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Gencode Genes

EIF2S1 (ENST00000256383.9) at chr14:67360328-67386516 - Homo sapiens eukaryotic translation initiation factor 2 subunit alpha (EIF2S1), mRNA. (from RefSeq NM_004094)
EIF2S1 (ENST00000557310.5) at chr14:67360556-67382587 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt G3V4T5)
EIF2S1 (ENST00000556724.1) at chr14:67360353-67374648 - eukaryotic translation initiation factor 2 subunit alpha (from HGNC EIF2S1)
EIF2S1 (ENST00000555876.1) at chr14:67364898-67382681 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YJS4)
EIF2S1 (ENST00000554332.1) at chr14:67382411-67383668 - eukaryotic translation initiation factor 2 subunit alpha (from HGNC EIF2S1)
EIF2S1 (ENST00000466499.6) at chr14:67364008-67384122 - eukaryotic translation initiation factor 2 subunit alpha (from HGNC EIF2S1)
NRF1 (ENST00000353868.5) at chr7:129630078-129757080 - Transcription factor that activates the expression of  the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation  of key metabolic genes to cellular growth and development.  Implicated in the control of nuclear genes required for  respiration, heme biosynthesis, and mitochondrial DNA  transcription and replication. (from UniProt Q16656)
NRF1 (ENST00000223190.8) at chr7:129611756-129756015 - Transcription factor that activates the expression of  the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation  of key metabolic genes to cellular growth and development.  Implicated in the control of nuclear genes required for  respiration, heme biosynthesis, and mitochondrial DNA  transcription and replication. (from UniProt Q16656)
NCK1 (ENST00000288986.6) at chr3:136862208-136949126 - Adapter protein which associates with tyrosine-  phosphorylated growth factor receptors, such as KDR and PDGFRB, or  their cellular substrates. Maintains low levels of EIF2S1  phosphorylation by promoting its dephosphorylation by PP1. Plays a  role in the DNA damage response, not in the detection of the  damage by ATM/ATR, but for efficient activation of downstream  effectors, such as that of CHEK2. Plays a role in ELK1-dependent  transcriptional activation in response to activated Ras signaling. (from UniProt P16333)
EIF2AK2 (ENST00000647926.1) at chr2:37101935-37148988 - Following activation by double-stranded RNA in the  presence of ATP, the kinase becomes autophosphorylated and can  catalyze the phosphorylation of the translation initiation factor  EIF2S1, which leads to an inhibition of the initiation of protein  synthesis. Double-stranded RNA is generated during the course of a  viral infection. In addition to serine/threonine-protein kinase  activity, also has tyrosine-protein kinase activity:  phosphorylates CDK1 upon DNA damage. CDK1 phosphorylation triggers  CDK1 polyubiquitination and subsequent proteolysis, thus leading  to G2 arrest. (from UniProt P19525)
EIF2A (ENST00000465535.1) at chr3:150568032-150584234 - Homo sapiens eukaryotic translation initiation factor 2A (EIF2A), transcript variant 5, mRNA. (from RefSeq NM_001319046)
EIF2A (ENST00000273435.9) at chr3:150546794-150584242 - Homo sapiens eukaryotic translation initiation factor 2A (EIF2A), transcript variant 4, mRNA. (from RefSeq NM_001319045)
EIF2AK2 (ENST00000405334.5) at chr2:37107273-37147806 - Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), transcript variant 3, mRNA. (from RefSeq NM_001135652)
EIF2AK2 (ENST00000395127.6) at chr2:37105143-37157047 - Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), transcript variant 1, mRNA. (from RefSeq NM_002759)
EIF2AK2 (ENST00000233057.9) at chr2:37099210-37156980 - Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 2 (EIF2AK2), transcript variant 2, mRNA. (from RefSeq NM_001135651)
EIF2A (ENST00000487799.5) at chr3:150546685-150584023 - Homo sapiens eukaryotic translation initiation factor 2A (EIF2A), transcript variant 2, mRNA. (from RefSeq NM_001319043)
EIF2A (ENST00000406576.7) at chr3:150546787-150584115 - Homo sapiens eukaryotic translation initiation factor 2A (EIF2A), transcript variant 3, mRNA. (from RefSeq NM_001319044)
EIF2A (ENST00000460851.6) at chr3:150546787-150586016 - Homo sapiens eukaryotic translation initiation factor 2A (EIF2A), transcript variant 1, mRNA. (from RefSeq NM_032025)
PRKRA (ENST00000325748.9) at chr2:178431414-178451175 - Homo sapiens protein activator of interferon induced protein kinase EIF2AK2 (PRKRA), transcript variant 1, mRNA. (from RefSeq NM_003690)
PRKRA (ENST00000487082.5) at chr2:178431966-178450764 - Homo sapiens protein activator of interferon induced protein kinase EIF2AK2 (PRKRA), transcript variant 3, mRNA. (from RefSeq NM_001139518)
PRKRA (ENST00000432031.6) at chr2:178431976-178450757 - Homo sapiens protein activator of interferon induced protein kinase EIF2AK2 (PRKRA), transcript variant 4, mRNA. (from RefSeq NM_001316362)
