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Gencode Genes

MDM4 (ENST00000367182.8) at chr1:204516406-204558120 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 1, mRNA. (from RefSeq NM_002393)
MDM4 (ENST00000621032.4) at chr1:204516406-204554200 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000616250.4) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 6, mRNA. (from RefSeq NM_001278518)
MDM4 (ENST00000614459.4) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 5, mRNA. (from RefSeq NM_001278517)
MDM4 (ENST00000612738.4) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 7, mRNA. (from RefSeq NM_001278519)
MDM4 (ENST00000507825.3) at chr1:204525519-204546834 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000471783.1) at chr1:204516472-204544599 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000470908.5) at chr1:204516451-204546832 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000470797.5) at chr1:204516383-204532650 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000463049.5) at chr1:204516406-204554201 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000462012.1) at chr1:204537875-204542931 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000454264.6) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 2, mRNA. (from RefSeq NM_001204171)
MDM4 (ENST00000444261.1) at chr1:204542789-204549388 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000391947.6) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 4, mRNA. (from RefSeq NM_001278516)
MDM4 (ENST00000367183.7) at chr1:204516379-204558119 - Homo sapiens MDM4 regulator of p53 (MDM4), transcript variant 3, mRNA. (from RefSeq NM_001204172)
MDM4 (ENST00000367180.5) at chr1:204525490-204537041 - MDM4, p53 regulator (from HGNC MDM4)
MDM4 (ENST00000367179.7) at chr1:204537857-204549194 - MDM4, p53 regulator (from HGNC MDM4)
USP2 (ENST00000525735.1) at chr11:119356534-119364207 - Homo sapiens ubiquitin specific peptidase 2 (USP2), transcript variant 2, mRNA. (from RefSeq NM_171997)
USP2 (ENST00000455332.6) at chr11:119355215-119381711 - Homo sapiens ubiquitin specific peptidase 2 (USP2), transcript variant 3, mRNA. (from RefSeq NM_001243759)
USP2 (ENST00000260187.7) at chr11:119355215-119381690 - Homo sapiens ubiquitin specific peptidase 2 (USP2), transcript variant 1, mRNA. (from RefSeq NM_004205)
CHEK2 (ENST00000650281.1) at chr22:28687766-28741806 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000448511.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000433728.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000417588.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000405598.5) at chr22:28687762-28741800 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000403642.5) at chr22:28687897-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000402731.5) at chr22:28687897-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
MKRN3 (ENST00000314520.6) at chr15:23565674-23568044 - Homo sapiens makorin ring finger protein 3 (MKRN3), mRNA. (from RefSeq NM_005664)
MARCH7 (ENST00000259050.8) at chr2:159712499-159771027 - Homo sapiens membrane associated ring-CH-type finger 7 (MARCHF7), transcript variant 2, mRNA. (from RefSeq NM_022826)
MARCH7 (ENST00000409591.5) at chr2:159733965-159767409 - Homo sapiens membrane associated ring-CH-type finger 7 (MARCHF7), transcript variant 4, mRNA. (from RefSeq NM_001282807)
MARCH7 (ENST00000409175.6) at chr2:159712506-159771027 - Homo sapiens membrane associated ring-CH-type finger 7 (MARCHF7), transcript variant 1, mRNA. (from RefSeq NM_001282805)
UBE2D2 (ENST00000511725.5) at chr5:139526431-139626855 - Accepts ubiquitin from the E1 complex and catalyzes its  covalent attachment to other proteins. In vitro catalyzes 'Lys-  48'-linked polyubiquitination. Mediates the selective degradation  of short-lived and abnormal proteins. Functions in the E6/E6-AP-  induced ubiquitination of p53/TP53. Mediates ubiquitination of  PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the  signal-induced conjugation and subsequent degradation of NFKBIA,  FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent  degradation of p53/TP53 and the activation of MAVS in the  mitochondria by DDX58/RIG-I in response to viral infection.  Essential for viral activation of IRF3. (from UniProt P62837)
UBE2D2 (ENST00000398734.8) at chr5:139561726-139627686 - Accepts ubiquitin from the E1 complex and catalyzes its  covalent attachment to other proteins. In vitro catalyzes 'Lys-  48'-linked polyubiquitination. Mediates the selective degradation  of short-lived and abnormal proteins. Functions in the E6/E6-AP-  induced ubiquitination of p53/TP53. Mediates ubiquitination of  PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the  signal-induced conjugation and subsequent degradation of NFKBIA,  FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent  degradation of p53/TP53 and the activation of MAVS in the  mitochondria by DDX58/RIG-I in response to viral infection.  Essential for viral activation of IRF3. (from UniProt P62837)
