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Gencode Genes

JAK2 (ENST00000381652.3) at chr9:4985245-5128183 - Homo sapiens Janus kinase 2 (JAK2), transcript variant 1, mRNA. (from RefSeq NM_004972)
JAK2 (ENST00000636127.1) at chr9:4984390-5078444 - Janus kinase 2 (from HGNC JAK2)
JAK2 (ENST00000487310.1) at chr9:5125965-5126974 - Janus kinase 2 (from HGNC JAK2)
JAK2 (ENST00000476574.5) at chr9:4985033-5022065 - Janus kinase 2 (from HGNC JAK2)
LEPR (ENST00000371058.1) at chr1:65565546-65626234 - Receptor for obesity factor (leptin). On ligand binding,  mediates signaling through JAK2/STAT3. Involved in the regulation  of fat metabolism and, in a hematopoietic pathway, required for  normal lymphopoiesis. May play a role in reproduction. Can also  mediate the ERK/FOS signaling pathway (By similarity). (from UniProt P48357)
IL12RB2 (ENST00000648487.1) at chr1:67307905-67397090 - Receptor for interleukin-12. This subunit is the  signaling component coupling to the JAK2/STAT4 pathway. Promotes  the proliferation of T-cells as well as NK cells. Induces the  promotion of T-cells towards the Th1 phenotype by strongly  enhancing IFN-gamma production. (from UniProt Q99665)
EPOR (ENST00000592375.6) at chr19:11377625-11384312 - Receptor for erythropoietin. Mediates erythropoietin-  induced erythroblast proliferation and differentiation. Upon EPO  stimulation, EPOR dimerizes triggering the JAK2/STAT5 signaling  cascade. In some cell types, can also activate STAT1 and STAT3.  May also activate the LYN tyrosine kinase. (from UniProt P19235)
CRLF2 (ENST00000381566.6) at chrX:1187549-1212637 - Receptor for thymic stromal lymphopoietin (TSLP). Forms  a functional complex with TSLP and IL7R which is capable of  stimulating cell proliferation through activation of STAT3 and  STAT5. Also activates JAK2 (By similarity). Implicated in the  development of the hematopoietic system. (from UniProt Q9HC73)
CRLF2 (ENST00000381566.6) at chrY:1187549-1212637 - Receptor for thymic stromal lymphopoietin (TSLP). Forms  a functional complex with TSLP and IL7R which is capable of  stimulating cell proliferation through activation of STAT3 and  STAT5. Also activates JAK2 (By similarity). Implicated in the  development of the hematopoietic system. (from UniProt Q9HC73)
EPOR (ENST00000588681.5) at chr19:11377763-11384342 - Homo sapiens erythropoietin receptor (EPOR), transcript variant 2, non-coding RNA. (from RefSeq NR_033663)
ULBP3 (ENST00000438272.2) at chr6:150064607-150069066 - Ligand for the NKG2D receptor, together with at least  ULBP1 and ULBP2. ULBPs activate multiple signaling pathways in  primary NK cells, resulting in the production of cytokines and  chemokines. Binding of ULBPs ligands to NKG2D induces calcium  mobilization and activation of the JAK2, STAT5, ERK and PI3K  kinase/Akt signal transduction pathway. Has lower affinity for  NKG2D compared to ULBP1 and ULBP2 and induces weaker signaling  responses than does ULBP2 or ULBP1. (from UniProt Q9BZM4)
EPOR (ENST00000222139.11) at chr19:11377207-11384314 - Homo sapiens erythropoietin receptor (EPOR), transcript variant 1, mRNA. (from RefSeq NM_000121)
RNF41 (ENST00000547967.5) at chr12:56205450-56221866 - Homo sapiens ring finger protein 41 (RNF41), transcript variant 5, non-coding RNA. (from RefSeq NR_040053)
RNF41 (ENST00000615206.4) at chr12:56202504-56221701 - Homo sapiens ring finger protein 41 (RNF41), transcript variant 4, mRNA. (from RefSeq NM_001242826)
RNF41 (ENST00000552656.5) at chr12:56206447-56221933 - Homo sapiens ring finger protein 41 (RNF41), transcript variant 3, mRNA. (from RefSeq NM_194359)
RNF41 (ENST00000394013.6) at chr12:56205450-56221909 - Homo sapiens ring finger protein 41 (RNF41), transcript variant 2, mRNA. (from RefSeq NM_194358)
RNF41 (ENST00000345093.9) at chr12:56202179-56221922 - Homo sapiens ring finger protein 41 (RNF41), transcript variant 1, mRNA. (from RefSeq NM_005785)
IL15RA (ENST00000397250.6) at chr10:5953051-5977522 - High-affinity receptor for interleukin-15. Can signal  both in cis and trans where IL15R from one subset of cells  presents IL15 to neighboring IL2RG-expressing cells. Expression of  different isoforms may alter or interfere with signal  transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not  bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2  (By similarity) and SYK. (from UniProt Q13261)
IL15RA (ENST00000379971.5) at chr10:5953152-5977507 - High-affinity receptor for interleukin-15. Can signal  both in cis and trans where IL15R from one subset of cells  presents IL15 to neighboring IL2RG-expressing cells. Expression of  different isoforms may alter or interfere with signal  transduction. Isoform 5, isoform 6, isoform 7 and isoform 8 do not  bind IL15. Signal transduction involves STAT3, STAT5, STAT6, JAK2  (By similarity) and SYK. (from UniProt Q13261)
CRLF2 (ENST00000467626.6) at chrX:1190492-1212723 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 3, non-coding RNA. (from RefSeq NR_110830)