NCK1 (ENST00000481752.6) at chr3:136862208-136951606 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA. (from RefSeq NM_006153)
NCK1 (ENST00000469404.1) at chr3:136930470-136949823 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 2, mRNA. (from RefSeq NM_001190796)
EIF2AK1 (ENST00000199389.11) at chr7:6022247-6059175 - Homo sapiens eukaryotic translation initiation factor 2 alpha kinase 1 (EIF2AK1), transcript variant 1, mRNA. (from RefSeq NM_014413)
NCK2 (ENST00000393349.2) at chr2:105851782-105894272 - Homo sapiens NCK adaptor protein 2 (NCK2), transcript variant 2, mRNA. (from RefSeq NM_001004720)
NCK2 (ENST00000233154.9) at chr2:105744912-105894272 - Homo sapiens NCK adaptor protein 2 (NCK2), transcript variant 1, mRNA. (from RefSeq NM_003581)
NRF1 (ENST00000393230.6) at chr7:129630068-129757082 - Homo sapiens nuclear respiratory factor 1 (NRF1), transcript variant 2, mRNA. (from RefSeq NM_001040110)
NRF1 (ENST00000311967.6) at chr7:129611756-129756015 - Homo sapiens nuclear respiratory factor 1 (NRF1), transcript variant 3, mRNA. (from RefSeq NM_001293163)
NRF1 (ENST00000393232.6) at chr7:129611720-129757076 - Homo sapiens nuclear respiratory factor 1 (NRF1), transcript variant 1, mRNA. (from RefSeq NM_005011)
NANOS3 (ENST00000339133.5) at chr19:13877247-13880503 - Homo sapiens nanos C2HC-type zinc finger 3 (NANOS3), transcript variant 1, mRNA. (from RefSeq NM_001098622)
ABCF1 (ENST00000457111.6) at chr6_GL000251v2_alt:2051098-2071149 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000419893.6) at chr6_GL000252v2_alt:1827203-1847258 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000426219.6) at chr6_GL000253v2_alt:1881605-1901660 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000457078.6) at chr6_GL000254v2_alt:1915422-1935477 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000423247.6) at chr6_GL000256v2_alt:1872133-1892187 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000452530.6) at chr6_GL000251v2_alt:2051115-2071149 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000448939.6) at chr6_GL000252v2_alt:1827220-1847258 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000421042.6) at chr6_GL000253v2_alt:1881622-1901660 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000412443.6) at chr6_GL000254v2_alt:1915439-1935477 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000383588.8) at chr6_GL000255v2_alt:1826463-1846514 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
ABCF1 (ENST00000383587.8) at chr6_GL000255v2_alt:1826480-1846514 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000420257.6) at chr6_GL000256v2_alt:1872150-1892187 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000376545.7) at chr6:30571393-30591313 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 2, mRNA. (from RefSeq NM_001090)
ABCF1 (ENST00000326195.13) at chr6:30571442-30591522 - Homo sapiens ATP binding cassette subfamily F member 1 (ABCF1), transcript variant 1, mRNA. (from RefSeq NM_001025091)
PPP1R15A (ENST00000200453.6) at chr19:48872421-48876058 - Homo sapiens protein phosphatase 1 regulatory subunit 15A (PPP1R15A), mRNA. (from RefSeq NM_014330)
CALR3 (ENST00000269881.7) at chr19:16479057-16496192 - Homo sapiens calreticulin 3 (CALR3), mRNA. (from RefSeq NM_145046)
METAP2 (ENST00000546753.5) at chr12:95474081-95514299 - Homo sapiens methionyl aminopeptidase 2 (METAP2), transcript variant 2, mRNA. (from RefSeq NM_001317182)
METAP2 (ENST00000261220.13) at chr12:95474150-95514342 - Homo sapiens methionyl aminopeptidase 2 (METAP2), transcript variant 3, mRNA. (from RefSeq NM_001317183)
METAP2 (ENST00000323666.10) at chr12:95474152-95515839 - Homo sapiens methionyl aminopeptidase 2 (METAP2), transcript variant 4, non-coding RNA. (from RefSeq NR_133673)
NANOS3 (ENST00000397555.3) at chr19:13877249-13880750 - Plays a role in the maintenance of the undifferentiated  state of germ cells regulating the spermatogonia cell cycle and  inducing a prolonged transit in G1 phase. Affects cell  proliferation probably by repressing translation of specific  mRNAs. Maintains the germ cell lineage by suppressing both Bax-  dependent and -independent apoptotic pathways. Essential in the  early stage embryo to protect the migrating primordial germ cells  (PGCs) from apoptosis. (from UniProt P60323)
EIF2S3 (ENST00000253039.9) at chrX:24054956-24078810 - Homo sapiens eukaryotic translation initiation factor 2 subunit gamma (EIF2S3), mRNA. (from RefSeq NM_001415)
PPP1CC (ENST00000340766.9) at chr12:110719908-110742939 - Homo sapiens protein phosphatase 1 catalytic subunit gamma (PPP1CC), transcript variant 2, mRNA. (from RefSeq NM_001244974)
