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Gencode Genes

CDC42 (ENST00000656825.1) at chr1:22052709-22101360 - <b>CDC42</b> ENST00000656825.1 Homo sapiens cell division cycle 42 CDC42 transcript 
CDC42-AS1 (ENST00000649486.1) at chr1:22028317-22052927 - <b>CDC42-AS1</b> ENST00000649486.1 CDC42-AS1 from geneSymbol uc285gco.1 uc285gco.1 
CDC42-IT1 (ENST00000431803.2) at chr1:22059197-22064199 - <b>CDC42-IT1</b> ENST00000431803.2 CDC42 intronic transcript 1 from HGNC CDC42-IT1 AF086337 
CDC42SE1 (ENST00000357235.6) at chr1:151050985-151059622 - CDC42SE1 ENST00000357235.6 Homo sapiens <b>CDC42</b> small effector 1 CDC42SE1 transcript variant 2 mRNA from 
CDC42EP3 (ENST00000295324.4) at chr2:37641944-37671642 - CDC42EP3 ENST00000295324.4 Homo sapiens <b>CDC42</b> effector protein 3 CDC42EP3 transcript variant 1 mRNA from 
CDC42SE2 (ENST00000505065.2) at chr5:131264053-131394672 - CDC42SE2 ENST00000505065.2 Homo sapiens <b>CDC42</b> small effector 2 CDC42SE2 transcript variant 5 mRNA from 
CDC42BPG (ENST00000342711.6) at chr11:64823052-64844653 - CDC42BPG ENST00000342711.6 Homo sapiens <b>CDC42</b> binding protein kinase gamma CDC42BPG mRNA from RefSeq NM_017525 
CDC42EP2 (ENST00000279249.3) at chr11:65314866-65322417 - CDC42EP2 ENST00000279249.3 Homo sapiens <b>CDC42</b> effector protein 2 CDC42EP2 mRNA from RefSeq NM_006779 B2RD85 
CDC42BPB (ENST00000361246.7) at chr14:102932380-103057549 - CDC42BPB ENST00000361246.7 Homo sapiens <b>CDC42</b> binding protein kinase beta CDC42BPB mRNA from RefSeq NM_006035 
CDC42EP4 (ENST00000335793.4) at chr17:73283624-73312001 - CDC42EP4 ENST00000335793.4 Homo sapiens <b>CDC42</b> effector protein 4 CDC42EP4 mRNA from RefSeq NM_012121 BORG4 
CDC42EP5 (ENST00000301200.3) at chr19:54465026-54473296 - CDC42EP5 ENST00000301200.3 Homo sapiens <b>CDC42</b> effector protein 5 CDC42EP5 mRNA from RefSeq NM_145057 B0VJZ2 
CDC42EP1 (ENST00000249014.5) at chr22:37560480-37569405 - CDC42EP1 ENST00000249014.5 Homo sapiens <b>CDC42</b> effector protein 1 CDC42EP1 mRNA from RefSeq NM_152243 A8K825 
ARHGEF9 (ENST00000671741.2) at chrX:63634967-63785214 - ARHGEF9 ENST00000671741.2 Homo sapiens <b>Cdc42</b> guanine nucleotide exchange factor 9 ARHGEF9 transcript variant 6 
CDC42EP5 (ENST00000617756.1) at chr19_GL949746v1_alt:371539-379675 - CDC42EP5 ENST00000617756.1 Homo sapiens <b>CDC42</b> effector protein 5 CDC42EP5 mRNA from RefSeq NM_145057 B0VJZ2 
CDC42EP5 (ENST00000611094.1) at chr19_GL949752v1_alt:369718-377930 - CDC42EP5 ENST00000611094.1 Homo sapiens <b>CDC42</b> effector protein 5 CDC42EP5 mRNA from RefSeq NM_145057 B0VJZ2 
CDC42EP5 (ENST00000619217.1) at chr19_KI270938v1_alt:447324-455525 - CDC42EP5 ENST00000619217.1 Homo sapiens <b>CDC42</b> effector protein 5 CDC42EP5 mRNA from RefSeq NM_145057 B0VJZ2 
ARHGEF6 (ENST00000250617.7) at chrX:136665550-136780932 - ARHGEF6 ENST00000250617.7 Homo sapiens Rac <b>Cdc42</b> guanine nucleotide exchange factor 6 ARHGEF6 transcript variant 1 
CDC42BPA (ENST00000366766.8) at chr1:226989865-227318492 -  ... Serine threonine-protein kinase which is an important downstream effector of <b>CDC42</b> and plays a role in the regulation of cytoskeleton 
DOCK11 (ENST00000276202.9) at chrX:118495815-118686147 -  ... uc004eqp.1 uc004eqp.2 uc004eqp.3 uc004eqp.4 Guanine nucleotide-exchange factor GEF that activates <b>CDC42</b> by exchanging bound GDP for free GTP By similarity 
FGD6 (ENST00000343958.9) at chr12:95076749-95217467 -  ... Q9NUR8 Q9P2I5 ZFYVE24 uc001tdp.1 uc001tdp.2 uc001tdp.3 uc001tdp.4 uc001tdp.5 May activate <b>CDC42</b> a member of the Ras-like family of Rho and 