CRLF2 (ENST00000467626.6) at chrY:1190492-1212723 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 3, non-coding RNA. (from RefSeq NR_110830)
ULBP3 (ENST00000367339.7) at chr6:150061053-150069121 - Homo sapiens UL16 binding protein 3 (ULBP3), mRNA. (from RefSeq NM_024518)
CRLF2 (ENST00000400841.8) at chrX:1190490-1212649 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 1, mRNA. (from RefSeq NM_022148)
CRLF2 (ENST00000381567.8) at chrX:1190897-1212634 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 2, mRNA. (from RefSeq NM_001012288)
CRLF2 (ENST00000400841.8) at chrY:1190490-1212649 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 1, mRNA. (from RefSeq NM_022148)
CRLF2 (ENST00000381567.8) at chrY:1190897-1212634 - Homo sapiens cytokine receptor like factor 2 (CRLF2), transcript variant 2, mRNA. (from RefSeq NM_001012288)
CUL5 (ENST00000531427.5) at chr11:108009260-108106852 - Core component of multiple SCF-like ECS (Elongin-Cullin  2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which  mediate the ubiquitination and subsequent proteasomal degradation  of target proteins. As a scaffold protein may contribute to  catalysis through positioning of the substrate and the ubiquitin-  conjugating enzyme. The functional specificity of the E3  ubiquitin-protein ligase complex depends on the variable substrate  recognition component. ECS(SOCS1) seems to direct ubiquitination  of JAk2. Seems to be involved poteosomal degradation of p53/TP53  stimulated by adenovirus E1B-55 kDa protein. May form a cell  surface vasopressin receptor. (from UniProt Q93034)
SH2B1 (ENST00000395532.8) at chr16:28863975-28873607 - Adapter protein for several members of the tyrosine  kinase receptor family. Involved in multiple signaling pathways  mediated by Janus kinase (JAK) and receptor tyrosine kinases,  including the receptors of insulin (INS), insulin-like growth  factor I (IGF1), nerve growth factor (NGF), brain-derived  neurotrophic factor (BDNF), glial cell line-derived neurotrophic  factor (GDNF), platelet-derived growth factor (PDGF) and  fibroblast growth factors (FGFs). In growth hormone (GH)  signaling, autophosphorylated ('Tyr-813') JAK2 recruits SH2B1,  which in turn is phosphorylated by JAK2 on tyrosine residues.  These phosphotyrosines form potential binding sites for other  signaling proteins. GH also promotes serine/threonine  phosphorylation of SH2B1 and these phosphorylated residues may  serve to recruit other proteins to the GHR-JAK2-SH2B1 complexes,  such as RAC1. In leptin (LEP) signaling, binds to and potentiates  the activation of JAK2 by globally enhancing downstream pathways.  In response to leptin, binds simultaneously to both, JAK2 and IRS1  or IRS2, thus mediating formation of a complex of JAK2, SH2B1 and  IRS1 or IRS2. Mediates tyrosine phosphorylation of IRS1 and IRS2,  resulting in activation of the PI 3-kinase pathway. Acts as  positive regulator of NGF-mediated activation of the Akt/Forkhead  pathway; prolongs NGF-induced phosphorylation of AKT1 on 'Ser-473'  and AKT1 enzymatic activity. Enhances the kinase activity of the  cytokine receptor-associated tyrosine kinase JAK2 and of other  receptor tyrosine kinases, such as FGFR3 and NTRK1. For JAK2, the  mechanism seems to involve dimerization of both, SH2B1 and JAK2.  Enhances RET phosphorylation and kinase activity. Isoforms seem to  be differentially involved in IGF-I and PDGF-induced mitogenesis  (By similarity). (from UniProt Q9NRF2)
IL23R (ENST00000347310.10) at chr1:67166454-67259979 - Homo sapiens interleukin 23 receptor (IL23R), mRNA. (from RefSeq NM_144701)
ULBP1 (ENST00000229708.4) at chr6:149963943-149973715 - Homo sapiens UL16 binding protein 1 (ULBP1), transcript variant 3, non-coding RNA. (from RefSeq NR_133659)
SOCS3 (ENST00000330871.3) at chr17:78356778-78360077 - Homo sapiens suppressor of cytokine signaling 3 (SOCS3), mRNA. (from RefSeq NM_003955)
CUL5 (ENST00000393094.7) at chr11:108008898-108107761 - Homo sapiens cullin 5 (CUL5), mRNA. (from RefSeq NM_003478)
STAT5A (ENST00000588868.5) at chr17:42288543-42311940 - Homo sapiens signal transducer and activator of transcription 5A (STAT5A), transcript variant 4, mRNA. (from RefSeq NM_001288720)
STAT5A (ENST00000345506.8) at chr17:42287547-42311943 - Homo sapiens signal transducer and activator of transcription 5A (STAT5A), transcript variant 2, mRNA. (from RefSeq NM_003152)
STAT5A (ENST00000590949.5) at chr17:42287867-42310860 - Homo sapiens signal transducer and activator of transcription 5A (STAT5A), transcript variant 1, mRNA. (from RefSeq NM_001288718)
STAT5A (ENST00000546010.6) at chr17:42288076-42310927 - Homo sapiens signal transducer and activator of transcription 5A (STAT5A), transcript variant 3, mRNA. (from RefSeq NM_001288719)
CSF2RB (ENST00000406230.5) at chr22:36922134-36938611 - High affinity receptor for interleukin-3, interleukin-5  and granulocyte-macrophage colony-stimulating factor. (from UniProt P32927)