PPP1CC (ENST00000335007.10) at chr12:110719680-110742891 - Homo sapiens protein phosphatase 1 catalytic subunit gamma (PPP1CC), transcript variant 1, mRNA. (from RefSeq NM_002710)
PPP1R15B (ENST00000367188.5) at chr1:204403381-204411817 - Homo sapiens protein phosphatase 1 regulatory subunit 15B (PPP1R15B), mRNA. (from RefSeq NM_032833)
TARBP2 (ENST00000456234.6) at chr12:53500953-53506424 - Homo sapiens TARBP2 subunit of RISC loading complex (TARBP2), transcript variant 3, mRNA. (from RefSeq NM_004178)
TARBP2 (ENST00000394357.6) at chr12:53501619-53506412 - Homo sapiens TARBP2 subunit of RISC loading complex (TARBP2), transcript variant 2, mRNA. (from RefSeq NM_134324)
TARBP2 (ENST00000266987.7) at chr12:53501283-53506431 - Homo sapiens TARBP2 subunit of RISC loading complex (TARBP2), transcript variant 1, mRNA. (from RefSeq NM_134323)
PPP1CA (ENST00000358239.8) at chr11:67398431-67401871 - Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 2, mRNA. (from RefSeq NM_206873)
PPP1CA (ENST00000312989.11) at chr11:67398183-67401793 - Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 3, mRNA. (from RefSeq NM_001008709)
PPP1CA (ENST00000376745.9) at chr11:67398183-67401858 - Homo sapiens protein phosphatase 1 catalytic subunit alpha (PPP1CA), transcript variant 1, mRNA. (from RefSeq NM_002708)
CELF1 (ENST00000532048.5) at chr11:47470318-47523988 - Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript variant 4, mRNA. (from RefSeq NM_001172639)
CELF1 (ENST00000395292.6) at chr11:47468393-47494521 - Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript variant 2, mRNA. (from RefSeq NM_198700)
CELF1 (ENST00000395290.6) at chr11:47465944-47489024 - Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript variant 5, mRNA. (from RefSeq NM_001172640)
CELF1 (ENST00000310513.10) at chr11:47465933-47553117 - Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript variant 1, mRNA. (from RefSeq NM_006560)
CELF1 (ENST00000358597.7) at chr11:47468284-47489014 - Homo sapiens CUGBP Elav-like family member 1 (CELF1), transcript variant 3, mRNA. (from RefSeq NM_001025596)
CELF1 (ENST00000361904.7) at chr11:47468814-47489025 - RNA-binding protein implicated in the regulation of  several post-transcriptional events. Involved in pre-mRNA  alternative splicing, mRNA translation and stability. Mediates  exon inclusion and/or exclusion in pre-mRNA that are subject to  tissue-specific and developmentally regulated alternative  splicing. Specifically activates exon 5 inclusion of cardiac  isoforms of TNNT2 during heart remodeling at the juvenile to adult  transition. Acts as both an activator and repressor of a pair of  coregulated exons: promotes inclusion of the smooth muscle (SM)  exon but exclusion of the non-muscle (NM) exon in actinin pre-  mRNAs. Activates SM exon 5 inclusion by antagonizing the  repressive effect of PTB. Promotes exclusion of exon 11 of the  INSR pre-mRNA. Inhibits, together with HNRNPH1, insulin receptor  (IR) pre-mRNA exon 11 inclusion in myoblast. Increases translation  and controls the choice of translation initiation codon of CEBPB  mRNA. Increases mRNA translation of CEBPB in aging liver (By  similarity). Increases translation of CDKN1A mRNA by antagonizing  the repressive effect of CALR3. Mediates rapid cytoplasmic mRNA  deadenylation. Recruits the deadenylase PARN to the poly(A) tail  of EDEN-containing mRNAs to promote their deadenylation. Required  for completion of spermatogenesis (By similarity). Binds to (CUG)n  triplet repeats in the 3'-UTR of transcripts such as DMPK and to  Bruno response elements (BREs). Binds to muscle-specific splicing  enhancer (MSE) intronic sites flanking the alternative exon 5 of  TNNT2 pre-mRNA. Binds to AU-rich sequences (AREs or EDEN-like)  localized in the 3'-UTR of JUN and FOS mRNAs. Binds to the IR RNA.  Binds to the 5'-region of CDKN1A and CEBPB mRNAs. Binds with the  5'-region of CEBPB mRNA in aging liver. (from UniProt Q92879)
DDX3X (ENST00000457138.7) at chrX:41333913-41350224 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 3, mRNA. (from RefSeq NM_001193417)
DDX3X (ENST00000644876.1) at chrX:41333284-41351668 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 1, mRNA. (from RefSeq NM_001356)
DDX3X (ENST00000478993.5) at chrX:41333398-41364472 - Homo sapiens DEAD-box helicase 3 X-linked (DDX3X), transcript variant 4, non-coding RNA. (from RefSeq NR_126093)
DDX3X (ENST00000630255.2) at chrX:41333348-41364472 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
DDX3X (ENST00000629785.2) at chrX:41333348-41364472 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
