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Gencode Genes

RAF1 (ENST00000251849.8) at chr3:12583601-12664226 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 11, non-coding RNA. (from RefSeq NR_148942)
RAF1 (ENST00000494557.1) at chr3:12587979-12591916 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000492690.1) at chr3:12608446-12612001 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000491290.1) at chr3:12600199-12608867 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000475353.1) at chr3:12587577-12592068 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000471449.1) at chr3:12584346-12585905 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000465826.5) at chr3:12586847-12604213 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000460610.1) at chr3:12590641-12599755 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000442415.6) at chr3:12583798-12664148 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 7, mRNA. (from RefSeq NM_001354694)
RAF1 (ENST00000432427.2) at chr3:12584267-12612005 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 8, mRNA. (from RefSeq NM_001354695)
RAF1 (ENST00000423275.5) at chr3:12584333-12664125 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
RAF1 (ENST00000416093.1) at chr3:12604135-12664125 - Raf-1 proto-oncogene, serine/threonine kinase (from HGNC RAF1)
PAQR3 (ENST00000511594.5) at chr4:78910838-78939225 - Functions as a spatial regulator of RAF1 kinase by  sequestrating it to the Golgi. (from UniProt Q6TCH7)
PAQR3 (ENST00000515853.5) at chr4:78917942-78939224 - Functions as a spatial regulator of RAF1 kinase by  sequestrating it to the Golgi. (from UniProt Q6TCH7)
PAQR3 (ENST00000512760.5) at chr4:78887127-78939359 - Functions as a spatial regulator of RAF1 kinase by  sequestrating it to the Golgi. (from UniProt Q6TCH7)
ADCY6 (ENST00000357869.7) at chr12:48766198-48783441 - Membrane-bound, calcium-inhibitable adenylyl cyclase (By  similarity). (from UniProt O43306)
RIN1 (ENST00000311320.9) at chr11:66330241-66336434 - Homo sapiens Ras and Rab interactor 1 (RIN1), transcript variant 1, mRNA. (from RefSeq NM_004292)
ADCY6 (ENST00000550422.5) at chr12:48766198-48789037 - Membrane-bound, calcium-inhibitable adenylyl cyclase (By  similarity). (from UniProt O43306)
PAK5 (ENST00000378423.5) at chr20:9537389-9838831 - Serine/threonine protein kinase that plays a role in a  variety of different signaling pathways including cytoskeleton  regulation, cell migration, proliferation or cell survival.  Activation by various effectors including growth factor receptors  or active CDC42 and RAC1 results in a conformational change and a  subsequent autophosphorylation on several serine and/or threonine  residues. Phosphorylates the proto-oncogene RAF1 and stimulates  its kinase activity. Promotes cell survival by phosphorylating the  BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably  to regulate cytoskeletal organization and cell morphology. Keeps  microtubules stable through MARK2 inhibition and destabilizes the  F-actin network leading to the disappearance of stress fibers and  focal adhesions. (from UniProt Q9P286)
PIN1 (ENST00000588695.5) at chr19:9835341-9849682 - Essential PPIase that regulates mitosis presumably by  interacting with NIMA and attenuating its mitosis-promoting  activity. Displays a preference for an acidic residue N-terminal  to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans  isomerizations. Down-regulates kinase activity of BTK. Can  transactivate multiple oncogenes and induce centrosome  amplification, chromosome instability and cell transformation.  Required for the efficient dephosphorylation and recycling of RAF1  after mitogen activation. (from UniProt Q13526)
MKRN2 (ENST00000411987.5) at chr3:12557087-12582503 - Homo sapiens makorin ring finger protein 2 (MKRN2), transcript variant 2, mRNA. (from RefSeq NM_001271707)
MKRN2 (ENST00000170447.12) at chr3:12557087-12583713 - Homo sapiens makorin ring finger protein 2 (MKRN2), transcript variant 1, mRNA. (from RefSeq NM_014160)
YWHAE (ENST00000627231.2) at chr17_KI270862v1_alt:286301-342404 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), transcript variant 1, mRNA. (from RefSeq NM_006761)
RCAN1 (ENST00000487990.5) at chr21:34516484-34560179 - Inhibits calcineurin-dependent transcriptional responses  by binding to the catalytic domain of calcineurin A. Could play a  role during central nervous system development. (from UniProt P53805)
RCAN1 (ENST00000482533.5) at chr21:34516484-34524289 - Inhibits calcineurin-dependent transcriptional responses  by binding to the catalytic domain of calcineurin A. Could play a  role during central nervous system development. (from UniProt P53805)
YWHAB (ENST00000372839.7) at chr20:44885711-44908532 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta (YWHAB), transcript variant 1, mRNA. (from RefSeq NM_003404)
YWHAB (ENST00000353703.9) at chr20:44885705-44908532 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein beta (YWHAB), transcript variant 2, mRNA. (from RefSeq NM_139323)
YWHAE (ENST00000264335.13) at chr17:1344275-1400222 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), transcript variant 1, mRNA. (from RefSeq NM_006761)
YWHAE (ENST00000616643.3) at chr17_KI270862v1_alt:286566-342246 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), transcript variant 2, non-coding RNA. (from RefSeq NR_024058)
YWHAE (ENST00000571732.5) at chr17:1344540-1400220 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon (YWHAE), transcript variant 2, non-coding RNA. (from RefSeq NR_024058)
PAQR3 (ENST00000395594.2) at chr4:78917940-78939403 - Homo sapiens progestin and adipoQ receptor family member 3 (PAQR3), transcript variant 7, non-coding RNA. (from RefSeq NR_146465)
CPS1 (ENST00000430249.6) at chr2:210477709-210679107 - Involved in the urea cycle of ureotelic animals where  the enzyme plays an important role in removing excess ammonia from  the cell. (from UniProt P31327)
PAQR3 (ENST00000512733.5) at chr4:78911878-78939438 - Homo sapiens progestin and adipoQ receptor family member 3 (PAQR3), transcript variant 6, non-coding RNA. (from RefSeq NR_146464)
YWHAG (ENST00000307630.5) at chr7:76326799-76358991 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG), mRNA. (from RefSeq NM_012479)
DGKH (ENST00000379274.6) at chr13:42040036-42229755 - Homo sapiens diacylglycerol kinase eta (DGKH), transcript variant 3, mRNA. (from RefSeq NM_001204504)
DGKH (ENST00000337343.8) at chr13:42048753-42229750 - Homo sapiens diacylglycerol kinase eta (DGKH), transcript variant 2, mRNA. (from RefSeq NM_178009)
DGKH (ENST00000628433.2) at chr13:42138042-42229250 - Homo sapiens diacylglycerol kinase eta (DGKH), transcript variant 6, mRNA. (from RefSeq NM_001297429)
DGKH (ENST00000536612.3) at chr13:42138085-42229753 - Homo sapiens diacylglycerol kinase eta (DGKH), transcript variant 4, mRNA. (from RefSeq NM_001204505)
DGKH (ENST00000261491.9) at chr13:42048753-42242896 - Homo sapiens diacylglycerol kinase eta (DGKH), transcript variant 1, mRNA. (from RefSeq NM_152910)
PRKD1 (ENST00000616995.4) at chr14:29576479-29927512 - Serine/threonine-protein kinase that converts transient  diacylglycerol (DAG) signals into prolonged physiological effects  downstream of PKC, and is involved in the regulation of MAPK8/JNK1  and Ras signaling, Golgi membrane integrity and trafficking, cell  survival through NF-kappa-B activation, cell migration, cell  differentiation by mediating HDAC7 nuclear export, cell  proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in  cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced  apoptosis and flagellin-stimulated inflammatory response.  Phosphorylates the epidermal growth factor receptor (EGFR) on dual  threonine residues, which leads to the suppression of epidermal  growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent  JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to  14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition  with RAF1 for binding to GTP-bound form of Ras proteins (NRAS,  HRAS and KRAS). Acts downstream of the heterotrimeric G-protein  beta/gamma-subunit complex to maintain the structural integrity of  the Golgi membranes, and is required for protein transport along  the secretory pathway. In the trans-Golgi network (TGN), regulates  the fission of transport vesicles that are on their way to the  plasma membrane. May act by activating the lipid kinase  phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the  local synthesis of phosphorylated inositol lipids, which induces a  sequential production of DAG, phosphatidic acid (PA) and lyso-PA  (LPA) that are necessary for membrane fission and generation of  specific transport carriers to the cell surface. Under oxidative  stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes  to cell survival by activating IKK complex and subsequent nuclear  translocation and activation of NFKB1. Involved in cell migration  by regulating integrin alpha-5/beta-3 recycling and promoting its  recruitment in newly forming focal adhesion. In osteoblast  differentiation, mediates the bone morphogenic protein 2 (BMP2)-  induced nuclear export of HDAC7, which results in the inhibition  of HDAC7 transcriptional repression of RUNX2. In neurons, plays an  important role in neuronal polarity by regulating the biogenesis  of TGN-derived dendritic vesicles, and is involved in the  maintenance of dendritic arborization and Golgi structure in  hippocampal cells. May potentiate mitogenesis induced by the  neuropeptide bombesin or vasopressin by mediating an increase in  the duration of MAPK1/3 (ERK1/2) signaling, which leads to  accumulation of immediate-early gene products including FOS that  stimulate cell cycle progression. Plays an important role in the  proliferative response induced by low calcium in keratinocytes,  through sustained activation of MAPK1/3 (ERK1/2) pathway.  