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Gencode Genes

DAPK1-IT1 (ENST00000431813.1) at chr9:87553454-87554459 - Homo sapiens DAPK1 intronic transcript 1 (DAPK1-IT1), long non-coding RNA. (from RefSeq NR_146781)
DAPK1 (ENST00000358077.9) at chr9:87497228-87708631 - Homo sapiens death associated protein kinase 1 (DAPK1), transcript variant 4, mRNA. (from RefSeq NM_001288731)
DAPK1 (ENST00000622514.4) at chr9:87498535-87708633 - Homo sapiens death associated protein kinase 1 (DAPK1), transcript variant 2, mRNA. (from RefSeq NM_001288729)
DAPK1 (ENST00000497743.1) at chr9:87668453-87681522 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000496522.5) at chr9:87498535-87638027 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000495281.1) at chr9:87648586-87650479 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000495182.5) at chr9:87497835-87507002 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000494010.1) at chr9:87649990-87668047 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000491893.5) at chr9:87499005-87707382 - Calcium/calmodulin-dependent serine/threonine kinase  involved in multiple cellular signaling pathways that trigger cell  survival, apoptosis, and autophagy. Regulates both type I  apoptotic and type II autophagic cell deaths signal, depending on  the cellular setting. The former is caspase-dependent, while the  latter is caspase-independent and is characterized by the  accumulation of autophagic vesicles. Phosphorylates PIN1 resulting  in inhibition of its catalytic activity, nuclear localization, and  cellular function. Phosphorylates TPM1, enhancing stress fiber  formation in endothelial cells. Phosphorylates STX1A and  significantly decreases its binding to STXBP1. Phosphorylates  PRKD1 and regulates JNK signaling by binding and activating PRKD1  under oxidative stress. Phosphorylates BECN1, reducing its  interaction with BCL2 and BCL2L1 and promoting the induction of  autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex  and stimulating mTORC1 activity in a growth factor-dependent  pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling  amplifier of NMDA receptors at extrasynaptic sites for mediating  brain damage in stroke. Cerebral ischemia recruits DAPK1 into the  NMDA receptor complex and it phosphorylates GRINB at Ser-1303  inducing injurious Ca(2+) influx through NMDA receptor channels,  resulting in an irreversible neuronal death. (from UniProt P53355)
DAPK1 (ENST00000489291.5) at chr9:87499006-87707382 - Belongs to the protein kinase superfamily. (from UniProt F8WCQ3)
DAPK1 (ENST00000475804.1) at chr9:87648575-87651590 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000472344.1) at chr9:87498611-87639483 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000472284.5) at chr9:87497681-87708630 - Homo sapiens death associated protein kinase 1 (DAPK1), transcript variant 3, mRNA. (from RefSeq NM_001288730)
DAPK1 (ENST00000470267.1) at chr9:87497912-87499352 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000469640.6) at chr9:87497681-87708633 - Calcium/calmodulin-dependent serine/threonine kinase  involved in multiple cellular signaling pathways that trigger cell  survival, apoptosis, and autophagy. Regulates both type I  apoptotic and type II autophagic cell deaths signal, depending on  the cellular setting. The former is caspase-dependent, while the  latter is caspase-independent and is characterized by the  accumulation of autophagic vesicles. Phosphorylates PIN1 resulting  in inhibition of its catalytic activity, nuclear localization, and  cellular function. Phosphorylates TPM1, enhancing stress fiber  formation in endothelial cells. Phosphorylates STX1A and  significantly decreases its binding to STXBP1. Phosphorylates  PRKD1 and regulates JNK signaling by binding and activating PRKD1  under oxidative stress. Phosphorylates BECN1, reducing its  interaction with BCL2 and BCL2L1 and promoting the induction of  autophagy. Phosphorylates TSC2, disrupting the TSC1-TSC2 complex  and stimulating mTORC1 activity in a growth factor-dependent  pathway. Phosphorylates RPS6, MYL9 and DAPK3. Acts as a signaling  amplifier of NMDA receptors at extrasynaptic sites for mediating  brain damage in stroke. Cerebral ischemia recruits DAPK1 into the  NMDA receptor complex and it phosphorylates GRINB at Ser-1303  inducing injurious Ca(2+) influx through NMDA receptor channels,  resulting in an irreversible neuronal death. (from UniProt P53355)
DAPK1 (ENST00000469067.5) at chr9:87497736-87650511 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000468482.1) at chr9:87698409-87700217 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000466188.1) at chr9:87657416-87668948 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000463069.1) at chr9:87639438-87640412 - death associated protein kinase 1 (from HGNC DAPK1)
DAPK1 (ENST00000408954.8) at chr9:87497867-87708634 - Homo sapiens death associated protein kinase 1 (DAPK1), transcript variant 1, mRNA. (from RefSeq NM_004938)
RPS6KA1 (ENST00000526792.5) at chr1:26531218-26574431 - Serine/threonine-protein kinase that acts downstream of  ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic  and stress-induced activation of the transcription factors CREB1,  ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and  EIF4B phosphorylation, and mediates cellular proliferation,  survival, and differentiation by modulating mTOR signaling and  repressing pro-apoptotic function of BAD and DAPK1. In fibroblast,  is required for EGF-stimulated phosphorylation of CREB1, which  results in the subsequent transcriptional activation of several  immediate-early genes. In response to mitogenic stimulation (EGF  and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81  transcription factors and the cofactor CREBBP. Upon insulin-  derived signal, acts indirectly on the transcription regulation of  several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting  its activity. Phosphorylates RPS6 in response to serum or EGF via  an mTOR-independent mechanism and promotes translation initiation  by facilitating assembly of the preinitiation complex. In response  to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the  EIF3 complex and stimulating cap-dependent translation. Is  involved in the mTOR nutrient-sensing pathway by directly  phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2  ability to suppress mTOR signaling, and mediates phosphorylation  of RPTOR, which regulates mTORC1 activity and may promote  rapamycin-sensitive signaling independently of the PI3K/AKT  pathway. Mediates cell survival by phosphorylating the pro-  apoptotic proteins BAD and DAPK1 and suppressing their pro-  apoptotic function. Promotes the survival of hepatic stellate  cells by phosphorylating CEBPB in response to the hepatotoxin  carbon tetrachloride (CCl4). Is involved in cell cycle regulation  by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B  association with 14-3-3 proteins and prevents its translocation to  the nucleus and inhibition of G1 progression. (from UniProt Q15418)
DAPK2 (ENST00000612884.4) at chr15:63916147-64046322 - Homo sapiens death associated protein kinase 2 (DAPK2), transcript variant 2, mRNA. (from RefSeq NM_001363730)
RPS6KA1 (ENST00000631108.2) at chr1_KN196473v1_fix:18836-62049 - Serine/threonine-protein kinase that acts downstream of  ERK (MAPK1/ERK2 and MAPK3/ERK1) signaling and mediates mitogenic  and stress-induced activation of the transcription factors CREB1,  ETV1/ER81 and NR4A1/NUR77, regulates translation through RPS6 and  EIF4B phosphorylation, and mediates cellular proliferation,  survival, and differentiation by modulating mTOR signaling and  repressing pro-apoptotic function of BAD and DAPK1. In fibroblast,  is required for EGF-stimulated phosphorylation of CREB1, which  results in the subsequent transcriptional activation of several  immediate-early genes. In response to mitogenic stimulation (EGF  and PMA), phosphorylates and activates NR4A1/NUR77 and ETV1/ER81  transcription factors and the cofactor CREBBP. Upon insulin-  derived signal, acts indirectly on the transcription regulation of  several genes by phosphorylating GSK3B at 'Ser-9' and inhibiting  its activity. Phosphorylates RPS6 in response to serum or EGF via  an mTOR-independent mechanism and promotes translation initiation  by facilitating assembly of the preinitiation complex. In response  to insulin, phosphorylates EIF4B, enhancing EIF4B affinity for the  EIF3 complex and stimulating cap-dependent translation. Is  involved in the mTOR nutrient-sensing pathway by directly  phosphorylating TSC2 at 'Ser-1798', which potently inhibits TSC2  ability to suppress mTOR signaling, and mediates phosphorylation  of RPTOR, which regulates mTORC1 activity and may promote  rapamycin-sensitive signaling independently of the PI3K/AKT  pathway. Mediates cell survival by phosphorylating the pro-  apoptotic proteins BAD and DAPK1 and suppressing their pro-  apoptotic function. Promotes the survival of hepatic stellate  cells by phosphorylating CEBPB in response to the hepatotoxin  carbon tetrachloride (CCl4). Is involved in cell cycle regulation  by phosphorylating the CDK inhibitor CDKN1B, which promotes CDKN1B  association with 14-3-3 proteins and prevents its translocation to  the nucleus and inhibition of G1 progression. (from UniProt Q15418)
