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Gencode Genes

LEF1-AS1 (ENST00000665040.2) at chr4:108171891-108258037 - <b>LEF1-AS1</b> ENST00000665040.2 LEF1 antisense RNA 1 from HGNC LEF1-AS1 BC020624 
LEF1 (ENST00000265165.6) at chr4:108047548-108168932 - <b>LEF1</b> ENST00000265165.6 Homo sapiens lymphoid enhancer binding factor 1 LEF1 
TLE2 (ENST00000262953.11) at chr19:2997644-3029280 -  ... By similarity Homooligomer and heterooligomer with other family members Binds <b>LEF1</b> TCF7 TCF7L1 TCF7L2 UTY HES1 and HES5 Q16531 DDB1 
TLE1 (ENST00000376499.8) at chr9:81583683-81689547 -  ... for ESRRG Homooligomer and heterooligomer with other family members Binds <b>LEF1</b> RUNX1 RUNX3 FOXA2 KDM6A UTY histone H3 HESX1 ESRRG 
TLE4 (ENST00000376552.8) at chr9:79571965-79726882 -  ... similarity Homooligomer and heterooligomer with other family members Binds PAX5 <b>LEF1</b> TCF7 TCF7L1 and TCF7L2 Interacts with ZNF703 TLE4 may 
PIAS4 (ENST00000262971.3) at chr19:4007736-4039386 -  ... PARK7 HERC2 MYB TCF4 and RNF168 In Wnt signaling represses <b>LEF1</b> and enhances TCF4 transcriptional activities through promoting their sumoylations 
CALCOCO1 (ENST00000550804.6) at chr12:53708517-53727452 -  ... the Wnt CTNNB1 pathway Functions as a secondary coactivator in <b>LEF1</b> mediated transcriptional activation via its interaction with CTNNB1 Coactivator 
DACT2 (ENST00000366795.4) at chr6:168306904-168319777 -  ... CSNK2B DVL1 DVL2 DVL3 VANGL1 VANGL2 TGFBR1 CTNNB1 CTNND2 CTNND1 <b>LEF1</b> TCF7 TCF7L1 and HDAC1 By similarity Event Alternative splicing 
NLK (ENST00000407008.8) at chr17:28042677-28196381 -  ... beta-catenin signaling pathway Binds to and phosphorylates TCF7L2 TCF4 and <b>LEF1</b> promoting the dissociation of the TCF7L2 LEF1 beta-catenin complex 
FAIM2 (ENST00000320634.8) at chr12:49866896-49903900 -  ... the brain especially in the hippocampus Regulated by the AKT1 <b>LEF1</b> pathway in breast cancer cell lines Belongs to the 
DVL1 (ENST00000378888.10) at chr1:1335278-1349418 -  ... signal transduction pathways mediated by multiple Wnt genes Required for <b>LEF1</b> activation upon WNT1 and WNT3A signaling DVL1 and PAK1 
TLE3 (ENST00000451782.7) at chr15:70047790-70097917 -  ... By similarity Homotetramer and heterooligomer with other family members Binds <b>LEF1</b> TCF7 and TCF7L1 By similarity Binds FOXA2 Interacts with 
EBF2 (ENST00000520164.6) at chr8:25841725-26045413 -  ... regulates osteoclast differentiation Acts in synergy with the Wnt responsive <b>LEF1</b> CTNNB1 pathway Recognizes variations of the palindromic sequence 5 
MDFI (ENST00000230321.11) at chr6:41638468-41654244 -  ... signaling pathways By similarity The C-terminus interacts with AXIN1 and <b>LEF1</b> By similarity P29972 AQP1 NbExp 4 IntAct EBI-724076 EBI-745213 
SOX17 (ENST00000297316.5) at chr8:54457935-54460892 -  ... in the premeiotic germ cells By similarity Interacts with CTNNB1 <b>LEF1</b> and TCF4 By similarity Nucleus By similarity Expressed in 
DACT1 (ENST00000395153.8) at chr14:58637962-58648321 -  ... By similarity The nuclear form may prevent the formation of <b>LEF1</b> CTNNB1 complex and recruit HDAC1 to LEF1 at target 
MDFIC (ENST00000393486.6) at chr7:114922094-115019917 -  ... AXIN1 the histidine-rich region of CCNT1 cyclin-T and weakly with <b>LEF1</b> Isoform 1 Nucleus nucleolus Note Also shows a granular 
RUVBL1 (ENST00000322623.10) at chr3:128080810-128123812 -  ... transformation by MYC and also modulates transcriptional activation by the <b>LEF1</b> TCF1-CTNNB1 complex Essential for cell proliferation May be able 
CSNK2A1 (ENST00000217244.9) at chr20:472498-543790 -  ... Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor <b>LEF1</b> Acts as an ectokinase that phosphorylates several extracellular proteins 
RUVBL2 (ENST00000595090.6) at chr19:48993887-49015970 -  ... transformation by MYC and also modulates transcriptional activation by the <b>LEF1</b> TCF1-CTNNB1 complex May also inhibit the transcriptional activity of 
EP300 (ENST00000263253.9) at chr22:41092592-41180077 -  ... and enhanced by CITED1 Interacts with DTX1 EID1 ELF3 FEN1 <b>LEF1</b> NCOA1 NCOA6 NR3C1 PCAF PELP1 PRDM6 SP1 SP3 SPIB 
CSNK2A2 (ENST00000262506.8) at chr16:58157907-58198106 -  ... Regulates Wnt signaling by phosphorylating CTNNB1 and the transcription factor <b>LEF1</b> Acts as an ectokinase that phosphorylates several extracellular proteins 
CTNNB1 (ENST00000349496.11) at chr3:41199505-41240443 -  ... Binds CTNNBIP and EP300 CTNNB1 forms a ternary complex with <b>LEF1</b> and EP300 that is disrupted by CTNNBIP1 binding By 
ARRB1 (ENST00000420843.7) at chr11:75260122-75351661 -  ... resulting in acetylation of histone H4 Involved in regulation of <b>LEF1</b> transcriptional activity via interaction with DVL1 and or DVL2 
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