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Gencode Genes

CUL4A (ENST00000375440.9) at chr13:113209613-113267108 - Homo sapiens cullin 4A (CUL4A), transcript variant 1, mRNA. (from RefSeq NM_001008895)
CUL4A (ENST00000617546.4) at chr13:113208836-113267108 - Homo sapiens cullin 4A (CUL4A), transcript variant 9, mRNA. (from RefSeq NM_001354942)
CUL4A (ENST00000498562.2) at chr13:113209883-113235145 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000494985.5) at chr13:113209630-113228017 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000488558.2) at chr13:113209600-113230212 - Homo sapiens cullin 4A (CUL4A), transcript variant 11, mRNA. (from RefSeq NM_001354944)
CUL4A (ENST00000474116.5) at chr13:113209616-113219812 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000472083.1) at chr13:113245956-113263559 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000470067.5) at chr13:113244223-113254775 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000463426.5) at chr13:113209833-113230030 - cullin 4A (from HGNC CUL4A)
CUL4A (ENST00000451881.5) at chr13:113208772-113265077 - Homo sapiens cullin 4A (CUL4A), transcript variant 2, mRNA. (from RefSeq NM_003589)
CUL4A (ENST00000375441.7) at chr13:113208193-113265072 - Homo sapiens cullin 4A (CUL4A), transcript variant 3, mRNA. (from RefSeq NM_001278513)
CUL4A (ENST00000326335.8) at chr13:113208694-113265072 - Homo sapiens cullin 4A (CUL4A), transcript variant 4, mRNA. (from RefSeq NM_001278514)
DCAF1 (ENST00000335891.5) at chr3:51397842-51483838 - Component of the CUL4A-RBX1-DDB1-VprBP/DCAF1 E3  ubiquitin-protein ligase complex, VprBP/DCAF1 may function as the  substrate recognition module within this complex. For example,  VprBP/DCAF1 targets NF2 to the E3 ubiquitin-ligase complex for  ubiquitination and subsequent proteasome-dependent degradation. In  case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in  order to hijack the CUL4A-RBX1-DDB1 function leading to arrest the  cell cycle in G2 phase, and also to protect the viral protein from  proteasomal degradation by another E3 ubiquitin ligase. In case of  infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to  hijack the CUL4A-RBX1-DDB1 function leading to enhanced efficiency  of macrophage infection and promotion of the replication of  cognate primate lentiviruses in cells of monocyte/macrophage  lineage. Associated with chromatin in a DDB1-independent and cell  cycle-dependent manner, VprBP/DCAF1 is recruited to chromatin as  DNA is being replicated and is released from chromatin before  mitosis. (from UniProt Q9Y4B6)
WDR76 (ENST00000263795.11) at chr15:43827002-43868412 - Homo sapiens WD repeat domain 76 (WDR76), transcript variant 1, mRNA. (from RefSeq NM_024908)
DDA1 (ENST00000596582.1) at chr19:17309569-17320367 - May be involved in ubiquitination and subsequent  proteasomal degradation of target proteins. Component of the DDD-  E2 complexes which may provide a platform for interaction with  CUL4A and WD repeat proteins. (from UniProt Q9BW61)
DDA1 (ENST00000593466.5) at chr19:17309518-17320492 - May be involved in ubiquitination and subsequent  proteasomal degradation of target proteins. Component of the DDD-  E2 complexes which may provide a platform for interaction with  CUL4A and WD repeat proteins. (from UniProt Q9BW61)
DCAF1 (ENST00000423656.5) at chr3:51395867-51499994 - Homo sapiens DDB1 and CUL4 associated factor 1 (DCAF1), transcript variant 1, mRNA. (from RefSeq NM_014703)