DAPK2 (ENST00000261891.7) at chr15:63907036-64040267 - Homo sapiens death associated protein kinase 2 (DAPK2), transcript variant 1, mRNA. (from RefSeq NM_014326)
MIB1 (ENST00000261537.6) at chr18:21741320-21870957 - Homo sapiens mindbomb E3 ubiquitin protein ligase 1 (MIB1), mRNA. (from RefSeq NM_020774)
RPS6KA1 (ENST00000530003.5) at chr1:26543112-26575014 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 3, mRNA. (from RefSeq NM_001330441)
RPS6KA1 (ENST00000628256.2) at chr1_KN196473v1_fix:33470-61894 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 2, mRNA. (from RefSeq NM_001006665)
RPS6KA1 (ENST00000628081.2) at chr1_KN196473v1_fix:30730-62632 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 3, mRNA. (from RefSeq NM_001330441)
RPS6KA1 (ENST00000629832.3) at chr1_KN196473v1_fix:17379-62643 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 1, mRNA. (from RefSeq NM_002953)
RPS6KA1 (ENST00000531382.5) at chr1:26545852-26574276 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 2, mRNA. (from RefSeq NM_001006665)
RPS6KA1 (ENST00000374168.7) at chr1:26529761-26575025 - Homo sapiens ribosomal protein S6 kinase A1 (RPS6KA1), transcript variant 1, mRNA. (from RefSeq NM_002953)
PDCD6 (ENST00000264933.9) at chr5:271646-314974 - Homo sapiens programmed cell death 6 (PDCD6), transcript variant 1, mRNA. (from RefSeq NM_013232)
PDCD6 (ENST00000505221.5) at chr5:271647-314806 - Homo sapiens programmed cell death 6 (PDCD6), transcript variant 5, mRNA. (from RefSeq NM_001267559)
PDCD6 (ENST00000507528.5) at chr5:271657-314969 - Homo sapiens programmed cell death 6 (PDCD6), transcript variant 2, mRNA. (from RefSeq NM_001267556)
UNC5B (ENST00000335350.10) at chr10:71212570-71302864 - Homo sapiens unc-5 netrin receptor B (UNC5B), transcript variant 1, mRNA. (from RefSeq NM_170744)
UNC5B (ENST00000373192.4) at chr10:71212927-71302864 - Homo sapiens unc-5 netrin receptor B (UNC5B), transcript variant 2, mRNA. (from RefSeq NM_001244889)
PIN1 (ENST00000588695.5) at chr19:9835341-9849682 - Essential PPIase that regulates mitosis presumably by  interacting with NIMA and attenuating its mitosis-promoting  activity. Displays a preference for an acidic residue N-terminal  to the isomerized proline bond. Catalyzes pSer/Thr-Pro cis/trans  isomerizations. Down-regulates kinase activity of BTK. Can  transactivate multiple oncogenes and induce centrosome  amplification, chromosome instability and cell transformation.  Required for the efficient dephosphorylation and recycling of RAF1  after mitogen activation. (from UniProt Q13526)
KLHL20 (ENST00000209884.5) at chr1:173714981-173786692 - Homo sapiens kelch like family member 20 (KLHL20), mRNA. (from RefSeq NM_014458)
BECN1 (ENST00000361523.8) at chr17:42810134-42824263 - Homo sapiens beclin 1 (BECN1), transcript variant 1, mRNA. (from RefSeq NM_003766)
BECN1 (ENST00000590099.6) at chr17:42810134-42824282 - Homo sapiens beclin 1 (BECN1), transcript variant 3, mRNA. (from RefSeq NM_001313999)
RPS6KA3 (ENST00000379565.9) at chrX:20149911-20266909 - Homo sapiens ribosomal protein S6 kinase A3 (RPS6KA3), mRNA. (from RefSeq NM_004586)
TSC2 (ENST00000439673.6) at chr16:2048014-2088701 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 6, mRNA. (from RefSeq NM_001318827)
TSC2 (ENST00000382538.10) at chr16:2047980-2088700 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 7, mRNA. (from RefSeq NM_001318829)
TSC2 (ENST00000350773.9) at chr16:2048020-2088718 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 5, mRNA. (from RefSeq NM_001114382)
TSC2 (ENST00000219476.9) at chr16:2047985-2089491 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 1, mRNA. (from RefSeq NM_000548)
STX1A (ENST00000395156.7) at chr7:73699206-73719659 - Homo sapiens syntaxin 1A (STX1A), transcript variant 2, mRNA. (from RefSeq NM_001165903)
