RAB5A, member RAS oncogene family (RAB5A), transcript variant 1, mRNA. (from RefSeq NM_004162)
RIT2 (ENST00000589109.5) at chr18:42743227-43115691 - Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 2, mRNA. (from RefSeq NM_001272077)
RIT2 (ENST00000326695.10) at chr18:42743227-43115685 - Homo sapiens Ras like without CAAX 2 (RIT2), transcript variant 1, mRNA. (from RefSeq NM_002930)
PRKD1 (ENST00000616995.4) at chr14:29576479-29927512 - Serine/threonine-protein kinase that converts transient  diacylglycerol (DAG) signals into prolonged physiological effects  downstream of PKC, and is involved in the regulation of MAPK8/JNK1  and Ras signaling, Golgi membrane integrity and trafficking, cell  survival through NF-kappa-B activation, cell migration, cell  differentiation by mediating HDAC7 nuclear export, cell  proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in  cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced  apoptosis and flagellin-stimulated inflammatory response.  Phosphorylates the epidermal growth factor receptor (EGFR) on dual  threonine residues, which leads to the suppression of epidermal  growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent  JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to  14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition  with RAF1 for binding to GTP-bound form of Ras proteins (NRAS,  HRAS and KRAS). Acts downstream of the heterotrimeric G-protein  beta/gamma-subunit complex to maintain the structural integrity of  the Golgi membranes, and is required for protein transport along  the secretory pathway. In the trans-Golgi network (TGN), regulates  the fission of transport vesicles that are on their way to the  plasma membrane. May act by activating the lipid kinase  phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the  local synthesis of phosphorylated inositol lipids, which induces a  sequential production of DAG, phosphatidic acid (PA) and lyso-PA  (LPA) that are necessary for membrane fission and generation of  specific transport carriers to the cell surface. Under oxidative  stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes  to cell survival by activating IKK complex and subsequent nuclear  translocation and activation of NFKB1. Involved in cell migration  by regulating integrin alpha-5/beta-3 recycling and promoting its  recruitment in newly forming focal adhesion. In osteoblast  differentiation, mediates the bone morphogenic protein 2 (BMP2)-  induced nuclear export of HDAC7, which results in the inhibition  of HDAC7 transcriptional repression of RUNX2. In neurons, plays an  important role in neuronal polarity by regulating the biogenesis  of TGN-derived dendritic vesicles, and is involved in the  maintenance of dendritic arborization and Golgi structure in  hippocampal cells. May potentiate mitogenesis induced by the  neuropeptide bombesin or vasopressin by mediating an increase in  the duration of MAPK1/3 (ERK1/2) signaling, which leads to  accumulation of immediate-early gene products including FOS that  stimulate cell cycle progression. Plays an important role in the  proliferative response induced by low calcium in keratinocytes,  through sustained activation of MAPK1/3 (ERK1/2) pathway.  Downstream of novel PKC signaling, plays a role in cardiac  hypertrophy by phosphorylating HDAC5, which in turn triggers  XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional  activation and induction of downstream target genes that promote  myocyte hypertrophy and pathological cardiac remodeling. Mediates  cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which  results in reduced myofilament calcium sensitivity, and  accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway  is also involved in angiogenesis by mediating VEGFA-induced  specific subset of gene expression, cell migration, and tube  formation. In response to VEGFA, is necessary and required for  HDAC7 phosphorylation which induces HDAC7 nuclear export and  endothelial cell proliferation and migration. During apoptosis  induced by cytarabine and other genotoxic agents, PRKD1 is cleaved  by caspase-3 at Asp-378, resulting in activation of its kinase  function and increased sensitivity of cells to the cytotoxic  effects of genotoxic agents. In epithelial cells, is required for  transducing flagellin-stimulated inflammatory responses by binding  and phosphorylating TLR5, which contributes to MAPK14/p38  activation and production of inflammatory cytokines. May play a  role in inflammatory response by mediating activation of NF-kappa-  B. May be involved in pain transmission by directly modulating  TRPV1 receptor. (from UniProt Q15139)
