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Gencode Genes

PNN (ENST00000216832.9) at chr14:39175254-39183220 - Homo sapiens pinin, desmosome associated protein (PNN), mRNA. (from RefSeq NM_002687)
PNN (ENST00000557680.1) at chr14:39179090-39182750 - pinin, desmosome associated protein (from HGNC PNN)
PNN (ENST00000556530.1) at chr14:39175230-39177708 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt G3V5F0)
PNN (ENST00000554902.5) at chr14:39179002-39180701 - pinin, desmosome associated protein (from HGNC PNN)
PNN (ENST00000554117.1) at chr14:39175282-39176590 - pinin, desmosome associated protein (from HGNC PNN)
PNN (ENST00000553331.5) at chr14:39175183-39179246 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt G3V579)
PNISR (ENST00000498075.1) at chr6:99411736-99425270 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000492294.5) at chr6:99410941-99425275 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000481229.1) at chr6:99399975-99402597 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000476159.1) at chr6:99401462-99406127 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000466057.1) at chr6:99411791-99425258 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000463021.1) at chr6:99408153-99410992 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000460600.1) at chr6:99401460-99404546 - PNN interacting serine and arginine rich protein (from HGNC PNISR)
PNISR (ENST00000369239.10) at chr6:99398050-99425308 - Homo sapiens PNN interacting serine and arginine rich protein (PNISR), transcript variant 1, mRNA. (from RefSeq NM_032870)
PNISR (ENST00000647811.1) at chr6:99398051-99425277 - Homo sapiens PNN interacting serine and arginine rich protein (PNISR), transcript variant 4, mRNA. (from RefSeq NM_001322406)
PNISR (ENST00000478777.5) at chr6:99401461-99425308 - Interacts with PNN. (from UniProt Q8TF01)
PNISR (ENST00000438806.5) at chr6:99399964-99425331 - Homo sapiens PNN interacting serine and arginine rich protein (PNISR), transcript variant 15, non-coding RNA. (from RefSeq NR_136326)
ZCCHC17 (ENST00000546109.5) at chr1:31296982-31364953 - Homo sapiens zinc finger CCHC-type containing 17 (ZCCHC17), transcript variant 5, mRNA. (from RefSeq NM_001282569)
ZCCHC17 (ENST00000344147.9) at chr1:31296995-31364936 - Homo sapiens zinc finger CCHC-type containing 17 (ZCCHC17), transcript variant 3, mRNA. (from RefSeq NM_016505)
ZCCHC17 (ENST00000373714.5) at chr1:31297008-31364936 - Homo sapiens zinc finger CCHC-type containing 17 (ZCCHC17), transcript variant 4, mRNA. (from RefSeq NM_001282568)
PPIG (ENST00000260970.8) at chr2:169584351-169641406 - Homo sapiens peptidylprolyl isomerase G (PPIG), mRNA. (from RefSeq NM_004792)
PPIG (ENST00000462903.5) at chr2:169584387-169633566 - PPIases accelerate the folding of proteins. It catalyzes  the cis-trans isomerization of proline imidic peptide bonds in  oligopeptides. May be implicated in the folding, transport, and  assembly of proteins. May play an important role in the regulation  of pre-mRNA splicing. (from UniProt Q13427)
PPIG (ENST00000448752.6) at chr2:169584432-169637621 - PPIases accelerate the folding of proteins. It catalyzes  the cis-trans isomerization of proline imidic peptide bonds in  oligopeptides. May be implicated in the folding, transport, and  assembly of proteins. May play an important role in the regulation  of pre-mRNA splicing. (from UniProt Q13427)
KRT18 (ENST00000388837.6) at chr12:52948871-52952900 - Homo sapiens keratin 18 (KRT18), transcript variant 2, mRNA. (from RefSeq NM_199187)
KRT18 (ENST00000388835.4) at chr12:52949118-52952906 - Homo sapiens keratin 18 (KRT18), transcript variant 1, mRNA. (from RefSeq NM_000224)
KRT8 (ENST00000552150.5) at chr12:52897297-52926469 - Homo sapiens keratin 8 (KRT8), transcript variant 1, mRNA. (from RefSeq NM_001256282)
KRT8 (ENST00000546897.5) at chr12:52897281-52949824 - Homo sapiens keratin 8 (KRT8), transcript variant 3, mRNA. (from RefSeq NM_001256293)