SH2B1 (ENST00000337120.9) at chr16:28862804-28874201 - Homo sapiens SH2B adaptor protein 1 (SH2B1), transcript variant 2, mRNA. (from RefSeq NM_015503)
SH2B1 (ENST00000618521.4) at chr16:28863757-28874212 - Homo sapiens SH2B adaptor protein 1 (SH2B1), transcript variant 1, mRNA. (from RefSeq NM_001145795)
SH2B1 (ENST00000359285.9) at chr16:28863805-28874205 - Homo sapiens SH2B adaptor protein 1 (SH2B1), transcript variant 5, mRNA. (from RefSeq NM_001145797)
SH2B1 (ENST00000322610.12) at chr16:28846689-28874205 - Homo sapiens SH2B adaptor protein 1 (SH2B1), transcript variant 6, mRNA. (from RefSeq NM_001308293)
PTPN1 (ENST00000541713.5) at chr20:50510321-50584760 - Homo sapiens protein tyrosine phosphatase non-receptor type 1 (PTPN1), transcript variant 2, mRNA. (from RefSeq NM_001278618)
PTPN1 (ENST00000371621.5) at chr20:50510383-50585241 - Homo sapiens protein tyrosine phosphatase non-receptor type 1 (PTPN1), transcript variant 1, mRNA. (from RefSeq NM_002827)
GHR (ENST00000618088.4) at chr5:42548043-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 5, mRNA. (from RefSeq NM_001242402)
GHR (ENST00000612626.4) at chr5:42549556-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 7, mRNA. (from RefSeq NM_001242404)
GHR (ENST00000612382.4) at chr5:42548213-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 6, mRNA. (from RefSeq NM_001242403)
GHR (ENST00000537449.5) at chr5:42550080-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 8, mRNA. (from RefSeq NM_001242405)
GHR (ENST00000357703.6) at chr5:42565864-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 10, mRNA. (from RefSeq NM_001242460)
GHR (ENST00000615111.4) at chr5:42424452-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 3, mRNA. (from RefSeq NM_001242400)
GHR (ENST00000230882.9) at chr5:42423439-42721878 - Homo sapiens growth hormone receptor (GHR), transcript variant 1, mRNA. (from RefSeq NM_000163)
IL23R (ENST00000395227.2) at chr1:67219557-67259671 - Associates with IL12RB1 to form the interleukin-23  receptor. Binds IL23 and mediates T-cells, NK cells and possibly  certain macrophage/myeloid cells stimulation probably through  activation of the Jak-Stat signaling cascade. IL23 functions in  innate and adaptive immunity and may participate in acute response  to infection in peripheral tissues. IL23 may be responsible for  autoimmune inflammatory diseases and be important for  tumorigenesis. (from UniProt Q5VWK5)
LEPR (ENST00000344610.12) at chr1:65525689-65626234 - Homo sapiens leptin receptor (LEPR), transcript variant 5, mRNA. (from RefSeq NM_001198688)
LEPR (ENST00000349533.10) at chr1:65420652-65641559 - Homo sapiens leptin receptor (LEPR), transcript variant 1, mRNA. (from RefSeq NM_002303)
LEPR (ENST00000616738.4) at chr1:65525689-65635409 - Homo sapiens leptin receptor (LEPR), transcript variant 6, mRNA. (from RefSeq NM_001198689)
IL23R (ENST00000425614.3) at chr1:67207616-67259248 - Associates with IL12RB1 to form the interleukin-23  receptor. Binds IL23 and mediates T-cells, NK cells and possibly  certain macrophage/myeloid cells stimulation probably through  activation of the Jak-Stat signaling cascade. IL23 functions in  innate and adaptive immunity and may participate in acute response  to infection in peripheral tissues. IL23 may be responsible for  autoimmune inflammatory diseases and be important for  tumorigenesis. (from UniProt Q5VWK5)
LEPR (ENST00000371060.7) at chr1:65420652-65635428 - Homo sapiens leptin receptor (LEPR), transcript variant 3, mRNA. (from RefSeq NM_001003679)
LEPR (ENST00000371059.7) at chr1:65420652-65630422 - Homo sapiens leptin receptor (LEPR), transcript variant 4, mRNA. (from RefSeq NM_001198687)
IL12RB2 (ENST00000371000.5) at chr1:67307873-67395835 - Homo sapiens interleukin 12 receptor subunit beta 2 (IL12RB2), transcript variant 7, mRNA. (from RefSeq NM_001319233)
IL12RB2 (ENST00000544434.5) at chr1:67307364-67396900 - Homo sapiens interleukin 12 receptor subunit beta 2 (IL12RB2), transcript variant 3, mRNA. (from RefSeq NM_001258215)
IL12RB2 (ENST00000262345.5) at chr1:67307364-67396900 - Homo sapiens interleukin 12 receptor subunit beta 2 (IL12RB2), transcript variant 6, non-coding RNA. (from RefSeq NR_047584)
IFNGR2 (ENST00000576463.5) at chr21_GL383581v2_alt:9460-32093 - Homo sapiens interferon gamma receptor 2 (IFNGR2), transcript variant 2, mRNA. (from RefSeq NM_005534)
IFNGR2 (ENST00000290219.10) at chr21:33402896-33437521 - Homo sapiens interferon gamma receptor 2 (IFNGR2), transcript variant 2, mRNA. (from RefSeq NM_005534)
DNAJA3 (ENST00000612103.4) at chr16_KI270855v1_alt:128128-159098 - Homo sapiens DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3), transcript variant 1, mRNA. (from RefSeq NM_005147)
DNAJA3 (ENST00000431375.6) at chr16:4425805-4456772 - Homo sapiens DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3), transcript variant 3, mRNA. (from RefSeq NM_001286516)
DNAJA3 (ENST00000614397.4) at chr16_KI270855v1_alt:128183-159098 - Homo sapiens DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3), transcript variant 3, mRNA. (from RefSeq NM_001286516)
