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Gencode Genes

LATS2-AS1 (ENST00000422510.1) at chr13:21005157-21018122 - LATS2 antisense RNA 1 (from HGNC LATS2-AS1)
LATS2 (ENST00000382592.5) at chr13:20973036-21061586 - Homo sapiens large tumor suppressor kinase 2 (LATS2), mRNA. (from RefSeq NM_014572)
LATS2 (ENST00000472754.1) at chr13:20989010-21023129 - large tumor suppressor kinase 2 (from HGNC LATS2)
NF2 (ENST00000432151.5) at chr22:29603949-29694945 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000403435.5) at chr22:29603588-29684162 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000397789.3) at chr22:29603999-29694811 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000361166.9) at chr22:29654657-29695059 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
AURKA (ENST00000371356.6) at chr20:56369390-56392196 - Mitotic serine/threonine kinases that contributes to the  regulation of cell cycle progression. Associates with the  centrosome and the spindle microtubules during mitosis and plays a  critical role in various mitotic events including the  establishment of mitotic spindle, centrosome duplication,  centrosome separation as well as maturation, chromosomal  alignment, spindle assembly checkpoint, and cytokinesis. Required  for initial activation of CDK1 at centrosomes. Phosphorylates  numerous target proteins, including ARHGEF2, BORA, BRCA1, CDC25B,  DLGP5, HDAC6, KIF2A, LATS2, NDEL1, PARD3, PPP1R2, PLK1, RASSF1,  TACC3, p53/TP53 and TPX2. Regulates KIF2A tubulin depolymerase  activity. Required for normal axon formation. Plays a role in  microtubule remodeling during neurite extension. Important for  microtubule formation and/or stabilization. Also acts as a key  regulatory component of the p53/TP53 pathway, and particularly the  checkpoint-response pathways critical for oncogenic transformation  of cells, by phosphorylating and stabilizating p53/TP53.  Phosphorylates its own inhibitors, the protein phosphatase type 1  (PP1) isoforms, to inhibit their activity. Necessary for proper  cilia disassembly prior to mitosis. (from UniProt O14965)
WWC1 (ENST00000521089.5) at chr5:168292150-168469216 - Homo sapiens WW and C2 domain containing 1 (WWC1), transcript variant 2, mRNA. (from RefSeq NM_001161662)
WWC1 (ENST00000265293.8) at chr5:168291651-168472303 - Homo sapiens WW and C2 domain containing 1 (WWC1), transcript variant 3, mRNA. (from RefSeq NM_015238)
MOB1B (ENST00000396051.2) at chr4:70902378-70982242 - Homo sapiens MOB kinase activator 1B (MOB1B), transcript variant 1, mRNA. (from RefSeq NM_001244766)
MOB1B (ENST00000309395.6) at chr4:70902336-70988168 - Homo sapiens MOB kinase activator 1B (MOB1B), transcript variant 2, mRNA. (from RefSeq NM_173468)
WTIP (ENST00000590071.7) at chr19:34481758-34512304 - Homo sapiens WT1 interacting protein (WTIP), mRNA. (from RefSeq NM_001080436)
NF2 (ENST00000413209.6) at chr22:29603556-29698594 - Homo sapiens neurofibromin 2 (NF2), transcript variant 9, mRNA. (from RefSeq NM_181833)
NF2 (ENST00000403999.7) at chr22:29603633-29683915 - Homo sapiens neurofibromin 2 (NF2), transcript variant 12, mRNA. (from RefSeq NM_181825)
NF2 (ENST00000361676.8) at chr22:29603999-29694811 - Homo sapiens neurofibromin 2 (NF2), transcript variant 5, mRNA. (from RefSeq NM_181828)
NF2 (ENST00000361452.8) at chr22:29603617-29698594 - Homo sapiens neurofibromin 2 (NF2), transcript variant 6, mRNA. (from RefSeq NM_181829)
NF2 (ENST00000353887.8) at chr22:29603747-29694811 - Homo sapiens neurofibromin 2 (NF2), transcript variant 7, mRNA. (from RefSeq NM_181830)
NF2 (ENST00000334961.11) at chr22:29603727-29683915 - Homo sapiens neurofibromin 2 (NF2), transcript variant 13, mRNA. (from RefSeq NM_181831)
NF2 (ENST00000338641.9) at chr22:29603633-29698598 - Homo sapiens neurofibromin 2 (NF2), transcript variant 1, mRNA. (from RefSeq NM_000268)
STK3 (ENST00000523601.5) at chr8:98454695-98942571 - Homo sapiens serine/threonine kinase 3 (STK3), transcript variant 2, mRNA. (from RefSeq NM_001256312)
STK3 (ENST00000419617.7) at chr8:98454633-98825688 - Homo sapiens serine/threonine kinase 3 (STK3), transcript variant 1, mRNA. (from RefSeq NM_006281)
AURKA (ENST00000395914.5) at chr20:56369389-56392295 - Homo sapiens aurora kinase A (AURKA), transcript variant 3, mRNA. (from RefSeq NM_198434)
AURKA (ENST00000395911.5) at chr20:56369390-56392215 - Homo sapiens aurora kinase A (AURKA), transcript variant 1, mRNA. (from RefSeq NM_198433)
AURKA (ENST00000395913.7) at chr20:56369390-56392337 - Homo sapiens aurora kinase A (AURKA), transcript variant 4, mRNA. (from RefSeq NM_198435)