PIN1 (ENST00000247970.8) at chr19:9835323-9849682 - Homo sapiens peptidylprolyl cis/trans isomerase, NIMA-interacting 1 (PIN1), transcript variant 1, mRNA. (from RefSeq NM_006221)
MAPK3 (ENST00000395202.5) at chr16:30116668-30123209 - Serine/threonine kinase which acts as an essential  component of the MAP kinase signal transduction pathway.  MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important  role in the MAPK/ERK cascade. They participate also in a signaling  cascade initiated by activated KIT and KITLG/SCF. Depending on the  cellular context, the MAPK/ERK cascade mediates diverse biological  functions such as cell growth, adhesion, survival and  differentiation through the regulation of transcription,  translation, cytoskeletal rearrangements. The the MAPK/ERK cascade  plays also a role in initiation and regulation of meiosis,  mitosis, and postmitotic functions in differentiated cells by  phosphorylating a number of transcription factors. About 160  substrates have already been discovered for ERKs. Many of these  substrates are localized in the nucleus, and seem to participate  in the regulation of transcription upon stimulation. However,  other substrates are found in the cytosol as well as in other  cellular organelles, and those are responsible for processes such  as translation, mitosis and apoptosis. Moreover, the MAPK/ERK  cascade is also involved in the regulation of the endosomal  dynamics, including lysosome processing and endosome cycling  through the perinuclear recycling compartment (PNRC); as well as  in the fragmentation of the Golgi apparatus during mitosis. The  substrates include transcription factors (such as ATF2, BCL6,  ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as  CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of  apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),  regulators of translation (such as EIF4EBP1) and a variety of  other signaling-related molecules (like ARHGEF2, FRS2 or GRB10).  Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,  RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,  RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases  (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which  enable the propagation the MAPK/ERK signal to additional cytosolic  and nuclear targets, thereby extending the specificity of the  cascade. (from UniProt P27361)
MAPK1 (ENST00000544786.1) at chr22:21769204-21867440 - Serine/threonine kinase which acts as an essential  component of the MAP kinase signal transduction pathway.  MAPK1/ERK2 and MAPK3/ERK1 are the 2 MAPKs which play an important  role in the MAPK/ERK cascade. They participate also in a signaling  cascade initiated by activated KIT and KITLG/SCF. Depending on the  cellular context, the MAPK/ERK cascade mediates diverse biological  functions such as cell growth, adhesion, survival and  differentiation through the regulation of transcription,  translation, cytoskeletal rearrangements. The the MAPK/ERK cascade  plays also a role in initiation and regulation of meiosis,  mitosis, and postmitotic functions in differentiated cells by  phosphorylating a number of transcription factors. About 160  substrates have already been discovered for ERKs. Many of these  substrates are localized in the nucleus, and seem to participate  in the regulation of transcription upon stimulation. However,  other substrates are found in the cytosol as well as in other  cellular organelles, and those are responsible for processes such  as translation, mitosis and apoptosis. Moreover, the MAPK/ERK  cascade is also involved in the regulation of the endosomal  dynamics, including lysosome processing and endosome cycling  through the perinuclear recycling compartment (PNRC); as well as  in the fragmentation of the Golgi apparatus during mitosis. The  substrates include transcription factors (such as ATF2, BCL6,  ELK1, ERF, FOS, HSF4 or SPZ1), cytoskeletal elements (such as  CANX, CTTN, GJA1, MAP2, MAPT, PXN, SORBS3 or STMN1), regulators of  apoptosis (such as BAD, BTG2, CASP9, DAPK1, IER3, MCL1 or PPARG),  regulators of translation (such as EIF4EBP1) and a variety of  other signaling-related molecules (like ARHGEF2, DCC, FRS2 or  GRB10). Protein kinases (such as RAF1, RPS6KA1/RSK1, RPS6KA3/RSK2,  RPS6KA2/RSK3, RPS6KA6/RSK4, SYK, MKNK1/MNK1, MKNK2/MNK2,  RPS6KA5/MSK1, RPS6KA4/MSK2, MAPKAPK3 or MAPKAPK5) and phosphatases  (such as DUSP1, DUSP4, DUSP6 or DUSP16) are other substrates which  enable the propagation the MAPK/ERK signal to additional cytosolic  and nuclear targets, thereby extending the specificity of the  cascade. (from UniProt P28482)