YWHAG (ENST00000307630.5) at chr7:76326799-76358991 - Homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein gamma (YWHAG), mRNA. (from RefSeq NM_012479)
UBE2D2 (ENST00000505548.5) at chr5:139562029-139627115 - Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 2, mRNA. (from RefSeq NM_181838)
UBE2D2 (ENST00000398733.8) at chr5:139561339-139628434 - Homo sapiens ubiquitin conjugating enzyme E2 D2 (UBE2D2), transcript variant 1, mRNA. (from RefSeq NM_003339)
MDM2 (ENST00000299252.8) at chr12:68809212-68839849 - Homo sapiens MDM2 proto-oncogene (MDM2), transcript variant 5, mRNA. (from RefSeq NM_001278462)
MDM2 (ENST00000258149.10) at chr12:68808177-68850686 - Homo sapiens MDM2 proto-oncogene (MDM2), transcript variant 1, mRNA. (from RefSeq NM_002392)
MDM2 (ENST00000393413.7) at chr12:68809212-68839849 - E3 ubiquitin-protein ligase that mediates ubiquitination  of p53/TP53, leading to its degradation by the proteasome.  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and  apoptosis by binding its transcriptional activation domain. Also  acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits  the nuclear export of p53/TP53. Promotes proteasome-dependent  ubiquitin-independent degradation of retinoblastoma RB1 protein.  Inhibits DAXX-mediated apoptosis by inducing its ubiquitination  and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53  complex involved in stabilizing p53/TP53. Also component of the  TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA  damage response pathways. Mediates ubiquitination and subsequent  proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R  and promotes it to proteasomal degradation. (from UniProt Q00987)
MDM2 (ENST00000360430.6) at chr12:68809212-68839849 - E3 ubiquitin-protein ligase that mediates ubiquitination  of p53/TP53, leading to its degradation by the proteasome.  Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and  apoptosis by binding its transcriptional activation domain. Also  acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits  the nuclear export of p53/TP53. Promotes proteasome-dependent  ubiquitin-independent degradation of retinoblastoma RB1 protein.  Inhibits DAXX-mediated apoptosis by inducing its ubiquitination  and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53  complex involved in stabilizing p53/TP53. Also component of the  TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA  damage response pathways. Mediates ubiquitination and subsequent  proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R  and promotes it to proteasomal degradation. (from UniProt Q00987)
RFWD3 (ENST00000571750.5) at chr16:74623429-74666870 - Homo sapiens ring finger and WD repeat domain 3 (RFWD3), transcript variant 10, mRNA. (from RefSeq NM_001370543)
RFWD3 (ENST00000361070.9) at chr16:74621399-74666877 - Homo sapiens ring finger and WD repeat domain 3 (RFWD3), transcript variant 1, mRNA. (from RefSeq NM_018124)
CDK5RAP3 (ENST00000536708.6) at chr17:47970534-47981772 - Homo sapiens CDK5 regulatory subunit associated protein 3 (CDK5RAP3), transcript variant 4, mRNA. (from RefSeq NM_001278197)
CDK5RAP3 (ENST00000338399.9) at chr17:47971113-47981781 - Homo sapiens CDK5 regulatory subunit associated protein 3 (CDK5RAP3), transcript variant 3, mRNA. (from RefSeq NM_176096)
CHEK2 (ENST00000649563.1) at chr22:28687751-28741806 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 4, mRNA. (from RefSeq NM_001257387)
CHEK2 (ENST00000348295.7) at chr22:28687743-28741834 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 2, mRNA. (from RefSeq NM_145862)
CHEK2 (ENST00000404276.6) at chr22:28687743-28741820 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 1, mRNA. (from RefSeq NM_007194)
CHEK2 (ENST00000382580.6) at chr22:28687763-28741838 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3, mRNA. (from RefSeq NM_001005735)
MDM2 (ENST00000539479.6) at chr12:68809002-68840807 - Homo sapiens MDM2 proto-oncogene (MDM2), transcript variant 6, mRNA. (from RefSeq NM_001367990)
PSME3 (ENST00000441946.6) at chr17:42833418-42843216 - Homo sapiens proteasome activator subunit 3 (PSME3), transcript variant 3, mRNA. (from RefSeq NM_001267045)
PSME3 (ENST00000293362.7) at chr17:42833471-42843757 - Homo sapiens proteasome activator subunit 3 (PSME3), transcript variant 2, mRNA. (from RefSeq NM_176863)