KRT8 (ENST00000552551.5) at chr12:52897187-52949842 - Homo sapiens keratin 8 (KRT8), transcript variant 4, non-coding RNA. (from RefSeq NR_045962)
KRT8 (ENST00000293308.11) at chr12:52897194-52906618 - Homo sapiens keratin 8 (KRT8), transcript variant 2, mRNA. (from RefSeq NM_002273)
ACIN1 (ENST00000397341.7) at chr14:23058580-23071565 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Induces apoptotic chromatin  condensation after activation by CASP3. Regulates cyclin A1, but  not cyclin A2, expression in leukemia cells. (from UniProt Q9UKV3)
SRSF4 (ENST00000373795.7) at chr1:29147743-29181900 - Homo sapiens serine and arginine rich splicing factor 4 (SRSF4), mRNA. (from RefSeq NM_005626)
CTBP2 (ENST00000337195.9) at chr10:124984317-125160513 - Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 1, mRNA. (from RefSeq NM_001329)
CTBP2 (ENST00000411419.6) at chr10:124989225-125161026 - Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 3, mRNA. (from RefSeq NM_001083914)
CTBP2 (ENST00000309035.11) at chr10:124984317-125028071 - Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 2, mRNA. (from RefSeq NM_022802)
SAP18 (ENST00000607003.5) at chr13:21140578-21149082 - Component of the SIN3-repressing complex. Enhances the  ability of SIN3-HDAC1-mediated transcriptional repression. When  tethered to the promoter, it can direct the formation of a  repressive complex to core histone proteins. Component of a  splicing-dependent multiprotein exon junction complex (EJC)  deposited at splice junction on mRNAs. The EJC is a dynamic  structure consisting of a few core proteins and several more  peripheral nuclear and cytoplasmic associated factors that join  the complex only transiently either during EJC assembly or during  subsequent mRNA metabolism. (from UniProt O00422)
SAP18 (ENST00000382533.8) at chr13:21140514-21149082 - Component of the SIN3-repressing complex. Enhances the  ability of SIN3-HDAC1-mediated transcriptional repression. When  tethered to the promoter, it can direct the formation of a  repressive complex to core histone proteins. Component of a  splicing-dependent multiprotein exon junction complex (EJC)  deposited at splice junction on mRNAs. The EJC is a dynamic  structure consisting of a few core proteins and several more  peripheral nuclear and cytoplasmic associated factors that join  the complex only transiently either during EJC assembly or during  subsequent mRNA metabolism. (from UniProt O00422)
ACIN1 (ENST00000555053.5) at chr14:23059059-23095383 - Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 2, mRNA. (from RefSeq NM_001164814)
ACIN1 (ENST00000262710.5) at chr14:23058567-23095614 - Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 1, mRNA. (from RefSeq NM_014977)
ACIN1 (ENST00000357481.6) at chr14:23058567-23071617 - Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 5, mRNA. (from RefSeq NM_001164817)
ACIN1 (ENST00000338631.10) at chr14:23058567-23071561 - Homo sapiens apoptotic chromatin condensation inducer 1 (ACIN1), transcript variant 4, mRNA. (from RefSeq NM_001164816)
KRT19 (ENST00000361566.7) at chr17:41523617-41528308 - Homo sapiens keratin 19 (KRT19), mRNA. (from RefSeq NM_002276)
CTBP1 (ENST00000382952.7) at chr4:1211448-1249112 - Homo sapiens C-terminal binding protein 1 (CTBP1), transcript variant 2, mRNA. (from RefSeq NM_001012614)
SAP18 (ENST00000621421.4) at chr13:21140514-21149084 - Homo sapiens Sin3A associated protein 18 (SAP18), transcript variant 1, mRNA. (from RefSeq NM_005870)
CTBP2 (ENST00000531469.5) at chr10:124989225-125158716 - Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 7, mRNA. (from RefSeq NM_001321013)
CTBP2 (ENST00000494626.6) at chr10:124989225-125160499 - Homo sapiens C-terminal binding protein 2 (CTBP2), transcript variant 8, mRNA. (from RefSeq NM_001321014)
RNPS1 (ENST00000320225.10) at chr16:2253120-2268126 - Homo sapiens RNA binding protein with serine rich domain 1 (RNPS1), transcript variant 2, mRNA. (from RefSeq NM_080594)