RIT1 (ENST00000368322.7) at chr1:155900274-155910915 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 1, mRNA. (from RefSeq NM_001256821)
RIT1 (ENST00000539040.5) at chr1:155900183-155911402 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 3, mRNA. (from RefSeq NM_001256820)
RIT1 (ENST00000368323.8) at chr1:155897808-155911349 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 2, mRNA. (from RefSeq NM_006912)
PRKD1 (ENST00000331968.10) at chr14:29576479-29927847 - Homo sapiens protein kinase D1 (PRKD1), transcript variant 2, mRNA. (from RefSeq NM_002742)
HRAS (ENST00000493230.5) at chr11:532242-535538 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
HRAS (ENST00000397594.5) at chr11:532242-534375 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
HRAS (ENST00000634098.1) at chr11_KI270832v1_alt:61883-65179 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
HRAS (ENST00000631967.1) at chr11_KI270832v1_alt:61883-64016 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
ABL2 (ENST00000511413.5) at chr1:179107718-179229397 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant g, mRNA. (from RefSeq NM_001168237)
ABL2 (ENST00000507173.5) at chr1:179107718-179229397 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant h, mRNA. (from RefSeq NM_001168238)
ABL2 (ENST00000504405.5) at chr1:179107718-179143044 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant i, mRNA. (from RefSeq NM_001168239)
ABL2 (ENST00000367623.8) at chr1:179107718-179229397 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant f, mRNA. (from RefSeq NM_001168236)
ABL2 (ENST00000392043.4) at chr1:179110805-179229684 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant e, mRNA. (from RefSeq NM_001136001)
ABL2 (ENST00000512653.5) at chr1:179107599-179143056 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant c, mRNA. (from RefSeq NM_005158)
ABL2 (ENST00000344730.7) at chr1:179104048-179143089 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant d, mRNA. (from RefSeq NM_001136000)
ABL2 (ENST00000502732.6) at chr1:179099330-179229677 - Homo sapiens ABL proto-oncogene 2, non-receptor tyrosine kinase (ABL2), transcript variant b, mRNA. (from RefSeq NM_007314)
ABL1 (ENST00000372348.7) at chr9:130713016-130885683 - Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant b, mRNA. (from RefSeq NM_007313)
ABL1 (ENST00000318560.6) at chr9:130835254-130887675 - Homo sapiens ABL proto-oncogene 1, non-receptor tyrosine kinase (ABL1), transcript variant a, mRNA. (from RefSeq NM_005157)
STAM2 (ENST00000263904.5) at chr2:152116801-152175763 - Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA. (from RefSeq NM_005843)
HRAS (ENST00000616241.4) at chr11_KI270832v1_alt:61884-65191 - Homo sapiens HRas proto-oncogene, GTPase (HRAS), transcript variant 2, mRNA. (from RefSeq NM_176795)
HRAS (ENST00000417302.5) at chr11:532243-535550 - Homo sapiens HRas proto-oncogene, GTPase (HRAS), transcript variant 2, mRNA. (from RefSeq NM_176795)
EGFR (ENST00000342916.7) at chr7:55019032-55168635 - Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 2, mRNA. (from RefSeq NM_201282)
EGFR (ENST00000420316.6) at chr7:55019034-55156951 - Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 3, mRNA. (from RefSeq NM_201283)
EGFR (ENST00000344576.6) at chr7:55019033-55171045 - Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 4, mRNA. (from RefSeq NM_201284)
EGFR (ENST00000275493.7) at chr7:55019017-55211628 - Homo sapiens epidermal growth factor receptor (EGFR), transcript variant 1, mRNA. (from RefSeq NM_005228)
RAF1 (ENST00000251849.8) at chr3:12583601-12664226 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 11, non-coding RNA. (from RefSeq NR_148942)
RAF1 (ENST00000442415.6) at chr3:12583798-12664148 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 7, mRNA. (from RefSeq NM_001354694)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_004292.3 at chr11:66330241-66336434
NM_001363560.2 at chr11:66330241-66336434
NM_001363559.2 at chr11:66330241-66336774