PPARA (ENST00000402126.1) at chr22:46176748-46235403 - Ligand-activated transcription factor. Key regulator of  lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-  2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated  by oleylethanolamide, a naturally occurring lipid that regulates  satiety (By similarity). Receptor for peroxisome proliferators  such as hypolipidemic drugs and fatty acids. Regulates the  peroxisomal beta-oxidation pathway of fatty acids. Functions as  transcription activator for the ACOX1 and P450 genes.  Transactivation activity requires heterodimerization with RXRA and  is antagonized by NR2C2. (from UniProt Q07869)
PPARA (ENST00000262735.9) at chr22:46150596-46243756 - Homo sapiens peroxisome proliferator activated receptor alpha (PPARA), transcript variant 3, mRNA. (from RefSeq NM_001001928)
PPARA (ENST00000407236.5) at chr22:46151884-46243755 - Homo sapiens peroxisome proliferator activated receptor alpha (PPARA), transcript variant 5, mRNA. (from RefSeq NM_005036)
TP73 (ENST00000604479.5) at chr1:3682366-3733079 - Participates in the apoptotic response to DNA damage.  Isoforms containing the transactivation domain are pro-apoptotic,  isoforms lacking the domain are anti-apoptotic and block the  function of p53 and transactivating p73 isoforms. May be a tumor  suppressor protein. (from UniProt O15350)
TP73 (ENST00000603362.5) at chr1:3682366-3733079 - Participates in the apoptotic response to DNA damage.  Isoforms containing the transactivation domain are pro-apoptotic,  isoforms lacking the domain are anti-apoptotic and block the  function of p53 and transactivating p73 isoforms. May be a tumor  suppressor protein. (from UniProt O15350)
CDKN2A (ENST00000530628.2) at chr9:21968001-21994411 - Capable of inducing cell cycle arrest in G1 and G2  phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its  nucleocytoplasmic shuttling by sequestering it in the nucleolus.  This inhibits the oncogenic action of MDM2 by blocking MDM2-  induced degradation of p53 and enhancing p53-dependent  transactivation and apoptosis. Also induces G2 arrest and  apoptosis in a p53-independent manner by preventing the activation  of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates  BCL6-induced transcriptional repression. Binds to E2F1 and MYC and  blocks their transcriptional activator activity but has no effect  on MYC transcriptional repression. Binds to TOP1/TOPOI and  stimulates its activity. This complex binds to rRNA gene promoters  and may play a role in rRNA transcription and/or maturation.  Interacts with NPM1/B23 and promotes its polyubiquitination and  degradation, thus inhibiting rRNA processing. Interacts with  COMMD1 and promotes its 'Lys63'-linked polyubiquitination.  Interacts with UBE2I/UBC9 and enhances sumoylation of a number of  its binding partners including MDM2 and E2F1. Binds to HUWE1 and  represses its ubiquitin ligase activity. May play a role in  controlling cell proliferation and apoptosis during mammary gland  development. (from UniProt Q8N726)
CDKN2A (ENST00000579755.1) at chr9:21967753-21994624 - Homo sapiens cyclin dependent kinase inhibitor 2A (CDKN2A), transcript variant 4, mRNA. (from RefSeq NM_058195)
TP53 (ENST00000269305.8) at chr17:7668402-7687538 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001126112)
TP53 (ENST00000622645.4) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001276696)
TP53 (ENST00000510385.5) at chr17:7668402-7675493 - Homo sapiens tumor protein p53 (TP53), transcript variant 6, mRNA. (from RefSeq NM_001276698)
TP53 (ENST00000455263.6) at chr17:7668404-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 4, mRNA. (from RefSeq NM_001276695)
TP53 (ENST00000445888.6) at chr17:7668421-7687487 - Homo sapiens tumor protein p53 (TP53), transcript variant 2, mRNA. (from RefSeq NM_001276761)
TP53 (ENST00000610292.4) at chr17:7668402-7687481 - Homo sapiens tumor protein p53 (TP53), transcript variant 8, mRNA. (from RefSeq NM_001126118)
TP53 (ENST00000617185.4) at chr17:7668402-7687550 - Homo sapiens tumor protein p53 (TP53), transcript variant 3, mRNA. (from RefSeq NM_001126114)
TP73 (ENST00000604074.5) at chr1:3652520-3736201 - Homo sapiens tumor protein p73 (TP73), transcript variant 10, mRNA. (from RefSeq NM_001204186)
TP73 (ENST00000357733.7) at chr1:3652565-3736200 - Homo sapiens tumor protein p73 (TP73), transcript variant 11, mRNA. (from RefSeq NM_001204187)
TP73 (ENST00000354437.8) at chr1:3652565-3733292 - Homo sapiens tumor protein p73 (TP73), transcript variant 8, mRNA. (from RefSeq NM_001204184)
TP73 (ENST00000346387.8) at chr1:3652565-3736200 - Homo sapiens tumor protein p73 (TP73), transcript variant 12, mRNA. (from RefSeq NM_001204188)
TP73 (ENST00000378290.4) at chr1:3698058-3733091 - Homo sapiens tumor protein p73 (TP73), transcript variant 13, mRNA. (from RefSeq NM_001204192)
TP73 (ENST00000378288.8) at chr1:3690672-3736201 - Homo sapiens tumor protein p73 (TP73), transcript variant 7, mRNA. (from RefSeq NM_001204191)
