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Gencode Genes

COPS2 (ENST00000388901.10) at chr15:49122727-49155599 - Homo sapiens COP9 signalosome subunit 2 (COPS2), transcript variant 1, mRNA. (from RefSeq NM_004236)
COPS2 (ENST00000561248.1) at chr15:49134083-49155604 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YM03)
COPS2 (ENST00000560240.5) at chr15:49106068-49130773 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YMC2)
COPS2 (ENST00000559016.1) at chr15:49134135-49137459 - COP9 signalosome subunit 2 (from HGNC COPS2)
COPS2 (ENST00000558843.5) at chr15:49134033-49155590 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YKU5)
COPS2 (ENST00000558545.1) at chr15:49139258-49155604 - COP9 signalosome subunit 2 (from HGNC COPS2)
COPS2 (ENST00000542928.5) at chr15:49127536-49155604 - Contains 1 PCI domain. (from UniProt B4DIH5)
COPS2 (ENST00000299259.10) at chr15:49127350-49155661 - Homo sapiens COP9 signalosome subunit 2 (COPS2), transcript variant 2, mRNA. (from RefSeq NM_001143887)
NIF3L1 (ENST00000651500.1) at chr2:200889369-200903938 - Homodimer. Interacts with COPS2 (By similarity).  Interacts with THOC7. (from UniProt Q9GZT8)
NIF3L1 (ENST00000409357.5) at chr2:200889415-200903896 - Homo sapiens NGG1 interacting factor 3 like 1 (NIF3L1), transcript variant 6, mRNA. (from RefSeq NM_001369442)
NIF3L1 (ENST00000409020.5) at chr2:200889385-200903930 - Homo sapiens NGG1 interacting factor 3 like 1 (NIF3L1), transcript variant 9, mRNA. (from RefSeq NM_001369445)
NIF3L1 (ENST00000409588.1) at chr2:200891917-200903925 - Homo sapiens NGG1 interacting factor 3 like 1 (NIF3L1), transcript variant 4, mRNA. (from RefSeq NM_001142356)
NIF3L1 (ENST00000359683.8) at chr2:200889388-200903930 - Homo sapiens NGG1 interacting factor 3 like 1 (NIF3L1), transcript variant 2, mRNA. (from RefSeq NM_021824)
COPS7B (ENST00000410024.5) at chr2:231781671-231807724 - Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript variant 7, mRNA. (from RefSeq NM_001369483)
COPS7B (ENST00000620578.4) at chr2:231786383-231809254 - Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript variant 5, mRNA. (from RefSeq NM_001282952)
COPS7B (ENST00000373608.7) at chr2:231786448-231809253 - Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript variant 1, mRNA. (from RefSeq NM_001282950)
COPS7B (ENST00000350033.7) at chr2:231786414-231809253 - Homo sapiens COP9 signalosome subunit 7B (COPS7B), transcript variant 2, mRNA. (from RefSeq NM_022730)
COPS7A (ENST00000539735.5) at chr12:6724079-6731828 - Homo sapiens COP9 signalosome subunit 7A (COPS7A), transcript variant 3, mRNA. (from RefSeq NM_001164095)
COPS7A (ENST00000543155.6) at chr12:6724046-6731865 - Homo sapiens COP9 signalosome subunit 7A (COPS7A), transcript variant 4, mRNA. (from RefSeq NM_016319)
COPS7A (ENST00000534947.5) at chr12:6724287-6731875 - Homo sapiens COP9 signalosome subunit 7A (COPS7A), transcript variant 1, mRNA. (from RefSeq NM_001164093)
COPS3 (ENST00000539941.6) at chr17:17246820-17280777 - Homo sapiens COP9 signalosome subunit 3 (COPS3), transcript variant 7, mRNA. (from RefSeq NM_001316358)
COPS3 (ENST00000268717.10) at chr17:17246616-17281246 - Homo sapiens COP9 signalosome subunit 3 (COPS3), transcript variant 1, mRNA. (from RefSeq NM_003653)
NR0B1 (ENST00000378970.5) at chrX:30304206-30309390 - Homo sapiens nuclear receptor subfamily 0 group B member 1 (NR0B1), mRNA. (from RefSeq NM_000475)
