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Gencode Genes

PTK2B (ENST00000397501.5) at chr8:27311482-27459390 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1, mRNA. (from RefSeq NM_173174)
PTK2B (ENST00000522517.5) at chr8:27326823-27422385 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RJ77)
PTK2B (ENST00000522338.5) at chr8:27311629-27397789 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RHL2)
PTK2B (ENST00000522245.1) at chr8:27454031-27458474 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000521164.5) at chr8:27325345-27420001 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RK84)
PTK2B (ENST00000521000.1) at chr8:27422276-27431206 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000519650.5) at chr8:27311567-27322817 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000519512.5) at chr8:27430887-27436308 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YB74)
PTK2B (ENST00000517339.5) at chr8:27397452-27459386 - Non-receptor protein-tyrosine kinase that regulates  reorganization of the actin cytoskeleton, cell polarization, cell  migration, adhesion, spreading and bone remodeling. Plays a role  in the regulation of the humoral immune response, and is required  for normal levels of marginal B-cells in the spleen and normal  migration of splenic B-cells. Required for normal macrophage  polarization and migration towards sites of inflammation.  Regulates cytoskeleton rearrangement and cell spreading in T-  cells, and contributes to the regulation of T-cell responses.  Promotes osteoclastic bone resorption; this requires both  PTK2B/PYK2 and SRC. May inhibit differentiation and activity of  osteoprogenitor cells. Functions in signaling downstream of  integrin and collagen receptors, immune receptors, G-protein  coupled receptors (GPCR), cytokine, chemokine and growth factor  receptors, and mediates responses to cellular stress. Forms  multisubunit signaling complexes with SRC and SRC family members  upon activation; this leads to the phosphorylation of additional  tyrosine residues, creating binding sites for scaffold proteins,  effectors and substrates. Regulates numerous signaling pathways.  Promotes activation of phosphatidylinositol 3-kinase and of the  AKT1 signaling cascade. Promotes activation of NOS3. Regulates  production of the cellular messenger cGMP. Promotes activation of  the MAP kinase signaling cascade, including activation of  MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho  family GTPases, such as RHOA and RAC1. Recruits the ubiquitin  ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates  P53/TP53 activity, P53/TP53 ubiquitination and proteasomal  degradation. Acts as a scaffold, binding to both PDPK1 and SRC,  thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373',  and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC  family members, and thereby contributes to the regulation of NMDA  receptor ion channel activity and intracellular Ca(2+) levels. May  also regulate potassium ion transport by phosphorylation of  potassium channel subunits. Phosphorylates SRC; this increases SRC  kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1.  Promotes phosphorylation of ASAP2, RHOU and PXN; this requires  both SRC and PTK2/PYK2. (from UniProt Q14289)
PTK2B (ENST00000496920.1) at chr8:27380654-27396295 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000495097.1) at chr8:27437455-27437992 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000482543.1) at chr8:27452857-27454587 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000461615.1) at chr8:27432103-27434522 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000420218.3) at chr8:27325564-27459391 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 4, mRNA. (from RefSeq NM_173175)
PTK2B (ENST00000412793.5) at chr8:27380651-27430388 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt C9JHV9)
PTK2B (ENST00000397497.8) at chr8:27430899-27452559 - protein tyrosine kinase 2 beta (from HGNC PTK2B)
PTK2B (ENST00000346049.10) at chr8:27325552-27459386 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 3, mRNA. (from RefSeq NM_173176)
MYLK (ENST00000583087.5) at chr3:123614064-123620626 - Calcium/calmodulin-dependent myosin light chain kinase  implicated in smooth muscle contraction via phosphorylation of  myosin light chains (MLC). Also regulates actin-myosin interaction  through a non-kinase activity. Phosphorylates PTK2B/PYK2 and  myosin light-chains. Involved in the inflammatory response (e.g.  apoptosis, vascular permeability, leukocyte diapedesis), cell  motility and morphology, airway hyperreactivity and other  activities relevant to asthma. Required for tonic airway smooth  muscle contraction that is necessary for physiological and  asthmatic airway resistance. Necessary for gastrointestinal  motility. Implicated in the regulation of endothelial as well as  vascular permeability, probably via the regulation of cytoskeletal  rearrangements. In the nervous system it has been shown to control  the growth initiation of astrocytic processes in culture and to  participate in transmitter release at synapses formed between  cultured sympathetic ganglion cells. Critical participant in  signaling sequences that result in fibroblast apoptosis. Plays a  role in the regulation of epithelial cell survival. Required for  epithelial wound healing, especially during actomyosin ring  contraction during purse-string wound closure. Mediates RhoA-  dependent membrane blebbing. Triggers TRPC5 channel activity in a  calcium-dependent signaling, by inducing its subcellular  localization at the plasma membrane. Promotes cell migration  (including tumor cells) and tumor metastasis. PTK2B/PYK2  activation by phosphorylation mediates ITGB2 activation and is  thus essential to trigger neutrophil transmigration during acute  lung injury (ALI). May regulate optic nerve head astrocyte  migration. Probably involved in mitotic cytoskeletal regulation.  Regulates tight junction probably by modulating ZO-1 exchange in  the perijunctional actomyosin ring. Mediates burn-induced  microvascular barrier injury; triggers endothelial contraction in  the development of microvascular hyperpermeability by  phosphorylating MLC. Essential for intestinal barrier dysfunction.  Mediates Giardia spp.-mediated reduced epithelial barrier function  during giardiasis intestinal infection via reorganization of  cytoskeletal F-actin and tight junctional ZO-1. Necessary for  hypotonicity-induced Ca(2+) entry and subsequent activation of  volume-sensitive organic osmolyte/anion channels (VSOAC) in  cervical cancer cells. Responsible for high proliferative ability  of breast cancer cells through anti-apoptosis. (from UniProt Q15746)
MYLK (ENST00000475616.5) at chr3:123614105-123793841 - Calcium/calmodulin-dependent myosin light chain kinase  implicated in smooth muscle contraction via phosphorylation of  myosin light chains (MLC). Also regulates actin-myosin interaction  through a non-kinase activity. Phosphorylates PTK2B/PYK2 and  myosin light-chains. Involved in the inflammatory response (e.g.  apoptosis, vascular permeability, leukocyte diapedesis), cell  motility and morphology, airway hyperreactivity and other  activities relevant to asthma. Required for tonic airway smooth  muscle contraction that is necessary for physiological and  asthmatic airway resistance. Necessary for gastrointestinal  motility. Implicated in the regulation of endothelial as well as  vascular permeability, probably via the regulation of cytoskeletal  rearrangements. In the nervous system it has been shown to control  the growth initiation of astrocytic processes in culture and to  participate in transmitter release at synapses formed between  cultured sympathetic ganglion cells. Critical participant in  signaling sequences that result in fibroblast apoptosis. Plays a  role in the regulation of epithelial cell survival. Required for  epithelial wound healing, especially during actomyosin ring  contraction during purse-string wound closure. Mediates RhoA-  dependent membrane blebbing. Triggers TRPC5 channel activity in a  calcium-dependent signaling, by inducing its subcellular  localization at the plasma membrane. Promotes cell migration  (including tumor cells) and tumor metastasis. PTK2B/PYK2  activation by phosphorylation mediates ITGB2 activation and is  thus essential to trigger neutrophil transmigration during acute  lung injury (ALI). May regulate optic nerve head astrocyte  migration. Probably involved in mitotic cytoskeletal regulation.  Regulates tight junction probably by modulating ZO-1 exchange in  the perijunctional actomyosin ring. Mediates burn-induced  microvascular barrier injury; triggers endothelial contraction in  the development of microvascular hyperpermeability by  phosphorylating MLC. Essential for intestinal barrier dysfunction.  Mediates Giardia spp.-mediated reduced epithelial barrier function  during giardiasis intestinal infection via reorganization of  cytoskeletal F-actin and tight junctional ZO-1. Necessary for  hypotonicity-induced Ca(2+) entry and subsequent activation of  volume-sensitive organic osmolyte/anion channels (VSOAC) in  cervical cancer cells. Responsible for high proliferative ability  of breast cancer cells through anti-apoptosis. (from UniProt Q15746)
MYLK (ENST00000359169.5) at chr3:123612298-123876618 - Calcium/calmodulin-dependent myosin light chain kinase  implicated in smooth muscle contraction via phosphorylation of  myosin light chains (MLC). Also regulates actin-myosin interaction  through a non-kinase activity. Phosphorylates PTK2B/PYK2 and  myosin light-chains. Involved in the inflammatory response (e.g.  apoptosis, vascular permeability, leukocyte diapedesis), cell  motility and morphology, airway hyperreactivity and other  activities relevant to asthma. Required for tonic airway smooth  muscle contraction that is necessary for physiological and  asthmatic airway resistance. Necessary for gastrointestinal  motility. Implicated in the regulation of endothelial as well as  vascular permeability, probably via the regulation of cytoskeletal  rearrangements. In the nervous system it has been shown to control  the growth initiation of astrocytic processes in culture and to  participate in transmitter release at synapses formed between  cultured sympathetic ganglion cells. Critical participant in  signaling sequences that result in fibroblast apoptosis. Plays a  role in the regulation of epithelial cell survival. Required for  epithelial wound healing, especially during actomyosin ring  contraction during purse-string wound closure. Mediates RhoA-  dependent membrane blebbing. Triggers TRPC5 channel activity in a  calcium-dependent signaling, by inducing its subcellular  localization at the plasma membrane. Promotes cell migration  (including tumor cells) and tumor metastasis. PTK2B/PYK2  activation by phosphorylation mediates ITGB2 activation and is  thus essential to trigger neutrophil transmigration during acute  lung injury (ALI). May regulate optic nerve head astrocyte  migration. Probably involved in mitotic cytoskeletal regulation.  Regulates tight junction probably by modulating ZO-1 exchange in  the perijunctional actomyosin ring. Mediates burn-induced  microvascular barrier injury; triggers endothelial contraction in  the development of microvascular hyperpermeability by  phosphorylating MLC. Essential for intestinal barrier dysfunction.  Mediates Giardia spp.-mediated reduced epithelial barrier function  during giardiasis intestinal infection via reorganization of  cytoskeletal F-actin and tight junctional ZO-1. Necessary for  hypotonicity-induced Ca(2+) entry and subsequent activation of  volume-sensitive organic osmolyte/anion channels (VSOAC) in  cervical cancer cells. Responsible for high proliferative ability  of breast cancer cells through anti-apoptosis. (from UniProt Q15746)
MYLK (ENST00000354792.9) at chr3:123612298-123876618 - Calcium/calmodulin-dependent myosin light chain kinase  implicated in smooth muscle contraction via phosphorylation of  myosin light chains (MLC). Also regulates actin-myosin interaction  through a non-kinase activity. Phosphorylates PTK2B/PYK2 and  myosin light-chains. Involved in the inflammatory response (e.g.  apoptosis, vascular permeability, leukocyte diapedesis), cell  motility and morphology, airway hyperreactivity and other  activities relevant to asthma. Required for tonic airway smooth  muscle contraction that is necessary for physiological and  asthmatic airway resistance. Necessary for gastrointestinal  motility. Implicated in the regulation of endothelial as well as  vascular permeability, probably via the regulation of cytoskeletal  rearrangements. In the nervous system it has been shown to control  the growth initiation of astrocytic processes in culture and to  participate in transmitter release at synapses formed between  cultured sympathetic ganglion cells. Critical participant in  signaling sequences that result in fibroblast apoptosis. Plays a  role in the regulation of epithelial cell survival. Required for  epithelial wound healing, especially during actomyosin ring  contraction during purse-string wound closure. Mediates RhoA-  dependent membrane blebbing. Triggers TRPC5 channel activity in a  calcium-dependent signaling, by inducing its subcellular  localization at the plasma membrane. Promotes cell migration  (including tumor cells) and tumor metastasis. PTK2B/PYK2  activation by phosphorylation mediates ITGB2 activation and is  thus essential to trigger neutrophil transmigration during acute  lung injury (ALI). May regulate optic nerve head astrocyte  migration. Probably involved in mitotic cytoskeletal regulation.  Regulates tight junction probably by modulating ZO-1 exchange in  the perijunctional actomyosin ring. Mediates burn-induced  microvascular barrier injury; triggers endothelial contraction in  the development of microvascular hyperpermeability by  phosphorylating MLC. Essential for intestinal barrier dysfunction.  Mediates Giardia spp.-mediated reduced epithelial barrier function  during giardiasis intestinal infection via reorganization of  cytoskeletal F-actin and tight junctional ZO-1. Necessary for  hypotonicity-induced Ca(2+) entry and subsequent activation of  volume-sensitive organic osmolyte/anion channels (VSOAC) in  cervical cancer cells. Responsible for high proliferative ability  of breast cancer cells through anti-apoptosis. (from UniProt Q15746)
PITPNM2 (ENST00000542749.5) at chr12:122983481-123034654 - Catalyzes the transfer of phosphatidylinositol and  phosphatidylcholine between membranes (in vitro). Binds calcium  ions. (from UniProt Q9BZ72)
PITPNM3 (ENST00000421306.7) at chr17:6451264-6556460 - Homo sapiens PITPNM family member 3 (PITPNM3), transcript variant 2, mRNA. (from RefSeq NM_001165966)
PITPNM3 (ENST00000262483.13) at chr17:6451263-6556555 - Homo sapiens PITPNM family member 3 (PITPNM3), transcript variant 1, mRNA. (from RefSeq NM_031220)
PITPNM2 (ENST00000280562.9) at chr12:122983480-123110495 - Homo sapiens phosphatidylinositol transfer protein membrane associated 2 (PITPNM2), transcript variant 2, mRNA. (from RefSeq NM_001300801)
PITPNM2 (ENST00000320201.8) at chr12:122983480-123110428 - Homo sapiens phosphatidylinositol transfer protein membrane associated 2 (PITPNM2), transcript variant 1, mRNA. (from RefSeq NM_020845)
SEMA4D (ENST00000422704.6) at chr9:89377391-89498089 - Cell surface receptor for PLXN1B and PLXNB2 that plays  an important role in cell-cell signaling. Promotes reorganization  of the actin cytoskeleton and plays a role in axonal growth cone  guidance in the developing central nervous system. Regulates  dendrite and axon branching and morphogenesis. Promotes the  migration of cerebellar granule cells and of endothelial cells.  Plays a role in the immune system; induces B-cells to aggregate  and improves their viability (in vitro). Promotes signaling via  SRC and PTK2B/PYK2, which then mediates activation of  phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.  Interaction with PLXNB1 mediates activation of RHOA. (from UniProt Q92854)
SEMA4D (ENST00000455551.6) at chr9:89361609-89498130 - Cell surface receptor for PLXN1B and PLXNB2 that plays  an important role in cell-cell signaling. Promotes reorganization  of the actin cytoskeleton and plays a role in axonal growth cone  guidance in the developing central nervous system. Regulates  dendrite and axon branching and morphogenesis. Promotes the  migration of cerebellar granule cells and of endothelial cells.  Plays a role in the immune system; induces B-cells to aggregate  and improves their viability (in vitro). Promotes signaling via  SRC and PTK2B/PYK2, which then mediates activation of  phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.  Interaction with PLXNB1 mediates activation of RHOA. (from UniProt Q92854)
SEMA4D (ENST00000450295.5) at chr9:89376386-89418833 - Cell surface receptor for PLXN1B and PLXNB2 that plays  an important role in cell-cell signaling. Promotes reorganization  of the actin cytoskeleton and plays a role in axonal growth cone  guidance in the developing central nervous system. Regulates  dendrite and axon branching and morphogenesis. Promotes the  migration of cerebellar granule cells and of endothelial cells.  Plays a role in the immune system; induces B-cells to aggregate  and improves their viability (in vitro). Promotes signaling via  SRC and PTK2B/PYK2, which then mediates activation of  phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.  Interaction with PLXNB1 mediates activation of RHOA. (from UniProt Q92854)
SEMA4D (ENST00000356444.6) at chr9:89377237-89455953 - Cell surface receptor for PLXN1B and PLXNB2 that plays  an important role in cell-cell signaling. Promotes reorganization  of the actin cytoskeleton and plays a role in axonal growth cone  guidance in the developing central nervous system. Regulates  dendrite and axon branching and morphogenesis. Promotes the  migration of cerebellar granule cells and of endothelial cells.  Plays a role in the immune system; induces B-cells to aggregate  and improves their viability (in vitro). Promotes signaling via  SRC and PTK2B/PYK2, which then mediates activation of  phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.  Interaction with PLXNB1 mediates activation of RHOA. (from UniProt Q92854)
SEMA4D (ENST00000339861.8) at chr9:89360787-89498038 - Cell surface receptor for PLXN1B and PLXNB2 that plays  an important role in cell-cell signaling. Promotes reorganization  of the actin cytoskeleton and plays a role in axonal growth cone  guidance in the developing central nervous system. Regulates  dendrite and axon branching and morphogenesis. Promotes the  migration of cerebellar granule cells and of endothelial cells.  Plays a role in the immune system; induces B-cells to aggregate  and improves their viability (in vitro). Promotes signaling via  SRC and PTK2B/PYK2, which then mediates activation of  phosphatidylinositol 3-kinase and of the AKT1 signaling cascade.  Interaction with PLXNB1 mediates activation of RHOA. (from UniProt Q92854)
ITGB2 (ENST00000397850.6) at chr21:44885953-44928873 - Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2,  ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are  receptors for the iC3b fragment of the third complement component  and for fibrinogen. Integrin alpha-X/beta-2 recognizes the  sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2  recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin  alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-  D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil  transmigration during lung injury through PTK2B/PYK2-mediated  activation. (from UniProt P05107)