DNAJA3 (ENST00000355296.8) at chr16:4425860-4456775 - Homo sapiens DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3), transcript variant 2, mRNA. (from RefSeq NM_001135110)
DNAJA3 (ENST00000262375.11) at chr16:4425868-4456775 - Homo sapiens DnaJ heat shock protein family (Hsp40) member A3 (DNAJA3), transcript variant 1, mRNA. (from RefSeq NM_005147)
IL15RA (ENST00000528354.5) at chr10:5952793-5977522 - Homo sapiens interleukin 15 receptor subunit alpha (IL15RA), transcript variant 2, mRNA. (from RefSeq NM_172200)
IL15RA (ENST00000525219.6) at chr10:5952372-5978187 - Homo sapiens interleukin 15 receptor subunit alpha (IL15RA), transcript variant 3, mRNA. (from RefSeq NM_001243539)
HCST (ENST00000437550.2) at chr19:35902538-35904270 - Homo sapiens hematopoietic cell signal transducer (HCST), transcript variant 2, mRNA. (from RefSeq NM_001007469)
IL15RA (ENST00000379977.8) at chr10:5952384-5977543 - Homo sapiens interleukin 15 receptor subunit alpha (IL15RA), transcript variant 1, mRNA. (from RefSeq NM_002189)
HCST (ENST00000246551.9) at chr19:35902529-35904377 - Homo sapiens hematopoietic cell signal transducer (HCST), transcript variant 1, mRNA. (from RefSeq NM_014266)
ULBP2 (ENST00000367351.4) at chr6:149942014-149949235 - Homo sapiens UL16 binding protein 2 (ULBP2), mRNA. (from RefSeq NM_025217)
IL15RA (ENST00000397255.7) at chr10:5953260-5977492 - Homo sapiens interleukin 15 receptor subunit alpha (IL15RA), transcript variant 7, mRNA. (from RefSeq NM_001351096)
CSF2RB (ENST00000403662.8) at chr22:36913628-36940439 - Homo sapiens colony stimulating factor 2 receptor beta common subunit (CSF2RB), mRNA. (from RefSeq NM_000395)
ARHGEF1 (ENST00000378152.8) at chr19:41884370-41907454 - Seems to play a role in the regulation of RhoA GTPase by  guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13)  subunits. Acts as GTPase-activating protein (GAP) for GNA12 and  GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA  GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity  through interaction with the RGS-like domain. This GEF activity is  inhibited by binding to activated GNA12. Mediates angiotensin-2-  induced RhoA activation. (from UniProt Q92888)
ARHGEF1 (ENST00000337665.8) at chr19:41884448-41907454 - Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), transcript variant 1, mRNA. (from RefSeq NM_199002)
ARHGEF1 (ENST00000354532.7) at chr19:41883161-41907443 - Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), transcript variant 2, mRNA. (from RefSeq NM_004706)
ARHGEF1 (ENST00000347545.8) at chr19:41883225-41907454 - Homo sapiens Rho guanine nucleotide exchange factor 1 (ARHGEF1), transcript variant 3, mRNA. (from RefSeq NM_198977)
IL15RA (ENST00000530685.5) at chr10:5953260-5977492 - Homo sapiens interleukin 15 receptor subunit alpha (IL15RA), transcript variant 6, mRNA. (from RefSeq NM_001351095)
CD300A (ENST00000361933.7) at chr17:74466675-74484167 - Inhibitory receptor which may contribute to the down-  regulation of cytolytic activity in natural killer (NK) cells, and  to the down-regulation of mast cell degranulation. (from UniProt Q9UGN4)
SIRPA (ENST00000400068.7) at chr20:1894167-1939894 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 1, mRNA. (from RefSeq NM_001040022)
SIRPA (ENST00000622179.4) at chr20:1894508-1940592 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 4, mRNA. (from RefSeq NM_001330728)
SIRPA (ENST00000358771.4) at chr20:1895296-1939897 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 2, mRNA. (from RefSeq NM_001040023)
SIRPA (ENST00000356025.7) at chr20:1894783-1939897 - Homo sapiens signal regulatory protein alpha (SIRPA), transcript variant 3, mRNA. (from RefSeq NM_080792)
STAM2 (ENST00000263904.5) at chr2:152116801-152175763 - Homo sapiens signal transducing adaptor molecule 2 (STAM2), mRNA. (from RefSeq NM_005843)
TEC (ENST00000381501.8) at chr4:48135783-48269838 - Homo sapiens tec protein tyrosine kinase (TEC), mRNA. (from RefSeq NM_003215)
ETV6 (ENST00000396373.8) at chr12:11649854-11895402 - Homo sapiens ETS variant 6 (ETV6), mRNA. (from RefSeq NM_001987)
GCH1 (ENST00000622544.4) at chr14:54842008-54902824 - Positively regulates nitric oxide synthesis in umbilical  vein endothelial cells (HUVECs). May be involved in dopamine  synthesis. May modify pain sensitivity and persistence. Isoform  GCH-1 is the functional enzyme, the potential function of the  enzymatically inactive isoforms remains unknown. (from UniProt P30793)
CD300A (ENST00000310828.9) at chr17:74466675-74484167 - Homo sapiens CD300a molecule (CD300A), transcript variant 2, mRNA. (from RefSeq NM_001256841)
CD300A (ENST00000360141.8) at chr17:74466634-74484794 - Homo sapiens CD300a molecule (CD300A), transcript variant 1, mRNA. (from RefSeq NM_007261)
STAT5B (ENST00000293328.7) at chr17:42199168-42276406 - Homo sapiens signal transducer and activator of transcription 5B (STAT5B), mRNA. (from RefSeq NM_012448)