Downstream of novel PKC signaling, plays a role in cardiac  hypertrophy by phosphorylating HDAC5, which in turn triggers  XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional  activation and induction of downstream target genes that promote  myocyte hypertrophy and pathological cardiac remodeling. Mediates  cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which  results in reduced myofilament calcium sensitivity, and  accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway  is also involved in angiogenesis by mediating VEGFA-induced  specific subset of gene expression, cell migration, and tube  formation. In response to VEGFA, is necessary and required for  HDAC7 phosphorylation which induces HDAC7 nuclear export and  endothelial cell proliferation and migration. During apoptosis  induced by cytarabine and other genotoxic agents, PRKD1 is cleaved  by caspase-3 at Asp-378, resulting in activation of its kinase  function and increased sensitivity of cells to the cytotoxic  effects of genotoxic agents. In epithelial cells, is required for  transducing flagellin-stimulated inflammatory responses by binding  and phosphorylating TLR5, which contributes to MAPK14/p38  activation and production of inflammatory cytokines. May play a  role in inflammatory response by mediating activation of NF-kappa-  B. May be involved in pain transmission by directly modulating  TRPV1 receptor. (from UniProt Q15139)
OIP5 (ENST00000220514.8) at chr15:41309273-41332591 - Homo sapiens Opa interacting protein 5 (OIP5), transcript variant 1, mRNA. (from RefSeq NM_007280)
SHOC2 (ENST00000265277.9) at chr10:110964125-111013664 - Homo sapiens SHOC2 leucine rich repeat scaffold protein (SHOC2), transcript variant 2, mRNA. (from RefSeq NM_001269039)
SPRY4 (ENST00000434127.2) at chr5:142312974-142325040 - Homo sapiens sprouty RTK signaling antagonist 4 (SPRY4), transcript variant 4, mRNA. (from RefSeq NM_001293290)
RASIP1 (ENST00000222145.9) at chr19:48720585-48740610 - Homo sapiens Ras interacting protein 1 (RASIP1), mRNA. (from RefSeq NM_017805)
RCAN1 (ENST00000620920.4) at chr21:34516445-34524637 - Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 7, mRNA. (from RefSeq NM_001285393)
CNKSR2 (ENST00000642359.1) at chrX:21374298-21643600 - Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 3, mRNA. (from RefSeq NM_001168648)
CNKSR2 (ENST00000379510.5) at chrX:21374418-21654689 - Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 1, mRNA. (from RefSeq NM_014927)
RCAN1 (ENST00000443408.6) at chr21:34516445-34614446 - Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 2, mRNA. (from RefSeq NM_203417)
RCAN1 (ENST00000399272.5) at chr21:34516484-34613843 - Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 4, mRNA. (from RefSeq NM_001285389)
RCAN1 (ENST00000313806.9) at chr21:34516442-34615113 - Homo sapiens regulator of calcineurin 1 (RCAN1), transcript variant 1, mRNA. (from RefSeq NM_004414)
MRAS (ENST00000621127.4) at chr3:138348666-138405534 - Homo sapiens muscle RAS oncogene homolog (MRAS), transcript variant 6, mRNA. (from RefSeq NM_001252093)
MRAS (ENST00000614350.4) at chr3:138347648-138405534 - Homo sapiens muscle RAS oncogene homolog (MRAS), transcript variant 4, mRNA. (from RefSeq NM_001252091)
MRAS (ENST00000464896.5) at chr3:138348850-138403186 - Homo sapiens muscle RAS oncogene homolog (MRAS), transcript variant 5, mRNA. (from RefSeq NM_001252092)
ADCY5 (ENST00000309879.9) at chr3:123284578-123416342 - Homo sapiens adenylate cyclase 5 (ADCY5), transcript variant 2, mRNA. (from RefSeq NM_001199642)
ADCY5 (ENST00000462833.5) at chr3:123282296-123449758 - Homo sapiens adenylate cyclase 5 (ADCY5), transcript variant 1, mRNA. (from RefSeq NM_183357)
RIT1 (ENST00000368322.7) at chr1:155900274-155910915 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 1, mRNA. (from RefSeq NM_001256821)
TIMM50 (ENST00000544017.5) at chr19:39480412-39490888 - Essential component of the TIM23 complex, a complex that  mediates the translocation of transit peptide-containing proteins  across the mitochondrial inner membrane. Has some phosphatase  activity in vitro; however such activity may not be relevant in  vivo. Isoform 2 may participate in the release of snRNPs and SMN  from the Cajal body. (from UniProt Q3ZCQ8)
RIT1 (ENST00000539040.5) at chr1:155900183-155911402 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 3, mRNA. (from RefSeq NM_001256820)
RIT1 (ENST00000368323.8) at chr1:155897808-155911349 - Homo sapiens Ras like without CAAX 1 (RIT1), transcript variant 2, mRNA. (from RefSeq NM_006912)
PPP2CA (ENST00000481195.6) at chr5:134194332-134226073 - Homo sapiens protein phosphatase 2 catalytic subunit alpha (PPP2CA), transcript variant 1, mRNA. (from RefSeq NM_002715)
PRIMA1 (ENST00000477603.5) at chr14:93721038-93788420 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
PRIMA1 (ENST00000393143.5) at chr14:93718298-93787759 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
PRIMA1 (ENST00000316227.3) at chr14:93721038-93787759 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
PRIMA1 (ENST00000627063.2) at chr14_KI270847v1_alt:835600-902982 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
PRIMA1 (ENST00000617019.3) at chr14_KI270847v1_alt:835600-902321 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
PRIMA1 (ENST00000611347.2) at chr14_KI270847v1_alt:832860-902321 - Required to anchor acetylcholinesterase (ACHE) to the  basal lamina of the neuromuscular junction and to the membrane of  neuronal synapses in brain. Also able to organize ACHE into  tetramers (By similarity). (from UniProt Q86XR5)
KRAS (ENST00000311936.8) at chr12:25205246-25250929 - Homo sapiens KRAS proto-oncogene, GTPase (KRAS), transcript variant b, mRNA. (from RefSeq NM_004985)
KRAS (ENST00000256078.9) at chr12:25205246-25250929 - Homo sapiens KRAS proto-oncogene, GTPase (KRAS), transcript variant a, mRNA. (from RefSeq NM_033360)
ADCY2 (ENST00000338316.9) at chr5:7396138-7830081 - Homo sapiens adenylate cyclase 2 (ADCY2), mRNA. (from RefSeq NM_020546)
KITLG (ENST00000644744.1) at chr12:88492793-88580471 - Homo sapiens KIT ligand (KITLG), transcript variant b, mRNA. (from RefSeq NM_000899)
SPRY2 (ENST00000377102.5) at chr13:80335976-80339659 - Homo sapiens sprouty RTK signaling antagonist 2 (SPRY2), transcript variant 4, mRNA. (from RefSeq NM_001318538)
SPRY2 (ENST00000377104.4) at chr13:80335976-80341126 - Homo sapiens sprouty RTK signaling antagonist 2 (SPRY2), transcript variant 1, mRNA. (from RefSeq NM_005842)
KITLG (ENST00000347404.10) at chr12:88492793-88580851 - Homo sapiens KIT ligand (KITLG), transcript variant a, mRNA. (from RefSeq NM_003994)
HRAS (ENST00000493230.5) at chr11:532242-535538 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
HRAS (ENST00000397594.5) at chr11:532242-534375 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
CNKSR2 (ENST00000543067.6) at chrX:21374421-21642730 - Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 4, mRNA. (from RefSeq NM_001168649)
HRAS (ENST00000634098.1) at chr11_KI270832v1_alt:61883-65179 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
HRAS (ENST00000631967.1) at chr11_KI270832v1_alt:61883-64016 - Ras proteins bind GDP/GTP and possess intrinsic GTPase  activity. (from UniProt P01112)
CPS1 (ENST00000451903.2) at chr2:210593366-210679107 - Homo sapiens carbamoyl-phosphate synthase 1 (CPS1), transcript variant 3, non-coding RNA. (from RefSeq NR_163592)
HSP90AB1 (ENST00000371554.2) at chr6:44247866-44253883 - Molecular chaperone that promotes the maturation,  structural maintenance and proper regulation of specific target  proteins involved for instance in cell cycle control and signal  transduction. Undergoes a functional cycle that is linked to its  ATPase activity. This cycle probably induces conformational  changes in the client proteins, thereby causing their activation.  Interacts dynamically with various co-chaperones that modulate its  substrate recognition, ATPase cycle and chaperone function. (from UniProt P08238)
TIMM50 (ENST00000607714.6) at chr19:39480838-39493779 - Homo sapiens translocase of inner mitochondrial membrane 50 (TIMM50), transcript variant 2, mRNA. (from RefSeq NM_001329559)
KIT (ENST00000288135.5) at chr4:54657918-54740715 - Homo sapiens KIT proto-oncogene, receptor tyrosine kinase (KIT), transcript variant 1, mRNA. (from RefSeq NM_000222)
KIT (ENST00000412167.6) at chr4:54657918-54739011 - Homo sapiens KIT proto-oncogene, receptor tyrosine kinase (KIT), transcript variant 2, mRNA. (from RefSeq NM_001093772)
PAK1 (ENST00000356341.7) at chr11:77321707-77474062 - Homo sapiens p21 (RAC1) activated kinase 1 (PAK1), transcript variant 2, mRNA. (from RefSeq NM_002576)
PRKD1 (ENST00000331968.10) at chr14:29576479-29927847 - Homo sapiens protein kinase D1 (PRKD1), transcript variant 2, mRNA. (from RefSeq NM_002742)
PAK1 (ENST00000278568.8) at chr11:77322948-77474060 - Homo sapiens p21 (RAC1) activated kinase 1 (PAK1), transcript variant 1, mRNA. (from RefSeq NM_001128620)
PIN1 (ENST00000247970.8) at chr19:9835323-9849682 - Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), transcript variant 1, mRNA. (from RefSeq NM_006221)
BCL2 (ENST00000333681.5) at chr18:63123346-63319769 - Suppresses apoptosis in a variety of cell systems  including factor-dependent lymphohematopoietic and neural cells.  Regulates cell death by controlling the mitochondrial membrane  permeability. Appears to function in a feedback loop system with  caspases. Inhibits caspase activity either by preventing the  release of cytochrome c from the mitochondria and/or by binding to  the apoptosis-activating factor (APAF-1). (from UniProt P10415)