ITGB2 (ENST00000397857.5) at chr21:44885953-44911460 - Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2,  ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are  receptors for the iC3b fragment of the third complement component  and for fibrinogen. Integrin alpha-X/beta-2 recognizes the  sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2  recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin  alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-  D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil  transmigration during lung injury through PTK2B/PYK2-mediated  activation. (from UniProt P05107)
ITGB2 (ENST00000397852.5) at chr21:44885953-44910826 - Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2,  ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are  receptors for the iC3b fragment of the third complement component  and for fibrinogen. Integrin alpha-X/beta-2 recognizes the  sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2  recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin  alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-  D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil  transmigration during lung injury through PTK2B/PYK2-mediated  activation. (from UniProt P05107)
ITGB2 (ENST00000302347.10) at chr21:44885965-44920899 - Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2,  ICAM3 and ICAM4. Integrins alpha-M/beta-2 and alpha-X/beta-2 are  receptors for the iC3b fragment of the third complement component  and for fibrinogen. Integrin alpha-X/beta-2 recognizes the  sequence G-P-R in fibrinogen alpha-chain. Integrin alpha-M/beta-2  recognizes P1 and P2 peptides of fibrinogen gamma chain. Integrin  alpha-M/beta-2 is also a receptor for factor X. Integrin alpha-  D/beta-2 is a receptor for ICAM3 and VCAM1. Triggers neutrophil  transmigration during lung injury through PTK2B/PYK2-mediated  activation. (from UniProt P05107)
SEMA4D (ENST00000420987.5) at chr9:89360791-89455953 - Homo sapiens semaphorin 4D (SEMA4D), transcript variant 2, mRNA. (from RefSeq NM_001142287)
SEMA4D (ENST00000438547.6) at chr9:89377235-89479890 - Homo sapiens semaphorin 4D (SEMA4D), transcript variant 1, mRNA. (from RefSeq NM_006378)
ARHGAP10 (ENST00000336498.8) at chr4:147732088-148072776 - Homo sapiens Rho GTPase activating protein 10 (ARHGAP10), mRNA. (from RefSeq NM_024605)
SH2D3C (ENST00000373277.8) at chr9:127738317-127771438 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 2, mRNA. (from RefSeq NM_005489)
SH2D3C (ENST00000629203.2) at chr9:127738486-127755274 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 6, mRNA. (from RefSeq NM_001142534)
SH2D3C (ENST00000420366.5) at chr9:127738318-127755304 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 5, mRNA. (from RefSeq NM_001142533)
SH2D3C (ENST00000373276.7) at chr9:127738318-127771369 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 7, mRNA. (from RefSeq NM_001252334)
SH2D3C (ENST00000429553.5) at chr9:127738318-127762418 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 4, mRNA. (from RefSeq NM_001142532)
SH2D3C (ENST00000314830.13) at chr9:127738317-127778666 - Homo sapiens SH2 domain containing 3C (SH2D3C), transcript variant 1, mRNA. (from RefSeq NM_170600)
PTPN12 (ENST00000435495.6) at chr7:77538069-77639620 - Homo sapiens protein tyrosine phosphatase non-receptor type 12 (PTPN12), transcript variant 3, mRNA. (from RefSeq NM_001131009)
PTPN12 (ENST00000415482.6) at chr7:77538035-77639280 - Homo sapiens protein tyrosine phosphatase non-receptor type 12 (PTPN12), transcript variant 2, mRNA. (from RefSeq NM_001131008)
PTPN12 (ENST00000248594.11) at chr7:77537295-77640069 - Homo sapiens protein tyrosine phosphatase non-receptor type 12 (PTPN12), transcript variant 1, mRNA. (from RefSeq NM_002835)
RB1CC1 (ENST00000435644.6) at chr8:52622459-52714423 - Homo sapiens RB1 inducible coiled-coil 1 (RB1CC1), transcript variant 2, mRNA. (from RefSeq NM_001083617)
RB1CC1 (ENST00000025008.10) at chr8:52622458-52714435 - Homo sapiens RB1 inducible coiled-coil 1 (RB1CC1), transcript variant 1, mRNA. (from RefSeq NM_014781)
PITPNM1 (ENST00000436757.6) at chr11:67491768-67505365 - Homo sapiens phosphatidylinositol transfer protein membrane associated 1 (PITPNM1), transcript variant 2, mRNA. (from RefSeq NM_001130848)
PITPNM1 (ENST00000356404.8) at chr11:67491768-67505363 - Homo sapiens phosphatidylinositol transfer protein membrane associated 1 (PITPNM1), transcript variant 1, mRNA. (from RefSeq NM_004910)
PXN (ENST00000267257.11) at chr12:120210439-120265771 - Homo sapiens paxillin (PXN), transcript variant 3, mRNA. (from RefSeq NM_001243756)
PXN (ENST00000228307.11) at chr12:120210447-120265771 - Homo sapiens paxillin (PXN), transcript variant 2, mRNA. (from RefSeq NM_001080855)
PXN (ENST00000458477.6) at chr12:120210447-120250161 - Homo sapiens paxillin (PXN), transcript variant 4, mRNA. (from RefSeq NM_025157)
PXN (ENST00000424649.6) at chr12:120210447-120265771 - Homo sapiens paxillin (PXN), transcript variant 1, mRNA. (from RefSeq NM_002859)
PITPNM1 (ENST00000534749.5) at chr11:67491768-67504369 - Regulates RHOA activity, and plays a role in  cytoskeleton remodeling. Necessary for normal completion of  cytokinesis. Plays a role in maintaining normal diacylglycerol  levels in the Golgi apparatus. Binds phosphatidyl inositol  phosphates (in vitro). May catalyze the transfer of  phosphatidylinositol and phosphatidylcholine between membranes (By  similarity). Necessary for maintaining the normal structure of the  endoplasmic reticulum and the Golgi apparatus. Required for  protein export from the endoplasmic reticulum and the Golgi. Binds  calcium ions. (from UniProt O00562)
ITGB2 (ENST00000355153.8) at chr21:44885953-44928838 - Homo sapiens integrin subunit beta 2 (ITGB2), transcript variant 2, mRNA. (from RefSeq NM_001127491)
ASAP1 (ENST00000518721.6) at chr8:130052104-130443674 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1), transcript variant 1, mRNA. (from RefSeq NM_018482)
RHOU (ENST00000646945.2) at chr1_KZ208906v1_fix:312483-323668 - Homo sapiens ras homolog family member U (RHOU), transcript variant 1, mRNA. (from RefSeq NM_021205)
RHOU (ENST00000366691.4) at chr1:228735479-228746664 - Homo sapiens ras homolog family member U (RHOU), transcript variant 1, mRNA. (from RefSeq NM_021205)