DDX3X (ENST00000629496.3) at chrX:41333348-41350287 - Multifunctional ATP-dependent RNA helicase. The ATPase  activity can be stimulated by various ribo- and deoxynucleic acids  indicative for a relaxed substrate specificity. In vitro can  unwind partially double stranded DNA with a preference for 5'-  single stranded DNA overhangs. Is involved in several steps of  gene expression, such as transcription, mRNA maturation, mRNA  export and translation. However, the exact mechanisms are not  known and some functions may be specific for a subset of mRNAs.  Involved in transcriptional regulation. Can enhance transcription  from the CDKN1A/WAF1 promoter in a SP1-dependent manner. Found  associated with the E-cadherin promoter and can down-regulate  transcription from the promoter. Involved in regulation of  translation initiation. Proposed to be involved in positive  regulation of translation such as of cyclin E1/CCNE1 mRNA and  specifically of mRNAs containing complex secondary structures in  their 5'UTRs; these functions seem to require RNA helicase  activity. Specifically promotes translation of a subset of viral  and cellular mRNAs carrying a 5'proximal stem-loop structure in  their 5'UTRs and cooperates with the eIF4F complex. Proposed to  act prior to 43S ribosomal scanning and to locally destabilize  these RNA structures to allow recognition of the mRNA cap or  loading onto the 40S subunit. After association with 40S ribosomal  subunits seems to be involved in the functional assembly of 80S  ribosomes; the function seems to cover translation of mRNAs with  structured and non-structured 5'UTRs and is independent of RNA  helicase activity. Also proposed to inhibit cap-dependent  translation by competetive interaction with EIF4E which can block  the EIF4E:EIF4G complex formation. Proposed to be involved in  stress response and stress granule assembly; the function is  independent of RNA helicase activity and seems to involve  association with EIF4E. May be involved in nuclear export of  specific mRNAs but not in bulk mRNA export via interactions with  XPO1 and NXF1. Also associates with polyadenylated mRNAs  independently of NXF1. Associates with spliced mRNAs in an exon  junction complex (EJC)-dependent manner and seems not to be  directly involved in splicing. May be involved in nuclear mRNA  export by association with DDX5 and regulating its nuclear  location. Involved in innate immune signaling promoting the  production of type I interferon (IFN-alpha and IFN-beta); proposed  to act as viral RNA sensor, signaling intermediate and  transcriptional coactivator. Involved in TBK1 and IKBKE-dependent  IRF3 activation leading to IFN-beta induction. Also found  associated with IFN-beta promoters; the function is independent of  IRF3. Can bind to viral RNAs and via association with MAVS/IPS1  and DDX58/RIG-I is thought to induce signaling in early stages of  infection. Involved in regulation of apoptosis. May be required  for activation of the intrinsic but inhibit activation of the  extrinsic apoptotic pathway. Acts as an antiapoptotic protein  through association with GSK3A/B and BIRC2 in an apoptosis  antagonizing signaling complex; activation of death receptors  promotes caspase-dependent cleavage of BIRC2 and DDX3X and  relieves the inhibition. May be involved in mitotic chromosome  segregation. Appears to be a prime target for viral manipulations.  Hepatitis B virus (HBV) polymerase and possibly vaccinia virus  (VACV) protein K7 inhibit IFN-beta induction probably by  dissociating DDX3X from TBK1 or IKBKE. Is involved in hepatitis C  virus (HCV) replication; the function may involve the association  with HCV core protein. HCV core protein inhibits the IPS1-  dependent function in viral RNA sensing and may switch the  function from a INF-beta inducing to a HCV replication mode.  Involved in HIV-1 replication. Acts as a cofactor for XPO1-  mediated nuclear export of incompletely spliced HIV-1 Rev RNAs. (from UniProt O00571)
EIF3K (ENST00000634491.1) at chr19_KQ458386v1_fix:28847-46589 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 2, mRNA. (from RefSeq NM_001300992)
EIF3K (ENST00000634474.1) at chr19_KQ458386v1_fix:28731-46589 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 3, mRNA. (from RefSeq NM_001308393)
EIF3K (ENST00000593149.5) at chr19:38619095-38636953 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 3, mRNA. (from RefSeq NM_001308393)
EIF3K (ENST00000592558.1) at chr19:38619211-38636953 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 2, mRNA. (from RefSeq NM_001300992)
EIF3K (ENST00000635567.2) at chr19_KQ458386v1_fix:28824-46590 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 1, mRNA. (from RefSeq NM_013234)
EIF3K (ENST00000248342.9) at chr19:38619188-38636954 - Homo sapiens eukaryotic translation initiation factor 3 subunit K (EIF3K), transcript variant 1, mRNA. (from RefSeq NM_013234)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_004094.4 at chr14:67360317-67386516