YWHAZ (ENST00000395957.6) at chr8:100916525-100952983 - Adapter protein implicated in the regulation of a large  spectrum of both general and specialized signaling pathways. Binds  to a large number of partners, usually by recognition of a  phosphoserine or phosphothreonine motif. Binding generally results  in the modulation of the activity of the binding partner. (from UniProt P63104)
YWHAZ (ENST00000522542.5) at chr8:100919829-100948162 - Adapter protein implicated in the regulation of a large  spectrum of both general and specialized signaling pathways. Binds  to a large number of partners, usually by recognition of a  phosphoserine or phosphothreonine motif. Binding generally results  in the modulation of the activity of the binding partner. (from UniProt P63104)
YWHAZ (ENST00000395953.6) at chr8:100920587-100951594 - Adapter protein implicated in the regulation of a large  spectrum of both general and specialized signaling pathways. Binds  to a large number of partners, usually by recognition of a  phosphoserine or phosphothreonine motif. Binding generally results  in the modulation of the activity of the binding partner. (from UniProt P63104)
SNAI2 (ENST00000020945.4) at chr8:48917598-48921429 - Homo sapiens snail family transcriptional repressor 2 (SNAI2), mRNA. (from RefSeq NM_003068)
SHOC2 (ENST00000369452.8) at chr10:110919547-111013667 - Homo sapiens SHOC2 leucine rich repeat scaffold protein (SHOC2), transcript variant 5, non-coding RNA. (from RefSeq NR_136749)
HSP90AB1 (ENST00000620073.4) at chr6:44246166-44253888 - Homo sapiens heat shock protein 90 alpha family class B member 1 (HSP90AB1), transcript variant 3, mRNA. (from RefSeq NM_001271970)
PRKCZ (ENST00000461106.6) at chr1:2073986-2185190 - Homo sapiens protein kinase C zeta (PRKCZ), transcript variant 4, mRNA. (from RefSeq NM_001242874)
RAP1A (ENST00000369709.3) at chr1:111619783-111716691 - Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 2, mRNA. (from RefSeq NM_002884)
HSP90AB1 (ENST00000353801.7) at chr6:44247087-44253883 - Homo sapiens heat shock protein 90 alpha family class B member 1 (HSP90AB1), transcript variant 1, mRNA. (from RefSeq NM_001271969)
PRKCZ (ENST00000378567.8) at chr1:2050411-2185395 - Homo sapiens protein kinase C zeta (PRKCZ), transcript variant 1, mRNA. (from RefSeq NM_002744)
HSP90AB1 (ENST00000371646.10) at chr6:44247101-44253883 - Homo sapiens heat shock protein 90 alpha family class B member 1 (HSP90AB1), transcript variant 2, mRNA. (from RefSeq NM_007355)
RAP1A (ENST00000356415.5) at chr1:111542218-111713113 - Homo sapiens RAP1A, member of RAS oncogene family (RAP1A), transcript variant 4, mRNA. (from RefSeq NM_001370216)
BCL2 (ENST00000398117.1) at chr18:63123346-63320128 - Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant alpha, mRNA. (from RefSeq NM_000633)
BCL2 (ENST00000589955.2) at chr18:63313802-63318812 - Homo sapiens BCL2 apoptosis regulator (BCL2), transcript variant beta, mRNA. (from RefSeq NM_000657)
PEBP1 (ENST00000261313.3) at chr12:118136124-118145584 - Homo sapiens phosphatidylethanolamine binding protein 1 (PEBP1), mRNA. (from RefSeq NM_002567)
CNKSR2 (ENST00000425654.7) at chrX:21374418-21654695 - Homo sapiens connector enhancer of kinase suppressor of Ras 2 (CNKSR2), transcript variant 2, mRNA. (from RefSeq NM_001168647)
MAP2K1 (ENST00000307102.9) at chr15:66386817-66492312 - Homo sapiens mitogen-activated protein kinase kinase 1 (MAP2K1), mRNA. (from RefSeq NM_002755)
PAK5 (ENST00000378429.3) at chr20:9537389-9839041 - Homo sapiens p21 (RAC1) activated kinase 5 (PAK5), transcript variant 1, mRNA. (from RefSeq NM_020341)
PAK5 (ENST00000353224.9) at chr20:9537389-9838867 - Homo sapiens p21 (RAC1) activated kinase 5 (PAK5), transcript variant 2, mRNA. (from RefSeq NM_177990)
CCT3 (ENST00000368259.6) at chr1:156308969-156338245 - Homo sapiens chaperonin containing TCP1 subunit 3 (CCT3), transcript variant 3, mRNA. (from RefSeq NM_001008800)
CDC25A (ENST00000351231.7) at chr3:48157146-48188356 - Homo sapiens cell division cycle 25A (CDC25A), transcript variant 2, mRNA. (from RefSeq NM_201567)
CCT3 (ENST00000295688.8) at chr1:156308968-156338292 - Homo sapiens chaperonin containing TCP1 subunit 3 (CCT3), transcript variant 1, mRNA. (from RefSeq NM_005998)
CDC25A (ENST00000302506.8) at chr3:48157146-48188417 - Homo sapiens cell division cycle 25A (CDC25A), transcript variant 1, mRNA. (from RefSeq NM_001789)
PRIMA1 (ENST00000629961.2) at chr14_KI270847v1_alt:832860-903043 - Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA. (from RefSeq NM_178013)
PRIMA1 (ENST00000393140.6) at chr14:93718298-93788485 - Homo sapiens proline rich membrane anchor 1 (PRIMA1), mRNA. (from RefSeq NM_178013)
ADCY6 (ENST00000307885.4) at chr12:48766329-48784129 - Homo sapiens adenylate cyclase 6 (ADCY6), mRNA. (from RefSeq NM_015270)
CPS1 (ENST00000233072.10) at chr2:210556599-210679107 - Homo sapiens carbamoyl-phosphate synthase 1 (CPS1), transcript variant 6, non-coding RNA. (from RefSeq NR_161225)
YWHAZ (ENST00000419477.6) at chr8:100920642-100951276 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 5, mRNA. (from RefSeq NM_001135701)
YWHAZ (ENST00000395951.7) at chr8:100920630-100950557 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 6, mRNA. (from RefSeq NM_001135702)
YWHAZ (ENST00000457309.2) at chr8:100918579-100952993 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 3, mRNA. (from RefSeq NM_001135699)
YWHAZ (ENST00000395956.7) at chr8:100918683-100951449 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 4, mRNA. (from RefSeq NM_001135700)
YWHAZ (ENST00000353245.7) at chr8:100918686-100953341 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 1, mRNA. (from RefSeq NM_003406)
PRKCZ (ENST00000400921.6) at chr1:2073462-2185390 - Homo sapiens protein kinase C zeta (PRKCZ), transcript variant 9, non-coding RNA. (from RefSeq NR_146911)
YWHAZ (ENST00000395958.6) at chr8:100916523-100952020 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta (YWHAZ), transcript variant 2, mRNA. (from RefSeq NM_145690)
PPP2R1B (ENST00000311129.9) at chr11:111726908-111766382 - Homo sapiens protein phosphatase 2 scaffold subunit Abeta (PPP2R1B), transcript variant 2, mRNA. (from RefSeq NM_181699)
PPP2R1B (ENST00000426998.6) at chr11:111726914-111766386 - Homo sapiens protein phosphatase 2 scaffold subunit Abeta (PPP2R1B), transcript variant 3, mRNA. (from RefSeq NM_181700)
PPP2R1B (ENST00000393055.6) at chr11:111741517-111766382 - Homo sapiens protein phosphatase 2 scaffold subunit Abeta (PPP2R1B), transcript variant 5, mRNA. (from RefSeq NM_001177563)
PPP2R1B (ENST00000341980.10) at chr11:111741321-111766368 - Homo sapiens protein phosphatase 2 scaffold subunit Abeta (PPP2R1B), transcript variant 4, mRNA. (from RefSeq NM_001177562)
PPP2R1B (ENST00000527614.6) at chr11:111737877-111766389 - Homo sapiens protein phosphatase 2 scaffold subunit Abeta (PPP2R1B), transcript variant 1, mRNA. (from RefSeq NM_002716)
MAPK3 (ENST00000395202.5) at chr16:30116668-30123209 - Serine/threonine kinase which acts as an essential  component of the MAP kinase signal transduction pathway.  MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important  role in the MAPK/ERK cascade. They participate also in a signaling  cascade initiated by activated KIT and KITLG/SCF. Depending on the  cellular context, the MAPK/ERK cascade mediates diverse biological  functions such as cell growth, adhesion, survival and  differentiation through the regulation of transcription,  translation, cytoskeletal rearrangements. The the MAPK/ERK cascade  plays also a role in initiation and regulation of meiosis,  mitosis, and postmitotic functions in differentiated cells by  phosphorylating a number of transcription factors. About 160  substrates have already been discovered for ERKs. Many of these  substrates are localized in the nucleus, and seem to participate  in the regulation of transcription upon stimulation. However,  other substrates are found in the cytosol as well as in other  cellular organelles, and those are responsible for processes such  as translation, mitosis and apoptosis. Moreover, the MAPK/ERK  cascade is also involved in the regulation of the endosomal  dynamics, including lysosome processing and endosome cycling  through the perinuclear recycling compartment (PNRC); as well as  in the fragmentation of the Golgi apparatus during mitosis. The  substrates include transcription factors (such as ATF2, BCL6,  ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as  CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of  apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),  regulators of translation (such as EIF4EBP1) and a variety of  other signaling-related molecules (like ARHGEF2, FRS2 or GRB10).  Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,  RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,  RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases  (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which  enable the propagation the MAPK/ERK signal to additional cytosolic  and nuclear targets, thereby extending the specificity of the  cascade. (from UniProt P27361)
