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Gencode Genes

CDC25C (ENST00000513970.5) at chr5:138285580-138338355 - Homo sapiens cell division cycle 25C (CDC25C), transcript variant 6, mRNA. (from RefSeq NM_001364026)
CDC25C (ENST00000648466.1) at chr5:138285577-138331869 - cell division cycle 25C (from HGNC CDC25C)
CDC25C (ENST00000514555.5) at chr5:138285692-138331180 - Functions as a dosage-dependent inducer in mitotic  control. Tyrosine protein phosphatase required for progression of  the cell cycle. When phosphorylated, highly effective in  activating G2 cells into prophase. Directly dephosphorylates CDK1  and activates its kinase activity. (from UniProt P30307)
CDC25C (ENST00000514017.1) at chr5:138285744-138292114 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0Y999)
CDC25C (ENST00000510119.1) at chr5:138325815-138338325 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt D6RD20)
CDC25C (ENST00000504831.1) at chr5:138325918-138328882 - cell division cycle 25C (from HGNC CDC25C)
CDC25C (ENST00000503022.5) at chr5:138291985-138331872 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt D6RJC2)
CDC25C (ENST00000415130.6) at chr5:138285573-138331794 - Functions as a dosage-dependent inducer in mitotic  control. Tyrosine protein phosphatase required for progression of  the cell cycle. When phosphorylated, highly effective in  activating G2 cells into prophase. Directly dephosphorylates CDK1  and activates its kinase activity. (from UniProt P30307)
CDC25C (ENST00000348983.7) at chr5:138285265-138331877 - Homo sapiens cell division cycle 25C (CDC25C), transcript variant 2, mRNA. (from RefSeq NM_022809)
CDC25C (ENST00000323760.11) at chr5:138285269-138331804 - Homo sapiens cell division cycle 25C (CDC25C), transcript variant 1, mRNA. (from RefSeq NM_001790)
MARK3 (ENST00000416682.6) at chr14:103385453-103503360 - Involved in the specific phosphorylation of microtubule-  associated proteins for tau, MAP2 and MAP4. Phosphorylates CDC25C  on 'Ser-216'. Regulates localization and activity of some histone  deacetylases by mediating phosphorylation of HDAC7, promoting  subsequent interaction between HDAC7 and 14-3-3 and export from  the nucleus. (from UniProt P27448)
BRSK1 (ENST00000590333.5) at chr19:55282072-55312533 - Serine/threonine-protein kinase that plays a key role in  polarization of neurons and centrosome duplication. Phosphorylates  CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following  phosphorylation and activation by STK11/LKB1, acts as a key  regulator of polarization of cortical neurons, probably by  mediating phosphorylation of microtubule-associated proteins such  as MAPT/TAU at 'Ser-579'. Also regulates neuron polarization by  mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic  neurons, leading to down-regulate WEE1 activity in polarized  neurons. In neurons, localizes to synaptic vesicles and plays a  role in neurotransmitter release, possibly by phosphorylating  RIMS1. Also acts as a positive regulator of centrosome duplication  by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at  'Ser-131', leading to translocation of gamma-tubulin and its  associated proteins to the centrosome. Involved in the UV-induced  DNA damage checkpoint response, probably by inhibiting CDK1  activity through phosphorylation and activation of WEE1, and  inhibition of CDC25B and CDC25C. (from UniProt Q8TDC3)
BRSK1 (ENST00000585418.1) at chr19:55284421-55302921 - Serine/threonine-protein kinase that plays a key role in  polarization of neurons and centrosome duplication. Phosphorylates  CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following  phosphorylation and activation by STK11/LKB1, acts as a key  regulator of polarization of cortical neurons, probably by  mediating phosphorylation of microtubule-associated proteins such  as MAPT/TAU at 'Ser-579'. Also regulates neuron polarization by  mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic  neurons, leading to down-regulate WEE1 activity in polarized  neurons. In neurons, localizes to synaptic vesicles and plays a  role in neurotransmitter release, possibly by phosphorylating  RIMS1. Also acts as a positive regulator of centrosome duplication  by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at  'Ser-131', leading to translocation of gamma-tubulin and its  associated proteins to the centrosome. Involved in the UV-induced  DNA damage checkpoint response, probably by inhibiting CDK1  activity through phosphorylation and activation of WEE1, and  inhibition of CDC25B and CDC25C. (from UniProt Q8TDC3)
BRSK1 (ENST00000309383.6) at chr19:55283997-55312562 - Homo sapiens BR serine/threonine kinase 1 (BRSK1), mRNA. (from RefSeq NM_032430)
CHEK2 (ENST00000650281.1) at chr22:28687766-28741806 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000448511.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000433728.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000417588.5) at chr22:28687887-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000405598.5) at chr22:28687762-28741800 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000403642.5) at chr22:28687897-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CHEK2 (ENST00000402731.5) at chr22:28687897-28734721 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest, activation of DNA repair  and apoptosis in response to the presence of DNA double-strand  breaks. May also negatively regulate cell cycle progression during  unperturbed cell cycles. Following activation, phosphorylates  numerous effectors preferentially at the consensus sequence [L-X-  R-X-X-S/T]. Regulates cell cycle checkpoint arrest through  phosphorylation of CDC25A, CDC25B and CDC25C, inhibiting their  activity. Inhibition of CDC25 phosphatase activity leads to  increased inhibitory tyrosine phosphorylation of CDK-cyclin  complexes and blocks cell cycle progression. May also  phosphorylate NEK6 which is involved in G2/M cell cycle arrest.  Regulates DNA repair through phosphorylation of BRCA2, enhancing  the association of RAD51 with chromatin which promotes DNA repair  by homologous recombination. Also stimulates the transcription of  genes involved in DNA repair (including BRCA2) through the  phosphorylation and activation of the transcription factor FOXM1.  Regulates apoptosis through the phosphorylation of p53/TP53, MDM4  and PML. Phosphorylation of p53/TP53 at 'Ser-20' by CHEK2 may  alleviate inhibition by MDM2, leading to accumulation of active  p53/TP53. Phosphorylation of MDM4 may also reduce degradation of  p53/TP53. Also controls the transcription of pro-apoptotic genes  through phosphorylation of the transcription factor E2F1. Tumor  suppressor, it may also have a DNA damage-independent function in  mitotic spindle assembly by phosphorylating BRCA1. Its absence may  be a cause of the chromosomal instability observed in some cancer  cells. (from UniProt O96017)
CDK1 (ENST00000373809.2) at chr10:60780153-60794852 - Plays a key role in the control of the eukaryotic cell  cycle by modulating the centrosome cycle as well as mitotic onset;  promotes G2-M transition, and regulates G1 progress and G1-S  transition via association with multiple interphase cyclins.  Required in higher cells for entry into S-phase and mitosis.  Phosphorylates PARVA/actopaxin, APC, AMPH, APC, BARD1, