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Gencode Genes

CSF1R (ENST00000286301.7) at chr5:150053291-150113372 - Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 1, mRNA. (from RefSeq NM_005211)
CSF1R (ENST00000543093.1) at chr5:150070540-150086427 - Tyrosine-protein kinase that acts as cell-surface  receptor for CSF1 and IL34 and plays an essential role in the  regulation of survival, proliferation and differentiation of  hematopoietic precursor cells, especially mononuclear phagocytes,  such as macrophages and monocytes. Promotes the release of  proinflammatory chemokines in response to IL34 and CSF1, and  thereby plays an important role in innate immunity and in  inflammatory processes. Plays an important role in the regulation  of osteoclast proliferation and differentiation, the regulation of  bone resorption, and is required for normal bone and tooth  development. Required for normal male and female fertility, and  for normal development of milk ducts and acinar structures in the  mammary gland during pregnancy. Promotes reorganization of the  actin cytoskeleton, regulates formation of membrane ruffles, cell  adhesion and cell migration, and promotes cancer cell invasion.  Activates several signaling pathways in response to ligand  binding. Phosphorylates PIK3R1, PLCG2, GRB2, SLA2 and CBL.  Activation of PLCG2 leads to the production of the cellular  signaling molecules diacylglycerol and inositol 1,4,5-  trisphosphate, that then lead to the activation of protein kinase  C family members, especially PRKCD. Phosphorylation of PIK3R1, the  regulatory subunit of phosphatidylinositol 3-kinase, leads to  activation of the AKT1 signaling pathway. Activated CSF1R also  mediates activation of the MAP kinases MAPK1/ERK2 and/or  MAPK3/ERK1, and of the SRC family kinases SRC, FYN and YES1.  Activated CSF1R transmits signals both via proteins that directly  interact with phosphorylated tyrosine residues in its  intracellular domain, or via adapter proteins, such as GRB2.  Promotes activation of STAT family members STAT3, STAT5A and/or  STAT5B. Promotes tyrosine phosphorylation of SHC1 and INPP5D/SHIP-  1. Receptor signaling is down-regulated by protein phosphatases,  such as INPP5D/SHIP-1, that dephosphorylate the receptor and its  downstream effectors, and by rapid internalization of the  activated receptor. (from UniProt P07333)
CSF1R (ENST00000515239.5) at chr5:150059778-150067181 - colony stimulating factor 1 receptor (from HGNC CSF1R)
CSF1R (ENST00000515068.1) at chr5:150056026-150061668 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YAL5)
CSF1R (ENST00000513609.1) at chr5:150059778-150067181 - colony stimulating factor 1 receptor (from HGNC CSF1R)
CSF1R (ENST00000511344.1) at chr5:150080052-150113372 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt D6RGW1)
CSF1R (ENST00000509861.1) at chr5:150053838-150054820 - colony stimulating factor 1 receptor (from HGNC CSF1R)
CSF1R (ENST00000504875.5) at chr5:150053291-150086590 - Homo sapiens colony stimulating factor 1 receptor (CSF1R), transcript variant 3, non-coding RNA. (from RefSeq NR_109969)
CSF1R (ENST00000502660.5) at chr5:150076904-150086554 - colony stimulating factor 1 receptor (from HGNC CSF1R)
YES1 (ENST00000584307.5) at chr18:721588-812546 - Non-receptor protein tyrosine kinase that is involved in  the regulation of cell growth and survival, apoptosis, cell-cell  adhesion, cytoskeleton remodeling, and differentiation.  Stimulation by receptor tyrosine kinases (RTKs) including EGRF,  PDGFR, CSF1R and FGFR leads to recruitment of YES1 to the  phosphorylated receptor, and activation and phosphorylation of  downstream substrates. Upon EGFR activation, promotes the  phosphorylation of PARD3 to favor epithelial tight junction  assembly. Participates in the phosphorylation of specific  junctional components such as CTNND1 by stimulating the FYN and  FER tyrosine kinases at cell-cell contacts. Upon T-cell  stimulation by CXCL12, phosphorylates collapsin response mediator  protein 2/DPYSL2 and induces T-cell migration. Participates in  CD95L/FASLG signaling pathway and mediates AKT-mediated cell  migration. Plays a role in cell cycle progression by  phosphorylating the cyclin-dependent kinase 4/CDK4 thus regulating  the G1 phase. Also involved in G2/M progression and cytokinesis. (from UniProt P07947)
