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Gencode Genes

MERTK (ENST00000295408.9) at chr2:111898607-112029561 - Homo sapiens MER proto-oncogene, tyrosine kinase (MERTK), mRNA. (from RefSeq NM_006343)
MERTK (ENST00000616902.4) at chr2:111898614-112028563 - MER proto-oncogene, tyrosine kinase (from HGNC MERTK)
MERTK (ENST00000473065.1) at chr2:111997370-112003443 - MER proto-oncogene, tyrosine kinase (from HGNC MERTK)
MERTK (ENST00000449344.2) at chr2:112019413-112028663 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H7C3L9)
MERTK (ENST00000439966.5) at chr2:111898664-112029000 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PD22)
MERTK (ENST00000421804.6) at chr2:111898608-112029366 - Receptor tyrosine kinase that transduces signals from  the extracellular matrix into the cytoplasm by binding to several  ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many  physiological processes including cell survival, migration,  differentiation, and phagocytosis of apoptotic cells  (efferocytosis). Ligand binding at the cell surface induces  autophosphorylation of MERTK on its intracellular domain that  provides docking sites for downstream signaling molecules.  Following activation by ligand, interacts with GRB2 or PLCG2 and  induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK  signaling plays a role in various processes such as macrophage  clearance of apoptotic cells, platelet aggregation, cytoskeleton  reorganization and engulfment. Functions in the retinal pigment  epithelium (RPE) as a regulator of rod outer segments fragments  phagocytosis. Plays also an important role in inhibition of Toll-  like receptors (TLRs)-mediated innate immune response by  activating STAT1, which selectively induces production of  suppressors of cytokine signaling SOCS1 and SOCS3. (from UniProt Q12866)
MERTK (ENST00000409780.5) at chr2:111898629-112029367 - ATP + a [protein]-L-tyrosine = ADP + a  [protein]-L-tyrosine phosphate. (from UniProt E9PHX8)
TNK2 (ENST00000333602.13) at chr3:195863364-195909084 - Homo sapiens tyrosine kinase non receptor 2 (TNK2), transcript variant 1, mRNA. (from RefSeq NM_005781)
TNK2 (ENST00000439230.6) at chr3:195868223-195895961 - Non-receptor tyrosine-protein and serine/threonine-  protein kinase that is implicated in cell spreading and migration,  cell survival, cell growth and proliferation. Transduces  extracellular signals to cytosolic and nuclear effectors.  Phosphorylates AKT1, AR, MCF2, WASL and WWOX. Implicated in  trafficking and clathrin-mediated endocytosis through binding to  epidermal growth factor receptor (EGFR) and clathrin. Binds to  both poly- and mono-ubiquitin and regulates ligand-induced  degradation of EGFR, thereby contributing to the accumulation of  EGFR at the limiting membrane of early endosomes. Downstream  effector of CDC42 which mediates CDC42-dependent cell migration  via phosphorylation of BCAR1. May be involved both in adult  synaptic function and plasticity and in brain development.  Activates AKT1 by phosphorylating it on 'Tyr-176'. Phosphorylates  AR on 'Tyr-267' and 'Tyr-363' thereby promoting its recruitment to  androgen-responsive enhancers (AREs). Phosphorylates WWOX on 'Tyr-  287'. Phosphorylates MCF2, thereby enhancing its activity as a  guanine nucleotide exchange factor (GEF) toward Rho family  proteins. Contributes to the control of AXL receptor levels.  Confers metastatic properties on cancer cells and promotes tumor  growth by negatively regulating tumor suppressor such as WWOX and  positively regulating pro-survival factors such as AKT1 and AR. (from UniProt Q07912)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_006343.3 at chr2:111898607-112029561

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

MERTK at chr2:111898607-112029561

RefSeq Genes

MERTK at chr2:111898607-112029558 - (NM_006343) tyrosine-protein kinase Mer precursor

Non-Human RefSeq Genes

MERTK at chr2:111898636-112029368 - (NM_001192024) tyrosine-protein kinase Mer precursor
MERTK at chr2:111898629-112029367 - (NM_001131516) tyrosine-protein kinase Mer
MERTK at chr2:111947393-112028507 - (NM_204988) tyrosine-protein kinase Mer precursor
Mertk at chr2:111929219-112028864 - (NM_022943) tyrosine-protein kinase Mer precursor
Mertk at chr2:111929255-112029087 - (NM_008587) tyrosine-protein kinase Mer precursor

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

MERTK at chr2:111898607-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

MERTK at chr2:111898607-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898614-112028563
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898629-112029367
MERTK at chr2:111982913-112028563

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MERTK at chr2:111898479-112029561
MERTK at chr2:111898608-112029366
MERTK at chr2:111898629-112029367
MERTK at chr2:111898664-112029000
MERTK at chr2:111982913-112028563
MERTK at chr2:111997370-112003443
MERTK at chr2:112019413-112028663

International Knockout Mouse Consortium Genes Mapped to Human Genome

Mertk_27769 at chr2:111898614-112029368
Mertk_27770 at chr2:111898614-112029368
Mertk_71391 at chr2:111898614-112029368
Mertk_74955 at chr2:111898614-112029368
Mertk_82534 at chr2:111898614-112029368
Mertk_88961 at chr2:111898614-112029368
Mertk_93793 at chr2:111898614-112029368

Human Aligned mRNA Search Results

BC114917 - Homo sapiens c-mer proto-oncogene tyrosine kinase, mRNA (cDNA clone MGC:133349 IMAGE:40068588), complete cds.
BC114918 - Homo sapiens c-mer proto-oncogene tyrosine kinase, mRNA (cDNA clone MGC:133084 IMAGE:40012335), complete cds.
AK316584 - Homo sapiens cDNA, FLJ95000, highly similar to Homo sapiens c-mer proto-oncogene tyrosine kinase (MERTK), mRNA.

Non-Human Aligned mRNA Search Results

AF208235 - Rattus norvegicus MERTK (Mertk) mRNA, complete cds.
BC156360 - Synthetic construct Mus musculus clone IMAGE:100061852, MGC:190305 c-mer proto-oncogene tyrosine kinase (Mertk) mRNA, encodes complete protein.
BC157109 - Synthetic construct Mus musculus clone IMAGE:100063424, MGC:191082 c-mer proto-oncogene tyrosine kinase (Mertk) mRNA, encodes complete protein.
JU325869 - TSA: Macaca mulatta Mamu_531525 mRNA sequence.
JU328888 - TSA: Macaca mulatta Mamu_529146 mRNA sequence.

GeneReviews

MERTK at chr2:111898607-112029561