TSC2 (ENST00000644043.1) at chr16:2048041-2088718 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 2, mRNA. (from RefSeq NM_021055)
MAP1B (ENST00000296755.12) at chr5:72107475-72209565 - Homo sapiens microtubule associated protein 1B (MAP1B), transcript variant 1, mRNA. (from RefSeq NM_005909)
GRIN2B (ENST00000609686.3) at chr12:13537337-13980363 - Homo sapiens glutamate ionotropic receptor NMDA type subunit 2B (GRIN2B), mRNA. (from RefSeq NM_000834)
TSC2 (ENST00000642936.1) at chr16:2047986-2088716 - Homo sapiens TSC complex subunit 2 (TSC2), transcript variant 11, mRNA. (from RefSeq NM_001370404)
MAPK3 (ENST00000395199.7) at chr16:30116837-30123209 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 2, mRNA. (from RefSeq NM_001040056)
MAPK3 (ENST00000263025.9) at chr16:30114105-30123220 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 1, mRNA. (from RefSeq NM_002746)
MAPK3 (ENST00000322266.9) at chr16:30114106-30123309 - Homo sapiens mitogen-activated protein kinase 3 (MAPK3), transcript variant 3, mRNA. (from RefSeq NM_001109891)
TPM1 (ENST00000561266.6) at chr15:63042777-63066091 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.2, mRNA. (from RefSeq NM_001301244)
TPM1 (ENST00000358278.7) at chr15:63042685-63071889 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.7, mRNA. (from RefSeq NM_001018006)
TPM1 (ENST00000288398.10) at chr15:63042632-63066093 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.5, mRNA. (from RefSeq NM_000366)
TPM1 (ENST00000267996.11) at chr15:63042758-63071915 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.4, mRNA. (from RefSeq NM_001018007)
TPM1 (ENST00000559397.6) at chr15:63042770-63071190 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.3, mRNA. (from RefSeq NM_001018020)
TPM1 (ENST00000334895.10) at chr15:63048439-63070632 - Homo sapiens tropomyosin 1 (TPM1), transcript variant Tpm1.12, mRNA. (from RefSeq NM_001018008)
TPM1 (ENST00000559556.5) at chr15:63042758-63071222 - Homo sapiens tropomyosin 1 (TPM1), transcript variant TmBr1, mRNA. (from RefSeq NM_001365776)
TPM1 (ENST00000403994.8) at chr15:63042747-63066178 - Homo sapiens tropomyosin 1 (TPM1), transcript variant 14, mRNA. (from RefSeq NM_001365777)
DAPK3 (ENST00000545797.7) at chr19:3958453-3971099 - Homo sapiens death associated protein kinase 3 (DAPK3), mRNA. (from RefSeq NM_001348)
DAPK3 (ENST00000301264.7) at chr19:3958454-3969828 - Serine/threonine kinase which is involved in the  regulation of apoptosis, autophagy, transcription, actin  cytoskeleton reorganization, cell motility, smooth muscle  contraction, and mitosis, particularly cytokinesis. Regulates both  type I apoptotic and type II autophagic cell deaths signal,  depending on the cellular setting. The former is caspase-  dependent, while the latter is caspase-independent and is  characterized by the accumulation of autophagic vesicles.  Regulates myosin phosphorylation in both smooth muscle and non-  muscle cells. In smooth muscle, regulates myosin either directly  by phosphorylating MYL12B and MYL9 or through inhibition of smooth  muscle myosin phosphatase (SMPP1M) via phosphorylation of  PPP1R12A, and the inhibition of SMPP1M functions to enhance muscle  responsiveness to Ca(2+) and promote a contractile state. Enhances  transcription from AR-responsive promoters in a hormone- and  kinase-dependent manner. Phosphorylates STAT3 and enhances its  transcriptional activity. Positively regulates the canonical  Wnt/beta-catenin signaling through interaction with NLK and  TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby influencing the  phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3 on  'Thr-11' at centromeres during mitosis. Involved in the formation  of promyelocytic leukemia protein nuclear body (PML-NB), one of  many subnuclear domains in the eukaryotic cell nucleus, and which  is involved in oncogenesis and viral infection. (from UniProt O43293)
PRKD1 (ENST00000331968.10) at chr14:29576479-29927847 - Homo sapiens protein kinase D1 (PRKD1), transcript variant 2, mRNA. (from RefSeq NM_002742)