RNPS1 (ENST00000566458.5) at chr16:2253117-2268397 - Homo sapiens RNA binding protein with serine rich domain 1 (RNPS1), transcript variant 4, mRNA. (from RefSeq NM_001286626)
RNPS1 (ENST00000565678.5) at chr16:2253130-2267603 - Homo sapiens RNA binding protein with serine rich domain 1 (RNPS1), transcript variant 3, mRNA. (from RefSeq NM_001286625)
RNPS1 (ENST00000397086.6) at chr16:2253116-2267848 - Homo sapiens RNA binding protein with serine rich domain 1 (RNPS1), transcript variant 1, mRNA. (from RefSeq NM_006711)
RNPS1 (ENST00000568631.5) at chr16:2253828-2267829 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Part of pre- and post-  splicing multiprotein mRNP complexes. Enhances the formation of  the ATP-dependent A complex of the spliceosome. Involved in both  constitutive splicing and, in association with SRP54 and  TRA2B/SFRS10, in distinctive modulation of alternative splicing in  a substrate-dependent manner. Participates in mRNA 3'-end  cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD)  of mRNAs containing premature stop codons. Also mediates increase  of mRNA abundance and translational efficiency. Binds spliced mRNA  20-25 nt upstream of exon-exon junctions. (from UniProt Q15287)
RNPS1 (ENST00000301730.12) at chr16:2253846-2268114 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Part of pre- and post-  splicing multiprotein mRNP complexes. Enhances the formation of  the ATP-dependent A complex of the spliceosome. Involved in both  constitutive splicing and, in association with SRP54 and  TRA2B/SFRS10, in distinctive modulation of alternative splicing in  a substrate-dependent manner. Participates in mRNA 3'-end  cleavage. Involved in UPF2-dependent nonsense-mediated decay (NMD)  of mRNAs containing premature stop codons. Also mediates increase  of mRNA abundance and translational efficiency. Binds spliced mRNA  20-25 nt upstream of exon-exon junctions. (from UniProt Q15287)
MAGOH (ENST00000371470.8) at chr1:53226900-53238518 - Homo sapiens mago homolog, exon junction complex subunit (MAGOH), mRNA. (from RefSeq NM_002370)
MAGOH (ENST00000371466.4) at chr1:53226926-53238499 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Core components of the EJC,  that remains bound to spliced mRNAs throughout all stages of mRNA  metabolism, functions to mark the position of the exon-exon  junction in the mature mRNA and thereby influences downstream  processes of gene expression including mRNA splicing, nuclear mRNA  export, subcellular mRNA localization, translation efficiency and  nonsense-mediated mRNA decay (NMD). Remains associated with the  mRNA after its export to the cytoplasm and require translation of  the mRNA for removal. The heterodimer MAGOH-RBM8A interacts with  PYM that function to enhance the translation of EJC-bearing  spliced mRNAs by recruiting them to the ribosomal 48S  preinitiation complex. (from UniProt P61326)
CASC3 (ENST00000264645.12) at chr17:40140537-40172171 - Homo sapiens CASC3 exon junction complex subunit (CASC3), mRNA. (from RefSeq NM_007359)
RBM8A (ENST00000632555.1) at chr1:145921632-145927447 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Core components of the EJC,  that remains bound to spliced mRNAs throughout all stages of mRNA  metabolism, functions to mark the position of the exon-exon  junction in the mature mRNA and thereby influences downstream  processes of gene expression including mRNA splicing, nuclear mRNA  export, subcellular mRNA localization, translation efficiency and  nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A  interacts with PYM that function to enhance the translation of  EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S  preinitiation complex. Remains associated with mRNAs in the  cytoplasm until the mRNAs engage the translation machinery. Its  removal from cytoplasmic mRNAs requires translation initiation  from EJC-bearing spliced mRNAs. Associates preferentially with  mRNAs produced by splicing. Does not interact with pre-mRNAs,  introns, or mRNAs produced from intronless cDNAs. Associates with  both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex  with MAGOH is a component of the nonsense mediated decay (NMD)  pathway. (from UniProt Q9Y5S9)
