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Gencode Genes

ITGA2B (ENST00000262407.6) at chr17:44372181-44389649 - Homo sapiens integrin subunit alpha 2b (ITGA2B), mRNA. (from RefSeq NM_000419)
ITGA2B (ENST00000648408.1) at chr17:44372180-44385340 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000592944.1) at chr17:44384321-44385809 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000592462.5) at chr17:44373924-44383497 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000592253.5) at chr17:44383938-44385341 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000592226.5) at chr17:44380057-44385202 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000592075.5) at chr17:44383938-44385202 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000591990.5) at chr17:44383683-44385195 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000589645.5) at chr17:44383764-44385363 - integrin subunit alpha 2b (from HGNC ITGA2B)
ITGA2B (ENST00000587295.5) at chr17:44372181-44376184 - integrin subunit alpha 2b (from HGNC ITGA2B)
RNF181 (ENST00000306368.9) at chr2:85595745-85597708 - Homo sapiens ring finger protein 181 (RNF181), mRNA. (from RefSeq NM_016494)
ZFPM1 (ENST00000319555.8) at chr16:88453280-88537031 - Homo sapiens zinc finger protein, FOG family member 1 (ZFPM1), mRNA. (from RefSeq NM_153813)
PIK3CB (ENST00000477593.5) at chr3:138654018-138834752 - Phosphoinositide-3-kinase (PI3K) that phosphorylates  PtdIns (Phosphatidylinositol), PtdIns4P (Phosphatidylinositol 4-  phosphate) and PtdIns(4,5)P2 (Phosphatidylinositol 4,5-  bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate  (PIP3). PIP3 plays a key role by recruiting PH domain-containing  proteins to the membrane, including AKT1 and PDPK1, activating  signaling cascades involved in cell growth, survival,  proliferation, motility and morphology. Involved in the activation  of AKT1 upon stimulation by G-protein coupled receptors (GPCRs)  ligands such as CXCL12, sphingosine 1-phosphate, and  lysophosphatidic acid. May also act downstream receptor tyrosine  kinases. Required in different signaling pathways for stable  platelet adhesion and aggregation. Plays a role in platelet  activation signaling triggered by GPCRs, alpha-IIb/beta-3  integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based  activation motif)-bearing receptors such as GP6. Regulates the  strength of adhesion of ITGA2B/ ITGB3 activated receptors  necessary for the cellular transmission of contractile forces.  Required for platelet aggregation induced by F2 (thrombin) and  thromboxane A2 (TXA2). Has a role in cell survival. May have a  role in cell migration. Involved in the early stage of  autophagosome formation. Modulates the intracellular level of  PtdIns3P (Phosphatidylinositol 3-phosphate) and activates PIK3C3  kinase activity. May act as a scaffold, independently of its lipid  kinase activity to positively regulate autophagy. May have a role  in insulin signaling as scaffolding protein in which the lipid  kinase activity is not required. May have a kinase-independent  function in regulating cell proliferation and in clathrin-mediated  endocytosis. Mediator of oncogenic signal in cell lines lacking  PTEN. The lipid kinase activity is necessary for its role in  oncogenic transformation. Required for the growth of ERBB2 and RAS  driven tumors. (from UniProt P42338)
FERMT1 (ENST00000217289.8) at chr20:6074845-6123544 - Homo sapiens fermitin family member 1 (FERMT1), mRNA. (from RefSeq NM_017671)
PIK3CG (ENST00000440650.6) at chr7:106865278-106905821 - Phosphoinositide-3-kinase (PI3K) that phosphorylates  PtdIns(4,5)P2 (Phosphatidylinositol 4,5-bisphosphate) to generate  phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key  role by recruiting PH domain-containing proteins to the membrane,  including AKT1 and PDPK1, activating signaling cascades involved  in cell growth, survival, proliferation, motility and morphology.  Links G-protein coupled receptor activation to PIP3 production.  Involved in immune, inflammatory and allergic responses. Modulates  leukocyte chemotaxis to inflammatory sites and in response to  chemoattractant agents. May control leukocyte polarization and  migration by regulating the spatial accumulation of PIP3 and by  regulating the organization of F-actin formation and integrin-  based adhesion at the leading edge. Controls motility of dendritic  cells. Together with PIK3CD is involved in natural killer (NK)  cell development and migration towards the sites of  inflammation.Participates in T-lymphocyte migration. Regulates T-  lymphocyte proliferation and cytokine production. Together with  PIK3CD participates in T-lymphocyte development. Required for B-  lymphocyte development and signaling. Together with PIK3CD  participates in neutrophil respiratory burst. Together with PIK3CD  is involved in neutrophil chemotaxis and extravasation. Together  with PIK3CB promotes platelet aggregation and thrombosis.  Regulates alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) adhesive  function in platelets downstream of P2Y12 through a lipid kinase  activity-independent mechanism. May have also a lipid kinase  activity-dependent function in platelet aggregation. Involved in  endothelial progenitor cell migration. Negative regulator of  cardiac contractility. Modulates cardiac contractility by  anchoring protein kinase A (PKA) and PDE3B activation, reducing  cAMP levels. Regulates cardiac contractility also by promoting  beta-adrenergic receptor internalization by binding to ADRBK1 and  by non-muscle tropomyosin phosphorylation. Also has  serine/threonine protein kinase activity: both lipid and protein  kinase activities are required for beta-adrenergic receptor  endocytosis. May also have a scaffolding role in modulating  cardiac contractility. Contributes to cardiac hypertrophy under  pathological stress. Through simultaneous binding of PDE3B to  RAPGEF3 and PIK3R6 is assembled in a signaling complex in which  the PI3K gamma complex is activated by RAPGEF3 and which is  involved in angiogenesis. (from UniProt P48736)
AUP1 (ENST00000425118.5) at chr2:74526645-74529760 - Homo sapiens AUP1 lipid droplet regulating VLDL assembly factor (AUP1), transcript variant 3, non-coding RNA. (from RefSeq NR_126510)
AUP1 (ENST00000377526.4) at chr2:74526652-74529706 - Homo sapiens AUP1 lipid droplet regulating VLDL assembly factor (AUP1), transcript variant 2, mRNA. (from RefSeq NM_181575)
PIK3CB (ENST00000289153.6) at chr3:138652699-138759359 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta (PIK3CB), transcript variant 1, mRNA. (from RefSeq NM_006219)
PIK3CG (ENST00000359195.3) at chr7:106865479-106907145 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG), transcript variant 1, mRNA. (from RefSeq NM_002649)
PIK3CG (ENST00000496166.6) at chr7:106865282-106908980 - Homo sapiens phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma (PIK3CG), transcript variant 3, mRNA. (from RefSeq NM_001282427)
ITGB3 (ENST00000559488.5) at chr17:47253846-47311816 - Homo sapiens integrin subunit beta 3 (ITGB3), mRNA. (from RefSeq NM_000212)
PRKCQ (ENST00000539722.5) at chr10:6427143-6580301 - Homo sapiens protein kinase C theta (PRKCQ), transcript variant 6, mRNA. (from RefSeq NM_001323266)
PRKCQ (ENST00000397176.6) at chr10:6427143-6580301 - Homo sapiens protein kinase C theta (PRKCQ), transcript variant 2, mRNA. (from RefSeq NM_001242413)
PRKCQ (ENST00000263125.10) at chr10:6427148-6580276 - Homo sapiens protein kinase C theta (PRKCQ), transcript variant 1, mRNA. (from RefSeq NM_006257)
PRKCA (ENST00000413366.8) at chr17:66302613-66810743 - Homo sapiens protein kinase C alpha (PRKCA), mRNA. (from RefSeq NM_002737)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_000419.4 at chr17:44372181-44389601