IL34 (ENST00000288098.6) at chr16:70646565-70660682 - Homo sapiens interleukin 34 (IL34), transcript variant 3, mRNA. (from RefSeq NM_001172772)
IL34 (ENST00000429149.6) at chr16:70579895-70660682 - Homo sapiens interleukin 34 (IL34), transcript variant 1, mRNA. (from RefSeq NM_152456)
STAP2 (ENST00000600324.5) at chr19:4324043-4338821 - Homo sapiens signal transducing adaptor family member 2 (STAP2), transcript variant 1, mRNA. (from RefSeq NM_017720)
STAP2 (ENST00000594605.5) at chr19:4324043-4338877 - Homo sapiens signal transducing adaptor family member 2 (STAP2), transcript variant 2, mRNA. (from RefSeq NM_001013841)
FIZ1 (ENST00000221665.5) at chr19:55591376-55599517 - Homo sapiens FLT3 interacting zinc finger 1 (FIZ1), mRNA. (from RefSeq NM_032836)
SLA2 (ENST00000360672.2) at chr20:36612519-36645881 - Homo sapiens Src like adaptor 2 (SLA2), transcript variant 2, mRNA. (from RefSeq NM_175077)
SLA2 (ENST00000262866.9) at chr20:36612318-36646196 - Homo sapiens Src like adaptor 2 (SLA2), transcript variant 1, mRNA. (from RefSeq NM_032214)
STAP1 (ENST00000396225.1) at chr4:67558728-67607337 - Homo sapiens signal transducing adaptor family member 1 (STAP1), transcript variant 2, mRNA. (from RefSeq NM_001317769)
STAP1 (ENST00000265404.7) at chr4:67558727-67607337 - Homo sapiens signal transducing adaptor family member 1 (STAP1), transcript variant 1, mRNA. (from RefSeq NM_012108)
YES1 (ENST00000314574.5) at chr18:721588-812242 - Homo sapiens YES proto-oncogene 1, Src family tyrosine kinase (YES1), mRNA. (from RefSeq NM_005433)
CSF1 (ENST00000420111.6) at chr1:109910908-109929034 - Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 3, mRNA. (from RefSeq NM_172211)
CSF1 (ENST00000369802.7) at chr1:109910899-109926743 - Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 4, mRNA. (from RefSeq NM_172212)
CSF1 (ENST00000369801.1) at chr1:109910986-109925198 - Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 2, mRNA. (from RefSeq NM_172210)
CSF1 (ENST00000329608.11) at chr1:109910849-109930992 - Homo sapiens colony stimulating factor 1 (CSF1), transcript variant 1, mRNA. (from RefSeq NM_000757)
PIK3R1 (ENST00000521657.5) at chr5:68215776-68298753 - Binds to activated (phosphorylated) protein-Tyr kinases,  through its SH2 domain, and acts as an adapter, mediating the  association of the p110 catalytic unit to the plasma membrane.  Necessary for the insulin-stimulated increase in glucose uptake  and glycogen synthesis in insulin-sensitive tissues. Plays an  important role in signaling in response to FGFR1, FGFR2, FGFR3,  FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB. Likewise, plays a role  in ITGB2 signaling. (from UniProt P27986)
THOC5 (ENST00000490103.5) at chr22:29505879-29553782 - Homo sapiens THO complex 5 (THOC5), transcript variant 4, mRNA. (from RefSeq NM_003678)
THOC5 (ENST00000397873.6) at chr22:29508358-29553766 - Homo sapiens THO complex 5 (THOC5), transcript variant 3, mRNA. (from RefSeq NM_001002877)
THOC5 (ENST00000397872.5) at chr22:29508168-29553655 - Homo sapiens THO complex 5 (THOC5), transcript variant 1, mRNA. (from RefSeq NM_001002878)
THOC5 (ENST00000397871.5) at chr22:29508168-29553655 - Homo sapiens THO complex 5 (THOC5), transcript variant 2, mRNA. (from RefSeq NM_001002879)
PIK3R1 (ENST00000523872.1) at chr5:68292568-68298756 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 4, mRNA. (from RefSeq NM_001242466)
PIK3R1 (ENST00000336483.9) at chr5:68290637-68298583 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 2, mRNA. (from RefSeq NM_181504)
PIK3R1 (ENST00000320694.12) at chr5:68288368-68298583 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 3, mRNA. (from RefSeq NM_181524)
PIK3R1 (ENST00000521381.6) at chr5:68215756-68301821 - Homo sapiens phosphoinositide-3-kinase regulatory subunit 1 (PIK3R1), transcript variant 1, mRNA. (from RefSeq NM_181523)
PLCG2 (ENST00000564138.6) at chr16:81779291-81962685 - Homo sapiens phospholipase C gamma 2 (PLCG2), mRNA. (from RefSeq NM_002661)