PRKD1 (ENST00000616995.4) at chr14:29576479-29927512 - Serine/threonine-protein kinase that converts transient  diacylglycerol (DAG) signals into prolonged physiological effects  downstream of PKC, and is involved in the regulation of MAPK8/JNK1  and Ras signaling, Golgi membrane integrity and trafficking, cell  survival through NF-kappa-B activation, cell migration, cell  differentiation by mediating HDAC7 nuclear export, cell  proliferation via MAPK1/3 (ERK1/2) signaling, and plays a role in  cardiac hypertrophy, VEGFA-induced angiogenesis, genotoxic-induced  apoptosis and flagellin-stimulated inflammatory response.  Phosphorylates the epidermal growth factor receptor (EGFR) on dual  threonine residues, which leads to the suppression of epidermal  growth factor (EGF)-induced MAPK8/JNK1 activation and subsequent  JUN phosphorylation. Phosphorylates RIN1, inducing RIN1 binding to  14-3-3 proteins YWHAB, YWHAE and YWHAZ and increased competition  with RAF1 for binding to GTP-bound form of Ras proteins (NRAS,  HRAS and KRAS). Acts downstream of the heterotrimeric G-protein  beta/gamma-subunit complex to maintain the structural integrity of  the Golgi membranes, and is required for protein transport along  the secretory pathway. In the trans-Golgi network (TGN), regulates  the fission of transport vesicles that are on their way to the  plasma membrane. May act by activating the lipid kinase  phosphatidylinositol 4-kinase beta (PI4KB) at the TGN for the  local synthesis of phosphorylated inositol lipids, which induces a  sequential production of DAG, phosphatidic acid (PA) and lyso-PA  (LPA) that are necessary for membrane fission and generation of  specific transport carriers to the cell surface. Under oxidative  stress, is phosphorylated at Tyr-463 via SRC-ABL1 and contributes  to cell survival by activating IKK complex and subsequent nuclear  translocation and activation of NFKB1. Involved in cell migration  by regulating integrin alpha-5/beta-3 recycling and promoting its  recruitment in newly forming focal adhesion. In osteoblast  differentiation, mediates the bone morphogenic protein 2 (BMP2)-  induced nuclear export of HDAC7, which results in the inhibition  of HDAC7 transcriptional repression of RUNX2. In neurons, plays an  important role in neuronal polarity by regulating the biogenesis  of TGN-derived dendritic vesicles, and is involved in the  maintenance of dendritic arborization and Golgi structure in  hippocampal cells. May potentiate mitogenesis induced by the  neuropeptide bombesin or vasopressin by mediating an increase in  the duration of MAPK1/3 (ERK1/2) signaling, which leads to  accumulation of immediate-early gene products including FOS that  stimulate cell cycle progression. Plays an important role in the  proliferative response induced by low calcium in keratinocytes,  through sustained activation of MAPK1/3 (ERK1/2) pathway.  Downstream of novel PKC signaling, plays a role in cardiac  hypertrophy by phosphorylating HDAC5, which in turn triggers  XPO1/CRM1-dependent nuclear export of HDAC5, MEF2A transcriptional  activation and induction of downstream target genes that promote  myocyte hypertrophy and pathological cardiac remodeling. Mediates  cardiac troponin I (TNNI3) phosphorylation at the PKA sites, which  results in reduced myofilament calcium sensitivity, and  accelerated crossbridge cycling kinetics. The PRKD1-HDAC5 pathway  is also involved in angiogenesis by mediating VEGFA-induced  specific subset of gene expression, cell migration, and tube  formation. In response to VEGFA, is necessary and required for  HDAC7 phosphorylation which induces HDAC7 nuclear export and  endothelial cell proliferation and migration. During apoptosis  induced by cytarabine and other genotoxic agents, PRKD1 is cleaved  by caspase-3 at Asp-378, resulting in activation of its kinase  function and increased sensitivity of cells to the cytotoxic  effects of genotoxic agents. In epithelial cells, is required for  transducing flagellin-stimulated inflammatory responses by binding  and phosphorylating TLR5, which contributes to MAPK14/p38  activation and production of inflammatory cytokines. May play a  role in inflammatory response by mediating activation of NF-kappa-  B. May be involved in pain transmission by directly modulating  TRPV1 receptor. (from UniProt Q15139)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001288731.1 at chr9:87497228-87708634
NM_001288730.1 at chr9:87497681-87708634
NM_004938.3 at chr9:87497681-87708634
NM_001288729.1 at chr9:87498535-87708634
NR_146781.1 at chr9:87553454-87554459