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017018587.1 at chr11:66332063-66336434

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

RIN1 at chr11:66330241-66336434

RefSeq Genes

RIN1 at chr11:66330241-66336774 - (NM_001363559) ras and Rab interactor 1 isoform 2
RIN1 at chr11:66330241-66336434 - (NM_001363560) ras and Rab interactor 1 isoform 3
RIN1 at chr11:66330241-66336434 - (NM_004292) ras and Rab interactor 1 isoform 1

Non-Human RefSeq Genes

Rin1 at chr11:66332483-66336495 - (NM_139038) ras and Rab interactor 1
RIN1 at chr11:66332016-66336386 - (NM_001192217) ras and Rab interactor 1
Rin1 at chr11:66332156-66336419 - (NM_145495) ras and Rab interactor 1 isoform 2
RIN1 at chr3:128081259-128119414 - (NM_122138) P-loop containing nucleoside triphosphate hydrolases superfamily protein
Rin1 at chr11:66332156-66336419 - (NM_001374051) ras and Rab interactor 1 isoform 1
Rin1 at chr11:66332156-66336419 - (NM_001374052) ras and Rab interactor 1 isoform 3

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

RIN1 at chr11:66330241-66336434
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

RIN1 at chr11:66330241-66336434
RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

RIN1 at chr11:66330241-66336434
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

RIN1 at chr11:66330241-66336434
RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66335641-66336402

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700
RIN1 at chr11:66335641-66336402

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332223-66336840

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

RIN1 at chr11:66330242-66336008
RIN1 at chr11:66332062-66336529
RIN1 at chr11:66332210-66335691
RIN1 at chr11:66332223-66336840
RIN1 at chr11:66332590-66333553
RIN1 at chr11:66332609-66336436
RIN1 at chr11:66334999-66335700

International Knockout Mouse Consortium Genes Mapped to Human Genome

Rin1_40196 at chr11:66332071-66336529
Rin1_73396 at chr11:66332071-66336529
Rin1_VG13776 at chr11:66332071-66336529

Human Aligned mRNA Search Results

AB209445 - Homo sapiens mRNA for ras inhibitor RIN1 variant protein.
KU178481 - Homo sapiens Ras and Rab interactor 1 isoform 1 (RIN1) mRNA, partial cds.
KU178482 - Homo sapiens Ras and Rab interactor 1 isoform 2 (RIN1) mRNA, partial cds, alternatively spliced.
KU178483 - Homo sapiens Ras and Rab interactor 1 isoform 3 (RIN1) mRNA, complete cds, alternatively spliced.
BC014417 - Homo sapiens Ras and Rab interactor 1, mRNA (cDNA clone MGC:20059 IMAGE:4549333), complete cds.
L36463 - Homo sapiens ras interactor (RIN1) mRNA, complete cds.

Non-Human Aligned mRNA Search Results

U80076 - Rattus norvegicus RIN1 mRNA, complete cds.
BC011277 - Mus musculus Ras and Rab interactor 1, mRNA (cDNA clone MGC:12160 IMAGE:3711198), complete cds.
JU323803 - TSA: Macaca mulatta Mamu_507340 mRNA sequence.
JV564959 - TSA: Macaca mulatta Mamu_240860 mRNA sequence.
U30290 - Rattus norvegicus galanin receptor GALR1 mRNA, complete cds.
S69329 - isl-1=homeobox [rats, keratinocytes, islet cell line RIN1056A, mRNA, 1060 nt].
FJ004894 - Rattus norvegicus clone RIN122 TDPOZ-T2 mRNA, complete cds.

GeneReviews

GRIN1-Related Neurodevelopmental Disorder at chr9:137139154-137168756 - (GRIN1)