ARHGAP10 (ENST00000336498.8) at chr4:147732088-148072776 -  ... uc003ilf.4 uc003ilf.5 GTPase activator for the small GTPases RhoA and <b>Cdc42</b> by converting them to an inactive GDP-bound state Essential 
FGD5 (ENST00000285046.10) at chr3:14818962-14934571 -  ... Q8IYP3 Q8N861 Q8N8G4 ZFYVE23 uc003bzc.1 uc003bzc.2 uc003bzc.3 uc003bzc.4 uc003bzc.5 Activates <b>CDC42</b> a member of the Ras-like family of Rho and 
FGD3 (ENST00000375482.8) at chr9:92947523-93036233 -  ... uc004asw.2 uc004asw.3 uc004asw.4 Promotes the formation of filopodia May activate <b>CDC42</b> a member of the Ras-like family of Rho and 
FAM168B (ENST00000389915.4) at chr2:131047876-131093460 -  ... neuronal axonal outgrowth by acting as a negative regulator of <b>CDC42</b> and STAT3 and a positive regulator of STMN2 Positive 
DEF6 (ENST00000316637.7) at chr6:35297818-35321771 -  ... guanine nucleotide exchange factor GEF for RAC MIM 602048 and <b>CDC42</b> MIM 116952 that is highly expressed in B and 
GMIP (ENST00000203556.9) at chr19:19629476-19643657 -  ... encodes a member of the ARHGAP family of Rho Rac <b>Cdc42-like</b> GTPase activating proteins The encoded protein interacts with the 
SRGAP3 (ENST00000383836.8) at chr3:8980591-9249646 -  ... uc003brf.2 uc003brf.3 uc003brf.4 uc003brf.5 GTPase-activating protein for RAC1 and perhaps <b>Cdc42</b> but not for RhoA small GTPase May attenuate RAC1 
ARHGAP21 (ENST00000396432.7) at chr10:24583614-24723887 -  ... uc001isb.3 ARHGAP21 functions preferentially as a GTPase-activating protein GAP for <b>CDC42</b> MIM 116952 and regulates the ARP2 3 complex MIM 
ARHGAP30 (ENST00000368013.8) at chr1:161046946-161069891 -  ... GTPase-activating protein GAP for RAC1 and RHOA but not for <b>CDC42</b> Interacts with RHOU in a GTP-independent manner Cytoplasmic vesicle 
SPATA13 (ENST00000382108.8) at chr13:24160720-24307069 -  ... as guanine nucleotide exchange factor GEF for RHOA RAC1 and <b>CDC42</b> GTPases Regulates cell migration and adhesion assembly and disassembly 
SRGAP1 (ENST00000355086.8) at chr12:63844700-64162217 -  ... this gene is a GTPase activator working with the GTPase <b>CDC42</b> to negatively regulate neuronal migration The encoded protein interacts 
PLEKHG2 (ENST00000425673.6) at chr19:39412669-39428415 -  ... encoded by this gene is a RhoGTPase that can activate <b>CDC42</b> by promoting exchange of GDP for GTP on CDC42 
NGEF (ENST00000264051.8) at chr2:232878701-233013256 -  ... factor GEF which differentially activates the GTPases RHOA RAC1 and <b>CDC42</b> Plays a role in axon guidance regulating ephrin-induced growth 
FNBP1L (ENST00000271234.13) at chr1:93448118-93554661 -  ... uc010otk.5 The protein encoded by this gene binds to both <b>CDC42</b> and N-WASP This protein promotes CDC42-induced actin polymerization by 
FNBP1 (ENST00000446176.7) at chr9:129887187-130043189 -  ... of the formin-binding-protein family The protein contains an N-terminal Fer <b>Cdc42-interacting</b> protein 4 CIP4 homology FCH domain followed by a 
FICD (ENST00000552695.6) at chr12:108515277-108521210 -  ... GTPases in vitro by adding AMP to RhoA Rac and <b>Cdc42</b> It is however unclear whether it inactivates GTPases in 
ARHGAP17 (ENST00000673560.1) at chr16_ML143373v1_fix:172872-268852 -  ... proteins such as RHOA MIM 165390 RAC1 MIM 602048 and <b>CDC42</b> MIM 116952 supplied by OMIM Apr 2004 Rho GTPase-activating 
BNIPL (ENST00000368931.8) at chr1:151036586-151047720 -  ... may function as a bridge molecule between BCL2 and ARHGAP1 <b>CDC42</b> in promoting cell death Alternatively spliced transcript variants encoding 
