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Gencode Genes

MAPKAPK2 (ENST00000294981.8) at chr1:206684944-206732863 - Homo sapiens MAPK activated protein kinase 2 (MAPKAPK2), transcript variant 1, mRNA. (from RefSeq NM_004759)
MAPKAPK2 (ENST00000493447.1) at chr1:206728934-206729470 - mitogen-activated protein kinase-activated protein kinase 2 (from HGNC MAPKAPK2)
MAPKAPK2 (ENST00000479009.1) at chr1:206731288-206732116 - mitogen-activated protein kinase-activated protein kinase 2 (from HGNC MAPKAPK2)
MAPKAPK2 (ENST00000367103.3) at chr1:206685037-206734283 - Homo sapiens MAPK activated protein kinase 2 (MAPKAPK2), transcript variant 2, mRNA. (from RefSeq NM_032960)
MAPKAPK3 (ENST00000357955.6) at chr3:50617170-50649288 - Stress-activated serine/threonine-protein kinase  involved in cytokines production, endocytosis, cell migration,  chromatin remodeling and transcriptional regulation. Following  stress, it is phosphorylated and activated by MAP kinase p38-  alpha/MAPK14, leading to phosphorylation of substrates.  Phosphorylates serine in the peptide sequence, Hyd-X-R-X(2)-S,  where Hyd is a large hydrophobic residue. MAPKAPK2 and MAPKAPK3,  share the same function and substrate specificity, but MAPKAPK3  kinase activity and level in protein expression are lower compared  to MAPKAPK2. Phosphorylates HSP27/HSPB1, KRT18, KRT20, RCSD1,  RPS6KA3, TAB3 and TTP/ZFP36. Mediates phosphorylation of  HSP27/HSPB1 in response to stress, leading to dissociate  HSP27/HSPB1 from large small heat-shock protein (sHsps) oligomers  and impair their chaperone activities and ability to protect  against oxidative stress effectively. Involved in inflammatory  response by regulating tumor necrosis factor (TNF) and IL6  production post-transcriptionally: acts by phosphorylating AU-rich  elements (AREs)-binding proteins, such as TTP/ZFP36, leading to  regulate the stability and translation of TNF and IL6 mRNAs.  Phosphorylation of TTP/ZFP36, a major post-transcriptional  regulator of TNF, promotes its binding to 14-3-3 proteins and  reduces its ARE mRNA affinity leading to inhibition of dependent  degradation of ARE-containing transcript. Involved in toll-like  receptor signaling pathway (TLR) in dendritic cells: required for  acute TLR-induced macropinocytosis by phosphorylating and  activating RPS6KA3. Also acts as a modulator of Polycomb-mediated  repression. (from UniProt Q16644)
ZFP36 (ENST00000597629.3) at chr19:39406847-39409407 - Homo sapiens ZFP36 ring finger protein (ZFP36), mRNA. (from RefSeq NM_003407)
LSP1 (ENST00000612798.4) at chr11:1870252-1892263 - Homo sapiens lymphocyte specific protein 1 (LSP1), transcript variant 6, mRNA. (from RefSeq NM_001289005)
LSP1 (ENST00000311604.7) at chr11:1852970-1892263 - Homo sapiens lymphocyte specific protein 1 (LSP1), transcript variant 1, mRNA. (from RefSeq NM_002339)
LSP1 (ENST00000405957.6) at chr11:1868673-1892263 - Homo sapiens lymphocyte specific protein 1 (LSP1), transcript variant 2, mRNA. (from RefSeq NM_001013253)
LSP1 (ENST00000381775.5) at chr11:1865165-1892263 - Homo sapiens lymphocyte specific protein 1 (LSP1), transcript variant 5, mRNA. (from RefSeq NM_001242932)
LSP1 (ENST00000406638.6) at chr11:1870244-1892263 - Homo sapiens lymphocyte specific protein 1 (LSP1), transcript variant 4, mRNA. (from RefSeq NM_001013255)
ELAVL1 (ENST00000596459.5) at chr19:7963159-8002203 - Involved in 3'-UTR ARE-mediated MYC stabilization. Binds  avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs.  In the case of the FOS AU-rich element, HUR binds to a core  element of 27 nucleotides that contain AUUUA, AUUUUA and AUUUUUA  motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in  vitro. (from UniProt Q15717)
MAPK12 (ENST00000622558.4) at chr22:50252903-50261716 - Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 2, mRNA. (from RefSeq NM_001303252)
MAPK12 (ENST00000215659.13) at chr22:50252901-50261683 - Homo sapiens mitogen-activated protein kinase 12 (MAPK12), transcript variant 1, mRNA. (from RefSeq NM_002969)
HNRNPA0 (ENST00000314940.7) at chr5:137745651-137754363 - Homo sapiens heterogeneous nuclear ribonucleoprotein A0 (HNRNPA0), mRNA. (from RefSeq NM_006805)