CBL (ENST00000264033.5) at chr11:119206276-119308149 - Homo sapiens Cbl proto-oncogene (CBL), mRNA. (from RefSeq NM_005188)
FYN (ENST00000368682.7) at chr6:111660332-111873067 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 2, mRNA. (from RefSeq NM_153047)
FYN (ENST00000354650.7) at chr6:111660332-111873452 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 1, mRNA. (from RefSeq NM_002037)
FYN (ENST00000229471.8) at chr6:111661282-111759131 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 3, mRNA. (from RefSeq NM_153048)
GRB2 (ENST00000648046.1) at chr17:75319479-75405699 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392564.5) at chr17:75318076-75393864 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392563.5) at chr17:75318076-75393656 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392562.5) at chr17:75318076-75405486 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
FYN (ENST00000368667.6) at chr6:111661282-111793886 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 4, mRNA. (from RefSeq NM_001370529)
GRB2 (ENST00000316615.9) at chr17:75318076-75405709 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 2, mRNA. (from RefSeq NM_203506)
GRB2 (ENST00000316804.10) at chr17:75318076-75405678 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1, mRNA. (from RefSeq NM_002086)
FYN (ENST00000368678.8) at chr6:111661286-111873430 - Non-receptor tyrosine-protein kinase that plays a role  in many biological processes including regulation of cell growth  and survival, cell adhesion, integrin-mediated signaling,  cytoskeletal remodeling, cell motility, immune response and axon  guidance. Inactive FYN is phosphorylated on its C-terminal tail  within the catalytic domain. Following activation by PKA, the  protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1  phosphorylation, activation and targeting to focal adhesions.  Involved in the regulation of cell adhesion and motility through  phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-  catenin). Regulates cytoskeletal remodeling by phosphorylating  several proteins including the actin regulator WAS and the  microtubule-associated proteins MAP2 and MAPT. Promotes cell  survival by phosphorylating AGAP2/PIKE-A and preventing its  apoptotic cleavage. Participates in signal transduction pathways  that regulate the integrity of the glomerular slit diaphragm (an  essential part of the glomerular filter of the kidney) by  phosphorylating several slit diaphragm components including NPHS1,  KIRREL and TRPC6. Plays a role in neural processes by  phosphorylating DPYSL2, a multifunctional adapter protein within  the central nervous system, ARHGAP32, a regulator for Rho family  GTPases implicated in various neural functions, and SNCA, a small  pre-synaptic protein. Participates in the downstream signaling  pathways that lead to T-cell differentiation and proliferation  following T-cell receptor (TCR) stimulation. Also participates in  negative feedback regulation of TCR signaling through  phosphorylation of PAG1, thereby promoting interaction between  PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains  LCK and FYN in an inactive form. Promotes CD28-induced  phosphorylation of VAV1. (from UniProt P06241)
FYN (ENST00000538466.5) at chr6:111660332-111720062 - Non-receptor tyrosine-protein kinase that plays a role  in many biological processes including regulation of cell growth  and survival, cell adhesion, integrin-mediated signaling,  cytoskeletal remodeling, cell motility, immune response and axon  guidance. Inactive FYN is phosphorylated on its C-terminal tail  within the catalytic domain. Following activation by PKA, the  protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1  phosphorylation, activation and targeting to focal adhesions.  