RHOF (ENST00000267205.7) at chr12:121777754-121793688 -  ... of thin actin-rich surface projections called filopodia Functions cooperatively with <b>CDC42</b> and Rac to generate additional structures increasing the diversity 
ARHGAP44 (ENST00000379672.10) at chr17:12789498-12991643 -  ... GDP-bound state Acts as a GTPase activitor in vitro for <b>CDC42</b> and RAC1 Interacts with BST2 via cytoplasmic domain Highly 
PAK2 (ENST00000327134.7) at chr3:196739857-196832647 -  ... that serve as targets for the small GTP binding proteins <b>CDC42</b> and RAC1 and have been implicated in a wide 
PAK5 (ENST00000353224.10) at chr20:9537370-9839076 -  ... PAK family members are known to be effectors of Rac <b>Cdc42</b> GTPases which have been implicated in the regulation of 
FGD2 (ENST00000274963.13) at chr6:37005655-37029069 -  ... cytoskeleton-dependent membrane rearrangements by activating the cell division cycle 42 <b>CDC42</b> protein This gene is expressed in B lymphocytes macrophages 
DOCK7 (ENST00000635253.2) at chr1:62454726-62688386 -  ... toward RAC1 and RAC3 Rho small GTPases but not toward <b>CDC42</b> Several transcript variants encoding different isoforms have been found 
PAK1IP1 (ENST00000644756.2) at chr6_KZ208911v1_fix:205856-220666 -  ... which is activated by binding of small GTPases such as <b>CDC42</b> to an N-terminal regulatory domain PAK1IP1 also binds to 
ARHGAP17 (ENST00000289968.11) at chr16:24919389-25015369 -  ... proteins such as RHOA MIM 165390 RAC1 MIM 602048 and <b>CDC42</b> MIM 116952 supplied by OMIM Apr 2004 Rho GTPase-activating 
PAK4 (ENST00000360442.8) at chr19:39125786-39179404 -  ... They serve as targets for the small GTP binding proteins <b>Cdc42</b> and Rac and have been implicated in a wide 
PAK1IP1 (ENST00000379568.4) at chr6:10694972-10709782 -  ... which is activated by binding of small GTPases such as <b>CDC42</b> to an N-terminal regulatory domain PAK1IP1 also binds to 
PAK1 (ENST00000356341.8) at chr11:77322017-77474094 -  ... they serve as targets for the small GTP binding proteins <b>Cdc42</b> and Rac This specific family member regulates cell motility 
PARD6G (ENST00000353265.8) at chr18:80157232-80247514 -  ... similarity Interacts with PARD3 Probable Interacts with GTP-bound forms of <b>CDC42</b> ARHQ TC10 and RAC1 Interacts with the N-terminal part 
CCPG1 (ENST00000442196.8) at chr15:55355239-55408359 -  ... its transforming activity Does not inhibit activity of MCF2L toward <b>CDC42</b> or activity of MCF2 toward either RHOA or CDC42 
WASL (ENST00000223023.5) at chr7:123681943-123749003 -  ... involved in cytoskeletal organization including cell division control protein 42 <b>CDC42</b> and the actin-related protein-2 3 ARP2 3 complex The 
ITSN1 (ENST00000381318.8) at chr21:33642501-33899861 -  ... recycling This protein has been shown to interact with dynamin <b>CDC42</b> SNAP23 SNAP25 SPIN90 EPS15 EPN1 EPN2 and STN2 Multiple 
FGD4 (ENST00000534526.7) at chr12:32399558-32646050 -  ... domain and it is also involved in the activation of <b>CDC42</b> via the exchange of bound GDP for free GTP 
DOCK6 (ENST00000294618.12) at chr19:11199295-11262524 -  ... role in actin cytoskeletal reorganization by activating the Rho GTPases <b>Cdc42</b> and Rac1 Mutations in this gene are associated with 
WAS (ENST00000376701.5) at chrX:48683799-48691427 -  ... these proteins directly or indirectly associate with the small GTPase <b>Cdc42</b> known to regulate formation of actin filaments and the 