DCAF1 (ENST00000504652.5) at chr3:51395867-51500002 - Homo sapiens DDB1 and CUL4 associated factor 1 (DCAF1), transcript variant 7, non-coding RNA. (from RefSeq NR_146065)
DCAF17 (ENST00000611110.4) at chr2:171453122-171481167 - May function as a substrate receptor for CUL4-DDB1 E3  ubiquitin-protein ligase complex. (from UniProt Q5H9S7)
DCAF16 (ENST00000382247.6) at chr4:17800655-17810757 - Homo sapiens DDB1 and CUL4 associated factor 16 (DCAF16), transcript variant 2, mRNA. (from RefSeq NM_017741)
DCAF15 (ENST00000254337.10) at chr19:13952492-13961449 - Homo sapiens DDB1 and CUL4 associated factor 15 (DCAF15), mRNA. (from RefSeq NM_138353)
DCAF5 (ENST00000556847.5) at chr14:69053802-69152609 - May function as a substrate receptor for CUL4-DDB1 E3  ubiquitin-protein ligase complex. (from UniProt Q96JK2)
DDA1 (ENST00000359866.9) at chr19:17309563-17323298 - Homo sapiens DET1 and DDB1 associated 1 (DDA1), mRNA. (from RefSeq NM_024050)
DCAF5 (ENST00000554215.5) at chr14:69051855-69152599 - Homo sapiens DDB1 and CUL4 associated factor 5 (DCAF5), transcript variant 3, mRNA. (from RefSeq NM_001284207)
DCAF8 (ENST00000326837.6) at chr1:160215715-160262476 - May function as a substrate receptor for CUL4-DDB1 E3  ubiquitin-protein ligase complex. (from UniProt Q5TAQ9)
DCAF5 (ENST00000557386.5) at chr14:69053825-69153003 - Homo sapiens DDB1 and CUL4 associated factor 5 (DCAF5), transcript variant 2, mRNA. (from RefSeq NM_001284206)
DCAF5 (ENST00000341516.10) at chr14:69050881-69153119 - Homo sapiens DDB1 and CUL4 associated factor 5 (DCAF5), transcript variant 1, mRNA. (from RefSeq NM_003861)
DCAF11 (ENST00000646524.1) at chr14_KZ208920v1_fix:416352-424959 - May function as a substrate receptor for CUL4-DDB1 E3  ubiquitin-protein ligase complex. (from UniProt Q8TEB1)
DCAF11 (ENST00000396936.5) at chr14:24115374-24123981 - May function as a substrate receptor for CUL4-DDB1 E3  ubiquitin-protein ligase complex. (from UniProt Q8TEB1)
DET1 (ENST00000268148.12) at chr15:88512483-88546675 - Homo sapiens DET1 partner of COP1 E3 ubiquitin ligase (DET1), transcript variant 7, non-coding RNA. (from RefSeq NR_135740)
DET1 (ENST00000564406.5) at chr15:88512483-88546653 - Homo sapiens DET1 partner of COP1 E3 ubiquitin ligase (DET1), transcript variant 8, non-coding RNA. (from RefSeq NR_135741)
DCAF4 (ENST00000509153.5) at chr14:72926480-72958946 - Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 3, mRNA. (from RefSeq NM_181341)
DCAF8 (ENST00000368074.5) at chr1:160215715-160262501 - Homo sapiens DDB1 and CUL4 associated factor 8 (DCAF8), transcript variant 1, mRNA. (from RefSeq NM_015726)
DCAF4 (ENST00000555042.5) at chr14:72926487-72959644 - Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 4, mRNA. (from RefSeq NM_001163508)
DCAF4 (ENST00000394234.6) at chr14:72926478-72959703 - Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 2, mRNA. (from RefSeq NM_181340)
DCAF8 (ENST00000368073.7) at chr1:160215715-160262451 - Homo sapiens DDB1 and CUL4 associated factor 8 (DCAF8), transcript variant 3, non-coding RNA. (from RefSeq NR_028104)
DET1 (ENST00000444300.1) at chr15:88512483-88536334 - Component of the E3 ubiquitin ligase DCX DET1-COP1  complex, which is required for ubiquitination and subsequent  degradation of target proteins. The complex is involved in JUN  ubiquitination and degradation. (from UniProt Q7L5Y6)