TP73 (ENST00000378285.5) at chr1:3690672-3733292 - Homo sapiens tumor protein p73 (TP73), transcript variant 3, mRNA. (from RefSeq NM_001126241)
TP73 (ENST00000378295.9) at chr1:3652516-3736201 - Homo sapiens tumor protein p73 (TP73), transcript variant 1, mRNA. (from RefSeq NM_005427)
TP53 (ENST00000504937.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000504290.5) at chr17:7668402-7675493 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000420246.6) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000620739.4) at chr17:7668402-7687538 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000610538.4) at chr17:7668404-7687481 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP53 (ENST00000619485.4) at chr17:7668421-7687487 - Acts as a tumor suppressor in many tumor types; induces  growth arrest or apoptosis depending on the physiological  circumstances and cell type. Involved in cell cycle regulation as  a trans-activator that acts to negatively regulate cell division  by controlling a set of genes required for this process. One of  the activated genes is an inhibitor of cyclin-dependent kinases.  Apoptosis induction seems to be mediated either by stimulation of  BAX and FAS antigen expression, or by repression of Bcl-2  expression. Induces the transcription of long intergenic non-  coding RNA p21 (lincRNA-p21) and lincRNA-Mkln1. LincRNA-p21  participates in TP53-dependent transcriptional repression leading  to apoptosis and seem to have to effect on cell-cycle regulation.  Implicated in Notch signaling cross-over. Prevents CDK7 kinase  activity when associated to CAK complex in response to DNA damage,  thus stopping cell cycle progression. Isoform 2 enhances the  transactivation activity of isoform 1 from some but not all TP53-  inducible promoters. Isoform 4 suppresses transactivation activity  and impairs growth suppression mediated by isoform 1. Isoform 7  inhibits isoform 1-mediated apoptosis. (from UniProt P04637)
TP63 (ENST00000456148.1) at chr3:189789801-189894502 - Acts as a sequence specific DNA binding transcriptional  activator or repressor. The isoforms contain a varying set of  transactivation and auto-regulating transactivation inhibiting  domains thus showing an isoform specific activity. Isoform 2  activates RIPK4 transcription. May be required in conjunction with  TP73/p73 for initiation of p53/TP53 dependent apoptosis in  response to genotoxic insults and the presence of activated  oncogenes. Involved in Notch signaling by probably inducing JAG1  and JAG2. Plays a role in the regulation of epithelial  morphogenesis. The ratio of DeltaN-type and TA*-type isoforms may  govern the maintenance of epithelial stem cell compartments and  regulate the initiation of epithelial stratification from the  undifferentiated embryonal ectoderm. Required for limb formation  from the apical ectodermal ridge. Activates transcription of the  p21 promoter. (from UniProt Q9H3D4)
TP63 (ENST00000449992.5) at chr3:189789801-189894502 - Homo sapiens tumor protein p63 (TP63), transcript variant 9, mRNA. (from RefSeq NM_001329146)
TP63 (ENST00000440651.6) at chr3:189631516-189894502 - Homo sapiens tumor protein p63 (TP63), transcript variant 10, mRNA. (from RefSeq NM_001329148)
TP63 (ENST00000392461.7) at chr3:189789801-189894231 - Homo sapiens tumor protein p63 (TP63), transcript variant 12, mRNA. (from RefSeq NM_001329150)
TP63 (ENST00000320472.9) at chr3:189631488-189894702 - Homo sapiens tumor protein p63 (TP63), transcript variant 7, mRNA. (from RefSeq NM_001329144)
TP63 (ENST00000264731.8) at chr3:189631389-189897276 - Homo sapiens tumor protein p63 (TP63), transcript variant 1, mRNA. (from RefSeq NM_003722)
TP63 (ENST00000437221.5) at chr3:189789801-189881496 - Homo sapiens tumor protein p63 (TP63), transcript variant 6, mRNA. (from RefSeq NM_001114982)
TP63 (ENST00000418709.6) at chr3:189631488-189881496 - Homo sapiens tumor protein p63 (TP63), transcript variant 3, mRNA. (from RefSeq NM_001114979)
TP63 (ENST00000392463.6) at chr3:189789801-189894221 - Homo sapiens tumor protein p63 (TP63), transcript variant 5, mRNA. (from RefSeq NM_001114981)
TP63 (ENST00000392460.7) at chr3:189631516-189894221 - Homo sapiens tumor protein p63 (TP63), transcript variant 2, mRNA. (from RefSeq NM_001114978)
TP63 (ENST00000354600.9) at chr3:189789660-189897268 - Homo sapiens tumor protein p63 (TP63), transcript variant 4, mRNA. (from RefSeq NM_001114980)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001204172.1 at chr1:204516379-204558120
NM_001278517.1 at chr1:204516379-204558120
NM_001278519.1 at chr1:204516379-204558120
NM_001278518.1 at chr1:204516379-204558120
NM_001278516.1 at chr1:204516379-204558120
NM_001204171.1 at chr1:204516379-204558120
NM_002393.5 at chr1:204516406-204558120