MAPK1 (ENST00000544786.1) at chr22:21769204-21867440 - Serine/threonine kinase which acts as an essential  component of the MAP kinase signal transduction pathway.  MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important  role in the MAPK/ERK cascade. They participate also in a signaling  cascade initiated by activated KIT and KITLG/SCF. Depending on the  cellular context, the MAPK/ERK cascade mediates diverse biological  functions such as cell growth, adhesion, survival and  differentiation through the regulation of transcription,  translation, cytoskeletal rearrangements. The the MAPK/ERK cascade  plays also a role in initiation and regulation of meiosis,  mitosis, and postmitotic functions in differentiated cells by  phosphorylating a number of transcription factors. About 160  substrates have already been discovered for ERKs. Many of these  substrates are localized in the nucleus, and seem to participate  in the regulation of transcription upon stimulation. However,  other substrates are found in the cytosol as well as in other  cellular organelles, and those are responsible for processes such  as translation, mitosis and apoptosis. Moreover, the MAPK/ERK  cascade is also involved in the regulation of the endosomal  dynamics, including lysosome processing and endosome cycling  through the perinuclear recycling compartment (PNRC); as well as  in the fragmentation of the Golgi apparatus during mitosis. The  substrates include transcription factors (such as ATF2, BCL6,  ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as  CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of  apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),  regulators of translation (such as EIF4EBP1) and a variety of  other signaling-related molecules (like ARHGEF2, DCC, FRS2 or  GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,  RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,  RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases  (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which  enable the propagation the MAPK/ERK signal to additional cytosolic  and nuclear targets, thereby extending the specificity of the  cascade. (from UniProt P28482)
PRKCA (ENST00000413366.8) at chr17:66302613-66810743 - Homo sapiens protein kinase C alpha (PRKCA), mRNA. (from RefSeq NM_002737)
DMPK (ENST00000618091.4) at chr19:45769847-45782388 - Non-receptor serine/threonine protein kinase which is  necessary for the maintenance of skeletal muscle structure and  function. May play a role in myocyte differentiation and survival  by regulating the integrity of the nuclear envelope and the  expression of muscle-specific genes. May also phosphorylate  PPP1R12A and inhibit the myosin phosphatase activity to regulate  myosin phosphorylation. Also critical to the modulation of cardiac  contractility and to the maintenance of proper cardiac conduction  activity probably through the regulation of cellular calcium  homeostasis. Phosphorylates PLN, a regulator of calcium pumps and  may regulate sarcoplasmic reticulum calcium uptake in myocytes.  May also phosphorylate FXYD1/PLM which is able to induce chloride  currents. May also play a role in synaptic plasticity. (from UniProt Q09013)
BRAF (ENST00000646891.1) at chr7:140730665-140924928 - Homo sapiens B-Raf proto-oncogene, serine/threonine kinase (BRAF), transcript variant 1, mRNA. (from RefSeq NM_004333)
STK3 (ENST00000523601.5) at chr8:98454695-98942571 - Homo sapiens serine/threonine kinase 3 (STK3), transcript variant 2, mRNA. (from RefSeq NM_001256312)
STK3 (ENST00000419617.7) at chr8:98454633-98825688 - Homo sapiens serine/threonine kinase 3 (STK3), transcript variant 1, mRNA. (from RefSeq NM_006281)
PPP1R12A (ENST00000261207.9) at chr12:79773563-79935455 - Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 2, mRNA. (from RefSeq NM_001143885)
PPP1R12A (ENST00000546369.5) at chr12:79775923-79913911 - Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 3, mRNA. (from RefSeq NM_001143886)
PPP1R12A (ENST00000550107.5) at chr12:79775929-79934931 - Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 5, mRNA. (from RefSeq NM_001244992)
PPP1R12A (ENST00000437004.6) at chr12:79774406-79935460 - Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 4, mRNA. (from RefSeq NM_001244990)
PPP1R12A (ENST00000450142.7) at chr12:79773568-79935097 - Homo sapiens protein phosphatase 1 regulatory subunit 12A (PPP1R12A), transcript variant 1, mRNA. (from RefSeq NM_002480)
DMPK (ENST00000291270.8) at chr19:45769717-45782478 - Homo sapiens DM1 protein kinase (DMPK), transcript variant 2, mRNA. (from RefSeq NM_004409)
DMPK (ENST00000458663.6) at chr19:45769847-45782388 - Homo sapiens DM1 protein kinase (DMPK), transcript variant 4, mRNA. (from RefSeq NM_001081562)
DMPK (ENST00000447742.6) at chr19:45769736-45782479 - Homo sapiens DM1 protein kinase (DMPK), transcript variant 3, mRNA. (from RefSeq NM_001081560)
DMPK (ENST00000354227.9) at chr19:45770381-45782489 - Homo sapiens DM1 protein kinase (DMPK), transcript variant 7, mRNA. (from RefSeq NM_001288766)
DMPK (ENST00000343373.8) at chr19:45769725-45780603 - Homo sapiens DM1 protein kinase (DMPK), transcript variant 1, mRNA. (from RefSeq NM_001081563)
PRMT5 (ENST00000324366.13) at chr14:22920529-22929376 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 1, mRNA. (from RefSeq NM_006109)
PRMT5 (ENST00000553897.5) at chr14:22920876-22929408 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 5, mRNA. (from RefSeq NM_001282955)
PRMT5 (ENST00000397441.6) at chr14:22920525-22929401 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 2, mRNA. (from RefSeq NM_001039619)
PRMT5 (ENST00000397440.8) at chr14:22920529-22929356 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 6, mRNA. (from RefSeq NM_001282956)
PRMT5 (ENST00000216350.12) at chr14:22920530-22929391 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 4, mRNA. (from RefSeq NM_001282954)
ROCK2 (ENST00000315872.11) at chr2:11179759-11344636 - Homo sapiens Rho associated coiled-coil containing protein kinase 2 (ROCK2), transcript variant 1, mRNA. (from RefSeq NM_004850)
HRAS (ENST00000616241.4) at chr11_KI270832v1_alt:61884-65191 - Homo sapiens HRas proto-oncogene, GTPase (HRAS), transcript variant 2, mRNA. (from RefSeq NM_176795)
HRAS (ENST00000417302.5) at chr11:532243-535550 - Homo sapiens HRas proto-oncogene, GTPase (HRAS), transcript variant 2, mRNA. (from RefSeq NM_176795)
YWHAH (ENST00000248975.6) at chr22:31944535-31957603 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta (YWHAH), mRNA. (from RefSeq NM_003405)
MAPK3 (ENST00000395199.7) at chr16:30116837-30123209 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 2, mRNA. (from RefSeq NM_001040056)
MAPK3 (ENST00000263025.9) at chr16:30114105-30123220 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 1, mRNA. (from RefSeq NM_002746)
MAPK3 (ENST00000322266.9) at chr16:30114106-30123309 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 3, mRNA. (from RefSeq NM_001109891)
PRKCB (ENST00000643927.1) at chr16:23835983-24220611 - Homo sapiens protein kinase C beta (PRKCB), transcript variant 2, mRNA. (from RefSeq NM_002738)
PRKCB (ENST00000321728.12) at chr16:23835983-24220611 - Homo sapiens protein kinase C beta (PRKCB), transcript variant 1, mRNA. (from RefSeq NM_212535)
LCK (ENST00000336890.10) at chr1:32251265-32286165 - Homo sapiens LCK proto-oncogene, Src family tyrosine kinase (LCK), transcript variant 2, mRNA. (from RefSeq NM_005356)
LCK (ENST00000619559.4) at chr1:32274111-32286164 - Homo sapiens LCK proto-oncogene, Src family tyrosine kinase (LCK), transcript variant 1, mRNA. (from RefSeq NM_001042771)
PAK2 (ENST00000327134.7) at chr3:196739857-196832647 - Homo sapiens p21 (RAC1) activated kinase 2 (PAK2), mRNA. (from RefSeq NM_002577)
RGS14 (ENST00000408923.8) at chr5:177357924-177372596 - Homo sapiens regulator of G protein signaling 14 (RGS14), transcript variant 1, mRNA. (from RefSeq NM_006480)
PDGFRB (ENST00000261799.9) at chr5:150113839-150155845 - Homo sapiens platelet derived growth factor receptor beta (PDGFRB), transcript variant 1, mRNA. (from RefSeq NM_002609)
AKT1 (ENST00000649815.1) at chr14:104769371-104795555 - AKT1 is one of 3 closely related serine/threonine-  protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and  which regulate many processes including metabolism, proliferation,  cell survival, growth and angiogenesis. This is mediated through  serine and/or threonine phosphorylation of a range of downstream  substrates. Over 100 substrate candidates have been reported so  far, but for most of them, no isoform specificity has been  reported. AKT is responsible of the regulation of glucose uptake  by mediating insulin-induced translocation of the SLC2A4/GLUT4  glucose transporter to the cell surface. Phosphorylation of PTPN1  at 'Ser-50' negatively modulates its phosphatase activity  preventing dephosphorylation of the insulin receptor and the  attenuation of insulin signaling. Phosphorylation of TBC1D4  triggers the binding of this effector to inhibitory 14-3-3  proteins, which is required for insulin-stimulated glucose  transport. AKT regulates also the storage of glucose in the form  of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at  'Ser-9', resulting in inhibition of its kinase activity.  Phosphorylation of GSK3 isoforms by AKT is also thought to be one  mechanism by which cell proliferation is driven. AKT regulates  also cell survival via the phosphorylation of MAP3K5 (apoptosis  signal-related kinase). Phosphorylation of 'Ser-83' decreases  MAP3K5 kinase activity stimulated by oxidative stress and thereby  prevents apoptosis. AKT mediates insulin-stimulated protein  synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462',  thereby activating mTORC1 signaling and leading to both  phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is  involved in the phosphorylation of members of the FOXO factors  (Forkhead family of transcription factors), leading to binding of  14-3-3 proteins and cytoplasmic localization. In particular, FOXO1  is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and  FOXO4 are phosphorylated on equivalent sites. AKT has an important  role in the regulation of NF-kappa-B-dependent gene transcription  and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-  response element binding protein). The phosphorylation of CREB1  induces the binding of accessory proteins that are necessary for  the transcription of pro-survival genes such as BCL2 and MCL1. AKT  phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby  potentially regulating ACLY activity and fatty acid synthesis.  