RBM8A (ENST00000369307.4) at chr1:145925642-145927460 - Component of a splicing-dependent multiprotein exon  junction complex (EJC) deposited at splice junction on mRNAs. The  EJC is a dynamic structure consisting of a few core proteins and  several more peripheral nuclear and cytoplasmic associated factors  that join the complex only transiently either during EJC assembly  or during subsequent mRNA metabolism. Core components of the EJC,  that remains bound to spliced mRNAs throughout all stages of mRNA  metabolism, functions to mark the position of the exon-exon  junction in the mature mRNA and thereby influences downstream  processes of gene expression including mRNA splicing, nuclear mRNA  export, subcellular mRNA localization, translation efficiency and  nonsense-mediated mRNA decay (NMD). The heterodimer MAGOH-RBM8A  interacts with PYM that function to enhance the translation of  EJC-bearing spliced mRNAs by recruiting them to the ribosomal 48S  preinitiation complex. Remains associated with mRNAs in the  cytoplasm until the mRNAs engage the translation machinery. Its  removal from cytoplasmic mRNAs requires translation initiation  from EJC-bearing spliced mRNAs. Associates preferentially with  mRNAs produced by splicing. Does not interact with pre-mRNAs,  introns, or mRNAs produced from intronless cDNAs. Associates with  both nuclear mRNAs and newly exported cytoplasmic mRNAs. Complex  with MAGOH is a component of the nonsense mediated decay (NMD)  pathway. (from UniProt Q9Y5S9)
EIF4A3 (ENST00000647795.1) at chr17:80135299-80147151 - ATP-dependent RNA helicase. Component of a splicing-  dependent multiprotein exon junction complex (EJC) deposited at  splice junction on mRNAs. The EJC is a dynamic structure  consisting of a few core proteins and several more peripheral  nuclear and cytoplasmic associated factors that join the complex  only transiently either during EJC assembly or during subsequent  mRNA metabolism. Core components of the EJC, that remains bound to  spliced mRNAs throughout all stages of mRNA metabolism, functions  to mark the position of the exon-exon junction in the mature mRNA  and thereby influences downstream processes of gene expression  including mRNA splicing, nuclear mRNA export, subcellular mRNA  localization, translation efficiency and nonsense-mediated mRNA  decay (NMD). Constitutes at least part of the platform anchoring  other EJC proteins to spliced mRNAs. Its RNA-dependent ATPase and  RNA-helicase activities are induced by CASC3, but abolished in  presence of the MAGOH/RBM8A heterodimer, thereby trapping the ATP-  bound EJC core onto spliced mRNA in a stable conformation. The  inhibition of ATPase activity by the MAGOH/RBM8A heterodimer  increases the RNA-binding affinity of the EJC. Involved in  translational enhancement of spliced mRNAs after formation of the  80S ribosome complex. Binds spliced mRNA in sequence-independent  manner, 20-24 nucleotides upstream of mRNA exon-exon junctions.  Shows higher affinity for single-stranded RNA in an ATP-bound core  EJC complex than after the ATP is hydrolyzed. (from UniProt P38919)
RBM8A (ENST00000583313.6) at chr1:145921556-145927536 - Homo sapiens RNA binding motif protein 8A (RBM8A), mRNA. (from RefSeq NM_005105)
EIF4A3 (ENST00000649764.2) at chr17:80134369-80147128 - Homo sapiens eukaryotic translation initiation factor 4A3 (EIF4A3), mRNA. (from RefSeq NM_014740)
SRC (ENST00000373578.6) at chr20:37346154-37406050 - Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase (SRC), transcript variant 2, mRNA. (from RefSeq NM_198291)
SRC (ENST00000373567.6) at chr20:37383668-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000373558.2) at chr20:37384150-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000358208.8) at chr20:37382604-37405432 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_002687.3 at chr14:39175183-39183218