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_005251757.4 at chr9:87497841-87687291
XM_017014360.1 at chr9:87647796-87708634

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

DAPK1 at chr9:87497867-87708634

RefSeq Genes

DAPK1 at chr9:87498535-87708634 - (NM_001288729) death-associated protein kinase 1
DAPK1 at chr9:87497734-87708634 - (NM_001288730) death-associated protein kinase 1
DAPK1 at chr9:87497228-87708634 - (NM_001288731) death-associated protein kinase 1
DAPK1 at chr9:87497867-87708634 - (NM_004938) death-associated protein kinase 1
DAPK1-IT1 at chr9:87553454-87554448 - (NR_146781) 

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

DAPK1 intronic transcript 1 at chr9:87553454-87554459 - (NR_146781.1)

Non-Human RefSeq Genes

DAPK1 at chr9:87498078-87708629 - (NM_001257788) death-associated protein kinase 1
dapk1 at chr9:87499078-87707364 - (NM_001123439) death-associated protein kinase 1
DAPK1 at chr9:87498978-87707388 - (NM_001197157) death-associated protein kinase 1
DAPK1 at chr9:87604946-87700243 - (NM_001031613) death-associated protein kinase 1 isoform 2
Dapk1 at chr9:87498969-87708579 - (NM_001107335) death-associated protein kinase 1
DAPK1 at chr9:87604946-87707364 - (NM_001278031) death-associated protein kinase 1 isoform 1
DAPK1 at chr9:87498031-87707753 - (NM_001206038) death-associated protein kinase 1
Dapk1 at chr9:87498979-87708606 - (NM_001285917) death-associated protein kinase 1 isoform 2
Dapk1 at chr9:87498979-87708606 - (NM_029653) death-associated protein kinase 1 isoform 1
Dapk1 at chr9:87498979-87708606 - (NM_134062) death-associated protein kinase 1 isoform 1
dapk1 at chr9:87604946-87707364 - (NM_001099990) death-associated protein kinase 1
dapk1.L at chr9:87604946-87707364 - (NM_001093258) death associated protein kinase 1 L homeolog
dapk1.S at chr9:87604946-87707364 - (NM_001091302) death associated protein kinase 1 S homeolog