Activates the 3B isoform of cyclic nucleotide phosphodiesterase  (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced  cyclic AMP levels and inhibition of lipolysis. Phosphorylates  PIKFYVE on 'Ser-318', which results in increased PI(3)P-5  activity. The Rho GTPase-activating protein DLC1 is another  substrate and its phosphorylation is implicated in the regulation  cell proliferation and cell growth. AKT plays a role as key  modulator of the AKT-mTOR signaling pathway controlling the tempo  of the process of newborn neurons integration during adult  neurogenesis, including correct neuron positioning, dendritic  development and synapse formation. Signals downstream of  phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of  various growth factors such as platelet-derived growth factor  (PDGF), epidermal growth factor (EGF), insulin and insulin-like  growth factor I (IGF-I). AKT mediates the antiapoptotic effects of  IGF-I. Essential for the SPATA13-mediated regulation of cell  migration and adhesion assembly and disassembly. May be involved  in the regulation of the placental development. Phosphorylates  STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its:  kinase activity, nuclear translocation, autophosphorylation and  ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-  117' and 'Thr-384' leading to inhibition of its: cleavage, kinase  activity, autophosphorylation at Thr-180, binding to RASSF1 and  nuclear translocation. Phosphorylates SRPK2 and enhances its  kinase activity towards SRSF2 and ACIN1 and promotes its nuclear  translocation. Phosphorylates RAF1 at 'Ser-259' and negatively  regulates its activity. Phosphorylation of BAD stimulates its pro-  apoptotic activity. (from UniProt P31749)
AKT1 (ENST00000554848.5) at chr14:104770341-104794191 - AKT1 is one of 3 closely related serine/threonine-  protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and  which regulate many processes including metabolism, proliferation,  cell survival, growth and angiogenesis. This is mediated through  serine and/or threonine phosphorylation of a range of downstream  substrates. Over 100 substrate candidates have been reported so  far, but for most of them, no isoform specificity has been  reported. AKT is responsible of the regulation of glucose uptake  by mediating insulin-induced translocation of the SLC2A4/GLUT4  glucose transporter to the cell surface. Phosphorylation of PTPN1  at 'Ser-50' negatively modulates its phosphatase activity  preventing dephosphorylation of the insulin receptor and the  attenuation of insulin signaling. Phosphorylation of TBC1D4  triggers the binding of this effector to inhibitory 14-3-3  proteins, which is required for insulin-stimulated glucose  transport. AKT regulates also the storage of glucose in the form  of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at  'Ser-9', resulting in inhibition of its kinase activity.  Phosphorylation of GSK3 isoforms by AKT is also thought to be one  mechanism by which cell proliferation is driven. AKT regulates  also cell survival via the phosphorylation of MAP3K5 (apoptosis  signal-related kinase). Phosphorylation of 'Ser-83' decreases  MAP3K5 kinase activity stimulated by oxidative stress and thereby  prevents apoptosis. AKT mediates insulin-stimulated protein  synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462',  thereby activating mTORC1 signaling and leading to both  phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is  involved in the phosphorylation of members of the FOXO factors  (Forkhead family of transcription factors), leading to binding of  14-3-3 proteins and cytoplasmic localization. In particular, FOXO1  is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and  FOXO4 are phosphorylated on equivalent sites. AKT has an important  role in the regulation of NF-kappa-B-dependent gene transcription  and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-  response element binding protein). The phosphorylation of CREB1  induces the binding of accessory proteins that are necessary for  the transcription of pro-survival genes such as BCL2 and MCL1. AKT  phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby  potentially regulating ACLY activity and fatty acid synthesis.  Activates the 3B isoform of cyclic nucleotide phosphodiesterase  (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced  cyclic AMP levels and inhibition of lipolysis. Phosphorylates  PIKFYVE on 'Ser-318', which results in increased PI(3)P-5  activity. The Rho GTPase-activating protein DLC1 is another  substrate and its phosphorylation is implicated in the regulation  cell proliferation and cell growth. AKT plays a role as key  modulator of the AKT-mTOR signaling pathway controlling the tempo  of the process of newborn neurons integration during adult  neurogenesis, including correct neuron positioning, dendritic  development and synapse formation. Signals downstream of  phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of  various growth factors such as platelet-derived growth factor  (PDGF), epidermal growth factor (EGF), insulin and insulin-like  growth factor I (IGF-I). AKT mediates the antiapoptotic effects of  IGF-I. Essential for the SPATA13-mediated regulation of cell  migration and adhesion assembly and disassembly. May be involved  in the regulation of the placental development. Phosphorylates  STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its:  kinase activity, nuclear translocation, autophosphorylation and  ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-  117' and 'Thr-384' leading to inhibition of its: cleavage, kinase  activity, autophosphorylation at Thr-180, binding to RASSF1 and  nuclear translocation. Phosphorylates SRPK2 and enhances its  kinase activity towards SRSF2 and ACIN1 and promotes its nuclear  translocation. Phosphorylates RAF1 at 'Ser-259' and negatively  regulates its activity. Phosphorylation of BAD stimulates its pro-  apoptotic activity. (from UniProt P31749)
AKT1 (ENST00000554581.5) at chr14:104769349-104794124 - AKT1 is one of 3 closely related serine/threonine-  protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and  which regulate many processes including metabolism, proliferation,  cell survival, growth and angiogenesis. This is mediated through  serine and/or threonine phosphorylation of a range of downstream  substrates. Over 100 substrate candidates have been reported so  far, but for most of them, no isoform specificity has been  reported. AKT is responsible of the regulation of glucose uptake  by mediating insulin-induced translocation of the SLC2A4/GLUT4  glucose transporter to the cell surface. Phosphorylation of PTPN1  at 'Ser-50' negatively modulates its phosphatase activity  preventing dephosphorylation of the insulin receptor and the  attenuation of insulin signaling. Phosphorylation of TBC1D4  triggers the binding of this effector to inhibitory 14-3-3  proteins, which is required for insulin-stimulated glucose  transport. AKT regulates also the storage of glucose in the form  of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at  'Ser-9', resulting in inhibition of its kinase activity.  Phosphorylation of GSK3 isoforms by AKT is also thought to be one  mechanism by which cell proliferation is driven. AKT regulates  also cell survival via the phosphorylation of MAP3K5 (apoptosis  signal-related kinase). Phosphorylation of 'Ser-83' decreases  MAP3K5 kinase activity stimulated by oxidative stress and thereby  prevents apoptosis. AKT mediates insulin-stimulated protein  synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462',  thereby activating mTORC1 signaling and leading to both  phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is  involved in the phosphorylation of members of the FOXO factors  (Forkhead family of transcription factors), leading to binding of  14-3-3 proteins and cytoplasmic localization. In particular, FOXO1  is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and  FOXO4 are phosphorylated on equivalent sites. AKT has an important  role in the regulation of NF-kappa-B-dependent gene transcription  and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-  response element binding protein). The phosphorylation of CREB1  induces the binding of accessory proteins that are necessary for  the transcription of pro-survival genes such as BCL2 and MCL1. AKT  phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby  potentially regulating ACLY activity and fatty acid synthesis.  Activates the 3B isoform of cyclic nucleotide phosphodiesterase  (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced  cyclic AMP levels and inhibition of lipolysis. Phosphorylates  PIKFYVE on 'Ser-318', which results in increased PI(3)P-5  activity. The Rho GTPase-activating protein DLC1 is another  substrate and its phosphorylation is implicated in the regulation  cell proliferation and cell growth. AKT plays a role as key  modulator of the AKT-mTOR signaling pathway controlling the tempo  of the process of newborn neurons integration during adult  neurogenesis, including correct neuron positioning, dendritic  development and synapse formation. Signals downstream of  phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of  various growth factors such as platelet-derived growth factor  (PDGF), epidermal growth factor (EGF), insulin and insulin-like  growth factor I (IGF-I). AKT mediates the antiapoptotic effects of  IGF-I. Essential for the SPATA13-mediated regulation of cell  migration and adhesion assembly and disassembly. May be involved  in the regulation of the placental development. Phosphorylates  STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its:  kinase activity, nuclear translocation, autophosphorylation and  ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-  117' and 'Thr-384' leading to inhibition of its: cleavage, kinase  activity, autophosphorylation at Thr-180, binding to RASSF1 and  nuclear translocation. Phosphorylates SRPK2 and enhances its  kinase activity towards SRSF2 and ACIN1 and promotes its nuclear  translocation. Phosphorylates RAF1 at 'Ser-259' and negatively  regulates its activity. Phosphorylation of BAD stimulates its pro-  apoptotic activity. (from UniProt P31749)
