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Gencode Genes

IRF3 (ENST00000377139.8) at chr19:49659572-49665857 - <b>IRF3</b> ENST00000377139.8 Homo sapiens interferon regulatory factor 3 IRF3 transcript 
TSKS (ENST00000246801.8) at chr19:49739760-49763306 -  ... RAS viral oncogene homolog RRAS and interferon regulatory factor 3 <b>IRF3</b> genes which are both involved in tumorigenesis pathways and 
SIKE1 (ENST00000060969.6) at chr1:114769479-114780685 -  ... TBK1 that plays an inhibitory role in virus and TLR3-triggered <b>IRF3</b> Inhibits TLR3-mediated activation of interferon-stimulated response elements ISRE and 
MAVS (ENST00000428216.4) at chr20:3846834-3876118 -  ... replication to coordinate pathways leading to the activation of NF-kappa-B <b>IRF3</b> and IRF7 and to the subsequent induction of antiviral 
RNF41 (ENST00000345093.9) at chr12:56202179-56221922 -  ... of type I interferon Promotes also activation of TBK1 and <b>IRF3</b> Involved in the ubiquitination of erythropoietin EPO and interleukin-3 
TRAFD1 (ENST00000412615.7) at chr12:112125560-112153604 -  ... RLH pathway downstream from MAVS and upstream of NF-kappa-B and <b>IRF3</b> By similarity Interacts with MAVS TICAM1 TRAF1 TRAF2 TRAF3 
ZBP1 (ENST00000371173.8) at chr20:57603852-57620426 -  ... sensor which when activated induces the recruitment of TBK1 and <b>IRF3</b> to its C-terminal region and activates the downstream interferon 
DHX58 (ENST00000251642.8) at chr17:42101411-42112714 -  ... MAVS IPS1 thereby inhibiting activation of interferon regulatory factor 3 <b>IRF3</b> Its positive regulatory role may involve unwinding or stripping 
IKBKE (ENST00000581977.7) at chr1:206470476-206496889 -  ... Interacts with AZI2 Interacts with SIKE1 Interacts with TICAM1 TRIF <b>IRF3</b> and DDX58 RIG-I interactions are disrupted by the interaction 
TICAM2 (ENST00000427199.3) at chr5:115578496-115602479 -  ... transmits LPS-TRL4 signal to TICAM1 Homodimer Interacts with TLR4 TICAM1 <b>IRF3</b> and IRF7 in response to LPS Interacts with IL1R1 
STING1 (ENST00000672102.1) at chr5_ML143350v1_fix:65328-72553 -  ... delivered to the cytoplasm Able to activate both NF-kappa-B and <b>IRF3</b> transcription pathways to induce expression of type I interferon 
STING1 (ENST00000330794.9) at chr5:139475533-139482758 -  ... delivered to the cytoplasm Able to activate both NF-kappa-B and <b>IRF3</b> transcription pathways to induce expression of type I interferon 
RNF216 (ENST00000389902.8) at chr7:5620047-5781663 -  ... the regulation of antiviral responses Down regulates activation of NF-kappa-B <b>IRF3</b> activation and IFNB production Isoform 3 ZIN inhibits TNF 
SGTA (ENST00000221566.7) at chr19:2754715-2783273 -  ... CoV accessory protein 7a Interacts with DNAJC5 and DNAJC5B Q14653 <b>IRF3</b> NbExp 3 IntAct EBI-347996 EBI-2650369 Q13568 IRF5 NbExp 3 
RBCK1 (ENST00000356286.10) at chr20:408299-432139 -  ... are necessary for IREB2 ubiquitination Promotes ubiquitination of TAB2 and <b>IRF3</b> and their degradation by the proteasome Component of the 
TBK1 (ENST00000331710.10) at chr12:64452120-64502114 -  ... with TRAF3 and TANK and phosphorylates interferon regulatory factors IRFs <b>IRF3</b> and IRF7 as well as DDX3X This activity allows 
UBE2D1 (ENST00000373910.9) at chr10:58335006-58370748 -  ... particular lysine residue of ubiquitin Essential for viral activation of <b>IRF3</b> Mediates polyubiquitination of CYP3A4 ATP ubiquitin protein lysine AMP 