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

EIF2S1 at chr14:67360328-67386516

RefSeq Genes

EIF2S1 at chr14:67360328-67386516 - (NM_004094) eukaryotic translation initiation factor 2 subunit 1

Non-Human RefSeq Genes

EIF2S1 at chr14:67360362-67384368 - (NM_001257466) eukaryotic translation initiation factor 2 subunit 1
EIF2S1 at chr14:67364764-67383440 - (NM_001245693) eukaryotic translation initiation factor 2 subunit 1
eif2s1 at chr14:67364764-67383452 - (NM_001292271) eukaryotic translation initiation factor 2 subunit 1
EIF2S1 at chr14:67364008-67384122 - (NM_001283137) eukaryotic translation initiation factor 2 subunit 1
eif2s1 at chr14:67364768-67383440 - (NM_001200408) eukaryotic translation initiation factor 2 subunit 1
EIF2S1 at chr14:67360358-67386302 - (NM_001133534) eukaryotic translation initiation factor 2 subunit 1
EIF2S1 at chr14:67364765-67383537 - (NM_001006477) eukaryotic translation initiation factor 2 subunit 1
EIF2S1 at chr14:67360343-67383825 - (NM_175813) eukaryotic translation initiation factor 2 subunit 1
Eif2s1 at chr14:67364761-67383894 - (NM_026114) eukaryotic translation initiation factor 2 subunit 1
eif2s1 at chr14:67364768-67383440 - (NM_001005630) eukaryotic translation initiation factor 2 subunit 1
Eif2s1 at chr14:67364761-67383858 - (NM_019356) eukaryotic translation initiation factor 2 subunit 1
eif2s1.S at chr14:67364768-67644700 - (NM_001087283) eukaryotic translation initiation factor 2 subunit 1
eif2s1a at chr14:67364768-67383440 - (NM_199569) eukaryotic translation initiation factor 2, subunit 1 alpha
eif2s1b at chr14:67364768-67383440 - (NM_131800) eukaryotic translation initiation factor 2 subunit 1