GCH1 (ENST00000543643.6) at chr14:54842016-54902807 - Homo sapiens GTP cyclohydrolase 1 (GCH1), transcript variant 3, mRNA. (from RefSeq NM_001024070)
GCH1 (ENST00000536224.2) at chr14:54842029-54902816 - Homo sapiens GTP cyclohydrolase 1 (GCH1), transcript variant 4, mRNA. (from RefSeq NM_001024071)
GCH1 (ENST00000491895.7) at chr14:54842017-54902826 - Homo sapiens GTP cyclohydrolase 1 (GCH1), transcript variant 1, mRNA. (from RefSeq NM_000161)
GCH1 (ENST00000395514.5) at chr14:54842008-54902824 - Homo sapiens GTP cyclohydrolase 1 (GCH1), transcript variant 2, mRNA. (from RefSeq NM_001024024)
CD300A (ENST00000392625.7) at chr17:74466658-74484790 - Homo sapiens CD300a molecule (CD300A), transcript variant 4, mRNA. (from RefSeq NM_001330457)
PRMT5 (ENST00000324366.13) at chr14:22920529-22929376 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 1, mRNA. (from RefSeq NM_006109)
PRMT5 (ENST00000553897.5) at chr14:22920876-22929408 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 5, mRNA. (from RefSeq NM_001282955)
PRMT5 (ENST00000397441.6) at chr14:22920525-22929401 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 2, mRNA. (from RefSeq NM_001039619)
PRMT5 (ENST00000397440.8) at chr14:22920529-22929356 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 6, mRNA. (from RefSeq NM_001282956)
PRMT5 (ENST00000216350.12) at chr14:22920530-22929391 - Homo sapiens protein arginine methyltransferase 5 (PRMT5), transcript variant 4, mRNA. (from RefSeq NM_001282954)
PCM1 (ENST00000325083.12) at chr8:17922840-18027968 - Homo sapiens pericentriolar material 1 (PCM1), transcript variant 33, non-coding RNA. (from RefSeq NR_148032)
STAT1 (ENST00000361099.7) at chr2:190969034-191014250 - Homo sapiens signal transducer and activator of transcription 1 (STAT1), transcript variant alpha, mRNA. (from RefSeq NM_007315)
STAT1 (ENST00000392322.7) at chr2:190975537-191014168 - Homo sapiens signal transducer and activator of transcription 1 (STAT1), transcript variant beta, mRNA. (from RefSeq NM_139266)
STAT1 (ENST00000409465.5) at chr2:190970291-191013955 - Signal transducer and transcription activator that  mediates cellular responses to interferons (IFNs), cytokine  KITLG/SCF and other cytokines and growth factors. Following type I  IFN (IFN-alpha and IFN-beta) binding to cell surface receptors,  signaling via protein kinases leads to activation of Jak kinases  (TYK2 and JAK1) and to tyrosine phosphorylation of STAT1 and  STAT2. The phosphorylated STATs dimerize, associate with  ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor,  that enters the nucleus. ISGF3 binds to the IFN stimulated  response element (ISRE) to activate the transcription of  interferon stimulated genes, which drive the cell in an antiviral  state. In response to type II IFN (IFN-gamma), STAT1 is tyrosine-  and serine-phosphorylated. It then forms a homodimer termed IFN-  gamma-activated factor (GAF), migrates into the nucleus and binds  to the IFN gamma activated sequence (GAS) to drive the expression  of the target genes, inducing a cellular antiviral state. Becomes  activated in response to KITLG/SCF and KIT signaling. May mediate  cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. (from UniProt P42224)
NCK1 (ENST00000288986.6) at chr3:136862208-136949126 - Adapter protein which associates with tyrosine-  phosphorylated growth factor receptors, such as KDR and PDGFRB, or  their cellular substrates. Maintains low levels of EIF2S1  phosphorylation by promoting its dephosphorylation by PP1. Plays a  role in the DNA damage response, not in the detection of the  damage by ATM/ATR, but for efficient activation of downstream  effectors, such as that of CHEK2. Plays a role in ELK1-dependent  transcriptional activation in response to activated Ras signaling. (from UniProt P16333)
NCK1 (ENST00000481752.6) at chr3:136862208-136951606 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA. (from RefSeq NM_006153)
NCK1 (ENST00000469404.1) at chr3:136930470-136949823 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 2, mRNA. (from RefSeq NM_001190796)
H3F3C (ENST00000340398.5) at chr12:31791185-31792298 - Homo sapiens H3 histone family member 3C (H3F3C), mRNA. (from RefSeq NM_001013699)
HIST1H3E (ENST00000634733.1) at chr6:26224199-26227473 - Core component of nucleosome. Nucleosomes wrap and  compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P68431)
H3F3A (ENST00000366816.5) at chr1:226061851-226071523 - Variant histone H3 which replaces conventional H3 in a  wide range of nucleosomes in active genes. Constitutes the  predominant form of histone H3 in non-dividing cells and is  incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout  transcribed genes, suggesting that it represents an epigenetic  imprint of transcriptionally active chromatin. Nucleosomes wrap  and compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P84243)