PHC2 (ENST00000257118.5) at chr1:33323626-33375593 - Homo sapiens polyhomeotic homolog 2 (PHC2), transcript variant 1, mRNA. (from RefSeq NM_198040)
PHC2 (ENST00000373418.7) at chr1:33323626-33349885 - Homo sapiens polyhomeotic homolog 2 (PHC2), transcript variant 2, mRNA. (from RefSeq NM_004427)
TAB3 (ENST00000378930.7) at chrX:30827443-30859720 - Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator  of MAP3K7 activation, respectively in the IL1 and TNF signaling  pathways. Plays a role in activation of NF-kappa-B and AP1  transcription factor. Isoform 2 may be an oncogenic factor. (from UniProt Q8N5C8)
MAPK13 (ENST00000211287.9) at chr6:36130513-36144521 - Homo sapiens mitogen-activated protein kinase 13 (MAPK13), transcript variant 1, mRNA. (from RefSeq NM_002754)
MAPK13 (ENST00000373766.9) at chr6:36130484-36144524 - Homo sapiens mitogen-activated protein kinase 13 (MAPK13), transcript variant 2, non-coding RNA. (from RefSeq NR_072996)
TAB3 (ENST00000378932.6) at chrX:30830331-30975084 - Adapter linking MAP3K7/TAK1 and TRAF6 or TRAF2. Mediator  of MAP3K7 activation, respectively in the IL1 and TNF signaling  pathways. Plays a role in activation of NF-kappa-B and AP1  transcription factor. Isoform 2 may be an oncogenic factor. (from UniProt Q8N5C8)
MAPKAPK3 (ENST00000446044.5) at chr3:50611908-50649289 - Homo sapiens MAPK activated protein kinase 3 (MAPKAPK3), transcript variant 1, mRNA. (from RefSeq NM_001243926)
MAPKAPK3 (ENST00000621469.5) at chr3:50617151-50649291 - Homo sapiens MAPK activated protein kinase 3 (MAPKAPK3), transcript variant 3, mRNA. (from RefSeq NM_004635)
ALOX5 (ENST00000622021.4) at chr10_GL383546v1_alt:215007-286950 - Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 3, mRNA. (from RefSeq NM_001256154)
ALOX5 (ENST00000610656.4) at chr10_GL383546v1_alt:215058-286944 - Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 5, mRNA. (from RefSeq NM_001320862)
ALOX5 (ENST00000542434.5) at chr10:45374176-45446119 - Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 3, mRNA. (from RefSeq NM_001256154)
ALOX5 (ENST00000374391.7) at chr10:45374216-45446117 - Homo sapiens arachidonate 5-lipoxygenase (ALOX5), transcript variant 5, mRNA. (from RefSeq NM_001320862)
HSF1 (ENST00000646252.2) at chr8_KZ208914v1_fix:22207-45323 - Homo sapiens heat shock transcription factor 1 (HSF1), mRNA. (from RefSeq NM_005526)
HSF1 (ENST00000528838.6) at chr8:144291604-144314720 - Homo sapiens heat shock transcription factor 1 (HSF1), mRNA. (from RefSeq NM_005526)
MAPK11 (ENST00000395764.5) at chr22:50263715-50270393 - Homo sapiens mitogen-activated protein kinase 11 (MAPK11), transcript variant 2, non-coding RNA. (from RefSeq NR_110887)
MAPK11 (ENST00000330651.11) at chr22:50263713-50270380 - Homo sapiens mitogen-activated protein kinase 11 (MAPK11), transcript variant 1, mRNA. (from RefSeq NM_002751)
ELAVL1 (ENST00000407627.7) at chr19:7958573-8005641 - Homo sapiens ELAV like RNA binding protein 1 (ELAVL1), mRNA. (from RefSeq NM_001419)
MAPK14 (ENST00000229794.8) at chr6:36027770-36110755 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, mRNA. (from RefSeq NM_139012)
MAPK14 (ENST00000310795.8) at chr6:36028158-36108509 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 4, mRNA. (from RefSeq NM_139014)
MAPK14 (ENST00000229795.7) at chr6:36027711-36111236 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1, mRNA. (from RefSeq NM_001315)
PARN (ENST00000634004.1) at chr16_KI270853v1_alt:9462-203132 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 2, mRNA. (from RefSeq NM_001134477)
PARN (ENST00000615183.4) at chr16_KI270853v1_alt:8558-203123 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 1, mRNA. (from RefSeq NM_002582)
PARN (ENST00000618929.2) at chr16_KI270853v1_alt:9130-203115 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 3, mRNA. (from RefSeq NM_001242992)
PARN (ENST00000420015.6) at chr16:14436273-14630259 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 3, mRNA. (from RefSeq NM_001242992)
PARN (ENST00000341484.11) at chr16:14436605-14630276 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 2, mRNA. (from RefSeq NM_001134477)