ARHGAP26 (ENST00000645722.2) at chr5:142770377-143229007 -  ... mediates the activity of the GTP binding proteins RhoA and <b>Cdc42</b> Defects in this gene are a cause of juvenile 
STARD8 (ENST00000374599.8) at chrX:68647666-68725836 -  ... by RefSeq Mar 2010 Accelerates GTPase activity of RHOA and <b>CDC42</b> but not RAC1 Stimulates the hydrolysis of phosphatidylinositol 4 
TRIP10 (ENST00000313244.14) at chr19:6739680-6751530 -  ... promotes membrane invagination and the formation of tubules Also promotes <b>CDC42-induced</b> actin polymerization by recruiting WASL N WASP which in 
ARHGAP27 (ENST00000685559.1) at chr17:45393908-45432870 -  ... converting them to an inactive GDP-bound state Has activity toward <b>CDC42</b> and RAC1 By similarity Interacts with SH3KBP1 CIN85 By 
ABR (ENST00000625740.2) at chr17_KI270910v1_alt:45155-149117 -  ... provided by RefSeq Feb 2012 GTPase-activating protein for RAC and <b>CDC42</b> Promotes the exchange of RAC or CDC42-bound GDP by 
ARHGAP27 (ENST00000610792.3) at chr17_KI270908v1_alt:84405-120802 -  ... converting them to an inactive GDP-bound state Has activity toward <b>CDC42</b> and RAC1 By similarity Interacts with SH3KBP1 CIN85 By 
MAP3K11 (ENST00000309100.8) at chr11:65597757-65614221 -  ... transcription activity of NF-kappaB mediated by Rho family GTPases and <b>CDC42</b> provided by RefSeq Jul 2008 Publication Note This RefSeq 
RAB3IP (ENST00000247833.12) at chr12:69738860-69823199 -  ... Together with RAB11A RAB8A the exocyst complex PARD3 PRKCI ANXA2 <b>CDC42</b> and DNMBP promotes transcytosis of PODXL to the apical 
ARHGEF15 (ENST00000361926.8) at chr17:8310241-8322511 -  ... Specific GEF for RhoA activation Does not activate RAC1 or <b>CDC42</b> Regulates vascular smooth muscle contractility Negatively regulates excitatory synapse 
ARHGAP9 (ENST00000393791.8) at chr12:57472269-57479866 -  ... an inactive GDP-bound state Has a substantial GAP activity toward <b>CDC42</b> and RAC1 and less toward RHOA Has a role 
USP6 (ENST00000574788.6) at chr17:5116032-5174991 -  ... proteins as an intracellular targeting signal Interacts with RAC1 and <b>CDC42</b> Interacts via Rab-GAP TBC domain with ARF6 Interacts with 
IQGAP2 (ENST00000274364.11) at chr5:76403285-76708132 -  ... transcript variants provided by RefSeq Apr 2017 Binds to activated <b>CDC42</b> and RAC1 but does not seem to stimulate their 
TIAM1 (ENST00000541036.6) at chr21:31118418-31344261 -  ... RAC1 the encoded protein activates additional Rho-like GTPases such as <b>CDC42</b> RAC2 RAC3 and RHOA This gene encodes multiple protein 
RAB11A (ENST00000261890.7) at chr15:65869491-65891989 -  ... Together with RAB3IP RAB8A the exocyst complex PARD3 PRKCI ANXA2 <b>CDC42</b> and DNMBP promotes transcytosis of PODXL to the apical 
ARHGAP29 (ENST00000260526.11) at chr1:94168905-94237584 -  ... strong activity toward RHOA and weaker activity toward RAC1 and <b>CDC42</b> May act as a specific effector of RAP2A to 
COPG2 (ENST00000425248.5) at chr7:130506238-130668748 -  ... recycling of LDL receptors By similarity Oligomeric complex Binds to <b>CDC42</b> Cytoplasm By similarity Golgi apparatus membrane Peripheral membrane protein 
PPM1E (ENST00000308249.4) at chr17:58755854-58985179 -  ... fiber stress breakdown and in morphological changes driven by TNK2 <b>CDC42</b> A phosphoprotein H 2 O a protein phosphate Binds 
MCF2 (ENST00000519895.6) at chrX:139581770-139708167 -  ... form Isoform 1 exhibits no activity toward RHOA RAC1 or <b>CDC42</b> Isoform 2 exhibits decreased GEF activity toward CDC42 Isoform 