H3F3B (ENST00000586607.5) at chr17:75778576-75785486 - Variant histone H3 which replaces conventional H3 in a  wide range of nucleosomes in active genes. Constitutes the  predominant form of histone H3 in non-dividing cells and is  incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout  transcribed genes, suggesting that it represents an epigenetic  imprint of transcriptionally active chromatin. Nucleosomes wrap  and compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P84243)
H3F3B (ENST00000589599.5) at chr17:75778574-75779780 - Variant histone H3 which replaces conventional H3 in a  wide range of nucleosomes in active genes. Constitutes the  predominant form of histone H3 in non-dividing cells and is  incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout  transcribed genes, suggesting that it represents an epigenetic  imprint of transcriptionally active chromatin. Nucleosomes wrap  and compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P84243)
H3F3B (ENST00000587560.5) at chr17:75778567-75779286 - Variant histone H3 which replaces conventional H3 in a  wide range of nucleosomes in active genes. Constitutes the  predominant form of histone H3 in non-dividing cells and is  incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout  transcribed genes, suggesting that it represents an epigenetic  imprint of transcriptionally active chromatin. Nucleosomes wrap  and compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P84243)
H3F3A (ENST00000366813.1) at chr1:226063977-226072001 - Variant histone H3 which replaces conventional H3 in a  wide range of nucleosomes in active genes. Constitutes the  predominant form of histone H3 in non-dividing cells and is  incorporated into chromatin independently of DNA synthesis.  Deposited at sites of nucleosomal displacement throughout  transcribed genes, suggesting that it represents an epigenetic  imprint of transcriptionally active chromatin. Nucleosomes wrap  and compact DNA into chromatin, limiting DNA accessibility to the  cellular machineries which require DNA as a template. Histones  thereby play a central role in transcription regulation, DNA  repair, DNA replication and chromosomal stability. DNA  accessibility is regulated via a complex set of post-translational  modifications of histones, also called histone code, and  nucleosome remodeling. (from UniProt P84243)
HIST2H3D (ENST00000331491.1) at chr1:149813271-149813681 - Homo sapiens histone cluster 2 H3 family member d (HIST2H3D), mRNA. (from RefSeq NM_001123375)
HIST3H3 (ENST00000366696.1) at chr1:228424845-228425325 - Homo sapiens histone cluster 3 H3 (HIST3H3), mRNA. (from RefSeq NM_003493)
HIST3H3 (ENST00000644869.1) at chr1_KZ208906v1_fix:16044-16524 - Homo sapiens histone cluster 3 H3 (HIST3H3), mRNA. (from RefSeq NM_003493)
HIST2H3A (ENST00000403683.1) at chr1:149852619-149854274 - Homo sapiens histone cluster 2 H3 family member a (HIST2H3A), mRNA. (from RefSeq NM_001005464)
HIST2H3C (ENST00000369158.1) at chr1:149839538-149841193 - Homo sapiens histone cluster 2 H3 family member c (HIST2H3C), mRNA. (from RefSeq NM_021059)
HIST1H3E (ENST00000614911.2) at chr6:26225155-26225616 - Homo sapiens histone cluster 1 H3 family member e (HIST1H3E), mRNA. (from RefSeq NM_003532)
HIST1H3G (ENST00000614378.1) at chr6:26269405-26271815 - Homo sapiens histone cluster 1 H3 family member g (HIST1H3G), mRNA. (from RefSeq NM_003534)
HIST1H3J (ENST00000359303.3) at chr6:27890382-27890792 - Homo sapiens histone cluster 1 H3 family member j (HIST1H3J), mRNA. (from RefSeq NM_003535)
HIST1H3I (ENST00000616365.1) at chr6:27871905-27872315 - Homo sapiens histone cluster 1 H3 family member i (HIST1H3I), mRNA. (from RefSeq NM_003533)
HIST1H3C (ENST00000612966.2) at chr6:26045411-26045869 - Homo sapiens histone cluster 1 H3 family member c (HIST1H3C), mRNA. (from RefSeq NM_003531)
HIST1H3H (ENST00000369163.3) at chr6:27810064-27811300 - Homo sapiens histone cluster 1 H3 family member h (HIST1H3H), mRNA. (from RefSeq NM_003536)
HIST1H3F (ENST00000618052.1) at chr6:26250195-26250605 - Homo sapiens histone cluster 1 H3 family member f (HIST1H3F), mRNA. (from RefSeq NM_021018)
HIST1H3A (ENST00000613854.1) at chr6:26020490-26020900 - Homo sapiens histone cluster 1 H3 family member a (HIST1H3A), mRNA. (from RefSeq NM_003529)
HIST1H3B (ENST00000621411.2) at chr6:26031594-26032099 - Homo sapiens histone cluster 1 H3 family member b (HIST1H3B), mRNA. (from RefSeq NM_003537)
HIST1H3D (ENST00000356476.2) at chr6:26196840-26197250 - Homo sapiens histone cluster 1 H3 family member d (HIST1H3D), mRNA. (from RefSeq NM_003530)
H3F3B (ENST00000254810.8) at chr17:75776434-75779779 - Homo sapiens H3 histone family member 3B (H3F3B), mRNA. (from RefSeq NM_005324)
H3F3A (ENST00000366815.8) at chr1:226062716-226072007 - Homo sapiens H3 histone family member 3A (H3F3A), mRNA. (from RefSeq NM_002107)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001322195.1 at chr9:4985086-5128183
NM_001322194.1 at chr9:4985086-5128183
NM_001322199.1 at chr9:4985230-5128183
NM_001322196.1 at chr9:4985230-5128183
NM_001322198.1 at chr9:4985230-5128183
NM_004972.3 at chr9:4985245-5128183
NM_001322204.1 at chr9:5041693-5128183