COPS7B (ENST00000409091.5) at chr2:231781685-231807695 - Component of the COP9 signalosome complex (CSN), a  complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl)  conjugation pathway by mediating the deneddylation of the cullin  subunits of SCF-type E3 ligase complexes, leading to decrease the  Ubl ligase activity of SCF-type complexes such as SCF, CSA or  DDB2. The complex is also involved in phosphorylation of p53/TP53,  JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via  its association with CK2 and PKD kinases. CSN-dependent  phosphorylation of TP53 and JUN promotes and protects degradation  by the Ubl system, respectively. (from UniProt Q9H9Q2)
COPS4 (ENST00000509093.5) at chr4:83034447-83075789 - Homo sapiens COP9 signalosome subunit 4 (COPS4), transcript variant 2, mRNA. (from RefSeq NM_001258006)
COPS4 (ENST00000264389.7) at chr4:83035183-83075818 - Homo sapiens COP9 signalosome subunit 4 (COPS4), transcript variant 1, mRNA. (from RefSeq NM_016129)
COPS8 (ENST00000392008.6) at chr2:237085882-237098618 - Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 2, mRNA. (from RefSeq NM_198189)
COPS7A (ENST00000534877.5) at chr12:6724298-6731842 - Component of the COP9 signalosome complex (CSN), a  complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl)  conjugation pathway by mediating the deneddylation of the cullin  subunits of SCF-type E3 ligase complexes, leading to decrease the  Ubl ligase activity of SCF-type complexes such as SCF, CSA or  DDB2. The complex is also involved in phosphorylation of p53/TP53,  JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via  its association with CK2 and PKD kinases. CSN-dependent  phosphorylation of TP53 and JUN promotes and protects degradation  by the Ubl system, respectively. (from UniProt Q9UBW8)
COPS8 (ENST00000354371.7) at chr2:237085889-237100474 - Homo sapiens COP9 signalosome subunit 8 (COPS8), transcript variant 1, mRNA. (from RefSeq NM_006710)
NR2F1 (ENST00000327111.8) at chr5:93583222-93594611 - Homo sapiens nuclear receptor subfamily 2 group F member 1 (NR2F1), mRNA. (from RefSeq NM_005654)
COPS7A (ENST00000229251.7) at chr12:6724071-6731807 - Component of the COP9 signalosome complex (CSN), a  complex involved in various cellular and developmental processes.  The CSN complex is an essential regulator of the ubiquitin (Ubl)  conjugation pathway by mediating the deneddylation of the cullin  subunits of SCF-type E3 ligase complexes, leading to decrease the  Ubl ligase activity of SCF-type complexes such as SCF, CSA or  DDB2. The complex is also involved in phosphorylation of p53/TP53,  JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via  its association with CK2 and PKD kinases. CSN-dependent  phosphorylation of TP53 and JUN promotes and protects degradation  by the Ubl system, respectively. (from UniProt Q9UBW8)
GPS1 (ENST00000392358.6) at chr17:82051958-82057470 - Homo sapiens G protein pathway suppressor 1 (GPS1), transcript variant 1, mRNA. (from RefSeq NM_212492)
GPS1 (ENST00000578552.5) at chr17:82051865-82057470 - Homo sapiens G protein pathway suppressor 1 (GPS1), transcript variant 6, mRNA. (from RefSeq NM_001321092)
GPS1 (ENST00000306823.10) at chr17:82051909-82057470 - Homo sapiens G protein pathway suppressor 1 (GPS1), transcript variant 2, mRNA. (from RefSeq NM_004127)
CUL2 (ENST00000374751.7) at chr10:35008551-35090642 - Homo sapiens cullin 2 (CUL2), transcript variant 6, mRNA. (from RefSeq NM_001324376)
CUL2 (ENST00000421317.4) at chr10:35010292-35074288 - Homo sapiens cullin 2 (CUL2), transcript variant 1, mRNA. (from RefSeq NM_001198778)
CUL2 (ENST00000374749.7) at chr10:35008551-35090366 - Homo sapiens cullin 2 (CUL2), transcript variant 3, mRNA. (from RefSeq NM_003591)
