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Gencode Genes

LTN1 (ENST00000614971.4) at chr21:28928144-28992956 - E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept  ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a  thioester and then directly transfer the ubiquitin to targeted  substrates (By similarity). (from UniProt O94822)
LTN1 (ENST00000486427.1) at chr21:28958406-28959862 - listerin E3 ubiquitin protein ligase 1 (from HGNC LTN1)
LTN1 (ENST00000483326.1) at chr21:28966895-28986761 - listerin E3 ubiquitin protein ligase 1 (from HGNC LTN1)
LTN1 (ENST00000475344.1) at chr21:28958450-28960821 - listerin E3 ubiquitin protein ligase 1 (from HGNC LTN1)
LTN1 (ENST00000389195.7) at chr21:28961317-28992949 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H7BYG8)
LTN1 (ENST00000389194.7) at chr21:28928144-28992949 - E3 ubiquitin-protein ligase. E3 ubiquitin ligases accept  ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a  thioester and then directly transfer the ubiquitin to targeted  substrates (By similarity). (from UniProt O94822)
LTN1 (ENST00000361371.10) at chr21:28928144-28992877 - Homo sapiens listerin E3 ubiquitin protein ligase 1 (LTN1), transcript variant 1, mRNA. (from RefSeq NM_015565)
TIRAP (ENST00000479770.1) at chr11:126290856-126298845 - Adapter involved in TLR2 and TLR4 signaling pathways in  the innate immune response. Acts via IRAK2 and TRAF-6, leading to  the activation of NF-kappa-B, MAPK1, MAPK3 and JNK, and resulting  in cytokine secretion and the inflammatory response. Positively  regulates the production of TNF-alpha and interleukin-6. (from UniProt P58753)
TIRAP (ENST00000392679.5) at chr11:126283087-126294933 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 5, mRNA. (from RefSeq NM_001318777)
TIRAP (ENST00000392680.6) at chr11:126283118-126294684 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 3, mRNA. (from RefSeq NM_001039661)
TIRAP (ENST00000392678.7) at chr11:126283110-126293244 - Homo sapiens TIR domain containing adaptor protein (TIRAP), transcript variant 2, mRNA. (from RefSeq NM_148910)
TMEM173 (ENST00000330794.9) at chr5:139475533-139482758 - Homo sapiens transmembrane protein 173 (TMEM173), transcript variant 1, mRNA. (from RefSeq NM_198282)
TMEM173 (ENST00000652271.1) at chr5:139475575-139482173 - Facilitator of innate immune signaling that promotes the  production of type I interferon (IFN-alpha and IFN-beta). Innate  immune response is triggered in response to non-CpG double-  stranded DNA from viruses and bacteria delivered to the cytoplasm.  Able to activate both NF-kappa-B and IRF3 transcription pathways  to induce expression of type I interferon and exert a potent anti-  viral state following expression. May be involved in translocon  function, the translocon possibly being able to influence the  induction of type I interferons. May be involved in transduction  of apoptotic signals via its association with the major  histocompatibility complex class II (MHC-II). Mediates death  signaling via activation of the extracellular signal-regulated  kinase (ERK) pathway. (from UniProt Q86WV6)
TMEM173 (ENST00000651699.1) at chr5:139475638-139482361 - Facilitator of innate immune signaling that promotes the  production of type I interferon (IFN-alpha and IFN-beta). Innate  immune response is triggered in response to non-CpG double-  stranded DNA from viruses and bacteria delivered to the cytoplasm.  Able to activate both NF-kappa-B and IRF3 transcription pathways  to induce expression of type I interferon and exert a potent anti-  viral state following expression. May be involved in translocon  function, the translocon possibly being able to influence the  induction of type I interferons. May be involved in transduction  of apoptotic signals via its association with the major  histocompatibility complex class II (MHC-II). Mediates death  signaling via activation of the extracellular signal-regulated  kinase (ERK) pathway. (from UniProt Q86WV6)
IRF7 (ENST00000330243.9) at chr11:612591-615970 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant d, mRNA. (from RefSeq NM_004031)
IRF7 (ENST00000525445.6) at chr11:612555-615950 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant a, mRNA. (from RefSeq NM_001572)
IRF7 (ENST00000348655.11) at chr11:612555-615921 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant b, mRNA. (from RefSeq NM_004029)
IRF7 (ENST00000633943.1) at chr11_KI270832v1_alt:142448-145543 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant b, mRNA. (from RefSeq NM_004029)
IRF7 (ENST00000632827.1) at chr11_KI270832v1_alt:142484-145869 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant d, mRNA. (from RefSeq NM_004031)
IRF7 (ENST00000621391.4) at chr11_KI270832v1_alt:142452-145898 - Homo sapiens interferon regulatory factor 7 (IRF7), transcript variant a, mRNA. (from RefSeq NM_001572)
IRF7 (ENST00000533182.5) at chr11:612561-615950 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)
IRF7 (ENST00000634105.1) at chr11_KI270832v1_alt:142476-145543 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)
IRF7 (ENST00000633274.1) at chr11_KI270832v1_alt:142454-145849 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)
IRF7 (ENST00000612534.4) at chr11_KI270832v1_alt:142448-145621 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)
IRF7 (ENST00000469048.6) at chr11:612583-615612 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)
IRF7 (ENST00000397566.5) at chr11:612555-615728 - Key transcriptional regulator of type I interferon  (IFN)-dependent immune responses and plays a critical role in the  innate immune response against DNA and RNA viruses. Regulates the  transcription of type I IFN genes (IFN-alpha and IFN-beta) and  IFN-stimulated genes (ISG) by binding to an interferon-stimulated  response element (ISRE) in their promoters. Can efficiently  activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes  and mediate their induction via both the virus-activated, MyD88-  independent pathway and the TLR-activated, MyD88-dependent  pathway. Required during both the early and late phases of the IFN  gene induction but is more critical for the late than for the  early phase. Exists in an inactive form in the cytoplasm of  uninfected cells and following viral infection, double-stranded  RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes  phosphorylated by IKBKE and TBK1 kinases. This induces a  conformational change, leading to its dimerization and nuclear  localization where along with other coactivators it can activate  transcription of the type I IFN and ISG genes. Can also play a  role in regulating adaptive immune responses by inducing  PSMB9/LMP2 expression, either directly or through induction of  IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a  (EBNA1) and may play a role in the regulation of EBV latency. Can  activate distinct gene expression programs in macrophages and  regulate the anti-tumor properties of primary macrophages. (from UniProt Q92985)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_015565.2 at chr21:28928144-28992956
NM_001320766.1 at chr21:28928145-28992959