RefSeq Genes

JAK2 at chr9:4985086-5128183 - (NM_001322195) tyrosine-protein kinase JAK2 isoform a
JAK2 at chr9:5041693-5128183 - (NM_001322204) tyrosine-protein kinase JAK2 isoform b
JAK2 at chr9:4985086-5128183 - (NM_001322194) tyrosine-protein kinase JAK2 isoform a
JAK2 at chr9:4985245-5128183 - (NM_004972) tyrosine-protein kinase JAK2 isoform a
JAK2 at chr9:4985230-5128183 - (NM_001322199) tyrosine-protein kinase JAK2 isoform c
JAK2 at chr9:4985230-5128183 - (NM_001322198) tyrosine-protein kinase JAK2 isoform c
JAK2 at chr9:4985230-5128183 - (NM_001322196) tyrosine-protein kinase JAK2 isoform a

Non-Human RefSeq Genes

jak2.L at chr9:5022111-5126740 - (NM_001091819) Janus kinase 2
Jak2 at chr9:4985457-5127690 - (NM_008413) tyrosine-protein kinase JAK2
Jak2 at chr9:4985457-5127690 - (NM_001048177) tyrosine-protein kinase JAK2
Jak2 at chr9:4985938-5126906 - (NM_031514) tyrosine-protein kinase JAK2
JAK2 at chr9:5021994-5126806 - (NM_001030538) tyrosine-protein kinase JAK2
jak2b at chr9:5044401-5123124 - (NM_131087) tyrosine-protein kinase JAK2
JAK2 at chr9:4985555-5128080 - (NM_001132128) tyrosine-protein kinase JAK2
JAK2 at chr9:4985436-5127611 - (NM_214113) tyrosine-protein kinase JAK2
jak2a at chr9:5054561-5126446 - (NM_131093) tyrosine-protein kinase JAK2
jak2 at chr9:5022111-5126740 - (NM_001097165) tyrosine-protein kinase JAK2
JAK2 at chr9:4985241-5128080 - (NM_001265901) tyrosine-protein kinase JAK2

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

JAK2 at chr9:4984390-5078444
JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

JAK2 at chr9:4985245-5128183

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

JAK2 at chr9:4985033-5022065
JAK2 at chr9:4985245-5128183
JAK2 at chr9:5125965-5126974