PARN (ENST00000437198.7) at chr16:14435701-14630260 - Homo sapiens poly(A)-specific ribonuclease (PARN), transcript variant 1, mRNA. (from RefSeq NM_002582)
TAB3 (ENST00000378933.5) at chrX:30827442-30975084 - Homo sapiens TGF-beta activated kinase 1 (MAP3K7) binding protein 3 (TAB3), mRNA. (from RefSeq NM_152787)
PARN (ENST00000631868.1) at chr16_KI270853v1_alt:9525-203094 - 3'-exoribonuclease that has a preference for poly(A)  tails of mRNAs, thereby efficiently degrading poly(A) tails.  Exonucleolytic degradation of the poly(A) tail is often the first  step in the decay of eukaryotic mRNAs and is also used to silence  certain maternal mRNAs translationally during oocyte maturation  and early embryonic development. Interacts with both the 3'-end  poly(A) tail and the 5'-end cap structure during degradation, the  interaction with the cap structure being required for an efficient  degradation of poly(A) tails. Involved in nonsense-mediated mRNA  decay, a critical process of selective degradation of mRNAs that  contain premature stop codons. Also involved in degradation of  inherently unstable mRNAs that contain AU-rich elements (AREs) in  their 3'-UTR, possibly via its interaction with KHSRP. Probably  mediates the removal of poly(A) tails of AREs mRNAs, which  constitutes the first step of destabilization. (from UniProt O95453)
PARN (ENST00000539279.5) at chr16:14436668-14630238 - 3'-exoribonuclease that has a preference for poly(A)  tails of mRNAs, thereby efficiently degrading poly(A) tails.  Exonucleolytic degradation of the poly(A) tail is often the first  step in the decay of eukaryotic mRNAs and is also used to silence  certain maternal mRNAs translationally during oocyte maturation  and early embryonic development. Interacts with both the 3'-end  poly(A) tail and the 5'-end cap structure during degradation, the  interaction with the cap structure being required for an efficient  degradation of poly(A) tails. Involved in nonsense-mediated mRNA  decay, a critical process of selective degradation of mRNAs that  contain premature stop codons. Also involved in degradation of  inherently unstable mRNAs that contain AU-rich elements (AREs) in  their 3'-UTR, possibly via its interaction with KHSRP. Probably  mediates the removal of poly(A) tails of AREs mRNAs, which  constitutes the first step of destabilization. (from UniProt O95453)
LIMK1 (ENST00000435201.5) at chr7:74083991-74121301 - Serine/threonine-protein kinase that plays an essential  role in the regulation of actin filament dynamics. Acts downstream  of several Rho family GTPase signal transduction pathways.  Activated by upstream kinases including ROCK1, PAK1 and PAK4,  which phosphorylate LIMK1 on a threonine residue located in its  activation loop. LIMK1 subsequently phosphorylates and inactivates  the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-  2/CFL2 and destrin/DSTN, thereby preventing the cleavage of  filamentous actin (F-actin), and stabilizing the actin  cytoskeleton. In this way LIMK1 regulates several actin-dependent  biological processes including cell motility, cell cycle  progression, and differentiation. Phosphorylates TPPP on serine  residues, thereby promoting microtubule disassembly. Stimulates  axonal outgrowth and may be involved in brain development. Isoform  3 has a dominant negative effect on actin cytoskeletal changes. (from UniProt P53667)
PDE4A (ENST00000380702.7) at chr19:10420538-10469630 - Homo sapiens phosphodiesterase 4A (PDE4A), transcript variant 1, mRNA. (from RefSeq NM_001111307)
LIMK1 (ENST00000336180.7) at chr7:74083804-74122525 - Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 1, mRNA. (from RefSeq NM_002314)
LIMK1 (ENST00000538333.3) at chr7:74093079-74121458 - Homo sapiens LIM domain kinase 1 (LIMK1), transcript variant 2, mRNA. (from RefSeq NM_001204426)
RPS6KA3 (ENST00000379565.9) at chrX:20149911-20266909 - Homo sapiens ribosomal protein S6 kinase A3 (RPS6KA3), mRNA. (from RefSeq NM_004586)
PABPC1 (ENST00000318607.10) at chr8:100702916-100722088 - Homo sapiens poly(A) binding protein cytoplasmic 1 (PABPC1), mRNA. (from RefSeq NM_002568)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_032960.3 at chr1:206685020-206734285
NM_004759.4 at chr1:206685020-206734285