NF2 (ENST00000432151.5) at chr22:29603949-29694945 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000403435.5) at chr22:29603588-29684162 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000397789.3) at chr22:29603999-29694811 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
NF2 (ENST00000361166.9) at chr22:29654657-29695059 - Probable regulator of the Hippo/SWH (Sav/Wts/Hpo)  signaling pathway, a signaling pathway that plays a pivotal role  in tumor suppression by restricting proliferation and promoting  apoptosis. Along with WWC1 can synergistically induce the  phosphorylation of LATS1 and LATS2 and can probably function in  the regulation of the Hippo/SWH (Sav/Wts/Hpo) signaling pathway.  May act as a membrane stabilizing protein. May inhibit PI3 kinase  by binding to AGAP2 and impairing its stimulating activity.  Suppresses cell proliferation and tumorigenesis by inhibiting the  CUL4A-RBX1-DDB1-VprBP/DCAF1 E3 ubiquitin-protein ligase complex. (from UniProt P35240)
DCAF8 (ENST00000610139.5) at chr1:160239222-160262425 - Homo sapiens DDB1 and CUL4 associated factor 8 (DCAF8), transcript variant 4, non-coding RNA. (from RefSeq NR_028105)
DCAF8 (ENST00000475733.5) at chr1:160239222-160262436 - Homo sapiens DDB1 and CUL4 associated factor 8 (DCAF8), transcript variant 5, non-coding RNA. (from RefSeq NR_028106)
DCAF17 (ENST00000375255.8) at chr2:171434226-171485052 - Homo sapiens DDB1 and CUL4 associated factor 17 (DCAF17), transcript variant 3, non-coding RNA. (from RefSeq NR_028482)
DCAF11 (ENST00000646568.1) at chr14_KZ208920v1_fix:415758-426218 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 1, mRNA. (from RefSeq NM_025230)
DCAF11 (ENST00000644566.1) at chr14_KZ208920v1_fix:416304-425007 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 2, mRNA. (from RefSeq NM_181357)
DCAF11 (ENST00000642239.1) at chr14_KZ208920v1_fix:415605-425007 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 3, mRNA. (from RefSeq NM_001163484)
DCAF11 (ENST00000446197.7) at chr14:24114780-24125240 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 1, mRNA. (from RefSeq NM_025230)
DCAF11 (ENST00000559115.5) at chr14:24114627-24124029 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 3, mRNA. (from RefSeq NM_001163484)
DCAF11 (ENST00000396941.8) at chr14:24115326-24124029 - Homo sapiens DDB1 and CUL4 associated factor 11 (DCAF11), transcript variant 2, mRNA. (from RefSeq NM_181357)
DCAF4 (ENST00000358377.7) at chr14:72926464-72959703 - Homo sapiens DDB1 and CUL4 associated factor 4 (DCAF4), transcript variant 9, non-coding RNA. (from RefSeq NR_147990)
TRPC4AP (ENST00000451813.6) at chr20:35002404-35092807 - Homo sapiens transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP), transcript variant 2, mRNA. (from RefSeq NM_199368)
TRPC4AP (ENST00000252015.3) at chr20:35002404-35092807 - Homo sapiens transient receptor potential cation channel subfamily C member 4 associated protein (TRPC4AP), transcript variant 1, mRNA. (from RefSeq NM_015638)
DCAF6 (ENST00000432587.6) at chr1:167936559-168075841 - Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript variant 4, mRNA. (from RefSeq NM_001198957)
DCAF6 (ENST00000367840.3) at chr1:167936818-168075834 - Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript variant 5, mRNA. (from RefSeq NM_001349773)
DDIT4 (ENST00000307365.4) at chr10:72273924-72276036 - Homo sapiens DNA damage inducible transcript 4 (DDIT4), mRNA. (from RefSeq NM_019058)