International Knockout Mouse Consortium Genes Mapped to Human Genome

Jak2_22651 at chr9:4985245-5128183
Jak2_42222 at chr9:4985245-5128183

Human Aligned mRNA Search Results

BC039695 - Homo sapiens Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA clone MGC:46028 IMAGE:5556026), complete cds.
AF001362 - Homo sapiens Jak2 kinase (JAK2) mRNA, complete cds.
AF058925 - Homo sapiens Jak2 kinase mRNA, complete cds.
JN021381 - Homo sapiens breakpoint cluster region/Janus kinase 2 fusion protein (BCR/JAK2 fusion) mRNA, translocation breakpoint region and partial cds.
AF005216 - Homo sapiens receptor-associated tyrosine kinase (JAK2) mRNA, complete cds.
AY973034 - Homo sapiens Janus kinase 2 (JAK2) mRNA, complete cds.
AK302618 - Homo sapiens cDNA FLJ55319 complete cds, highly similar to Tyrosine-protein kinase JAK2 (EC 2.7.10.2).
AK292525 - Homo sapiens cDNA FLJ75233 complete cds, highly similar to Homo sapiens Janus kinase 2 (a protein tyrosine kinase) (JAK2), mRNA.

Human Unaligned mRNA Search Results

DL481804 - IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA.
DL481805 - IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA.
FV523212 - IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA.
FV523213 - IDENTIFICATION OF A JAK2 MUTATION IN POLYCYTHEMIA VERA.

Non-Human Aligned mRNA Search Results

BC073280 - Xenopus laevis Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA clone IMAGE:5506872), partial cds.
BC098977 - Xenopus laevis Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA clone MGC:114825 IMAGE:4965038), complete cds.
BC125682 - Xenopus tropicalis Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA clone MGC:145403 IMAGE:7679299), complete cds.
BC167392 - Xenopus tropicalis Janus kinase 2 (a protein tyrosine kinase), mRNA (cDNA clone MGC:136001 IMAGE:7734880), complete cds.
AY312055 - Danio rerio TEL/JAK2 fusion protein mRNA, complete cds.
DQ408763 - Danio rerio strain AB protein tyrosine kinase JAK2b (jak2b) mRNA, complete cds.
JU324692 - TSA: Macaca mulatta Mamu_521525 mRNA sequence.
JU327357 - TSA: Macaca mulatta Mamu_534145 mRNA sequence.
JU475502 - TSA: Macaca mulatta Mamu_365367 mRNA sequence.
JW861787 - TSA: Callorhinchus milii sp.comp316_c0_seq1 mRNA sequence.
JW862667 - TSA: Callorhinchus milii te.comp15748_c0_seq5 mRNA sequence.
JT416245 - TSA: Ictalurus punctatus aby_k57:993142 mRNA sequence.
JL622465 - TSA: Equus caballus contig06842.EqcaPBMC mRNA sequence.
JL640027 - TSA: Equus caballus contig26091.EqcaPBMC mRNA sequence.
JL640309 - TSA: Equus caballus contig26397.EqcaPBMC mRNA sequence.
GQ918493 - Synthetic construct JAK2bCA gene, complete cds.
BC054807 - Mus musculus Janus kinase 2, mRNA (cDNA clone MGC:64772 IMAGE:6838318), complete cds.
BC059834 - Mus musculus Janus kinase 2, mRNA (cDNA clone MGC:69632 IMAGE:6838318), complete cds.
AB036336 - Sus scrofa mRNA for kinase-defective JAK2 variant, complete cds.
AB036337 - Sus scrofa mRNA for kinase-defective JAK2 variant, complete cds.
AB006011 - Sus scrofa mRNA for JAK2, complete cds.
KJ782027 - Cyprinus carpio JAK2 mRNA, complete cds.
MK330872 - Ctenopharyngodon idella JAK2 (JAK2) mRNA, complete cds.
KP337351 - Tachysurus fulvidraco Janus kinase 2b transcript variant 1 (JAK2b) mRNA, complete cds.
KP337352 - Tachysurus fulvidraco Janus kinase 2b transcript variant 2 (JAK2b) mRNA, complete cds.
KU359046 - Acanthogobius hasta janus kinase 2b (JAK2b) mRNA, complete cds.
KP337350 - Tachysurus fulvidraco Janus kinase 2a (JAK2a) mRNA, complete cds.
KU359045 - Acanthogobius hasta janus kinase 2a (JAK2a) mRNA, complete cds.
AJ005691 - Danio rerio mRNA for protein tyrosine kinase (jak2b), partial.
AJ005690 - Danio rerio mRNA for protein tyrosine kinase (jak2a).
BC162596 - Danio rerio Janus kinase 2a, mRNA (cDNA clone MGC:193868 IMAGE:9038053), complete cds.
AB018218 - Danio rerio jak2 mRNA, complete cds.
L16956 - Mouse protein-tyrosine kinase (Jak2) mRNA, complete cds.
AJ000557 - Rattus norvegicus mRNA for Janus protein tyrosine kinase 2, JAK2.
U13396 - Rattus norvegicus protein-tyrosine kinase (JAK2) mRNA, complete cds.
AM179859 - Gallus gallus partial mRNA for janus kinase 2 (JAK2 gene).
JF825474 - Ctenopharyngodon idella Janus kinase 2 (JAK2) mRNA, partial cds.
KY606305 - Oryzias melastigma janus kinase 2 (JAK2) mRNA, partial cds.