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Gencode Genes

LIG4 (ENST00000405925.2) at chr13:108207439-108218368 - Homo sapiens DNA ligase 4 (LIG4), transcript variant 3, mRNA. (from RefSeq NM_001098268)
LIG4 (ENST00000614526.1) at chr13:108207446-108215523 - Homo sapiens DNA ligase 4 (LIG4), transcript variant 11, mRNA. (from RefSeq NM_001352604)
LIG4 (ENST00000611712.4) at chr13:108207439-108215535 - Homo sapiens DNA ligase 4 (LIG4), transcript variant 6, mRNA. (from RefSeq NM_001352599)
LIG4 (ENST00000442234.5) at chr13:108207439-108215534 - Homo sapiens DNA ligase 4 (LIG4), transcript variant 2, mRNA. (from RefSeq NM_206937)
LIG4 (ENST00000356922.5) at chr13:108207446-108214782 - Homo sapiens DNA ligase 4 (LIG4), transcript variant 1, mRNA. (from RefSeq NM_002312)
XRCC4 (ENST00000511817.1) at chr5:83077593-83353787 - Homo sapiens X-ray repair cross complementing 4 (XRCC4), transcript variant 4, mRNA. (from RefSeq NM_001318012)
XRCC4 (ENST00000396027.8) at chr5:83077570-83353711 - Homo sapiens X-ray repair cross complementing 4 (XRCC4), transcript variant 1, mRNA. (from RefSeq NM_003401)
XRCC4 (ENST00000338635.10) at chr5:83077527-83353711 - Homo sapiens X-ray repair cross complementing 4 (XRCC4), transcript variant 2, mRNA. (from RefSeq NM_022406)
XRCC4 (ENST00000282268.7) at chr5:83077498-83353758 - Homo sapiens X-ray repair cross complementing 4 (XRCC4), transcript variant 3, mRNA. (from RefSeq NM_022550)
NHEJ1 (ENST00000409720.5) at chr2:219075317-219158362 - DNA repair protein involved in DNA nonhomologous end  joining (NHEJ) required for double-strand break (DSB) repair and  V(D)J recombination. May serve as a bridge between XRCC4 and the  other NHEJ factors located at DNA ends, or may participate in  reconfiguration of the end bound NHEJ factors to allow XRCC4  access to the DNA termini. It may act in concert with XRCC6/XRCC5  (Ku) to stimulate XRCC4-mediated joining of blunt ends and several  types of mismatched ends that are noncomplementary or partially  complementary. (from UniProt Q9H9Q4)
APLF (ENST00000303795.9) at chr2:68467585-68580162 - Homo sapiens aprataxin and PNKP like factor (APLF), mRNA. (from RefSeq NM_173545)
PARP3 (ENST00000431474.5) at chr3:51942345-51948867 - Homo sapiens poly(ADP-ribose) polymerase family member 3 (PARP3), transcript variant 2, mRNA. (from RefSeq NM_005485)
PARP3 (ENST00000398755.7) at chr3:51942359-51948862 - Homo sapiens poly(ADP-ribose) polymerase family member 3 (PARP3), transcript variant 1, mRNA. (from RefSeq NM_001003931)
NHEJ1 (ENST00000356853.9) at chr2:219075321-219160853 - Homo sapiens non-homologous end joining factor 1 (NHEJ1), mRNA. (from RefSeq NM_024782)
PARP3 (ENST00000417220.6) at chr3:51942345-51948862 - Homo sapiens poly(ADP-ribose) polymerase family member 3 (PARP3), transcript variant 4, mRNA. (from RefSeq NM_001370240)
XRCC6 (ENST00000360079.7) at chr22:41621119-41664039 - Homo sapiens X-ray repair cross complementing 6 (XRCC6), transcript variant 1, mRNA. (from RefSeq NM_001469)
XRCC6 (ENST00000402580.7) at chr22:41621295-41664048 - Homo sapiens X-ray repair cross complementing 6 (XRCC6), transcript variant 3, mRNA. (from RefSeq NM_001288977)
XRCC6 (ENST00000359308.8) at chr22:41621350-41664039 - Homo sapiens X-ray repair cross complementing 6 (XRCC6), transcript variant 2, mRNA. (from RefSeq NM_001288976)