KCNA2 (ENST00000638616.1) at chr1:110602296-110606019 - Mediates the voltage-dependent potassium ion  permeability of excitable membranes. Assuming opened or closed  conformations in response to the voltage difference across the  membrane, the protein forms a potassium-selective channel through  which potassium ions may pass in accordance with their  electrochemical gradient. (from UniProt P16389)
KCNA2 (ENST00000638532.1) at chr1:110602997-110608025 - Mediates the voltage-dependent potassium ion  permeability of excitable membranes. Assuming opened or closed  conformations in response to the voltage difference across the  membrane, the protein forms a potassium-selective channel through  which potassium ions may pass in accordance with their  electrochemical gradient. (from UniProt P16389)
KCNA2 (ENST00000633222.1) at chr1:110593580-110607429 - Mediates the voltage-dependent potassium ion  permeability of excitable membranes. Assuming opened or closed  conformations in response to the voltage difference across the  membrane, the protein forms a potassium-selective channel through  which potassium ions may pass in accordance with their  electrochemical gradient. (from UniProt P16389)
KCNA2 (ENST00000485317.6) at chr1:110602998-110607816 - Mediates the voltage-dependent potassium ion  permeability of excitable membranes. Assuming opened or closed  conformations in response to the voltage difference across the  membrane, the protein forms a potassium-selective channel through  which potassium ions may pass in accordance with their  electrochemical gradient. (from UniProt P16389)
LPXN (ENST00000528954.5) at chr11:58526871-58578166 - Homo sapiens leupaxin (LPXN), transcript variant 1, mRNA. (from RefSeq NM_001143995)
LPXN (ENST00000395074.6) at chr11:58526871-58575861 - Homo sapiens leupaxin (LPXN), transcript variant 2, mRNA. (from RefSeq NM_004811)
FGR (ENST00000374004.5) at chr1:27612300-27624062 - Non-receptor tyrosine-protein kinase that transmits  signals from cell surface receptors devoid of kinase activity and  contributes to the regulation of immune responses, including  neutrophil, monocyte, macrophage and mast cell functions,  cytoskeleton remodeling in response to extracellular stimuli,  phagocytosis, cell adhesion and migration. Promotes mast cell  degranulation, release of inflammatory cytokines and IgE-mediated  anaphylaxis. Acts downstream of receptors that bind the Fc region  of immunoglobulins, such as MS4A2/FCER1B, FCGR2A and/or FCGR2B.  Acts downstream of ITGB1 and ITGB2, and regulates actin  cytoskeleton reorganization, cell spreading and adhesion.  Depending on the context, activates or inhibits cellular  responses. Functions as negative regulator of ITGB2 signaling,  phagocytosis and SYK activity in monocytes. Required for normal  ITGB1 and ITGB2 signaling, normal cell spreading and adhesion in  neutrophils and macrophages. Functions as positive regulator of  cell migration and regulates cytoskeleton reorganization via RAC1  activation. Phosphorylates SYK (in vitro) and promotes SYK-  dependent activation of AKT1 and MAP kinase signaling.  Phosphorylates PLD2 in antigen-stimulated mast cells, leading to  PLD2 activation and the production of the signaling molecules  lysophosphatidic acid and diacylglycerol. Promotes activation of  PIK3R1. Phosphorylates FASLG, and thereby regulates its  ubiquitination and subsequent internalization. Phosphorylates  ABL1. Promotes phosphorylation of CBL, CTTN, PIK3R1, PTK2/FAK1,  PTK2B/PYK2 and VAV2. Phosphorylates HCLS1 that has already been  phosphorylated by SYK, but not unphosphorylated HCLS1. (from UniProt P09769)
MYLK (ENST00000360772.7) at chr3:123610049-123884331 - Homo sapiens myosin light chain kinase (MYLK), transcript variant 3B, mRNA. (from RefSeq NM_053028)
MYLK (ENST00000360304.7) at chr3:123612298-123876618 - Homo sapiens myosin light chain kinase (MYLK), transcript variant 1, mRNA. (from RefSeq NM_053025)
MYLK (ENST00000578202.1) at chr3:123613340-123620514 - Homo sapiens myosin light chain kinase (MYLK), transcript variant 7, mRNA. (from RefSeq NM_053031)
MYLK (ENST00000418370.6) at chr3:123612310-123625316 - Homo sapiens myosin light chain kinase (MYLK), transcript variant 8, mRNA. (from RefSeq NM_053032)
MYLK (ENST00000346322.9) at chr3:123614045-123884314 - Homo sapiens myosin light chain kinase (MYLK), transcript variant 2, mRNA. (from RefSeq NM_053026)
NPHP1 (ENST00000316534.8) at chr2:110122311-110205042 - Homo sapiens nephrocystin 1 (NPHP1), transcript variant 1, mRNA. (from RefSeq NM_000272)
NPHP1 (ENST00000445609.6) at chr2:110123336-110204992 - Homo sapiens nephrocystin 1 (NPHP1), transcript variant 3, mRNA. (from RefSeq NM_001128178)
NPHP1 (ENST00000393272.7) at chr2:110123336-110205066 - Homo sapiens nephrocystin 1 (NPHP1), transcript variant 2, mRNA. (from RefSeq NM_207181)
NPHP1 (ENST00000355301.8) at chr2:110123708-110204972 - Homo sapiens nephrocystin 1 (NPHP1), transcript variant 4, mRNA. (from RefSeq NM_001128179)
EWSR1 (ENST00000414183.6) at chr22:29268316-29300343 - Homo sapiens EWS RNA binding protein 1 (EWSR1), transcript variant 1, mRNA. (from RefSeq NM_013986)
SORBS2 (ENST00000448662.6) at chr4:185585444-185810894 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 5, mRNA. (from RefSeq NM_001145672)
SORBS2 (ENST00000418609.5) at chr4:185585444-185656969 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 8, mRNA. (from RefSeq NM_001145675)
EWSR1 (ENST00000406548.5) at chr22:29268273-29300336 - Homo sapiens EWS RNA binding protein 1 (EWSR1), transcript variant 3, mRNA. (from RefSeq NM_001163285)
EWSR1 (ENST00000397938.6) at chr22:29268018-29300525 - Homo sapiens EWS RNA binding protein 1 (EWSR1), transcript variant 2, mRNA. (from RefSeq NM_005243)
EWSR1 (ENST00000332035.10) at chr22:29268326-29300336 - Homo sapiens EWS RNA binding protein 1 (EWSR1), transcript variant 4, mRNA. (from RefSeq NM_001163286)
SORBS2 (ENST00000393528.7) at chr4:185587323-185812221 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 1, mRNA. (from RefSeq NM_003603)
EWSR1 (ENST00000333395.10) at chr22:29268318-29290684 - Homo sapiens EWS RNA binding protein 1 (EWSR1), transcript variant 5, mRNA. (from RefSeq NM_001163287)
SORBS2 (ENST00000284776.11) at chr4:185585444-185956368 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 2, mRNA. (from RefSeq NM_021069)
SORBS2 (ENST00000449407.6) at chr4:185587306-185812238 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 3, mRNA. (from RefSeq NM_001145670)
SORBS2 (ENST00000437304.6) at chr4:185587305-185775912 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 6, mRNA. (from RefSeq NM_001145673)
SORBS2 (ENST00000355634.9) at chr4:185587322-185956652 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 9, mRNA. (from RefSeq NM_001270771)