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017028317.1 at chr21:28928144-28965165
XM_017028316.2 at chr21:28928144-28992831
XM_006723987.4 at chr21:28958450-28992988

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

LTN1 at chr21:28928144-28992877

RefSeq Genes

LTN1 at chr21:28928144-28992877 - (NM_015565) E3 ubiquitin-protein ligase listerin isoform 1
LTN1 at chr21:28928144-28992877 - (NM_001320766) E3 ubiquitin-protein ligase listerin isoform 2

Non-Human RefSeq Genes

LTN1 at chr21:28930245-28992805 - (NM_001192509) E3 ubiquitin-protein ligase listerin
Ltn1 at chr21:28930162-28992805 - (NM_001024235) E3 ubiquitin-protein ligase listerin
LTN1 at chr21:28930448-28992805 - (NM_001305161) E3 ubiquitin-protein ligase listerin
Ltn1 at chr21:28930017-28992842 - (NM_001081068) E3 ubiquitin-protein ligase listerin
ltn1 at chr21:28930445-28992805 - (NM_001079277) E3 ubiquitin-protein ligase listerin

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LTN1 at chr21:28928144-28992877
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LTN1 at chr21:28928144-28992877
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28961317-28992949

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LTN1 at chr21:28928144-28992885
LTN1 at chr21:28928144-28992949
LTN1 at chr21:28928144-28992956
LTN1 at chr21:28958406-28959862
LTN1 at chr21:28958450-28960821
LTN1 at chr21:28961317-28992949
LTN1 at chr21:28966895-28986761

International Knockout Mouse Consortium Genes Mapped to Human Genome

Ltn1_45593 at chr21:28928144-28992956
Ltn1_VG19473 at chr21:28928144-28992956

AB621822 Alignments in Human Aligned mRNAs

This aligns in multiple positions. Click on a hyperlink to go to tracks display at a particular alignment.
 SIZE IDENTITY CHROMOSOME STRAND  START     END       cDNA   START  END  TOTAL
------------------------------------------------------------------------------
  687  100.0%         21     -  28982316  28992863  AB621822     1   687   687