IRF8 (ENST00000268638.10) at chr16:85899162-85922606 - Homo sapiens interferon regulatory factor 8 (IRF8), transcript variant 2, mRNA. (from RefSeq NM_002163)
COPS6 (ENST00000303904.8) at chr7:100088969-100092187 - Homo sapiens COP9 signalosome subunit 6 (COPS6), mRNA. (from RefSeq NM_006833)
CUL2 (ENST00000374748.5) at chr10:35008551-35090364 - Core component of multiple cullin-RING-based ECS  (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase  complexes, which mediate the ubiquitination of target proteins.  May serve as a rigid scaffold in the complex and may contribute to  catalysis through positioning of the substrate and the ubiquitin-  conjugating enzyme. The E3 ubiquitin-protein ligase activity of  the complex is dependent on the neddylation of the cullin subunit  and is inhibited by the association of the deneddylated cullin  subunit with TIP120A/CAND1 (By similarity). The functional  specificity of the ECS complex depends on the substrate  recognition component. ECS(VHL) mediates the ubiquitination of  hypoxia-inducible factor (HIF). (from UniProt Q13617)
COPS5 (ENST00000357849.9) at chr8:67043079-67062133 - Homo sapiens COP9 signalosome subunit 5 (COPS5), mRNA. (from RefSeq NM_006837)
CUL1 (ENST00000602748.5) at chr7:148698645-148801025 - Homo sapiens cullin 1 (CUL1), transcript variant 5, mRNA. (from RefSeq NM_001370663)
CUL1 (ENST00000325222.9) at chr7:148698903-148801110 - Homo sapiens cullin 1 (CUL1), transcript variant 1, mRNA. (from RefSeq NM_003592)
CUL1 (ENST00000409469.5) at chr7:148697914-148800582 - Core component of multiple cullin-RING-based SCF (SKP1-  CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which  mediate the ubiquitination of proteins involved in cell cycle  progression, signal transduction and transcription. In the SCF  complex, serves as a rigid scaffold that organizes the SKP1-F-box  protein and RBX1 subunits. May contribute to catalysis through  positioning of the substrate and the ubiquitin-conjugating enzyme.  The E3 ubiquitin-protein ligase activity of the complex is  dependent on the neddylation of the cullin subunit and is  inhibited by the association of the deneddylated cullin subunit  with TIP120A/CAND1. The functional specificity of the SCF complex  depends on the F-box protein as substrate recognition component.  SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and  participate in Wnt signaling. SCF(FBXW11) directs ubiquitination  of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of  NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably  NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated  CDKN1B/p27kip and is involved in regulation of G1/S transition.  SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4,  CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7)  directs ubiquitination of cyclin E, NOTCH1 released notch  intracellular domain (NICD), and probably PSEN1. SCF(FBXW2)  directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination  of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5.  SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not  seem to direct ubiquitination of TP53. SCF(BTRC) mediates the  ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'; the degradation  frees the associated NFKB1-RELA dimer to translocate into the  nucleus and to activate transcription. SCF(Cyclin F) directs  ubiquitination of CP110 (By similarity). (from UniProt Q13616)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001143887.1 at chr15:49125274-49155657
NM_004236.3 at chr15:49125274-49155657