AKT1 (ENST00000402615.6) at chr14:104769352-104794528 - AKT1 is one of 3 closely related serine/threonine-  protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and  which regulate many processes including metabolism, proliferation,  cell survival, growth and angiogenesis. This is mediated through  serine and/or threonine phosphorylation of a range of downstream  substrates. Over 100 substrate candidates have been reported so  far, but for most of them, no isoform specificity has been  reported. AKT is responsible of the regulation of glucose uptake  by mediating insulin-induced translocation of the SLC2A4/GLUT4  glucose transporter to the cell surface. Phosphorylation of PTPN1  at 'Ser-50' negatively modulates its phosphatase activity  preventing dephosphorylation of the insulin receptor and the  attenuation of insulin signaling. Phosphorylation of TBC1D4  triggers the binding of this effector to inhibitory 14-3-3  proteins, which is required for insulin-stimulated glucose  transport. AKT regulates also the storage of glucose in the form  of glycogen by phosphorylating GSK3A at 'Ser-21' and GSK3B at  'Ser-9', resulting in inhibition of its kinase activity.  Phosphorylation of GSK3 isoforms by AKT is also thought to be one  mechanism by which cell proliferation is driven. AKT regulates  also cell survival via the phosphorylation of MAP3K5 (apoptosis  signal-related kinase). Phosphorylation of 'Ser-83' decreases  MAP3K5 kinase activity stimulated by oxidative stress and thereby  prevents apoptosis. AKT mediates insulin-stimulated protein  synthesis by phosphorylating TSC2 at 'Ser-939' and 'Thr-1462',  thereby activating mTORC1 signaling and leading to both  phosphorylation of 4E-BP1 and in activation of RPS6KB1. AKT is  involved in the phosphorylation of members of the FOXO factors  (Forkhead family of transcription factors), leading to binding of  14-3-3 proteins and cytoplasmic localization. In particular, FOXO1  is phosphorylated at 'Thr-24', 'Ser-256' and 'Ser-319'. FOXO3 and  FOXO4 are phosphorylated on equivalent sites. AKT has an important  role in the regulation of NF-kappa-B-dependent gene transcription  and positively regulates the activity of CREB1 (cyclic AMP (cAMP)-  response element binding protein). The phosphorylation of CREB1  induces the binding of accessory proteins that are necessary for  the transcription of pro-survival genes such as BCL2 and MCL1. AKT  phosphorylates 'Ser-454' on ATP citrate lyase (ACLY), thereby  potentially regulating ACLY activity and fatty acid synthesis.  Activates the 3B isoform of cyclic nucleotide phosphodiesterase  (PDE3B) via phosphorylation of 'Ser-273', resulting in reduced  cyclic AMP levels and inhibition of lipolysis. Phosphorylates  PIKFYVE on 'Ser-318', which results in increased PI(3)P-5  activity. The Rho GTPase-activating protein DLC1 is another  substrate and its phosphorylation is implicated in the regulation  cell proliferation and cell growth. AKT plays a role as key  modulator of the AKT-mTOR signaling pathway controlling the tempo  of the process of newborn neurons integration during adult  neurogenesis, including correct neuron positioning, dendritic  development and synapse formation. Signals downstream of  phosphatidylinositol 3-kinase (PI(3)K) to mediate the effects of  various growth factors such as platelet-derived growth factor  (PDGF), epidermal growth factor (EGF), insulin and insulin-like  growth factor I (IGF-I). AKT mediates the antiapoptotic effects of  IGF-I. Essential for the SPATA13-mediated regulation of cell  migration and adhesion assembly and disassembly. May be involved  in the regulation of the placental development. Phosphorylates  STK4/MST1 at 'Thr-120' and 'Thr-387' leading to inhibition of its:  kinase activity, nuclear translocation, autophosphorylation and  ability to phosphorylate FOXO3. Phosphorylates STK3/MST2 at 'Thr-  117' and 'Thr-384' leading to inhibition of its: cleavage, kinase  activity, autophosphorylation at Thr-180, binding to RASSF1 and  nuclear translocation. Phosphorylates SRPK2 and enhances its  kinase activity towards SRSF2 and ACIN1 and promotes its nuclear  translocation. Phosphorylates RAF1 at 'Ser-259' and negatively  regulates its activity. Phosphorylation of BAD stimulates its pro-  apoptotic activity. (from UniProt P31749)
PKM (ENST00000568459.5) at chr15:72199629-72229722 - Homo sapiens pyruvate kinase M1/2 (PKM), transcript variant 7, mRNA. (from RefSeq NM_001206799)
PKM (ENST00000565184.5) at chr15:72199032-72231171 - Homo sapiens pyruvate kinase M1/2 (PKM), transcript variant 8, mRNA. (from RefSeq NM_001316318)
PKM (ENST00000565154.5) at chr15:72199590-72231113 - Homo sapiens pyruvate kinase M1/2 (PKM), transcript variant 4, mRNA. (from RefSeq NM_001206796)
PKM (ENST00000319622.10) at chr15:72199029-72231386 - Homo sapiens pyruvate kinase M1/2 (PKM), transcript variant 3, mRNA. (from RefSeq NM_182471)
PKM (ENST00000449901.6) at chr15:72199029-72231386 - Homo sapiens pyruvate kinase M1/2 (PKM), transcript variant 6, mRNA. (from RefSeq NM_001206798)
LCK (ENST00000333070.4) at chr1:32274132-32286162 - Non-receptor tyrosine-protein kinase that plays an  essential role in the selection and maturation of developing T-  cells in the thymus and in the function of mature T-cells. Plays a  key role in T-cell antigen receptor (TCR)-linked signal  transduction pathways. Constitutively associated with the  cytoplasmic portions of the CD4 and CD8 surface receptors.  Association of the TCR with a peptide antigen-bound MHC complex  facilitates the interaction of CD4 and CD8 with MHC class II and  class I molecules, respectively, thereby recruiting the associated  LCK protein to the vicinity of the TCR/CD3 complex. LCK then  phosphorylates tyrosines residues within the immunoreceptor  tyrosine-based activation motifs (ITAM) of the cytoplasmic tails  of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3  signaling pathway. Once stimulated, the TCR recruits the tyrosine  kinase ZAP70, that becomes phosphorylated and activated by LCK.  Following this, a large number of signaling molecules are  recruited, ultimately leading to lymphokine production. LCK also  contributes to signaling by other receptor molecules. Associates  directly with the cytoplasmic tail of CD2, which leads to  hyperphosphorylation and activation of LCK. Also plays a role in  the IL2 receptor-linked signaling pathway that controls the T-cell  proliferative response. Binding of IL2 to its receptor results in  increased activity of LCK. Is expressed at all stages of thymocyte  development and is required for the regulation of maturation  events that are governed by both pre-TCR and mature alpha beta  TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2,  the microtubule-associated protein MAPT, RHOH or TYROBP. (from UniProt P06239)
RB1 (ENST00000267163.5) at chr13:48303726-48481890 - Homo sapiens RB transcriptional corepressor 1 (RB1), mRNA. (from RefSeq NM_000321)
MAP3K5 (ENST00000359015.5) at chr6:136557046-136792477 - Homo sapiens mitogen-activated protein kinase kinase kinase 5 (MAP3K5), mRNA. (from RefSeq NM_005923)
AKT1 (ENST00000555528.5) at chr14:104769371-104793700 - Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 1, mRNA. (from RefSeq NM_005163)
AKT1 (ENST00000349310.7) at chr14:104769349-104795751 - Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 2, mRNA. (from RefSeq NM_001014432)
AKT1 (ENST00000407796.6) at chr14:104769349-104795679 - Homo sapiens AKT serine/threonine kinase 1 (AKT1), transcript variant 3, mRNA. (from RefSeq NM_001014431)
ARRB1 (ENST00000360025.7) at chr11:75265599-75351705 - Homo sapiens arrestin beta 1 (ARRB1), transcript variant 2, mRNA. (from RefSeq NM_020251)
ARRB1 (ENST00000420843.7) at chr11:75260122-75351661 - Homo sapiens arrestin beta 1 (ARRB1), transcript variant 1, mRNA. (from RefSeq NM_004041)
ARRB2 (ENST00000412477.7) at chr17:4710693-4721496 - Homo sapiens arrestin beta 2 (ARRB2), transcript variant 3, mRNA. (from RefSeq NM_001257328)
ARRB2 (ENST00000381488.10) at chr17:4710693-4721061 - Homo sapiens arrestin beta 2 (ARRB2), transcript variant 2, mRNA. (from RefSeq NM_199004)
ARRB2 (ENST00000346341.6) at chr17:4710634-4721499 - Homo sapiens arrestin beta 2 (ARRB2), transcript variant 6, mRNA. (from RefSeq NM_001257331)
ARRB2 (ENST00000269260.7) at chr17:4710632-4721497 - Homo sapiens arrestin beta 2 (ARRB2), transcript variant 1, mRNA. (from RefSeq NM_004313)
RAF1P1 (ENST00000508566.2) at chr4:10254926-10256621 - RAF1 pseudogene 1 (from HGNC RAF1P1)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001354690.1 at chr3:12583601-12663508
NM_001354691.1 at chr3:12583601-12664201
NM_001354689.1 at chr3:12583601-12664201
NR_148940.1 at chr3:12583601-12664201
NR_148941.1 at chr3:12583601-12664201
NM_002880.3 at chr3:12583601-12664201
NR_148942.1 at chr3:12583601-12664201
NM_001354693.1 at chr3:12583601-12664201
NM_001354694.1 at chr3:12583601-12664201
NM_001354692.1 at chr3:12583601-12664201
NM_001354695.1 at chr3:12583601-12664201