AURKA (ENST00000395915.7) at chr20:56369390-56392296 - Homo sapiens aurora kinase A (AURKA), transcript variant 6, mRNA. (from RefSeq NM_198437)
AURKA (ENST00000347343.6) at chr20:56369390-56392205 - Homo sapiens aurora kinase A (AURKA), transcript variant 2, mRNA. (from RefSeq NM_003600)
AURKA (ENST00000312783.10) at chr20:56369390-56392295 - Homo sapiens aurora kinase A (AURKA), transcript variant 5, mRNA. (from RefSeq NM_198436)
MOB1A (ENST00000396049.5) at chr2:74152528-74178879 - Homo sapiens MOB kinase activator 1A (MOB1A), transcript variant 1, mRNA. (from RefSeq NM_018221)
LIMD1 (ENST00000273317.5) at chr3:45594751-45686341 - Homo sapiens LIM domains containing 1 (LIMD1), mRNA. (from RefSeq NM_014240)
AJUBA (ENST00000262713.7) at chr14:22971177-22982551 - Homo sapiens ajuba LIM protein (AJUBA), transcript variant 1, mRNA. (from RefSeq NM_032876)
AJUBA (ENST00000397388.7) at chr14:22971815-22977223 - Homo sapiens ajuba LIM protein (AJUBA), transcript variant 2, mRNA. (from RefSeq NM_198086)
STK4 (ENST00000372801.5) at chr20:44966522-45075608 - Homo sapiens serine/threonine kinase 4 (STK4), transcript variant 2, mRNA. (from RefSeq NM_001352385)
WWTR1 (ENST00000467467.5) at chr3:149520610-149658025 - Homo sapiens WW domain containing transcription regulator 1 (WWTR1), transcript variant 3, mRNA. (from RefSeq NM_001168280)
WWTR1 (ENST00000465804.5) at chr3:149517235-149703273 - Homo sapiens WW domain containing transcription regulator 1 (WWTR1), transcript variant 4, mRNA. (from RefSeq NM_001348362)
WWTR1 (ENST00000360632.7) at chr3:149520245-149658101 - Homo sapiens WW domain containing transcription regulator 1 (WWTR1), transcript variant 1, mRNA. (from RefSeq NM_015472)
YAP1 (ENST00000615667.4) at chr11:102110461-102233423 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 9, mRNA. (from RefSeq NM_001282101)
YAP1 (ENST00000537274.5) at chr11:102110461-102233423 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 8, mRNA. (from RefSeq NM_001282100)
YAP1 (ENST00000345877.6) at chr11:102110461-102233423 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 7, mRNA. (from RefSeq NM_001282099)
STK4 (ENST00000372806.8) at chr20:44966512-45080021 - Homo sapiens serine/threonine kinase 4 (STK4), transcript variant 1, mRNA. (from RefSeq NM_006282)
YAP1 (ENST00000629586.2) at chr11:102110849-102229940 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 5, mRNA. (from RefSeq NM_001282098)
YAP1 (ENST00000524575.5) at chr11:102112514-102230152 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 4, mRNA. (from RefSeq NM_001195045)
YAP1 (ENST00000282441.10) at chr11:102110447-102233424 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 1, mRNA. (from RefSeq NM_001130145)
YAP1 (ENST00000531439.5) at chr11:102110849-102229963 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 3, mRNA. (from RefSeq NM_001195044)
YAP1 (ENST00000526343.5) at chr11:102110461-102230592 - Homo sapiens Yes associated protein 1 (YAP1), transcript variant 2, mRNA. (from RefSeq NM_006106)
AJUBA (ENST00000361265.8) at chr14:22971819-22982338 - Adapter or scaffold protein which participates in the  assembly of numerous protein complexes and is involved in several  cellular processes such as cell fate determination, cytoskeletal  organization, repression of gene transcription, mitosis, cell-cell  adhesion, cell differentiation, proliferation and migration.  Contributes to the linking and/or strengthening of epithelia cell-  cell junctions in part by linking adhesive receptors to the actin  cytoskeleton. May be involved in signal transduction from cell  adhesion sites to the nucleus. Plays an important role in  regulation of the kinase activity of AURKA for mitotic commitment.  Also a component of the IL-1 signaling pathway modulating IL-1-  induced NFKB1 activation by influencing the assembly and activity  of the PRKCZ-SQSTM1-TRAF6 multiprotein signaling complex.  Functions as an HDAC-dependent corepressor for a subset of GFI1  target genes. Acts as a transcriptional corepressor for SNAI1 and  SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts  as a hypoxic regulator by bridging an association between the  prolyl hydroxylases and VHL enabling efficient degradation of  HIF1A. Positively regulates microRNA (miRNA)-mediated gene  silencing. Negatively regulates the Hippo signaling pathway and  antagonizes phosphorylation of YAP1. (from UniProt Q96IF1)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_014572.2 at chr13:20973036-21061583