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005273353.3 at chr1:206684912-206734283
XM_017002810.1 at chr1:206685703-206734283

RefSeq Genes

MAPKAPK2 at chr1:206684905-206734281 - (NM_004759) MAP kinase-activated protein kinase 2 isoform 1
MAPKAPK2 at chr1:206684905-206734281 - (NM_032960) MAP kinase-activated protein kinase 2 isoform 2

Non-Human RefSeq Genes

mapkapk2 at chr1:206685374-206732682 - (NM_001017347) MAP kinase-activated protein kinase 2
Mapkapk2 at chr1:206685013-206734282 - (NM_178102) MAP kinase-activated protein kinase 2
Mapkapk2 at chr1:206685013-206734283 - (NM_008551) MAP kinase-activated protein kinase 2
mapkapk2.L at chr1:206685374-206732682 - (NM_001091551) MAPK activated protein kinase 2 L homeolog
mapkapk2a at chr1:206685383-206732682 - (NM_201303) MAP kinase-activated protein kinase 2
mapkapk2b at chr1:206729395-206732682 - (NM_001101803) MAPK activated protein kinase 2b

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

MAPKAPK2 at chr1:206684944-206732863
MAPKAPK2 at chr1:206685037-206734283
MAPKAPK2 at chr1:206728934-206729470
MAPKAPK2 at chr1:206731288-206732116

Retroposed Genes V9, Including Pseudogenes

MAPKAPK2 at chr12:68776955-68777801 - (NM_032960.3-10)
MAPKAPK2 at chr12:68776955-68777801 - (NM_032960.3-10)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Mapkapk2_26205 at chr1:206684944-206734281
Mapkapk2_80365 at chr1:206684944-206734281
Mapkapk2_80490 at chr1:206684944-206734281

Human Aligned mRNA Search Results

BC036060 - Homo sapiens mitogen-activated protein kinase-activated protein kinase 2, mRNA (cDNA clone MGC:33670 IMAGE:5296259), complete cds.
BC052584 - Homo sapiens mitogen-activated protein kinase-activated protein kinase 2, mRNA (cDNA clone MGC:59706 IMAGE:6267183), complete cds.

Non-Human Aligned mRNA Search Results

BC024559 - Mus musculus MAP kinase-activated protein kinase 2, mRNA (cDNA clone IMAGE:5003277), partial cds.
BC054572 - Danio rerio mitogen-activated protein kinase-activated protein kinase 2a, mRNA (cDNA clone MGC:63925 IMAGE:6790835), complete cds.
CR761979 - Xenopus tropicalis finished cDNA, clone TEgg058i15.
BC062048 - Rattus norvegicus mitogen-activated protein kinase-activated protein kinase 2, mRNA (cDNA clone MGC:72264 IMAGE:5598069), complete cds.
BC063064 - Mus musculus MAP kinase-activated protein kinase 2, mRNA (cDNA clone MGC:67217 IMAGE:5687007), complete cds.
JT412334 - TSA: Ictalurus punctatus clc_555971 mRNA sequence.
AY335730 - Synthetic construct Homo sapiens mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2) mRNA, partial cds.
JU328604 - TSA: Macaca mulatta Mamu_501036 mRNA sequence.
EU441473 - Xenopus borealis clone Mapkapk2.a mitogen-activated protein kinase-activated protein kinase 3 (mapkapk3) mRNA, partial cds.