XRCC6 (ENST00000405878.5) at chr22:41621461-41664039 - Single stranded DNA-dependent ATP-dependent helicase.  Has a role in chromosome translocation. The DNA helicase II  complex binds preferentially to fork-like ends of double-stranded  DNA in a cell cycle-dependent manner. It works in the 3'-5'  direction. Binding to DNA may be mediated by XRCC6. Involved in  DNA non-homologous end joining (NHEJ) required for double-strand  break repair and V(D)J recombination. The XRCC5/6 dimer acts as  regulatory subunit of the DNA-dependent protein kinase complex  DNA-PK by increasing the affinity of the catalytic subunit PRKDC  to DNA by 100-fold. The XRCC5/6 dimer is probably involved in  stabilizing broken DNA ends and bringing them together. The  assembly of the DNA-PK complex to DNA ends is required for the  NHEJ ligation step. Required for osteocalcin gene expression.  Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP  lyase), by catalyzing the beta-elimination of the 5' deoxyribose-  5-phosphate at an abasic site near double-strand breaks. 5'-dRP  lyase activity allows to 'clean' the termini of abasic sites, a  class of nucleotide damage commonly associated with strand breaks,  before such broken ends can be joined. The XRCC5/6 dimer together  with APEX1 acts as a negative regulator of transcription. (from UniProt P12956)
XRCC5 (ENST00000392132.7) at chr2:216109348-216206293 - Homo sapiens X-ray repair cross complementing 5 (XRCC5), mRNA. (from RefSeq NM_021141)
XRCC5 (ENST00000392133.7) at chr2:216107464-216206303 - Single stranded DNA-dependent ATP-dependent helicase.  Has a role in chromosome translocation. The DNA helicase II  complex binds preferentially to fork-like ends of double-stranded  DNA in a cell cycle-dependent manner. It works in the 3'-5'  direction. Binding to DNA may be mediated by XRCC6. Involved in  DNA non-homologous end joining (NHEJ) required for double-strand  break repair and V(D)J recombination. The XRCC5/6 dimer acts as  regulatory subunit of the DNA-dependent protein kinase complex  DNA-PK by increasing the affinity of the catalytic subunit PRKDC  to DNA by 100-fold. The XRCC5/6 dimer is probably involved in  stabilizing broken DNA ends and bringing them together. The  assembly of the DNA-PK complex to DNA ends is required for the  NHEJ ligation step. In association with NAA15, the XRCC5/6 dimer  binds to the osteocalcin promoter and activates osteocalcin  expression. The XRCC5/6 dimer probably also acts as a 5'-  deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the  beta-elimination of the 5' deoxyribose-5-phosphate at an abasic  site near double-strand breaks. XRCC5 probably acts as the  catalytic subunit of 5'-dRP activity, and allows to 'clean' the  termini of abasic sites, a class of nucleotide damage commonly  associated with strand breaks, before such broken ends can be  joined. The XRCC5/6 dimer together with APEX1 acts as a negative  regulator of transcription. (from UniProt P13010)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_002312.3 at chr13:108207442-108214782
NM_001352603.1 at chr13:108207442-108215305
NM_001352601.2 at chr13:108207442-108215372
NM_001352602.2 at chr13:108207442-108215372
NM_001352604.1 at chr13:108207442-108215401
NM_001330595.1 at chr13:108207442-108215534
NM_206937.2 at chr13:108207442-108215536
NM_001352599.2 at chr13:108207442-108218349
NM_001352598.2 at chr13:108207442-108218349
NM_001352600.2 at chr13:108207442-108218349
NM_001098268.2 at chr13:108207442-108218349