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

PNN at chr14:39175254-39183220

RefSeq Genes

PNN at chr14:39175254-39183220 - (NM_002687) pinin

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

PNN interacting serine and arginine rich protein, transcript variant 1 at chr6:99398051-99425345 - (NM_032870.3)
PNN interacting serine and arginine rich protein, transcript variant 14 at chr6:99409346-99425345 - (NM_001322419.1)
PNN interacting serine and arginine rich protein, transcript variant 12 at chr6:99409346-99425345 - (NM_001322417.1)
PNN interacting serine and arginine rich protein, transcript variant 10 at chr6:99398051-99425345 - (NM_001322415.1)
PNN interacting serine and arginine rich protein, transcript variant 8 at chr6:99398051-99425345 - (NM_001322413.1)
PNN interacting serine and arginine rich protein, transcript variant 6 at chr6:99398051-99425345 - (NM_001322410.1)
PNN interacting serine and arginine rich protein, transcript variant 4 at chr6:99398051-99425345 - (NM_001322406.1)
PNN interacting serine and arginine rich protein, transcript variant 3 at chr6:99398051-99425345 - (NM_001322405.1)
PNN interacting serine and arginine rich protein, transcript variant 5 at chr6:99398051-99425345 - (NM_001322408.1)
PNN interacting serine and arginine rich protein, transcript variant 7 at chr6:99398051-99425345 - (NM_001322412.1)
PNN interacting serine and arginine rich protein, transcript variant 9 at chr6:99398051-99425345 - (NM_001322414.1)
PNN interacting serine and arginine rich protein, transcript variant 11 at chr6:99398051-99425345 - (NM_001322416.1)
PNN interacting serine and arginine rich protein, transcript variant 13 at chr6:99409346-99425345 - (NM_001322418.1)
PNN interacting serine and arginine rich protein, transcript variant 2 at chr6:99398051-99425345 - (NM_015491.2)
PNN interacting serine and arginine rich protein, transcript variant 15 at chr6:99398051-99425345 - (NR_136326.1)

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

PNN interacting serine and arginine rich protein, transcript variant X7 at chr6:99398655-99425298 - (XM_024446398.1)
PNN interacting serine and arginine rich protein, transcript variant X6 at chr6:99398655-99425342 - (XM_017010713.1)
PNN interacting serine and arginine rich protein, transcript variant X4 at chr6:99398655-99425308 - (XM_017010711.1)
PNN interacting serine and arginine rich protein, transcript variant X1 at chr6:99398655-99426306 - (XM_005266912.4)
PNN interacting serine and arginine rich protein, transcript variant X3 at chr6:99398655-99425308 - (XM_017010710.2)
PNN interacting serine and arginine rich protein, transcript variant X5 at chr6:99398655-99425342 - (XM_017010712.1)
PNN interacting serine and arginine rich protein, transcript variant X2 at chr6:99398655-99426306 - (XM_024446397.1)
PNN interacting serine and arginine rich protein, transcript variant X8 at chr6:99410360-99426306 - (XM_024446399.1)

Non-Human RefSeq Genes

PNN at chr14:39175260-39182950 - (NM_001244231) pinin
pnn at chr14:39175262-39181863 - (NM_001005707) pinin
PNN at chr14:39175260-39182939 - (NM_001242585) pinin
Pnn at chr14:39175262-39182487 - (NM_001109023) pinin
PNN at chr14:39175257-39182941 - (NM_001133190) pinin
PNN at chr14:39175260-39182941 - (NM_001003231) pinin
Pnn at chr14:39175260-39183043 - (NM_008891) pinin
pnn at chr14:39175277-39181857 - (NM_001172570) pinin
pnn.L at chr14:39175277-39181863 - (NM_001087460) pinin, desmosome associated protein L homeolog
pnn.S at chr14:39175274-39181863 - (NM_001087556) pinin, desmosome associated protein S homeolog
pnisr.S at chr6:99399982-99414662 - (NM_001091596) PNN-interacting serine/arginine-rich protein S homeolog