Involved in the regulation of cell adhesion and motility through  phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-  catenin). Regulates cytoskeletal remodeling by phosphorylating  several proteins including the actin regulator WAS and the  microtubule-associated proteins MAP2 and MAPT. Promotes cell  survival by phosphorylating AGAP2/PIKE-A and preventing its  apoptotic cleavage. Participates in signal transduction pathways  that regulate the integrity of the glomerular slit diaphragm (an  essential part of the glomerular filter of the kidney) by  phosphorylating several slit diaphragm components including NPHS1,  KIRREL and TRPC6. Plays a role in neural processes by  phosphorylating DPYSL2, a multifunctional adapter protein within  the central nervous system, ARHGAP32, a regulator for Rho family  GTPases implicated in various neural functions, and SNCA, a small  pre-synaptic protein. Participates in the downstream signaling  pathways that lead to T-cell differentiation and proliferation  following T-cell receptor (TCR) stimulation. Also participates in  negative feedback regulation of TCR signaling through  phosphorylation of PAG1, thereby promoting interaction between  PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains  LCK and FYN in an inactive form. Promotes CD28-induced  phosphorylation of VAV1. (from UniProt P06241)
INPPL1 (ENST00000298229.7) at chr11:72224767-72239147 - Homo sapiens inositol polyphosphate phosphatase like 1 (INPPL1), mRNA. (from RefSeq NM_001567)
INPPL1 (ENST00000538751.5) at chr11:72227881-72239105 - Phosphatidylinositol (PtdIns) phosphatase that  specifically hydrolyzes the 5-phosphate of phosphatidylinositol-  3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2,  thereby negatively regulating the PI3K (phosphoinositide 3-kinase)  pathways. Plays a central role in regulation of PI3K-dependent  insulin signaling, although the precise molecular mechanisms and  signaling pathways remain unclear. While overexpression reduces  both insulin-stimulated MAP kinase and Akt activation, its absence  does not affect insulin signaling or GLUT4 trafficking. Confers  resistance to dietary obesity. May act by regulating AKT2, but not  AKT1, phosphorylation at the plasma membrane. Part of a signaling  pathway that regulates actin cytoskeleton remodeling. Required for  the maintenance and dynamic remodeling of actin structures as well  as in endocytosis, having a major impact on ligand-induced EGFR  internalization and degradation. Participates in regulation of  cortical and submembraneous actin by hydrolyzing PtdIns(3,4,5)P3  thereby regulating membrane ruffling. Regulates cell adhesion and  cell spreading. Required for HGF-mediated lamellipodium formation,  cell scattering and spreading. Acts as a negative regulator of  EPHA2 receptor endocytosis by inhibiting via PI3K-dependent Rac1  activation. Acts as a regulator of neuritogenesis by regulating  PtdIns(3,4,5)P3 level and is required to form an initial  protrusive pattern, and later, maintain proper neurite outgrowth.  Acts as a negative regulator of the FC-gamma-RIIA receptor  (FCGR2A). Mediates signaling from the FC-gamma-RIIB receptor  (FCGR2B), playing a central role in terminating signal  transduction from activating immune/hematopoietic cell receptor  systems. Involved in EGF signaling pathway. Upon stimulation by  EGF, it is recruited by EGFR and dephosphorylates PtdIns(3,4,5)P3.  Plays a negative role in regulating the PI3K-PKB pathway, possibly  by inhibiting PKB activity. Down-regulates Fc-gamma-R-mediated  phagocytosis in macrophages independently of INPP5D/SHIP1. In  macrophages, down-regulates NF-kappa-B-dependent gene  transcription by regulating macrophage colony-stimulating factor  (M-CSF)-induced signaling. May also hydrolyze PtdIns(1,3,4,5)P4,  and could thus affect the levels of the higher inositol  polyphosphates like InsP6. (from UniProt O15357)
SRC (ENST00000373578.6) at chr20:37346154-37406050 - Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase (SRC), transcript variant 2, mRNA. (from RefSeq NM_198291)
SRC (ENST00000373567.6) at chr20:37383668-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000373558.2) at chr20:37384150-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000358208.8) at chr20:37382604-37405432 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NR_109969.1 at chr5:150053291-150086640
NM_001288705.2 at chr5:150053291-150086703
NM_001349736.1 at chr5:150053291-150092624
NM_005211.3 at chr5:150053291-150113372