MCC (ENST00000408903.7) at chr5:113022106-113488453 -  ... LEF transcription factors Involved in cell migration independently of RAC1 <b>CDC42</b> and p21-activated kinase PAK activation Interacts with SCRIB EZR 
NECTIN3 (ENST00000485303.6) at chr3:111071816-111137560 -  ... nectin-2 at Sertoli-spermatid junctions Trans-interaction with PVR induces activation of <b>CDC42</b> and RAC small G proteins through common signaling molecules 
RHOV (ENST00000220507.5) at chr15:40872214-40874234 -  ... membrane protein kinase binding cell projection assembly actin cytoskeleton organization <b>Cdc42</b> protein signal transduction regulation of actin cytoskeleton organization cell 
STARD13 (ENST00000336934.10) at chr13:33103137-33285755 -  ... RefSeq Aug 2011 GTPase-activating protein for RhoA and perhaps for <b>Cdc42</b> May be involved in regulation of cytoskeletal reorganization cell 
MARK4 (ENST00000262891.9) at chr19:45251271-45305284 -  ... protein ADP a phosphoprotein Activated by phosphorylation on Thr-214 P60953 <b>CDC42</b> NbExp 2 IntAct EBI-302319 EBI-81752 Q9BYG4 PARD6G NbExp 2 
PLD1 (ENST00000351298.9) at chr3:171600404-171810483 -  ... a lesser extent by GTP-binding proteins RHO A RAC-1 and <b>CDC42</b> Inhibited by oleate Interacts with PIP5K1B Cytoplasm perinuclear region 
ARHGEF16 (ENST00000378378.9) at chr1:3454665-3481113 -  ... mediating the activation of RAC1 by EPHA2 May also activate <b>CDC42</b> and mediate activation of CDC42 by the viral protein 
ARHGAP24 (ENST00000395184.6) at chr4:85475150-86002666 -  ... retraction to achieve cellular polarity Able to suppress RAC1 and <b>CDC42</b> activity in vitro Overexpression induces cell rounding with partial 
ARHGEF2 (ENST00000361247.9) at chr1:155946854-155978547 -  ... May stimulate instead the cortical activity of Rac Inactive toward <b>CDC42</b> TC10 or Ras GTPases Forms an intracellular sensing system 
PAK6 (ENST00000560346.6) at chr15:40239063-40277487 -  ... ADP a phosphoprotein Interacts tightly with GTP-bound but not GDP-bound <b>CDC42</b> p21 and RAC1 By similarity Interacts with the androgen 
RASA4 (ENST00000262940.12) at chr7:102579646-102616756 -  ... stimulus that elevates intracellular calcium Functions as an adaptor for <b>Cdc42</b> and Rac1 during FcR-mediated phagocytosis Cytoplasm cytosol Cell membrane 
IQGAP1 (ENST00000268182.10) at chr15:90388242-90502239 -  ... criteria based on single protein-coding transcript RefSeq-Attributes-END Binds to activated <b>CDC42</b> but does not stimulate its GTPase activity It associates 
ABR (ENST00000302538.10) at chr17:1003519-1179981 -  ... SAMEA1965299 SAMEA1966682 ECO 0000350 Evidence-Data-END GTPase-activating protein for RAC and <b>CDC42</b> Promotes the exchange of RAC or CDC42-bound GDP by 
PAK3 (ENST00000372007.10) at chrX:111096191-111227361 -  ... and plasticity Acts as downstream effector of the small GTPases <b>CDC42</b> and RAC1 Activation by the binding of active CDC42 
EXOC6 (ENST00000260762.10) at chr10:92848520-93059490 -  ... plasma membrane Together with RAB11A RAB3IP RAB8A PARD3 PRKCI ANXA2 <b>CDC42</b> and DNMBP promotes transcytosis of PODXL to the apical 
NET1 (ENST00000355029.9) at chr10:5412557-5459056 -  ... with RHOA in its GTP and GDP-bound states and with <b>CDC42</b> in its GTP-bound state Interacts with the PDZ 1 
ECT2 (ENST00000392692.8) at chr3:172750726-172821474 -  ... family members of small GTPases like RHOA RHOC RAC1 and <b>CDC42</b> Required for signal transduction pathways involved in the regulation 