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017006966.1 at chr3:12583601-12622995
XM_011533974.3 at chr3:12583601-12664117
XR_001740227.1 at chr3:12590941-12664117

RefSeq Genes

RAF1 at chr3:12583608-12664117 - (NM_001354691) RAF proto-oncogene serine/threonine-protein kinase isoform c
RAF1 at chr3:12583608-12663508 - (NM_001354690) RAF proto-oncogene serine/threonine-protein kinase isoform b
RAF1 at chr3:12583601-12664201 - (NM_002880) RAF proto-oncogene serine/threonine-protein kinase isoform b
RAF1 at chr3:12583608-12664117 - (NM_001354695) RAF proto-oncogene serine/threonine-protein kinase isoform f
RAF1 at chr3:12583608-12664117 - (NM_001354694) RAF proto-oncogene serine/threonine-protein kinase isoform e
RAF1 at chr3:12583608-12664117 - (NM_001354692) RAF proto-oncogene serine/threonine-protein kinase isoform c
RAF1 at chr3:12583601-12664117 - (NM_001354689) RAF proto-oncogene serine/threonine-protein kinase isoform a
RAF1 at chr3:12583608-12664117 - (NM_001354693) RAF proto-oncogene serine/threonine-protein kinase isoform d
RAF1 at chr3:12583608-12664117 - (NR_148940) 
RAF1 at chr3:12583608-12664117 - (NR_148942) 
RAF1 at chr3:12583608-12664117 - (NR_148941) 