COP1 (ENST00000308769.12) at chr1:175945153-176206978 - Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript variant 2, mRNA. (from RefSeq NM_001001740)
COP1 (ENST00000367669.8) at chr1:175944831-176207286 - Homo sapiens COP1 E3 ubiquitin ligase (COP1), transcript variant 1, mRNA. (from RefSeq NM_022457)
CRBN (ENST00000231948.8) at chr3:3150011-3179710 - Homo sapiens cereblon (CRBN), transcript variant 1, mRNA. (from RefSeq NM_016302)
CRBN (ENST00000432408.6) at chr3:3150011-3179710 - Homo sapiens cereblon (CRBN), transcript variant 2, mRNA. (from RefSeq NM_001173482)
DTL (ENST00000366991.5) at chr1:212035748-212105013 - Homo sapiens denticleless E3 ubiquitin protein ligase homolog (DTL), transcript variant 1, mRNA. (from RefSeq NM_016448)
ERCC8 (ENST00000265038.9) at chr5:60873832-60945051 - Homo sapiens ERCC excision repair 8, CSA ubiquitin ligase complex subunit (ERCC8), transcript variant 4, mRNA. (from RefSeq NM_001290285)
DCAF6 (ENST00000367843.7) at chr1:167936661-168075843 - Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript variant 14, non-coding RNA. (from RefSeq NR_146229)
DCAF6 (ENST00000312263.10) at chr1:167936708-168075834 - Homo sapiens DDB1 and CUL4 associated factor 6 (DCAF6), transcript variant 15, non-coding RNA. (from RefSeq NR_146230)
RNF7 (ENST00000480908.1) at chr3:141738277-141745700 - Homo sapiens ring finger protein 7 (RNF7), transcript variant 4, mRNA. (from RefSeq NM_001201370)
RNF7 (ENST00000477012.5) at chr3:141738304-141745669 - Homo sapiens ring finger protein 7 (RNF7), transcript variant 6, non-coding RNA. (from RefSeq NR_037703)
RNF7 (ENST00000393000.3) at chr3:141738297-141745702 - Homo sapiens ring finger protein 7 (RNF7), transcript variant 3, mRNA. (from RefSeq NM_183237)
RNF7 (ENST00000273480.4) at chr3:141738298-141747560 - Homo sapiens ring finger protein 7 (RNF7), transcript variant 1, mRNA. (from RefSeq NM_014245)
NF2 (ENST00000413209.6) at chr22:29603556-29698594 - Homo sapiens neurofibromin 2 (NF2), transcript variant 9, mRNA. (from RefSeq NM_181833)
NF2 (ENST00000403999.7) at chr22:29603633-29683915 - Homo sapiens neurofibromin 2 (NF2), transcript variant 12, mRNA. (from RefSeq NM_181825)
NF2 (ENST00000361676.8) at chr22:29603999-29694811 - Homo sapiens neurofibromin 2 (NF2), transcript variant 5, mRNA. (from RefSeq NM_181828)
NF2 (ENST00000361452.8) at chr22:29603617-29698594 - Homo sapiens neurofibromin 2 (NF2), transcript variant 6, mRNA. (from RefSeq NM_181829)
NF2 (ENST00000353887.8) at chr22:29603747-29694811 - Homo sapiens neurofibromin 2 (NF2), transcript variant 7, mRNA. (from RefSeq NM_181830)
NF2 (ENST00000334961.11) at chr22:29603727-29683915 - Homo sapiens neurofibromin 2 (NF2), transcript variant 13, mRNA. (from RefSeq NM_181831)
NF2 (ENST00000338641.9) at chr22:29603633-29698598 - Homo sapiens neurofibromin 2 (NF2), transcript variant 1, mRNA. (from RefSeq NM_000268)
ARIH1 (ENST00000379887.9) at chr15:72474330-72602987 - Homo sapiens ariadne RBR E3 ubiquitin protein ligase 1 (ARIH1), mRNA. (from RefSeq NM_005744)
CAND1 (ENST00000545606.6) at chr12:67269358-67319953 - Homo sapiens cullin associated and neddylation dissociated 1 (CAND1), transcript variant 1, mRNA. (from RefSeq NM_018448)
CUL4B (ENST00000404115.7) at chrX:120526641-120575794 - Homo sapiens cullin 4B (CUL4B), transcript variant 1, mRNA. (from RefSeq NM_003588)