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_011524750.1 at chr17:44372181-44389505
XM_011524749.1 at chr17:44372181-44389505

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

ITGA2B at chr17:44372181-44389649

RefSeq Genes

ITGA2B at chr17:44372181-44389649 - (NM_000419) integrin alpha-IIb preproprotein

Non-Human RefSeq Genes

ITGA2B at chr17:44372187-44389505 - (NM_001082065) integrin alpha-IIb precursor
ITGA2B at chr17:44372183-44389505 - (NM_001303547) integrin alpha-IIb precursor
ITGA2B at chr17:44372184-44389490 - (NM_213998) integrin alpha-IIb precursor
ITGA2B at chr17:44372187-44389489 - (NM_001003163) integrin alpha-IIb
ITGA2B at chr17:44372183-44389471 - (NM_001014929) integrin alpha-IIb
ITGA2B at chr17:44372374-44389473 - (NM_001081793) integrin alpha-IIb precursor
Itga2b at chr17:44372373-44389567 - (NM_010575) integrin alpha-IIb precursor

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

ITGA2B at chr17:44372180-44385340
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

ITGA2B at chr17:44372180-44385340
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

ITGA2B at chr17:44372183-44389505

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

ITGA2B at chr17:44372180-44374695
ITGA2B at chr17:44372181-44376184
ITGA2B at chr17:44372183-44389505
ITGA2B at chr17:44373924-44383497
ITGA2B at chr17:44380057-44385202
ITGA2B at chr17:44383683-44385195
ITGA2B at chr17:44383764-44385363
ITGA2B at chr17:44383938-44385202
ITGA2B at chr17:44383938-44385341
ITGA2B at chr17:44384321-44385809

International Knockout Mouse Consortium Genes Mapped to Human Genome

Itga2b_72028 at chr17:44372182-44389505
Itga2b_77428 at chr17:44372182-44389505
Itga2b_VG11590 at chr17:44372182-44389505

Human Aligned mRNA Search Results

BC117443 - Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), mRNA (cDNA clone MGC:151052 IMAGE:40125994), complete cds.
BC126442 - Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), mRNA (cDNA clone MGC:161720 IMAGE:8992158), complete cds.
J02764 - Human platelet membrane glycoprotein IIb (ITGA2B) mRNA, complete cds.
J02963 - Human platelet glycoprotein IIb mRNA, 3' end.
AK315335 - Homo sapiens cDNA, FLJ96376, highly similar to Homo sapiens integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) (ITGA2B), mRNA.

Non-Human Aligned mRNA Search Results

BC147903 - Bos taurus integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41), mRNA (cDNA clone MGC:152631 IMAGE:8436236), complete cds.
BC120493 - Mus musculus integrin alpha 2b, mRNA (cDNA clone MGC:155730 IMAGE:40129416), complete cds.
BC137570 - Mus musculus integrin alpha 2b, mRNA (cDNA clone MGC:169194 IMAGE:8860589), complete cds.
BT021597 - Bos taurus integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41B) (ITGA2B), mRNA, complete cds.