RefSeq Genes

LIG4 at chr13:108207444-108218349 - (NM_001098268) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108215534 - (NM_001330595) DNA ligase 4 isoform 2
LIG4 at chr13:108207444-108214782 - (NM_002312) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108218349 - (NM_001352600) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108218349 - (NM_001352599) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108215372 - (NM_001352602) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108215536 - (NM_206937) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108218349 - (NM_001352598) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108215305 - (NM_001352603) DNA ligase 4 isoform 1
LIG4 at chr13:108207444-108215401 - (NM_001352604) DNA ligase 4 isoform 3
LIG4 at chr13:108207444-108215372 - (NM_001352601) DNA ligase 4 isoform 1

Non-Human RefSeq Genes

LIG4 at chr13:108208533-108211268 - (NM_001318075) DNA ligase 4
lig4 at chr13:108208935-108211244 - (NM_001016981) DNA ligase 4
Lig4 at chr13:108208533-108211275 - (NM_001106095) DNA ligase 4
LIG4 at chr13:108207436-108211295 - (NM_001191126) DNA ligase 4
LIG4 at chr13:108208533-108211296 - (NM_001256929) DNA ligase 4
Lig4 at chr13:108208530-108211294 - (NM_176953) DNA ligase 4
LIG4 at chr13:108208578-108211244 - (NM_001030816) DNA ligase 4
lig4 at chr13:108208947-108211148 - (NM_001103123) DNA ligase 4
LIG4 at chr13:108207444-108215545 - (NM_001133050) DNA ligase 4
lig4.L at chr13:108208656-108211244 - (NM_001087645) DNA ligase (ATP) 4

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LIG4 at chr13:108207439-108215534
LIG4 at chr13:108207439-108215535
LIG4 at chr13:108207439-108218368
LIG4 at chr13:108207446-108214782
LIG4 at chr13:108207446-108215523

International Knockout Mouse Consortium Genes Mapped to Human Genome

Lig4_45953 at chr13:108207442-108218368

Alias of STS Marker

LIG4 at chr13:108109632-108309841 - (LIG4)

Human Aligned mRNA Search Results

BC037491 - Homo sapiens ligase IV, DNA, ATP-dependent, mRNA (cDNA clone MGC:33819 IMAGE:5259632), complete cds.
X83441 - H.sapiens mRNA for DNA ligase IV.
AK292419 - Homo sapiens cDNA FLJ75440 complete cds, highly similar to Homo sapiens ligase IV, DNA, ATP-dependent (LIG4) gene.
AK314844 - Homo sapiens cDNA, FLJ95736, highly similar to Homo sapiens ligase IV, DNA, ATP-dependent (LIG4), mRNA.

Non-Human Aligned mRNA Search Results

BC074385 - Xenopus laevis ligase IV, DNA, ATP-dependent, mRNA (cDNA clone MGC:84328 IMAGE:6957895), complete cds.
KT180155 - Ovis aries LIG4 mRNA, complete cds.
CR848338 - Xenopus tropicalis finished cDNA, clone TNeu022j24.
BC135341 - Xenopus tropicalis ligase IV, DNA, ATP-dependent, mRNA (cDNA clone MGC:121516 IMAGE:7615689), complete cds.
AY760066 - Muntiacus muntjak vaginalis DNA ligase IV ATP-dependent (LIG4) mRNA, partial cds.
JU322826 - TSA: Macaca mulatta Mamu_504137 mRNA sequence.
JU471470 - TSA: Macaca mulatta Mamu_369051 mRNA sequence.
BC141417 - Synthetic construct Mus musculus clone IMAGE:100014700, MGC:175485 ligase IV, DNA, ATP-dependent (Lig4) mRNA, encodes complete protein.
AB172356 - Macaca fascicularis brain cDNA clone: QflA-17811, similar to human ligase IV, DNA, ATP-dependent (LIG4), mRNA, RefSeq: NM_206937.1.