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_024447114.1 at chr1:204516377-204551977
XR_001737183.1 at chr1:204516393-204551949
XM_024447115.1 at chr1:204518307-204551977
XM_017001313.1 at chr1:204525217-204551977
XM_017001312.1 at chr1:204525217-204551977
XM_017001311.1 at chr1:204525217-204551977
XR_001737182.1 at chr1:204525217-204546809
XR_002956626.1 at chr1:204525217-204550894
XR_001737180.2 at chr1:204525217-204550894
XR_001737181.1 at chr1:204525217-204551949
XR_001737179.1 at chr1:204525217-204551949

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

MDM4 at chr1:204516406-204558120

RefSeq Genes

MDM4 at chr1:204516379-204558120 - (NM_001278517) protein Mdm4 isoform 5
MDM4 at chr1:204516406-204558120 - (NM_002393) protein Mdm4 isoform 1
MDM4 at chr1:204516379-204558120 - (NM_001204171) protein Mdm4 isoform 2
MDM4 at chr1:204516379-204558120 - (NM_001278519) protein Mdm4 isoform 7
MDM4 at chr1:204516379-204558120 - (NM_001204172) protein Mdm4 isoform 3
MDM4 at chr1:204516379-204558120 - (NM_001278516) protein Mdm4 isoform 4
MDM4 at chr1:204516379-204558120 - (NM_001278518) protein Mdm4 isoform 6

