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Gencode Genes

NUCKS1 (ENST00000367142.5) at chr1:205712822-205750182 - Homo sapiens nuclear casein kinase and cyclin dependent kinase substrate 1 (NUCKS1), mRNA. (from RefSeq NM_022731)
NUCKS1 (ENST00000464938.1) at chr1:205718452-205719726 - nuclear casein kinase and cyclin dependent kinase substrate 1 (from HGNC NUCKS1)
CDK1 (ENST00000373809.2) at chr10:60780153-60794852 - Plays a key role in the control of the eukaryotic cell  cycle by modulating the centrosome cycle as well as mitotic onset;  promotes G2-M transition, and regulates G1 progress and G1-S  transition via association with multiple interphase cyclins.  Required in higher cells for entry into S-phase and mitosis.  Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-  xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C,  CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1,  DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG,  FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1  proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR,  LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC,  NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1,  NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53,  NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP,  RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin,  STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1,  FOXO1, RUNX1/AML1 and RUNX2. CDK1/CDC2-cyclin-B controls  pronuclear union in interphase fertilized eggs. Essential for  early stages of embryonic development. During G2 and early  mitosis, CDC25A/B/C-mediated dephosphorylation activates  CDK1/cyclin complexes which phosphorylate several substrates that  trigger at least centrosome separation, Golgi dynamics, nuclear  envelope breakdown and chromosome condensation. Once chromosomes  are condensed and aligned at the metaphase plate, CDK1 activity is  switched off by WEE1- and PKMYT1-mediated phosphorylation to allow  sister chromatid separation, chromosome decondensation,  reformation of the nuclear envelope and cytokinesis. Inactivated  by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage  to stop cell cycle and genome replication at the G2 checkpoint  thus facilitating DNA repair. Reactivated after successful DNA  repair through WIP1-dependent signaling leading to CDC25A/B/C-  mediated dephosphorylation and restoring cell cycle progression.  In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the  G2-M phase represses FOXO1 interaction with 14-3-3 proteins and  thereby promotes FOXO1 nuclear accumulation and transcription  factor activity, leading to cell death of postmitotic neurons. The  phosphorylation of beta-tubulins regulates microtubule dynamics  during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1  phosphorylation and subsequent targeting of the gamma-tubulin ring  complex (gTuRC) to the centrosome, an important step for spindle  formation. In addition, CC2D1A phosphorylation regulates CC2D1A  spindle pole localization and association with SCC1/RAD21 and  centriole cohesion during mitosis. The phosphorylation of Bcl-  xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers  apoptosis. In contrast, CASP8 phosphorylation during mitosis  prevents its activation by proteolysis and subsequent apoptosis.  This phosphorylation occurs in cancer cell lines, as well as in  primary breast tissues and lymphocytes. EZH2 phosphorylation  promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1  phosphorylation promotes Schwann cell migration during peripheral  nerve regeneration. (from UniProt P06493)
CDK1 (ENST00000395284.8) at chr10:60778478-60794852 - Homo sapiens cyclin dependent kinase 1 (CDK1), transcript variant 1, mRNA. (from RefSeq NM_001786)
CDK1 (ENST00000316629.8) at chr10:60778454-60794843 - Homo sapiens cyclin dependent kinase 1 (CDK1), transcript variant 2, mRNA. (from RefSeq NM_033379)
NUCKS1P1 (ENST00000452067.1) at chr1:227410617-227411319 - nuclear casein kinase and cyclin dependent kinase substrate 1 pseudogene 1 (from HGNC NUCKS1P1)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_022731.4 at chr1:205712819-205750244

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005245453.1 at chr1:205713193-205750220

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

NUCKS1 at chr1:205712822-205750182

RefSeq Genes

NUCKS1 at chr1:205712822-205750182 - (NM_022731) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

Non-Human RefSeq Genes

NUCKS1 at chr1:205714499-205750046 - (NM_001266481) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
NUCKS1 at chr1:205717409-205750187 - (NM_001284904) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
NUCKS1 at chr1:205718249-205750155 - (NM_001244237) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
NUCKS1 at chr1:205718280-205729623 - (NM_213581) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
NUCKS1 at chr1:205717289-205750005 - (NM_001045920) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Nucks1 at chr1:205717717-205750133 - (NM_022799) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1
Nucks1 at chr1:205713193-205750254 - (NM_175294) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 1
Nucks1 at chr1:205713193-205750254 - (NM_001145804) nuclear ubiquitous casein and cyclin-dependent kinase substrate 1 isoform 2
nucks1.L at chr1:205718280-205729623 - (NM_001091242) nuclear casein kinase and cyclin-dependent kinase substrate 1 L homeolog

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

NUCKS1 at chr1:205712822-205750182

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

NUCKS1 at chr1:205712822-205750182
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

NUCKS1 at chr1:205712819-205750276

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

NUCKS1 at chr1:205712819-205750276
NUCKS1 at chr1:205718452-205719726

Retroposed Genes V9, Including Pseudogenes

NUCKS1 at chr1:227410278-227411481 - (BC000805.1-2)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Nucks1_71528 at chr1:205712819-205750233

Human Aligned mRNA Search Results

BC000805 - Homo sapiens nuclear casein kinase and cyclin-dependent kinase substrate 1, mRNA (cDNA clone MGC:5494 IMAGE:3452665), complete cds.
LG070620 - KR 1020150124006-A/5: NUCKS1, Novel Coactivator regulating the transcriptional activity of HIV-1 Tat.
LG070618 - KR 1020150124006-A/3: NUCKS1, Novel Coactivator regulating the transcriptional activity of HIV-1 Tat.

Non-Human Aligned mRNA Search Results

MG132937 - Synthetic construct Xenopus tropicalis clone IMAGE:5381323 nuclear casein kinase and cyclin-dependent kinase substrate 1 (nucks1) gene, encodes complete protein.
CR760325 - Xenopus tropicalis finished cDNA, clone TNeu112g21.
BC063335 - Xenopus tropicalis nuclear casein kinase and cyclin-dependent kinase substrate 1, mRNA (cDNA clone MGC:75738 IMAGE:5381323), complete cds.
BC039951 - Mus musculus nuclear casein kinase and cyclin-dependent kinase substrate 1, mRNA (cDNA clone MGC:49565 IMAGE:4188558), complete cds.
BC078818 - Rattus norvegicus nuclear casein kinase and cyclin-dependent kinase substrate 1, mRNA (cDNA clone MGC:93427 IMAGE:7128528), complete cds.
BC113259 - Bos taurus nuclear casein kinase and cyclin-dependent kinase substrate 1, mRNA (cDNA clone MGC:137955 IMAGE:8086412), complete cds.
JT413688 - TSA: Ictalurus punctatus aby_k31:1908184 mRNA sequence.
JU319617 - TSA: Macaca mulatta Mamu_500702 mRNA sequence.
JU319618 - TSA: Macaca mulatta Mamu_500703 mRNA sequence.
JU471457 - TSA: Macaca mulatta Mamu_368927 mRNA sequence.
JV635557 - TSA: Macaca mulatta Mamu_460970 mRNA sequence.