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_011535042.2 at chr13:20973036-21023228
XM_017020541.1 at chr13:20973036-21045738
XM_005266342.1 at chr13:20973036-21060405
XM_017020542.1 at chr13:20973036-21061549

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

LATS2 at chr13:20973036-21061586

RefSeq Genes

LATS2 at chr13:20973036-21061586 - (NM_014572) serine/threonine-protein kinase LATS2

Non-Human RefSeq Genes

Lats2 at chr13:21045684-21046230 - (NM_153382) serine/threonine-protein kinase LATS2 isoform 2
Lats2 at chr13:20973038-21061581 - (NM_015771) serine/threonine-protein kinase LATS2 isoform 1
lats2 at chr13:20974963-21046029 - (NM_001128256) serine/threonine-protein kinase LATS2 isoform 2
lats2 at chr13:20974963-21046029 - (NM_001123307) serine/threonine-protein kinase LATS2 isoform 1
Lats2 at chr13:20973038-21046226 - (NM_001107267) serine/threonine-protein kinase LATS2
LATS2 at chr13:20973038-21046209 - (NM_001177919) serine/threonine-protein kinase LATS2
lats2 at chr13:20974870-21046040 - (NM_001102704) serine/threonine-protein kinase LATS2

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LATS2 at chr13:20973036-21061586

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

LATS2 at chr13:20973036-21061586
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LATS2 at chr13:20973032-21061547

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

LATS2 at chr13:20973032-21061547
LATS2 at chr13:20989010-21023129

International Knockout Mouse Consortium Genes Mapped to Human Genome

Lats2_44000 at chr13:20973036-21061583
Lats2_75979 at chr13:20973036-21061583

AK314235 Alignments in Human Aligned mRNAs

This aligns in multiple positions. Click on a hyperlink to go to tracks display at a particular alignment.
 SIZE IDENTITY CHROMOSOME STRAND  START     END       cDNA   START  END  TOTAL
------------------------------------------------------------------------------
 3632  100.0%         13     -  20974870  21060290  AK314235     1  3632  3632

Non-Human Aligned mRNA Search Results

BC136036 - Xenopus tropicalis LATS, large tumor suppressor, homolog 2, mRNA (cDNA clone MGC:122292 IMAGE:7644910), complete cds.
EF524200 - Danio rerio Lats2-1 mRNA, complete cds.
EF524199 - Danio rerio Lats2-2 mRNA, complete cds.
JU327545 - TSA: Macaca mulatta Mamu_517827 mRNA sequence.
JW866494 - TSA: Callorhinchus milii sp.comp14257_c0_seq1 mRNA sequence.
AY015062 - Mus musculus LATS2C (Lats2) mRNA, complete cds, alternatively spliced.
AY015061 - Mus musculus LATS2B (Lats2) mRNA, complete cds, alternatively spliced.
BC053028 - Mus musculus large tumor suppressor 2, mRNA (cDNA clone MGC:62249 IMAGE:6409832), complete cds.
KY442318 - Mus musculus strain FVB/NJ Lats2 mRNA, 5' UTR.
KP203814 - Ovis aries large tumor suppressor-like 2 protein (lats2) mRNA, complete cds.
FJ825141 - Sus scrofa large tumor suppressor 2-like protein (LATS2) mRNA, complete cds.