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

EIF2S1 at chr14:67360328-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

EIF2S1 at chr14:67360328-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67364008-67384122

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

EIF2S1 at chr14:67359997-67386516
EIF2S1 at chr14:67360353-67374648
EIF2S1 at chr14:67360556-67382587
EIF2S1 at chr14:67364008-67384122
EIF2S1 at chr14:67364898-67382681
EIF2S1 at chr14:67382411-67383668

International Knockout Mouse Consortium Genes Mapped to Human Genome

Eif2s1_42274 at chr14:67360317-67386516
Eif2s1_47123 at chr14:67360317-67386516

Human Aligned mRNA Search Results

BC002513 - Homo sapiens eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, mRNA (cDNA clone MGC:1511 IMAGE:3139624), complete cds.
AK312442 - Homo sapiens cDNA, FLJ92791, Homo sapiens eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa (EIF2S1), mRNA.

Non-Human Aligned mRNA Search Results

BC065313 - Danio rerio eukaryotic translation initiation factor 2, subunit 1 alpha, like, mRNA (cDNA clone MGC:77143 IMAGE:6961197), complete cds.
BC046576 - Xenopus laevis eukaryotic translation initiation factor 2, subunit 1 (alpha), mRNA (cDNA clone MGC:53429 IMAGE:5571827), complete cds.
BC049468 - Danio rerio eukaryotic translation initiation factor 2, subunit 1 alpha, like, mRNA (cDNA clone MGC:56510 IMAGE:5913676), complete cds.
KJ513464 - Rachycentron canadum eukaryotic translation initiation factor 2 subunit 1 alpha b (eif2s1b) mRNA, complete cds.
BC005463 - Mus musculus eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:6420 IMAGE:3591411), complete cds.
BC016448 - Mus musculus eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:25452 IMAGE:4234809), complete cds.
BC016497 - Mus musculus eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:25484 IMAGE:4501321), complete cds.
BC087019 - Rattus norvegicus eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:93488 IMAGE:7191037), complete cds.
BC104590 - Bos taurus eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, mRNA (cDNA clone MGC:128972 IMAGE:8120790), complete cds.
AY891815 - Synthetic construct Homo sapiens clone FLH110764.01L eukaryotic translation initiation factor 2 subunit 1 alpha (EIF2S1) mRNA, partial cds.
AY891816 - Synthetic construct Homo sapiens clone FLH110765.01L eukaryotic translation initiation factor 2 subunit 1 alpha (EIF2S1) mRNA, partial cds.
JI861850 - TSA: Capra hircus 9500.1.Cahikidney mRNA sequence.
JU333282 - TSA: Macaca mulatta Mamu_508019 mRNA sequence.
JU474593 - TSA: Macaca mulatta Mamu_375451 mRNA sequence.
JV046375 - TSA: Macaca mulatta Mamu_433448 mRNA sequence.
FN314430 - Schistosoma japonicum isolate Anhui full length mRNA clone SJFCA2964.002|FSA001-P00015-E09, complete sequence.
FN318869 - Schistosoma japonicum isolate Anhui full length mRNA clone SJFCE2964.001|FSE001-P00010-G04, complete sequence.
FN318870 - Schistosoma japonicum isolate Anhui full length mRNA clone SJFCE2964.003|FSE001-P00029-K23, complete sequence.
MG133376 - Synthetic construct Xenopus tropicalis clone IMAGE:5336145 eukaryotic translation initiation factor 2 subunit alpha (eif2s1) gene, encodes complete protein.
CR761726 - Xenopus tropicalis finished cDNA, clone TGas059e16.
BC051785 - Danio rerio eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:56347 IMAGE:5604108), complete cds.
BC065879 - Danio rerio eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:77851 IMAGE:7002294), complete cds.
BC074615 - Xenopus tropicalis eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa, mRNA (cDNA clone MGC:69476 IMAGE:5336145), complete cds.
BC153605 - Danio rerio eukaryotic translation initiation factor 2, subunit 1 alpha, mRNA (cDNA clone MGC:174442 IMAGE:8806318), complete cds.
AB172712 - Macaca fascicularis brain cDNA clone: QflA-19301, similar to human eukaryotic translation initiation factor 2, subunit 1alpha, 35kDa (EIF2S1), mRNA, RefSeq: NM_004094.3.