SORBS2 (ENST00000319471.13) at chr4:185587305-185811071 - Homo sapiens sorbin and SH3 domain containing 2 (SORBS2), transcript variant 4, mRNA. (from RefSeq NM_001145671)
TGFB1I1 (ENST00000361773.7) at chr16:31472208-31477960 - Homo sapiens transforming growth factor beta 1 induced transcript 1 (TGFB1I1), transcript variant 3, mRNA. (from RefSeq NM_001164719)
TGFB1I1 (ENST00000394858.6) at chr16:31473205-31477960 - Homo sapiens transforming growth factor beta 1 induced transcript 1 (TGFB1I1), transcript variant 2, mRNA. (from RefSeq NM_015927)
TGFB1I1 (ENST00000394863.8) at chr16:31472152-31477958 - Homo sapiens transforming growth factor beta 1 induced transcript 1 (TGFB1I1), transcript variant 1, mRNA. (from RefSeq NM_001042454)
SKAP2 (ENST00000345317.7) at chr7:26667068-26864590 - Homo sapiens src kinase associated phosphoprotein 2 (SKAP2), transcript variant 1, mRNA. (from RefSeq NM_003930)
VAV1 (ENST00000596764.5) at chr19:6772728-6857360 - Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 3, mRNA. (from RefSeq NM_001258207)
VAV1 (ENST00000602142.6) at chr19:6772708-6857361 - Homo sapiens vav guanine nucleotide exchange factor 1 (VAV1), transcript variant 1, mRNA. (from RefSeq NM_005428)
TGFB1I1 (ENST00000567607.5) at chr16:31473426-31477958 - Functions as a molecular adapter coordinating multiple  protein-protein interactions at the focal adhesion complex and in  the nucleus. Links various intracellular signaling modules to  plasma membrane receptors and regulates the Wnt and TGFB signaling  pathways. May also regulate SLC6A3 and SLC6A4 targeting to the  plasma membrane hence regulating their activity. In the nucleus,  functions as a nuclear receptor coactivator regulating  glucocorticoid, androgen, mineralocorticoid and progesterone  receptor transcriptional activity. May play a role in the  processes of cell growth, proliferation, migration,  differentiation and senescence. May have a zinc-dependent DNA-  binding activity. (from UniProt O43294)
LCK (ENST00000333070.4) at chr1:32274132-32286162 - Non-receptor tyrosine-protein kinase that plays an  essential role in the selection and maturation of developing T-  cells in the thymus and in the function of mature T-cells. Plays a  key role in T-cell antigen receptor (TCR)-linked signal  transduction pathways. Constitutively associated with the  cytoplasmic portions of the CD4 and CD8 surface receptors.  Association of the TCR with a peptide antigen-bound MHC complex  facilitates the interaction of CD4 and CD8 with MHC class II and  class I molecules, respectively, thereby recruiting the associated  LCK protein to the vicinity of the TCR/CD3 complex. LCK then  phosphorylates tyrosines residues within the immunoreceptor  tyrosine-based activation motifs (ITAM) of the cytoplasmic tails  of the TCR-gamma chains and CD3 subunits, initiating the TCR/CD3  signaling pathway. Once stimulated, the TCR recruits the tyrosine  kinase ZAP70, that becomes phosphorylated and activated by LCK.  Following this, a large number of signaling molecules are  recruited, ultimately leading to lymphokine production. LCK also  contributes to signaling by other receptor molecules. Associates  directly with the cytoplasmic tail of CD2, which leads to  hyperphosphorylation and activation of LCK. Also plays a role in  the IL2 receptor-linked signaling pathway that controls the T-cell  proliferative response. Binding of IL2 to its receptor results in  increased activity of LCK. Is expressed at all stages of thymocyte  development and is required for the regulation of maturation  events that are governed by both pre-TCR and mature alpha beta  TCR. Phosphorylates other substrates including RUNX3, PTK2B/PYK2,  the microtubule-associated protein MAPT, RHOH or TYROBP. (from UniProt P06239)
BCAR1 (ENST00000542031.6) at chr16:75229453-75248240 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 7, mRNA. (from RefSeq NM_001170719)
BCAR1 (ENST00000535626.6) at chr16:75229062-75265948 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 8, mRNA. (from RefSeq NM_001170720)
BCAR1 (ENST00000420641.7) at chr16:75229455-75266781 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 3, mRNA. (from RefSeq NM_001170716)
BCAR1 (ENST00000418647.7) at chr16:75229159-75266007 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 1, mRNA. (from RefSeq NM_001170714)
BCAR1 (ENST00000538440.6) at chr16:75229103-75266007 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 5, mRNA. (from RefSeq NM_001170718)
BCAR1 (ENST00000393422.6) at chr16:75228187-75268053 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 9, mRNA. (from RefSeq NM_001170721)
BCAR1 (ENST00000393420.10) at chr16:75229511-75251482 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 4, mRNA. (from RefSeq NM_001170717)
BCAR1 (ENST00000162330.10) at chr16:75228181-75251624 - Homo sapiens BCAR1 scaffold protein, Cas family member (BCAR1), transcript variant 6, mRNA. (from RefSeq NM_014567)
ASAP2 (ENST00000315273.4) at chr2:9206765-9405683 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), transcript variant 2, mRNA. (from RefSeq NM_001135191)
SNCA (ENST00000508895.5) at chr4:89726258-89836213 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
SNCA (ENST00000506244.5) at chr4:89726577-89837168 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
SNCA (ENST00000505199.5) at chr4:89726616-89835685 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
SNCA (ENST00000345009.8) at chr4:89725884-89835680 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
SNCA (ENST00000394989.6) at chr4:89724105-89837199 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
ASAP2 (ENST00000281419.8) at chr2:9206812-9405678 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 2 (ASAP2), transcript variant 1, mRNA. (from RefSeq NM_003887)
SNCA (ENST00000618500.4) at chr4:89724099-89836213 - May be involved in the regulation of dopamine release  and transport. Induces fibrillization of microtubule-associated  protein tau. Reduces neuronal responsiveness to various apoptotic  stimuli, leading to a decreased caspase-3 activation. (from UniProt P37840)
KCNA2 (ENST00000369770.7) at chr1:110593580-110631474 - Homo sapiens potassium voltage-gated channel subfamily A member 2 (KCNA2), transcript variant 2, mRNA. (from RefSeq NM_001204269)
KCNA2 (ENST00000316361.10) at chr1:110593580-110606358 - Homo sapiens potassium voltage-gated channel subfamily A member 2 (KCNA2), transcript variant 1, mRNA. (from RefSeq NM_004974)