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

COPS2 at chr15:49122727-49155599

RefSeq Genes

COPS2 at chr15:49122727-49155599 - (NM_001143887) COP9 signalosome complex subunit 2 isoform 2
COPS2 at chr15:49122727-49155599 - (NM_004236) COP9 signalosome complex subunit 2 isoform 1

Non-Human RefSeq Genes

COPS2 at chr15:49127874-49155590 - (NM_001105301) COP9 signalosome complex subunit 2
COPS2 at chr15:49125274-49155648 - (NM_001193601) COP9 signalosome complex subunit 2
cops2 at chr15:49127356-49155587 - (NM_001015820) COP9 signalosome complex subunit 2
COPS2 at chr15:49127413-49155587 - (NM_001031596) COP9 signalosome complex subunit 2
Cops2 at chr15:49127353-49155625 - (NM_153297) COP9 signalosome complex subunit 2
Cops2 at chr15:49126031-49155651 - (NM_001285507) COP9 signalosome complex subunit 2 isoform a
Cops2 at chr15:49126031-49155651 - (NM_001285512) COP9 signalosome complex subunit 2 isoform c
Cops2 at chr15:49126031-49155651 - (NM_009939) COP9 signalosome complex subunit 2 isoform b
Cops2 at chr15:49126031-49155651 - (NM_001285513) COP9 signalosome complex subunit 2 isoform c
cops2 at chr15:49127944-49155587 - (NM_001002055) COP9 signalosome complex subunit 2
COPS2 at chr15:49125310-49155644 - (NM_001076279) COP9 signalosome complex subunit 2
cops2.L at chr15:49127356-49155587 - (NM_001091775) COP9 signalosome complex subunit 2

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

COPS2 at chr15:49122727-49155599
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122727-49155599
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

COPS2 at chr15:49106068-49130773
COPS2 at chr15:49122728-49155652
COPS2 at chr15:49127350-49155661
COPS2 at chr15:49127536-49155604
COPS2 at chr15:49134033-49155590
COPS2 at chr15:49134083-49155604
COPS2 at chr15:49134135-49137459
COPS2 at chr15:49139258-49155604

Retroposed Genes V9, Including Pseudogenes

COPS2 at chr9:123061881-123063261 - (CU680379.1-2)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Cops2_27180 at chr15:49125274-49155657
Cops2_27181 at chr15:49125274-49155657
Cops2_27182 at chr15:49125274-49155657
Cops2_79292 at chr15:49125274-49155657
Cops2_80526 at chr15:49125274-49155657
Cops2_89979 at chr15:49125274-49155657

Human Aligned mRNA Search Results

BC012629 - Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), mRNA (cDNA clone MGC:13684 IMAGE:4245220), complete cds.
AK312643 - Homo sapiens cDNA, FLJ93029, highly similar to Homo sapiens COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis) (COPS2), mRNA.

Non-Human Aligned mRNA Search Results

BC023096 - Mus musculus COP9 (constitutive photomorphogenic) homolog, subunit 2 (Arabidopsis thaliana), mRNA (cDNA clone MGC:18349 IMAGE:3675508), complete cds.
BC061864 - Rattus norvegicus COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), mRNA (cDNA clone MGC:72285 IMAGE:5597874), complete cds.
BC071320 - Danio rerio COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), mRNA (cDNA clone MGC:86624 IMAGE:6892859), complete cds.
EF468514 - Sus scrofa COP9 constitutive photomorphogenic-like subunit 2 (COPS2) mRNA, complete cds.
BC114035 - Bos taurus COP9 constitutive photomorphogenic homolog subunit 2 (Arabidopsis), mRNA (cDNA clone MGC:137288 IMAGE:8017545), complete cds.
AF071312 - Mus musculus COP9 complex subunit 2 (COPS2) mRNA, complete cds.
JU337117 - TSA: Macaca mulatta Mamu_505154 mRNA sequence.
JU337118 - TSA: Macaca mulatta Mamu_505156 mRNA sequence.
JU337119 - TSA: Macaca mulatta Mamu_505158 mRNA sequence.
JU337120 - TSA: Macaca mulatta Mamu_505155 mRNA sequence.
JU473340 - TSA: Macaca mulatta Mamu_386307 mRNA sequence.
JU473341 - TSA: Macaca mulatta Mamu_386308 mRNA sequence.