Non-Human RefSeq Genes

raf1 at chr3:12584541-12618721 - (NM_001037989) RAF proto-oncogene serine/threonine-protein kinase
raf1 at chr3:12584541-12618721 - (NM_001017117) RAF proto-oncogene serine/threonine-protein kinase
RAF1 at chr3:12583354-12664179 - (NM_001266302) RAF proto-oncogene serine/threonine-protein kinase
RAF1 at chr3:12583607-12664127 - (NM_001102505) RAF proto-oncogene serine/threonine-protein kinase
RAF1 at chr3:12584541-12618727 - (NM_205307) RAF proto-oncogene serine/threonine-protein kinase
Raf1 at chr3:12583601-12664105 - (NM_012639) RAF proto-oncogene serine/threonine-protein kinase
RAF1 at chr3:12583609-12664158 - (NM_001133258) RAF proto-oncogene serine/threonine-protein kinase
Raf1 at chr3:12583595-12664127 - (NM_029780) RAF proto-oncogene serine/threonine-protein kinase isoform 1
Raf1 at chr3:12583595-12664127 - (NM_001356333) RAF proto-oncogene serine/threonine-protein kinase isoform 2
Raf1 at chr3:12583595-12618752 - (NM_001356334) RAF proto-oncogene serine/threonine-protein kinase isoform 1
raf1.S at chr3:12584541-12618721 - (NM_001088006) RAF proto-oncogene serine/threonine-protein kinase
raf1a at chr3:12584541-12618574 - (NM_131439) RAF proto-oncogene serine/threonine-protein kinase
raf1b at chr3:12584544-12618568 - (NM_001199755) RAF proto-oncogene serine/threonine-protein kinase
Dsor1 at chr19:4097279-4110655 - (NM_001298115) downstream of raf1, isoform B
Dsor1 at chr7:129126668-129127513 - (NM_078543) downstream of raf1, isoform A
raf1c at chr3:12584541-12618721 - (NM_001123524) serine/threonine protein kinase RAF1c

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

RAF1 at chr3:12583601-12664226
RAF1 at chr3:12583798-12664148
RAF1 at chr3:12584267-12612005
RAF1 at chr3:12584333-12664125
RAF1 at chr3:12584346-12585905
RAF1 at chr3:12586847-12604213
RAF1 at chr3:12587577-12592068
RAF1 at chr3:12587979-12591916
RAF1 at chr3:12590641-12599755
RAF1 at chr3:12600199-12608867
RAF1 at chr3:12604135-12664125
RAF1 at chr3:12608446-12612001

International Knockout Mouse Consortium Genes Mapped to Human Genome

Raf1_25224 at chr3:12583601-12664201
Raf1_VG18087 at chr3:12583601-12664201

Human Aligned mRNA Search Results

GU149302 - Homo sapiens ESRP1/RAF1 fusion protein mRNA, complete cds.
FM209427 - Homo sapiens mRNA for SRGAP3:RAF1 fusion protein (SRGAP3:RAF1 gene).
KU178297 - Homo sapiens v-raf-1 murine leukemia viral oncogene-like protein 1 isoform 1 (RAF1) mRNA, partial cds.
KU178298 - Homo sapiens v-raf-1 murine leukemia viral oncogene-like protein 1 isoform 2 (RAF1) mRNA, partial cds, alternatively spliced.
KU178299 - Homo sapiens v-raf-1 murine leukemia viral oncogene-like protein 1 isoform 3 (RAF1) mRNA, partial cds, alternatively spliced.
BC018119 - Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1, mRNA (cDNA clone MGC:9026 IMAGE:3904404), complete cds.
AK312248 - Homo sapiens cDNA, FLJ92543, highly similar to Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1(RAF1), mRNA.

Human Unaligned mRNA Search Results

NR_148940 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 9, non-coding RNA.
NR_148942 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 11, non-coding RNA.
NR_148941 - Homo sapiens Raf-1 proto-oncogene, serine/threonine kinase (RAF1), transcript variant 10, non-coding RNA.

Non-Human Aligned mRNA Search Results

BC135311 - Xenopus tropicalis v-raf-1 murine leukemia viral oncogene homolog 1, mRNA (cDNA clone MGC:121506 IMAGE:7614841), complete cds.
AB196521 - Salmo salar RAF1c mRNA for serine/threonine protein kinase RAF1c, Type 3, complete cds.
AB197153 - Takifugu rubripes RAF1 mRNA for serine/threonine protein kinase RAF1, complete cds.
AB116254 - Danio rerio mRNA for serine/threonine protein kinase RAF1 short form 2, complete cds.
KJ411876 - Gobiocypris rarus serine threonine kinase raf1 mRNA, partial cds.
AB104854 - Danio rerio mRNA for short form RAF1, complete cds.
AB100685 - Danio rerio RAF1 mRNA for truncated RAF1, complete cds.
AB098701 - Danio rerio mRNA for trancated RAF1 serine/threonine protein kinase, complete cds.
AB098700 - Danio rerio mRNA for Serine/Threonine protein kinase RAF1, complete cds.
AB095292 - Danio rerio RAF1 mRNA for serine threonine protein kinase raf1, partial cds.
EF043865 - Synthetic construct clone ATCC 10627874 Raf1 mRNA, complete cds.
BC151319 - Bos taurus v-raf-1 murine leukemia viral oncogene homolog 1, mRNA (cDNA clone MGC:165882 IMAGE:8425700), complete cds.
AB547344 - Danio rerio raf1a mRNA for v-raf-1 murine leukemia viral oncogene homolog 1a, complete cds.
MG136146 - Synthetic construct Xenopus tropicalis clone IMAGE:7614841 Raf-1 proto-oncoprotein, serine/threonine kinase (raf1) gene, encodes complete protein.
CR761182 - Xenopus tropicalis finished cDNA, clone TEgg105m07.
BC015273 - Mus musculus v-raf-leukemia viral oncogene 1, mRNA (cDNA clone MGC:18681 IMAGE:4222659), complete cds.
BC062071 - Rattus norvegicus v-raf-leukemia viral oncogene 1, mRNA (cDNA clone MGC:72519 IMAGE:5599540), complete cds.
BC092040 - Mus musculus v-raf-leukemia viral oncogene 1, mRNA (cDNA clone MGC:102375 IMAGE:2645313), complete cds.
BT030695 - Bos taurus v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1), mRNA, complete cds.
AY335669 - Synthetic construct Homo sapiens v-raf-1 murine leukemia viral oncogene homolog 1 (RAF1) mRNA, partial cds.
AY890428 - Synthetic construct Homo sapiens clone FLH019484.01X v-raf-1 murine leukemia viral oncogene-like 1 (RAF1) mRNA, complete cds.
AY892889 - Synthetic construct Homo sapiens clone FLH019480.01L v-raf-1 murine leukemia viral oncogene-like 1 (RAF1) mRNA, partial cds.
AY893502 - Synthetic construct Homo sapiens clone FLH127857.01X v-raf-1 murine leukemia viral oncogene-like 1 (RAF1) mRNA, complete cds.
JT417504 - TSA: Ictalurus punctatus aby_k71:644442 mRNA sequence.
JU320542 - TSA: Macaca mulatta Mamu_517642 mRNA sequence.
JU476632 - TSA: Macaca mulatta Mamu_367347 mRNA sequence.
JV047817 - TSA: Macaca mulatta Mamu_420971 mRNA sequence.

GeneReviews

RAF1 at chr3:12583601-12664226