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

MDM4 regulator of p53, transcript variant 1 at chr1:204516406-204558120 - (NM_002393.5)
MDM4 regulator of p53, transcript variant 6 at chr1:204516379-204558120 - (NM_001278518.1)
MDM4 regulator of p53, transcript variant 4 at chr1:204516379-204558120 - (NM_001278516.1)
MDM4 regulator of p53, transcript variant 2 at chr1:204516379-204558120 - (NM_001204171.1)
MDM4 regulator of p53, transcript variant 3 at chr1:204516379-204558120 - (NM_001204172.1)
MDM4 regulator of p53, transcript variant 5 at chr1:204516379-204558120 - (NM_001278517.1)
MDM4 regulator of p53, transcript variant 7 at chr1:204516379-204558120 - (NM_001278519.1)

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

MDM4 regulator of p53, transcript variant X11 at chr1:204516393-204551949 - (XR_001737183.1)
MDM4 regulator of p53, transcript variant X8 at chr1:204525217-204551949 - (XR_001737181.1)
MDM4 regulator of p53, transcript variant X6 at chr1:204525217-204551949 - (XR_001737179.1)
MDM4 regulator of p53, transcript variant X3 at chr1:204516377-204551977 - (XM_024447114.1)
MDM4 regulator of p53, transcript variant X2 at chr1:204525217-204551977 - (XM_017001312.1)
MDM4 regulator of p53, transcript variant X1 at chr1:204525217-204551977 - (XM_017001311.1)
MDM4 regulator of p53, transcript variant X5 at chr1:204525217-204551977 - (XM_017001313.1)
MDM4 regulator of p53, transcript variant X4 at chr1:204518307-204551977 - (XM_024447115.1)
MDM4 regulator of p53, transcript variant X7 at chr1:204525217-204550894 - (XR_001737180.2)
MDM4 regulator of p53, transcript variant X10 at chr1:204525217-204546809 - (XR_001737182.1)
MDM4 regulator of p53, transcript variant X9 at chr1:204525217-204550894 - (XR_002956626.1)

Non-Human RefSeq Genes

Mdm4 at chr1:204516387-204558091 - (NR_126506) 
MDM4 at chr1:204525502-204549682 - (NM_001046169) protein Mdm4
MDM4 at chr1:204516409-204549719 - (NM_001280376) protein Mdm4
Mdm4 at chr1:204516435-204549682 - (NM_001012026) protein Mdm4
Mdm4 at chr1:204516387-204558091 - (NM_001302803) protein Mdm4 isoform 2
Mdm4 at chr1:204516387-204558091 - (NM_001302801) protein Mdm4 isoform 1
Mdm4 at chr1:204516387-204558091 - (NM_008575) protein Mdm4 isoform 2
Mdm4 at chr1:204516387-204558091 - (NM_001302804) protein Mdm4 isoform 3
mdm4 at chr1:204530681-204549682 - (NM_001142245) protein Mdm4

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204558120
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516406-204558120
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204558120
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516406-204558120
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516379-204558119
MDM4 at chr1:204516383-204532650
MDM4 at chr1:204516383-204558120
MDM4 at chr1:204516406-204554200
MDM4 at chr1:204516406-204554201
MDM4 at chr1:204516451-204546832
MDM4 at chr1:204516472-204544599
MDM4 at chr1:204525490-204537041
MDM4 at chr1:204525519-204546834
MDM4 at chr1:204537857-204549194
MDM4 at chr1:204537875-204542931
MDM4 at chr1:204542789-204549388

Retroposed Genes V9, Including Pseudogenes

MDM4 at chrX:17933215-17934822 - (BC067299.1-3)
MDM4 at chr22:35171200-35171878 - (CR749470.1-18)
MDM4 at chr11:16835129-16835471 - (AK303626.1-8)
MDM4 at chr1:1824756-1825381 - (CR749470.1-1)
MDM4 at chr20:44644705-44645193 - (CR749470.1-16)
MDM4 at chr22:35171200-35171878 - (CR749470.1-18)
MDM4 at chr20:44644705-44645193 - (CR749470.1-16)
MDM4 at chr6:18540528-18541075 - (CR749470.1-22)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Mdm4_71752 at chr1:204516383-204558120
Mdm4_93887 at chr1:204516383-204558120