EPHA1 (ENST00000645847.2) at chr7_KZ208912v1_fix:10493-28220 - Homo sapiens EPH receptor A1 (EPHA1), mRNA. (from RefSeq NM_005232)
LYN (ENST00000520220.6) at chr8:55879835-56014168 - Homo sapiens LYN proto-oncogene, Src family tyrosine kinase (LYN), transcript variant 2, mRNA. (from RefSeq NM_001111097)
LYN (ENST00000519728.6) at chr8:55879835-56014169 - Homo sapiens LYN proto-oncogene, Src family tyrosine kinase (LYN), transcript variant 1, mRNA. (from RefSeq NM_002350)
EPHA1 (ENST00000275815.4) at chr7:143391129-143408856 - Homo sapiens EPH receptor A1 (EPHA1), mRNA. (from RefSeq NM_005232)
FGR (ENST00000399173.5) at chr1:27612292-27626240 - Homo sapiens FGR proto-oncogene, Src family tyrosine kinase (FGR), transcript variant 2, mRNA. (from RefSeq NM_001042747)
FGR (ENST00000374003.7) at chr1:27612669-27626569 - Homo sapiens FGR proto-oncogene, Src family tyrosine kinase (FGR), transcript variant 3, mRNA. (from RefSeq NM_001042729)
FGR (ENST00000374005.8) at chr1:27612064-27635185 - Homo sapiens FGR proto-oncogene, Src family tyrosine kinase (FGR), transcript variant 1, mRNA. (from RefSeq NM_005248)
SNCA (ENST00000420646.6) at chr4:89724099-89836976 - Homo sapiens synuclein alpha (SNCA), transcript variant 4, mRNA. (from RefSeq NM_007308)
SNCA (ENST00000336904.7) at chr4:89724099-89838315 - Homo sapiens synuclein alpha (SNCA), transcript variant 3, mRNA. (from RefSeq NM_001146055)
SNCA (ENST00000394991.7) at chr4:89726053-89837228 - Homo sapiens synuclein alpha (SNCA), transcript variant 1, mRNA. (from RefSeq NM_000345)
SNCA (ENST00000394986.5) at chr4:89726053-89837139 - Homo sapiens synuclein alpha (SNCA), transcript variant 2, mRNA. (from RefSeq NM_001146054)
SIRPA (ENST00000400068.7) at chr20:1894167-1939894 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 1, mRNA. (from RefSeq NM_001040022)
SIRPA (ENST00000622179.4) at chr20:1894508-1940592 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 4, mRNA. (from RefSeq NM_001330728)
SIRPA (ENST00000358771.4) at chr20:1895296-1939897 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 2, mRNA. (from RefSeq NM_001040023)
SIRPA (ENST00000356025.7) at chr20:1894783-1939897 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 3, mRNA. (from RefSeq NM_080792)
LCK (ENST00000336890.10) at chr1:32251265-32286165 - Homo sapiens LCK proto-oncogene, Src family tyrosine kinase (LCK), transcript variant 2, mRNA. (from RefSeq NM_005356)
LCK (ENST00000619559.4) at chr1:32274111-32286164 - Homo sapiens LCK proto-oncogene, Src family tyrosine kinase (LCK), transcript variant 1, mRNA. (from RefSeq NM_001042771)
GRB2 (ENST00000648046.1) at chr17:75319479-75405699 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392564.5) at chr17:75318076-75393864 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392563.5) at chr17:75318076-75393656 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392562.5) at chr17:75318076-75405486 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
SRC (ENST00000373567.6) at chr20:37383668-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000373558.2) at chr20:37384150-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000358208.8) at chr20:37382604-37405432 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
PDPK1 (ENST00000441549.7) at chr16:2537997-2597920 - Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 3, mRNA. (from RefSeq NM_001261816)
PDPK1 (ENST00000268673.11) at chr16:2538003-2601095 - Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 2, mRNA. (from RefSeq NM_031268)
PDPK1 (ENST00000342085.9) at chr16:2538021-2603188 - Homo sapiens 3-phosphoinositide dependent protein kinase 1 (PDPK1), transcript variant 1, mRNA. (from RefSeq NM_002613)
SH3KBP1 (ENST00000379716.5) at chrX:19534007-19670998 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 10, mRNA. (from RefSeq NM_001353897)
SH3KBP1 (ENST00000379698.8) at chrX:19535693-19799751 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 2, mRNA. (from RefSeq NM_001024666)
SH3KBP1 (ENST00000397821.8) at chrX:19533977-19887600 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 1, mRNA. (from RefSeq NM_031892)
GRB2 (ENST00000316615.9) at chr17:75318076-75405709 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 2, mRNA. (from RefSeq NM_203506)
GRB2 (ENST00000316804.10) at chr17:75318076-75405678 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1, mRNA. (from RefSeq NM_002086)
SRC (ENST00000373578.6) at chr20:37346154-37406050 - Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase (SRC), transcript variant 2, mRNA. (from RefSeq NM_198291)
TP53 (ENST00000269305.8) at chr17:7668402-7687538 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001126112)
TP53 (ENST00000622645.4) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001276696)
TP53 (ENST00000510385.5) at chr17:7668402-7675493 - Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. (from RefSeq NM_001276698)
TP53 (ENST00000455263.6) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. (from RefSeq NM_001276695)
TP53 (ENST00000445888.6) at chr17:7668421-7687487 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001276761)
TP53 (ENST00000610292.4) at chr17:7668402-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. (from RefSeq NM_001126118)
TP53 (ENST00000617185.4) at chr17:7668402-7687550 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001126114)
TP53 (ENST00000504937.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000504290.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000420246.6) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000620739.4) at chr17:7668402-7687538 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000610538.4) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000619485.4) at chr17:7668421-7687487 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
SHC1 (ENST00000368450.5) at chr1:154962298-154974376 - Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 5, mRNA. (from RefSeq NM_001202859)
SHC1 (ENST00000448116.6) at chr1:154962298-154970747 - Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 3, mRNA. (from RefSeq NM_001130040)
SHC1 (ENST00000368453.8) at chr1:154962298-154974376 - Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 2, mRNA. (from RefSeq NM_003029)
SHC1 (ENST00000368445.9) at chr1:154962298-154970741 - Homo sapiens SHC adaptor protein 1 (SHC1), transcript variant 1, mRNA. (from RefSeq NM_183001)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_173174.2 at chr8:27311482-27459391
NM_004103.4 at chr8:27322402-27459391
NM_173176.2 at chr8:27325479-27459391
NM_173175.2 at chr8:27325564-27459391