RefSeq Genes

CSF1R at chr5:150053291-150113372 - (NM_005211) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150053291-150086703 - (NM_001288705) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150053291-150092624 - (NM_001349736) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150053291-150086640 - (NR_109969) 

Non-Human RefSeq Genes

CSF1R at chr5:150054352-150061852 - (NM_001193260) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150054069-150086427 - (NM_001242447) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150053371-150086572 - (NM_001075403) macrophage colony-stimulating factor 1 receptor precursor
Csf1r at chr5:150053294-150081022 - (NM_001029901) macrophage colony-stimulating factor 1 receptor precursor
CSF1R at chr5:150053320-150086493 - (NM_001009231) macrophage colony-stimulating factor 1 receptor precursor
Csf1r at chr5:150053294-150081025 - (NM_001037859) macrophage colony-stimulating factor 1 receptor precursor

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CSF1R at chr5:150053291-150113372
CSF1R at chr5:150070540-150086427

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CSF1R at chr5:150053291-150086590
CSF1R at chr5:150053291-150113372
CSF1R at chr5:150053838-150054820
CSF1R at chr5:150056026-150061668
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150059778-150067181
CSF1R at chr5:150070540-150086427
CSF1R at chr5:150076904-150086554
CSF1R at chr5:150080052-150113372

International Knockout Mouse Consortium Genes Mapped to Human Genome

Csf1r_40865 at chr5:150053291-150113372

Alias of STS Marker

CSF1R at chr5:150023037-150223220 - (CSF1R)

Human Aligned mRNA Search Results

EU826593 - Homo sapiens soluble CSF1R variant 1 (CSF1R) mRNA, complete cds, alternatively spliced.
BC129939 - Homo sapiens colony stimulating factor 1 receptor, mRNA (cDNA clone IMAGE:40117738), partial cds.
BC047521 - Homo sapiens colony stimulating factor 1 receptor, mRNA (cDNA clone MGC:26296 IMAGE:4819527), complete cds.

Non-Human Aligned mRNA Search Results

BC107475 - Rattus norvegicus colony stimulating factor 1 receptor, mRNA (cDNA clone IMAGE:7444694), complete cds.
BC153265 - Bos taurus colony stimulating factor 1 receptor, mRNA (cDNA clone MGC:179322 IMAGE:8168377), complete cds.
JT409827 - TSA: Ictalurus punctatus clc_366732 mRNA sequence.
JT417598 - TSA: Ictalurus punctatus vet_k71:11328 mRNA sequence.
AB457039 - Paralichthys olivaceus csf1r mRNA for colony stimulating factor 1 receptor, partial cds.
AB546838 - Paralichthys olivaceus csf1r mRNA for colony stimulating factor 1 receptor, partial cds.
MH384789 - Botia dario colony stimulating factor 1 receptor (csf1r) mRNA, partial cds.
BC036343 - Mus musculus colony stimulating factor 1 receptor, mRNA (cDNA clone MGC:36110 IMAGE:4948135), complete cds.
BC043054 - Mus musculus colony stimulating factor 1 receptor, mRNA (cDNA clone MGC:57956 IMAGE:6418718), complete cds.
BC066863 - Mus musculus colony stimulating factor 1 receptor, mRNA (cDNA clone MGC:76728 IMAGE:30436119), complete cds.
BT025482 - Bos taurus colony stimulating factor 1 receptor, formerly McDonough feline sarcoma viral (v-fms) oncogene homolog (CSF1R), mRNA, complete cds.
AY890719 - Synthetic construct Homo sapiens clone FLH147935.01L colony stimulating factor 1 receptor (CSF1R) mRNA, complete cds.
JU333045 - TSA: Macaca mulatta Mamu_520674 mRNA sequence.
GQ249407 - Taeniopygia guttata colony-stimulating factor 1 receptor (CSF1R) mRNA, complete cds.

GeneReviews

CSF1R-Related Adult-Onset Leukoencephalopathy with Axonal Spheroids and Pigmented Glia at chr5:150053291-150113372 - (CSF1R)