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

PNN at chr14:39175183-39179246
PNN at chr14:39175230-39177708
PNN at chr14:39175254-39183220

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

PNN at chr14:39175183-39179246
PNN at chr14:39175230-39177708
PNN at chr14:39175254-39183220
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

PNN at chr14:39175183-39179246
PNN at chr14:39175213-39183218
PNN at chr14:39175230-39177708
PNN at chr14:39175282-39176590
PNN at chr14:39179002-39180701
PNN at chr14:39179090-39182750

Retroposed Genes V9, Including Pseudogenes

PNN at chr5:159244721-159246290 - (HQ257989.1-65)
PNN at chr2:199108576-199110110 - (HQ257989.1-44)
PNN at chr11:111073133-111075309 - (HQ257989.1-14)
PNN at chr4:120149663-120150821 - (HQ257989.1-61)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Pnn_24292 at chr14:39175183-39183218
Pnn_49836 at chr14:39175183-39183218
Pnn_70143 at chr14:39175183-39183218
Pnn_VG19317 at chr14:39175183-39183218

Alias of STS Marker

PNN at chr14:39077633-39277906 - (PNN)

Human Aligned mRNA Search Results

BC062602 - Homo sapiens pinin, desmosome associated protein, mRNA (cDNA clone MGC:70809 IMAGE:5491466), complete cds.
AK292579 - Homo sapiens cDNA FLJ75071 complete cds, highly similar to Homo sapiens pinin, desmosome associated protein (PNN), mRNA.

Non-Human Aligned mRNA Search Results

BC056140 - Danio rerio pinin, desmosome associated protein, mRNA (cDNA clone IMAGE:3815401), partial cds.
BC081665 - Danio rerio pinin, desmosome associated protein, mRNA (cDNA clone IMAGE:7049098), partial cds.
BC095809 - Danio rerio pinin, desmosome associated protein, mRNA (cDNA clone IMAGE:7401418), partial cds.
BC125902 - Danio rerio pinin, desmosome associated protein, mRNA (cDNA clone IMAGE:7990774), partial cds.
JP286138 - TSA: Hymenochirus curtipes Hymenochirus_curtipes.contig178 mRNA sequence.
BC103403 - Bos taurus pinin, desmosome associated protein, mRNA (cDNA clone MGC:127754 IMAGE:30957312), complete cds.
JU062497 - TSA: Pipa carvalhoi pip_pnn mRNA sequence.
JU062498 - TSA: Rhinophrynus dorsalis rhi_pnn mRNA sequence.
JU062499 - TSA: Hymenochirus curtipes hym_pnn mRNA sequence.
BC075283 - Xenopus tropicalis pinin, desmosome associated protein, mRNA (cDNA clone MGC:88923 IMAGE:6999742), complete cds.
JT411990 - TSA: Ictalurus punctatus clc_475934 mRNA sequence.
JU335052 - TSA: Macaca mulatta Mamu_503790 mRNA sequence.
JU335053 - TSA: Macaca mulatta Mamu_503791 mRNA sequence.
JU476053 - TSA: Macaca mulatta Mamu_365925 mRNA sequence.
JU476054 - TSA: Macaca mulatta Mamu_365926 mRNA sequence.
JV047413 - TSA: Macaca mulatta Mamu_416282 mRNA sequence.
JV047414 - TSA: Macaca mulatta Mamu_416283 mRNA sequence.
BC132571 - Mus musculus pinin, mRNA (cDNA clone MGC:164202 IMAGE:40130848), complete cds.
BC138014 - Mus musculus pinin, mRNA (cDNA clone MGC:169638 IMAGE:8861033), complete cds.