GLMN (ENST00000495106.5) at chr1:92246490-92298987 - Homo sapiens glomulin, FKBP associated protein (GLMN), transcript variant 3, non-coding RNA. (from RefSeq NR_135089)
RBBP5 (ENST00000367164.1) at chr1:205086142-205122015 - Homo sapiens RB binding protein 5, histone lysine methyltransferase complex subunit (RBBP5), transcript variant 2, mRNA. (from RefSeq NM_001193272)
GLMN (ENST00000370360.8) at chr1:92246402-92298987 - Homo sapiens glomulin, FKBP associated protein (GLMN), transcript variant 1, mRNA. (from RefSeq NM_053274)
RBBP5 (ENST00000264515.11) at chr1:205086142-205121978 - Homo sapiens RB binding protein 5, histone lysine methyltransferase complex subunit (RBBP5), transcript variant 1, mRNA. (from RefSeq NM_005057)
COP1 (ENST00000474194.1) at chr1:176135010-176207083 - E3 ubiquitin-protein ligase that mediates ubiquitination  and subsequent proteasomal degradation of target proteins. E3  ubiquitin ligases accept ubiquitin from an E2 ubiquitin-  conjugating enzyme in the form of a thioester and then directly  transfers the ubiquitin to targeted substrates. Involved in JUN  ubiquitination and degradation. Directly involved in p53 (TP53)  ubiquitination and degradation, thereby abolishing p53-dependent  transcription and apoptosis. Ubiquitinates p53 independently of  MDM2 or RCHY1. Probably mediates E3 ubiquitin ligase activity by  functioning as the essential RING domain subunit of larger E3  complexes. In contrast, it does not constitute the catalytic RING  subunit in the DCX DET1-COP1 complex that negatively regulates  JUN, the ubiquitin ligase activity being mediated by RBX1.  Involved in 14-3-3 protein sigma/SFN ubiquitination and  proteasomal degradation, leading to AKT activation and promotion  of cell survival. (from UniProt Q8NHY2)
RBX1 (ENST00000216225.9) at chr22:40951378-40973309 - Homo sapiens ring-box 1 (RBX1), mRNA. (from RefSeq NM_014248)
DDB2 (ENST00000256996.8) at chr11:47214942-47239240 - Homo sapiens damage specific DNA binding protein 2 (DDB2), transcript variant WT, mRNA. (from RefSeq NM_000107)
DDB2 (ENST00000378600.7) at chr11:47215137-47238849 - Homo sapiens damage specific DNA binding protein 2 (DDB2), transcript variant D1, mRNA. (from RefSeq NM_001300734)
FBXW5 (ENST00000325285.8) at chr9:136940435-136944738 - Homo sapiens F-box and WD repeat domain containing 5 (FBXW5), mRNA. (from RefSeq NM_018998)
DDB2 (ENST00000616278.4) at chr11:47215137-47238849 - Required for DNA repair. Binds to DDB1 to form the UV-  damaged DNA-binding protein complex (the UV-DDB complex). The UV-  DDB complex may recognize UV-induced DNA damage and recruit  proteins of the nucleotide excision repair pathway (the NER  pathway) to initiate DNA repair. The UV-DDB complex preferentially  binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts  (6-4 PP), apurinic sites and short mismatches. Also appears to  function as the substrate recognition module for the DCX (DDB1-  CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1  (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-  ROC1 complex may ubiquitinate histone H2A, histone H3 and histone  H4 at sites of UV-induced DNA damage. The ubiquitination of  histones may facilitate their removal from the nucleosome and  promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also  ubiquitinates XPC, which may enhance DNA-binding by XPC and  promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA  repair. (from UniProt Q92466)