RALBP1 (ENST00000383432.8) at chr18:9475513-9538114 -  ... Can activate specifically hydrolysis of GTP bound to RAC1 and <b>CDC42</b> but not RALA Mediates ATP-dependent transport of S 2 
ARHGAP1 (ENST00000311956.9) at chr11:46677080-46700619 -  ... longest protein RefSeq-Attributes-END GTPase activator for the Rho Rac and <b>Cdc42</b> proteins converting them to the putatively inactive GDP-bound state 
BCR (ENST00000305877.13) at chr22:23180509-23318037 -  ... provided by RefSeq Jan 2020 GTPase-activating protein for RAC1 and <b>CDC42</b> Promotes the exchange of RAC or CDC42-bound GDP by 
ARHGAP31 (ENST00000264245.9) at chr3:119294383-119420714 -  ... RefSeq-Attributes-END Functions as a GTPase-activating protein GAP for RAC1 and <b>CDC42</b> Required for cell spreading polarized lamellipodia formation and cell 
NCKIPSD (ENST00000294129.7) at chr3:48673844-48685915 -  ... N-WASP induced ARP2 3 complex activation in the absence of <b>CDC42</b> By similarity May play an important role in the 
PARD6A (ENST00000458121.7) at chr16:67660960-67662774 -  ... By similarity Interacts with PARD3 Interacts with GTP-bound forms of <b>CDC42</b> ARHQ TC10 and RAC1 Interacts with the N-terminal part 
MCF2L (ENST00000535094.7) at chr13:112969214-113099742 -  ... that potentially links pathways that signal through RAC1 RHOA and <b>CDC42</b> Catalyzes guanine nucleotide exchange on RHOA and CDC42 and 
ABR (ENST00000620619.4) at chr17_KI270862v1_alt:42774-231794 -  ... SAMEA1965299 SAMEA1966682 ECO 0000350 Evidence-Data-END GTPase-activating protein for RAC and <b>CDC42</b> Promotes the exchange of RAC or CDC42-bound GDP by 
RACGAP1 (ENST00000312377.10) at chr12:49989162-50025494 -  ... in neuronal proliferation Shows strong GAP GTPase activation activity towards <b>CDC42</b> and RAC1 and less towards RHOA Essential for the 
FLII (ENST00000638207.2) at chr17_KV766198v1_alt:5189-19112 -  ... actin-rich structures in blastocysts and together with HRAS1 RHOA and <b>CDC42</b> in migrating fibroblasts Localizes to centrosomes By similarity Strongest 
CDK5 (ENST00000485972.6) at chr7:151053815-151057897 -  ... MCAM MUC18 SEPT5 SYN1 DNM1 AMPH SYNJ1 CDK16 RAC1 RHOA <b>CDC42</b> TONEBP NFAT5 MAPT TAU MAP1B histone H1 p53 TP53 
ARHGEF25 (ENST00000286494.9) at chr12:57611435-57617245 -  ... similarity Interacts with activated GNAQ and GNA11 Interacts with RHOA <b>CDC42</b> and RAC1 Cell membrane By similarity Cytoplasm myofibril sarcomere 
PARD6B (ENST00000371610.7) at chr20:50731580-50753741 -  ... C proteins Interacts with PARD3 Interacts with GTP-bound forms of <b>CDC42</b> and RAC1 Interacts with GTP-bound ARHQ TC10 Interacts with 
BAIAP2 (ENST00000428708.7) at chr17:81035151-81117434 -  ... membrane-bound small G proteins to cytoplasmic effector proteins Necessary for <b>CDC42</b> mediated reorganization of the actin cytoskeleton and for RAC1 
FLII (ENST00000327031.9) at chr17:18244815-18258738 -  ... actin-rich structures in blastocysts and together with HRAS1 RHOA and <b>CDC42</b> in migrating fibroblasts Localizes to centrosomes By similarity Strongest 
ARHGAP33 (ENST00000007510.9) at chr19:35775564-35788822 -  ... regulation of insulin-stimulated glucose transport By similarity Specifically interacts with <b>CDC42</b> and RHOQ TC10 through its Rho-GAP domain By similarity 
ARAP3 (ENST00000239440.9) at chr5:141653402-141682230 -  ... albeit with lower efficiency Acts on ARF6 RAC1 RHOA and <b>CDC42</b> Plays a role in the internalization of anthrax toxin 