TICAM1 (ENST00000248244.6) at chr19:4815932-4831712 -  ... which in turn lead to the activation of transcription factors <b>IRF3</b> and IRF7 NF-kappa-B and FADD respectively Homodimer Probable Interacts 
IKBKG (ENST00000594239.6) at chrX:154547620-154565033 -  ... from cytokine toxicity By similarity Essential for viral activation of <b>IRF3</b> Involved in TLR3 and IFIH1-mediated antiviral innate response this 
UBE2D2 (ENST00000398733.8) at chr5:139561339-139628434 -  ... in response to viral infection Essential for viral activation of <b>IRF3</b> ATP ubiquitin protein lysine AMP diphosphate protein N-ubiquityllysine Protein 
HERC5 (ENST00000264350.8) at chr4:88457119-88506163 -  ... in a broad and relatively non-specific manner Catalyzes ISGylation of <b>IRF3</b> which results in sustained activation it attenuates IRF3-PIN1 interaction 
ZC3HAV1 (ENST00000242351.10) at chr7:139043515-139109720 -  ... DDX58 RIG-I signaling resulting in activation of the downstream effector <b>IRF3</b> leading to the expression of type I IFNs and 
MAFB (ENST00000373313.3) at chr20:40685848-40689236 -  ... results in a moderate reduction of MAFB transcriptional potential Q14653 <b>IRF3</b> NbExp 4 IntAct EBI-3649340 EBI-2650369 Nucleus By similarity Ubiquitous 
TRIM21 (ENST00000254436.8) at chr11:4384897-4393702 -  ... regulates IFN-beta production post-pathogen recognition by polyubiquitin mediated degradation of <b>IRF3</b> Mediates the ubiquitin-mediated proteasomal degradation of IgG1 heavy chain 
IFIH1 (ENST00000649979.2) at chr2:162267074-162318684 -  ... IKK-related kinases TBK1 and IKBKE which phosphorylate interferon regulatory factors <b>IRF3</b> and IRF7 which in turn activate transcription of antiviral 
RIGI (ENST00000379883.3) at chr9:32455302-32526196 -  ... related kinases TBK1 and IKBKE which phosphorylate interferon regulatory factors <b>IRF3</b> and IRF7 which in turn activate transcription of antiviral 
IRF7 (ENST00000621391.4) at chr11_KI270832v1_alt:142452-145898 -  ... I IFN and ISG genes Monomer Homodimer phosphorylation-induced Heterodimer with <b>IRF3</b> Interacts with TICAM1 and TICAM2 Interacts with rotavirus A 
IRF7 (ENST00000525445.6) at chr11:612555-615950 -  ... I IFN and ISG genes Monomer Homodimer phosphorylation-induced Heterodimer with <b>IRF3</b> Interacts with TICAM1 and TICAM2 Interacts with rotavirus A 
RBL1 (ENST00000373664.8) at chr20:36996349-37095997 -  ... EBI-971402 EBI-295644 Q13574-2 DGKZ NbExp 2 IntAct EBI-971402 EBI-715527 Q14653 <b>IRF3</b> NbExp 2 IntAct EBI-971402 EBI-2650369 P24610 Pax3 xeno NbExp 
CREBBP (ENST00000262367.10) at chr16:3725054-3880713 -  ... EBI-81215 EBI-1108782 P48551 IFNAR2 NbExp 4 IntAct EBI-81215 EBI-958408 Q14653 <b>IRF3</b> NbExp 3 IntAct EBI-81215 EBI-2650369 Q92831 KAT2B NbExp 3 
RB1 (ENST00000267163.6) at chr13:48303751-48481890 -  ... EBI-912574 Q9R002 Ifi202 xeno NbExp 5 IntAct EBI-491274 EBI-3043899 Q14653 <b>IRF3</b> NbExp 2 IntAct EBI-491274 EBI-2650369 Q16539 MAPK14 NbExp 3 
DDX3X (ENST00000644876.2) at chrX:41334162-41350274 -  ... signaling intermediate and transcriptional coactivator Involved in TBK1 and IKBKE-dependent <b>IRF3</b> activation leading to IFN-beta induction Also found associated with 
PRKCE (ENST00000306156.8) at chr2:45651675-46187990 -  ... activating TICAM2 TRAM which in turn activates the transcription factor <b>IRF3</b> and subsequent cytokines production In differentiating erythroid progenitors is 
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