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497867-87708634
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497867-87708634
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87499005-87707382

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

DAPK1 at chr9:87497228-87708631
DAPK1 at chr9:87497681-87708630
DAPK1 at chr9:87497681-87708633
DAPK1 at chr9:87497736-87650511
DAPK1 at chr9:87497835-87507002
DAPK1 at chr9:87497881-87708628
DAPK1 at chr9:87497912-87499352
DAPK1 at chr9:87498535-87638027
DAPK1 at chr9:87498535-87708633
DAPK1 at chr9:87498611-87639483
DAPK1 at chr9:87499005-87707382
DAPK1 at chr9:87499006-87707382
DAPK1 at chr9:87639438-87640412
DAPK1 at chr9:87648575-87651590
DAPK1 at chr9:87648586-87650479
DAPK1 at chr9:87649990-87668047
DAPK1 at chr9:87657416-87668948
DAPK1 at chr9:87668453-87681522
DAPK1 at chr9:87698409-87700217

International Knockout Mouse Consortium Genes Mapped to Human Genome

Dapk1_36474 at chr9:87497841-87708634
Dapk1_72311 at chr9:87497841-87708634

Alias of STS Marker

DAPK1 at chr9:87606677-87806886 - (DAPK1)

Human Aligned mRNA Search Results

BC143759 - Homo sapiens death-associated protein kinase 1, mRNA (cDNA clone MGC:177290 IMAGE:9052273), complete cds.
BC113660 - Homo sapiens death-associated protein kinase 1, mRNA (cDNA clone MGC:142220 IMAGE:8322712), complete cds.
BC143733 - Homo sapiens death-associated protein kinase 1, mRNA (cDNA clone MGC:177264 IMAGE:9052247), complete cds.
EF090258 - Homo sapiens death-associated protein kinase beta (DAPK1) mRNA, partial cds.

Non-Human Aligned mRNA Search Results

BC159135 - Xenopus tropicalis death-associated protein kinase 1, mRNA (cDNA clone MGC:172570 IMAGE:7650444), complete cds.
BC077360 - Xenopus laevis death-associated protein kinase 1, mRNA (cDNA clone MGC:81366 IMAGE:6634221), complete cds.
KJ162054 - Struthio camelus DAPK1W mRNA, partial cds.
BC021490 - Mus musculus death associated protein kinase 1, mRNA (cDNA clone IMAGE:5345390), partial cds.
BC057317 - Mus musculus death associated protein kinase 1, mRNA (cDNA clone MGC:66655 IMAGE:6821014), complete cds.
BC060161 - Mus musculus death associated protein kinase 1, mRNA (cDNA clone MGC:61377 IMAGE:6821014), complete cds.
BC169063 - Rattus norvegicus death associated protein kinase 1, mRNA (cDNA clone IMAGE:5623417), partial cds.
HQ189123 - Canis lupus familiaris DAPK1 mRNA, complete cds.
JU321974 - TSA: Macaca mulatta Mamu_512044 mRNA sequence.
EU441373 - Xenopus borealis clone DAP.b death-associated protein kinase 1 (dapk1) mRNA, partial cds.
EU441681 - Xenopus borealis clone DAP.b2 death-associated protein kinase 1 (dapk1) mRNA, partial cds.
AF537368 - Danio rerio dorsal aorta proneprin kinesin-1 (dapk1) mRNA, complete cds.