NEK6 (ENST00000320246.10) at chr9:124257949-124353307 -  ... with APBB1 via WW domain Interacts with ANKRA2 ATF4 ARHGAP33 <b>CDC42</b> CIR1 PRAM1 PTN PRDX3 PIN1 RAD26L RBBP6 RPS7 and 
DOCK2 (ENST00000520908.7) at chr5:169637275-170083382 -  ... in response of chemokines Activates RAC1 and RAC2 but not <b>CDC42</b> by functioning as a guanine nucleotide exchange factor GEF 
SHTN1 (ENST00000355371.9) at chr10:116881477-117005187 -  ... kinesin binding lamellipodium filopodium axon growth cone cell leading edge <b>Cdc42</b> protein signal transduction netrin-activated signaling pathway cell projection perikaryon 
PRC1 (ENST00000394249.8) at chr15:90966040-90994535 -  ... RACGAP1 The interaction with RACGAP1 inhibits its GAP activity towards <b>CDC42</b> in vitro which may be required for maintaining normal 
PARD3 (ENST00000374788.8) at chr10:34109561-34815296 -  ... a complex with PARD6A or PARD6B PRKCI or PRKCZ and <b>CDC42</b> or RAC1 Component of a complex whose core is 
RIT2 (ENST00000326695.10) at chr18:42743227-43115685 -  ... GDP binding regulation of endocytosis semaphorin receptor binding regulation of <b>Cdc42</b> protein signal transduction maintenance of protein location in cell 
TIAM2 (ENST00000682666.1) at chr6:154995315-155257723 -  ... altered plasma membrane By similarity Activates specifically RAC1 but not <b>CDC42</b> and RHOA Interacts with MAP1A MAP1B PARP1 and YWHAE 
DAAM1 (ENST00000360909.8) at chr14:59188667-59371403 -  ... Abl BTK endophilin spectrin and SRC Binds specifically to GTP-bound <b>CDC42</b> and RHOA Cytoplasm Note Perinuclear Event Alternative splicing Named 
ENAH (ENST00000366843.7) at chr1:225486829-225653123 -  ... autoinhibitory region of BAIAP2-alpha has been blocked by interaction with <b>CDC42</b> Interacts via the EVH1 WH1 domain with the Pro-rich 
AKAP13 (ENST00000394518.7) at chr15:85380603-85749355 -  ... exchange activity on Rho proteins in vitro but not on <b>CDC42</b> Ras or Rac and may bind calcium ions Binds 
TAX1BP3 (ENST00000225525.4) at chr17:3662895-3668578 -  ... Rho signaling pathway May play a role in activation of <b>CDC42</b> by the viral protein HPV16 E6 Interacts via its 
BCAR1 (ENST00000162330.10) at chr16:75228181-75251624 -  ... of a collagen-stimulated complex involved in cell migration made of <b>CDC42</b> CRK TNK2 and BCAR1 p130cas Interacts with TNK2 via 
PLXNB2 (ENST00000359337.9) at chr22:50274979-50307646 -  ... and cell migration May modulate the activity of RAC1 and <b>CDC42</b> Down-regulates macrophage migration in wound healing assays in vitro 
CSPG4 (ENST00000308508.5) at chr15:75674322-75712848 -  ... and spreading by recruiting and activating a signaling cascade through <b>CDC42</b> ACK1 and BCAR1 May activate FAK and ERK1 ERK2 
ARHGEF18 (ENST00000668164.2) at chr19:7348937-7472478 -  ... oxygen species ROS Does not act as a GEF for <b>CDC42</b> The G protein beta-gamma Gbetagamma subunits of heterotrimeric G 
RAB8A (ENST00000300935.8) at chr19:16111889-16134234 -  ... Together with RAB11A RAB3IP the exocyst complex PARD3 PRKCI ANXA2 <b>CDC42</b> and DNMBP promotes transcytosis of PODXL to the apical 
CRK (ENST00000300574.3) at chr17:1420693-1456232 -  ... a collagen stimulated complex involved in cell migration composed of <b>CDC42</b> CRK TNK2 and p130cas BCAR1 Interacts via SH2 domain 
NTN1 (ENST00000173229.7) at chr17:9021510-9244000 -  ... cell migration negative regulation of axon extension mammary gland development <b>Cdc42</b> protein signal transduction anterior posterior axon guidance inner ear 