Human Aligned mRNA Search Results

KF435150 - Homo sapiens MDM4 protein variant Y (MDM4) mRNA, complete cds, alternatively spliced.
KF435149 - Homo sapiens MDM4 protein variant G (MDM4) mRNA, complete cds.
KC479043 - Homo sapiens Mdm4 p53 binding protein transcript variant B (MDM4) mRNA, partial cds, alternatively spliced.
BC105106 - Homo sapiens Mdm4 p53 binding protein homolog (mouse), mRNA (cDNA clone MGC:132766 IMAGE:8144109), complete cds.
AY949028 - Homo sapiens MDM4-related protein 1 mRNA, complete cds, alternatively spliced.
BC067299 - Homo sapiens Mdm4 p53 binding protein homolog (mouse), mRNA (cDNA clone MGC:75489 IMAGE:30390159), complete cds.
AY923176 - Homo sapiens double minute 4 variant (MDM4) mRNA, complete cds, alternatively spliced.
BC034945 - Homo sapiens Mdm4, transformed 3T3 cell double minute 1, p53 binding protein (mouse), mRNA (cDNA clone IMAGE:4821794).
AK304698 - Homo sapiens cDNA FLJ56709 complete cds, highly similar to Mdm4 protein.
AK303626 - Homo sapiens cDNA FLJ51436 complete cds, highly similar to Mdm4 protein.
AK297311 - Homo sapiens cDNA FLJ58512 complete cds, highly similar to Homo sapiens Mdm4, transformed 3T3 cell double minute 1, p53 binding protein, transcript variant 1, mRNA.
BC010622 - Homo sapiens Mdm4, transformed 3T3 cell double minute 1, p53 binding protein (mouse), mRNA (cDNA clone IMAGE:3874354), with apparent retained intron.
AK314461 - Homo sapiens cDNA, FLJ95264, highly similar to Homo sapiens Mdm4, transformed 3T3 cell double minute 1, p53 binding protein (mouse) (MDM1), transcript variant 2, mRNA.

Non-Human Aligned mRNA Search Results

JU322537 - TSA: Macaca mulatta Mamu_518161 mRNA sequence.
JU322538 - TSA: Macaca mulatta Mamu_518160 mRNA sequence.
JU470522 - TSA: Macaca mulatta Mamu_361576 mRNA sequence.
JU470523 - TSA: Macaca mulatta Mamu_361577 mRNA sequence.
JU470524 - TSA: Macaca mulatta Mamu_361579 mRNA sequence.
JU470525 - TSA: Macaca mulatta Mamu_361580 mRNA sequence.
JU470526 - TSA: Macaca mulatta Mamu_361581 mRNA sequence.
JU470527 - TSA: Macaca mulatta Mamu_361583 mRNA sequence.
JV045087 - TSA: Macaca mulatta Mamu_424491 mRNA sequence.
JV045088 - TSA: Macaca mulatta Mamu_424492 mRNA sequence.
JP013140 - TSA: Mustela putorius furo MPF81008357contig1/2 mRNA sequence.
JP013141 - TSA: Mustela putorius furo MPF81008358contig2/2 mRNA sequence.
JL626013 - TSA: Equus caballus contig10661.EqcaPBMC mRNA sequence.
AK305835 - Pan troglodytes mRNA for Mdm4 protein, complete cds, clone: PtsC-73-5_C04.
BC003750 - Mus musculus transformed mouse 3T3 cell double minute 4, mRNA (cDNA clone MGC:5861 IMAGE:3599906), complete cds.
BC113350 - Bos taurus Mdm4 p53 binding protein homolog (mouse), mRNA (cDNA clone MGC:138053 IMAGE:8087776), complete cds.
BC083647 - Rattus norvegicus Mdm4 p53 binding protein homolog (mouse), mRNA (cDNA clone MGC:94476 IMAGE:7135053), complete cds.
EU568360 - Mus musculus transformed mouse 3T3 cell double minute 4 (Mdm4) mRNA, complete cds.
MH033626 - Eospalax fontanierii baileyi MdmX protein (Mdm4) mRNA, complete cds.
MH033627 - Eospalax fontanierii cansus MdmX protein (Mdm4) mRNA, complete cds.
MH033628 - Microtus ochrogaster MdmX protein (Mdm4) mRNA, complete cds.
MH033629 - Microtus oeconomus MdmX protein (Mdm4) mRNA, complete cds.
HQ596523 - Equus caballus isolate Cornell mdm47-52 forkhead box P3 mRNA, complete cds.