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017013214.1 at chr8:27325345-27459390
XM_017013216.2 at chr8:27325534-27459390
XM_011544442.3 at chr8:27325534-27459390
XM_005273448.5 at chr8:27325534-27459390
XM_017013215.1 at chr8:27326743-27459390
XM_011544441.2 at chr8:27326743-27459390
XM_005273447.4 at chr8:27380662-27459390

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

PTK2B at chr8:27325552-27459386

RefSeq Genes

PTK2B at chr8:27322402-27459391 - (NM_004103) protein-tyrosine kinase 2-beta isoform a
PTK2B at chr8:27325564-27459391 - (NM_173175) protein-tyrosine kinase 2-beta isoform b
PTK2B at chr8:27311478-27459386 - (NM_173174) protein-tyrosine kinase 2-beta isoform a
PTK2B at chr8:27325552-27459386 - (NM_173176) protein-tyrosine kinase 2-beta isoform a

Non-Human RefSeq Genes

ptk2b at chr8:27419892-27458509 - (NM_001011049) protein-tyrosine kinase 2-beta
PTK2B at chr8:27325566-27459387 - (NM_001134064) protein-tyrosine kinase 2-beta
PTK2B at chr8:27325394-27459050 - (NM_001102252) protein-tyrosine kinase 2-beta
Ptk2b at chr8:27397547-27459374 - (NM_017318) protein-tyrosine kinase 2-beta
Ptk2b at chr8:27325487-27459376 - (NM_001162365) protein-tyrosine kinase 2-beta isoform 2
Ptk2b at chr8:27325487-27459376 - (NM_172498) protein-tyrosine kinase 2-beta isoform 3
Ptk2b at chr8:27325487-27459376 - (NM_001162366) protein-tyrosine kinase 2-beta isoform 1
Ptk2b at chr8:27397542-27459376 - (NM_001360233) protein-tyrosine kinase 2-beta isoform 1
ptk2bb at chr8:27419898-27458497 - (NM_212570) protein-tyrosine kinase 2-beta

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325552-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325552-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27430899-27452559

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27430899-27452559

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27430899-27452559

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27430899-27452559

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

PTK2B at chr8:27311482-27459390
PTK2B at chr8:27311567-27322817
PTK2B at chr8:27311629-27397789
PTK2B at chr8:27325345-27420001
PTK2B at chr8:27325479-27459386
PTK2B at chr8:27325564-27459391
PTK2B at chr8:27326823-27422385
PTK2B at chr8:27380651-27430388
PTK2B at chr8:27380654-27396295
PTK2B at chr8:27397452-27459386
PTK2B at chr8:27422276-27431206
PTK2B at chr8:27430887-27436308
PTK2B at chr8:27430899-27452559
PTK2B at chr8:27432103-27434522
PTK2B at chr8:27437455-27437992
PTK2B at chr8:27452857-27454587
PTK2B at chr8:27454031-27458474

International Knockout Mouse Consortium Genes Mapped to Human Genome

Ptk2b_32367 at chr8:27311482-27459386
Ptk2b_32368 at chr8:27311482-27459386
Ptk2b_32369 at chr8:27311482-27459386
Ptk2b_32370 at chr8:27311482-27459386
Ptk2b_65781 at chr8:27311482-27459386
Ptk2b_80182 at chr8:27311482-27459386
Ptk2b_89630 at chr8:27311482-27459386

Human Aligned mRNA Search Results

BC036651 - Homo sapiens PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:26516 IMAGE:4824966), complete cds.
BC042599 - Homo sapiens PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:17184 IMAGE:4343040), complete cds.
AB209085 - Homo sapiens mRNA for PTK2B protein tyrosine kinase 2 beta isoform a variant protein.
AY429564 - Homo sapiens PTK2Bv_2 mRNA sequence; alternatively spliced.

Non-Human Aligned mRNA Search Results

BC134027 - Danio rerio protein tyrosine kinase 2 beta, b, mRNA (cDNA clone IMAGE:6900512), partial cds.
BC137704 - Mus musculus PTK2 protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:169328 IMAGE:8860723), complete cds.
BC144849 - Mus musculus PTK2 protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:178405 IMAGE:9053397), complete cds.
BC101921 - Rattus norvegicus PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:124628 IMAGE:7937929), complete cds.
AY891239 - Synthetic construct Homo sapiens clone FLH147937.01L PTK2B protein tyrosine kinase 2 beta (PTK2B) mRNA, partial cds.
JP016364 - TSA: Mustela putorius furo MPF81011594contig1/1 mRNA sequence.
BC084174 - Xenopus tropicalis PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:79627 IMAGE:6979941), complete cds.
BC150125 - Bos taurus PTK2B protein tyrosine kinase 2 beta, mRNA (cDNA clone MGC:139227 IMAGE:8203485), complete cds.
JN971017 - Mus musculus protein-tyrosine kinase 2-beta (Ptk2b) mRNA, complete cds.
JU321507 - TSA: Macaca mulatta Mamu_506021 mRNA sequence.
JU321508 - TSA: Macaca mulatta Mamu_506022 mRNA sequence.
JU471069 - TSA: Macaca mulatta Mamu_366107 mRNA sequence.