PRKCZ (ENST00000378567.8) at chr1:2050411-2185395 -  ... forms a cytoplasmic complex with PARD6A and is recruited by <b>CDC42</b> to function in the establishment of cell polarity along 
WIPF1 (ENST00000679041.1) at chr2:174559574-174597804 -  ... the N-terminal region 170 at a site distinct from the <b>CDC42-binding</b> site Defects in WIPF1 are the cause of Wiskott-Aldrich 
PREX2 (ENST00000288368.5) at chr8:67952046-68237032 -  ... specificity and recognition Able to discriminate between RAC1 RHOA and <b>CDC42</b> DH domain alone was unable to confer substrate specificity 
PRKCE (ENST00000306156.8) at chr2:45651675-46187990 -  ... desmosomes and regulates cell-cell contact Phosphorylates IQGAP1 which binds to <b>CDC42</b> mediating epithelial cell-cell detachment prior to migration In HeLa 
APOC3 (ENST00000227667.8) at chr11:116829907-116833072 -  ... catabolic process triglyceride catabolic process enzyme regulator activity regulation of <b>Cdc42</b> protein signal transduction cholesterol efflux phospholipid efflux very-low-density lipoprotein 
NRP1 (ENST00000374867.7) at chr10:33177493-33334667 -  ... cell axon guidance cytoplasmic vesicle actin cytoskeleton reorganization regulation of <b>Cdc42</b> protein signal transduction substrate adhesion-dependent cell spreading cellular response 
PRKCI (ENST00000295797.5) at chr3:170222424-170305977 -  ... PARD6 protein PARD6A PARD6B or PARD6G and a GTPase protein <b>CDC42</b> or RAC1 Part of a complex with LLGL1 and 
ABCA1 (ENST00000374736.8) at chr9:104781006-104928155 -  ... phosphatidylcholine binding small GTPase binding intracellular cholesterol transport regulation of <b>Cdc42</b> protein signal transduction cholesterol efflux phospholipid efflux apolipoprotein binding 
APOA1 (ENST00000236850.5) at chr11:116835751-116837622 -  ... binding animal organ regeneration phosphatidylcholine binding cytoplasmic vesicle regulation of <b>Cdc42</b> protein signal transduction cholesterol efflux phospholipid efflux negative regulation 
APOE (ENST00000252486.9) at chr19:44905796-44909393 -  ... development negative regulation of cellular protein metabolic process regulation of <b>Cdc42</b> protein signal transduction positive regulation of low-density lipoprotein particle 
ABL1 (ENST00000318560.6) at chr9:130835254-130887675 -  ... of microtubule polymerization cell leading edge nuclear membrane regulation of <b>Cdc42</b> protein signal transduction regulation of actin cytoskeleton organization macromolecular 
RHOU (ENST00000366691.4) at chr1:228735479-228746664 -  ... RHOU transcript variant 1 mRNA from RefSeq NM_021205 ARHU B1AKN1 <b>CDC42L1</b> ENST00000366691.1 ENST00000366691.2 ENST00000366691.3 G28K NM_021205 Q59FE9 Q7L0Q8 Q8TDQ2 RHOU_HUMAN 
RHOU (ENST00000646945.2) at chr1_KZ208906v1_fix:312483-323668 -  ... RHOU transcript variant 1 mRNA from RefSeq NM_021205 ARHU B1AKN1 <b>CDC42L1</b> ENST00000646945.1 G28K NM_021205 Q59FE9 Q7L0Q8 Q8TDQ2 RHOU_HUMAN SB128 WRCH1 
FGD1 (ENST00000375135.4) at chrX:54445454-54496234 -  ... The encoded protein specifically binds to the Rho family GTPase <b>Cdc42Hs</b> and can stimulate the GDP-GTP exchange of the isoprenylated 
PPP1R12A (ENST00000450142.7) at chr12:79773568-79935097 -  ... CIT Rho-associated kinase By similarity Phosphorylated cooperatively by ROCK1 and <b>CDC42BP</b> on Thr-696 Phosphorylated on upon DNA damage probably by 
LIMK1 (ENST00000336180.7) at chr7:74083804-74122525 -  ... of endothelial cells Dephosphorylated and inactivated by SSH1 Phosphorylated by <b>CDC42BP</b> Ubiquitinated Lys-48 linked polyubiquitination by RNF6 leads to proteasomal