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Gencode Genes

HPSE2 (ENST00000370552.7) at chr10:98459118-99235862 - Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 1, mRNA. (from RefSeq NM_021828)
HPSE2 (ENST00000628193.2) at chr10:98459317-99235862 - Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 3, mRNA. (from RefSeq NM_001166245)
HPSE2 (ENST00000614306.1) at chr10:99232349-99235802 - heparanase 2 (inactive) (from HGNC HPSE2)
HPSE2 (ENST00000404542.5) at chr10:98457077-98744071 - heparanase 2 (inactive) (from HGNC HPSE2)
HPSE2 (ENST00000370549.5) at chr10:98459118-99235862 - Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 2, mRNA. (from RefSeq NM_001166244)
HPSE2 (ENST00000370546.5) at chr10:98459574-99235802 - Homo sapiens heparanase 2 (inactive) (HPSE2), transcript variant 4, mRNA. (from RefSeq NM_001166246)
HPSE (ENST00000512196.5) at chr4:83295320-83335153 - Homo sapiens heparanase (HPSE), transcript variant 3, mRNA. (from RefSeq NM_001166498)
HPSE (ENST00000405413.6) at chr4:83292461-83335153 - Homo sapiens heparanase (HPSE), transcript variant 1, mRNA. (from RefSeq NM_006665)
HPSE (ENST00000513463.1) at chr4:83295344-83334782 - Homo sapiens heparanase (HPSE), transcript variant 4, mRNA. (from RefSeq NM_001199830)
HPSE (ENST00000311412.10) at chr4:83292461-83334848 - Homo sapiens heparanase (HPSE), transcript variant 2, mRNA. (from RefSeq NM_001098540)
HPSE (ENST00000509906.5) at chr4:83295320-83335153 - Endoglycosidase that cleaves heparan sulfate  proteoglycans (HSPGs) into heparan sulfate side chains and core  proteoglycans. Participates in extracellular matrix (ECM)  degradation and remodeling. Selectively cleaves the linkage  between a glucuronic acid unit and an N-sulfo glucosamine unit  carrying either a 3-O-sulfo or a 6-O-sulfo group. Can also cleave  the linkage between a glucuronic acid unit and an N-sulfo  glucosamine unit carrying a 2-O-sulfo group, but not linkages  between a glucuronic acid unit and a 2-O-sulfated iduronic acid  moiety. It is essentially inactive at neutral pH but becomes  active under acidic conditions such as during tumor invasion and  in inflammatory processes. Facilitates cell migration associated  with metastasis, wound healing and inflammation. Enhances shedding  of syndecans, and increases endothelial invasion and angiogenesis  in myelomas. Acts as procoagulant by increasing the generation of  activation factor X in the presence of tissue factor and  activation factor VII. Increases cell adhesion to the extacellular  matrix (ECM), independent of its enzymatic activity. Induces  AKT1/PKB phosphorylation via lipid rafts increasing cell mobility  and invasion. Heparin increases this AKT1/PKB activation.  Regulates osteogenesis. Enhances angiogenesis through up-  regulation of SRC-mediated activation of VEGF. Implicated in hair  follicle inner root sheath differentiation and hair homeostasis. (from UniProt Q9Y251)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001166246.1 at chr10:98457077-99235875
NM_021828.4 at chr10:98457077-99235875
NM_001166244.1 at chr10:98457077-99235875
NM_001166245.1 at chr10:98457077-99235875

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017016497.1 at chr10:98457077-99208470
XM_011540031.2 at chr10:98457077-99208472
XM_024448119.1 at chr10:98457077-99233763
XM_006717937.2 at chr10:98457077-99234143
XM_024448120.1 at chr10:98457077-99234143
XM_017016498.1 at chr10:98457077-99234143
XM_011540030.1 at chr10:98457077-99235862
XR_001747170.1 at chr10:98457077-99235875
XM_011540029.1 at chr10:98457077-99235875
XM_017016495.1 at chr10:98471670-99235875
XM_017016496.2 at chr10:98620618-99235875

RefSeq Genes

HPSE2 at chr10:98457077-99235875 - (NM_001166245) inactive heparanase-2 isoform 3
HPSE2 at chr10:98457077-99235875 - (NM_001166244) inactive heparanase-2 isoform 2
HPSE2 at chr10:98457077-99235875 - (NM_021828) inactive heparanase-2 isoform 1
HPSE2 at chr10:98457077-99235875 - (NM_001166246) inactive heparanase-2 isoform 4

Non-Human RefSeq Genes

Hpse2 at chr10:98459574-99235802 - (NM_001135762) inactive heparanase-2 precursor
Hpse2 at chr10:98459358-99235843 - (NM_001081257) inactive heparanase-2 precursor

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459317-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

HPSE2 at chr10:98457077-98744071
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459118-99235862
HPSE2 at chr10:98459574-99235802
HPSE2 at chr10:99232349-99235802

International Knockout Mouse Consortium Genes Mapped to Human Genome

Hpse2_48052 at chr10:98457077-99235875
Hpse2_49793 at chr10:98457077-99235875
Hpse2_92335 at chr10:98457077-99235875

Human Aligned mRNA Search Results

BC112356 - Homo sapiens heparanase 2, mRNA (cDNA clone MGC:133234 IMAGE:40033830), complete cds.
AK314759 - Homo sapiens cDNA, FLJ95627, highly similar to Homo sapiens heparanase 2 (HPSE2), mRNA.

GeneReviews

HPSE2 at chr10:98459118-99235862