DDB2 (ENST00000378601.7) at chr11:47214992-47239189 - Required for DNA repair. Binds to DDB1 to form the UV-  damaged DNA-binding protein complex (the UV-DDB complex). The UV-  DDB complex may recognize UV-induced DNA damage and recruit  proteins of the nucleotide excision repair pathway (the NER  pathway) to initiate DNA repair. The UV-DDB complex preferentially  binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts  (6-4 PP), apurinic sites and short mismatches. Also appears to  function as the substrate recognition module for the DCX (DDB1-  CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1  (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-  ROC1 complex may ubiquitinate histone H2A, histone H3 and histone  H4 at sites of UV-induced DNA damage. The ubiquitination of  histones may facilitate their removal from the nucleosome and  promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also  ubiquitinates XPC, which may enhance DNA-binding by XPC and  promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA  repair. (from UniProt Q92466)
DDB2 (ENST00000378603.7) at chr11:47215137-47238849 - Required for DNA repair. Binds to DDB1 to form the UV-  damaged DNA-binding protein complex (the UV-DDB complex). The UV-  DDB complex may recognize UV-induced DNA damage and recruit  proteins of the nucleotide excision repair pathway (the NER  pathway) to initiate DNA repair. The UV-DDB complex preferentially  binds to cyclobutane pyrimidine dimers (CPD), 6-4 photoproducts  (6-4 PP), apurinic sites and short mismatches. Also appears to  function as the substrate recognition module for the DCX (DDB1-  CUL4-X-box) E3 ubiquitin-protein ligase complex DDB1-CUL4-ROC1  (also known as CUL4-DDB-ROC1 and CUL4-DDB-RBX1). The DDB1-CUL4-  ROC1 complex may ubiquitinate histone H2A, histone H3 and histone  H4 at sites of UV-induced DNA damage. The ubiquitination of  histones may facilitate their removal from the nucleosome and  promote subsequent DNA repair. The DDB1-CUL4-ROC1 complex also  ubiquitinates XPC, which may enhance DNA-binding by XPC and  promote NER. Isoform D1 and isoform D2 inhibit UV-damaged DNA  repair. (from UniProt Q92466)
CUL4B (ENST00000371322.9) at chrX:120524609-120560700 - Homo sapiens cullin 4B (CUL4B), transcript variant 4, mRNA. (from RefSeq NM_001369145)
BTRC (ENST00000408038.6) at chr10:101354107-101557321 - Homo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 2, mRNA. (from RefSeq NM_003939)
BTRC (ENST00000370187.8) at chr10:101354165-101557313 - Homo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 1, mRNA. (from RefSeq NM_033637)
DDB1 (ENST00000301764.11) at chr11:61299451-61333366 - Homo sapiens damage specific DNA binding protein 1 (DDB1), mRNA. (from RefSeq NM_001923)
CUL4AP1 (ENST00000514750.2) at chr4:116425983-116430892 - cullin 4A pseudogene 1 (from HGNC CUL4AP1)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001278513.2 at chr13:113208193-113267108
NM_001354938.1 at chr13:113208694-113267108
NM_001278514.2 at chr13:113208694-113267108
NM_001354944.1 at chr13:113208772-113230227
NM_001354939.1 at chr13:113208772-113267108
NM_003589.3 at chr13:113208772-113267108
NM_001354943.1 at chr13:113209505-113230227
NM_001354942.1 at chr13:113209505-113267108
NM_001354941.1 at chr13:113209505-113267108
NM_001008895.3 at chr13:113209505-113267108
NM_001354940.1 at chr13:113209508-113267108

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_011537523.2 at chr13:113210196-113265078

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

CUL4A at chr13:113209613-113267108

RefSeq Genes

CUL4A at chr13:113209613-113267108 - (NM_001354942) cullin-4A isoform 4
CUL4A at chr13:113209613-113230219 - (NM_001354943) cullin-4A isoform 5
CUL4A at chr13:113209613-113267108 - (NM_001354941) cullin-4A isoform 4
CUL4A at chr13:113208694-113267108 - (NM_001278514) cullin-4A isoform 3
CUL4A at chr13:113208772-113230226 - (NM_001354944) cullin-4A isoform 6
CUL4A at chr13:113208193-113267108 - (NM_001278513) cullin-4A isoform 2
CUL4A at chr13:113208772-113267108 - (NM_003589) cullin-4A isoform 2
CUL4A at chr13:113208694-113267108 - (NM_001354938) cullin-4A isoform 2
CUL4A at chr13:113209613-113267108 - (NM_001354940) cullin-4A isoform 2
CUL4A at chr13:113208772-113267108 - (NM_001354939) cullin-4A isoform 2
CUL4A at chr13:113209613-113267108 - (NM_001008895) cullin-4A isoform 1

Non-Human RefSeq Genes

cul4a at chr13:113209736-113263582 - (NM_201027) cullin-4A
cul4a at chr13:113209628-113263582 - (NM_001015893) cullin-4A
Cul4a at chr13:113209616-113263598 - (NM_001127301) cullin-4A
Cul4a at chr13:113209616-113264950 - (NM_001363450) cullin-4A isoform 3
Cul4a at chr13:113209616-113264950 - (NM_001363448) cullin-4A isoform 2
Cul4a at chr13:113209616-113264950 - (NM_146207) cullin-4A isoform 1

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209613-113267108

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209613-113267108
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CUL4A at chr13:113208193-113265072
CUL4A at chr13:113208694-113265072
CUL4A at chr13:113208772-113265077
CUL4A at chr13:113208836-113267108
CUL4A at chr13:113209544-113263582
CUL4A at chr13:113209600-113230212
CUL4A at chr13:113209616-113219812
CUL4A at chr13:113209630-113228017
CUL4A at chr13:113209833-113230030
CUL4A at chr13:113209883-113235145
CUL4A at chr13:113244223-113254775
CUL4A at chr13:113245956-113263559

Retroposed Genes V9, Including Pseudogenes

CUL4A at chr4:116426421-116430892 - (NM_001278514.1-3)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Cul4a_48089 at chr13:113208772-113265078
Cul4a_69916 at chr13:113208772-113265078

Human Aligned mRNA Search Results

U58090 - Homo sapiens CUL4A (CUL4A) mRNA, partial cds.
AB178950 - Homo sapiens CUL4A mRNA for cullin-4A, complete cds.
AF077188 - Homo sapiens cullin 4A (CUL4A) mRNA, complete cds.
AY365124 - Homo sapiens cullin 4A (CUL4A) mRNA, complete cds.
BC008308 - Homo sapiens cullin 4A, mRNA (cDNA clone MGC:15238 IMAGE:3537176), complete cds.
AK314835 - Homo sapiens cDNA, FLJ95721, highly similar to Homo sapiens cullin 4A (CUL4A), mRNA.

Non-Human Aligned mRNA Search Results

BC123909 - Xenopus tropicalis cullin 4A, mRNA (cDNA clone MGC:144998 IMAGE:7691148), complete cds.
BC165630 - Danio rerio cullin 4A, mRNA (cDNA clone MGC:192718 IMAGE:100061179), complete cds.
BC024113 - Mus musculus cullin 4A, mRNA (cDNA clone MGC:36573 IMAGE:5097944), complete cds.
BC054607 - Danio rerio cullin 4A, mRNA (cDNA clone MGC:64071 IMAGE:6794393), complete cds.
BC010211 - Mus musculus cullin 4A, mRNA (cDNA clone MGC:11743 IMAGE:3969515), complete cds.
DQ147981 - Macaca mulatta clone dl1_a12_t7_112 cullin 4A (CUL4A) mRNA, 3' UTR.
HQ890137 - Equus caballus clone 08_b02 cullin-4A-like protein (CUL4A) mRNA, partial cds.
AF508033 - Equus caballus cullin 4A (CUL4A) mRNA, partial cds.
AY892461 - Synthetic construct Homo sapiens clone FLH024180.01L cullin 4A (CUL4A) mRNA, partial cds.
JU336744 - TSA: Macaca mulatta Mamu_523410 mRNA sequence.
JU477512 - TSA: Macaca mulatta Mamu_369093 mRNA sequence.
JV048459 - TSA: Macaca mulatta Mamu_425038 mRNA sequence.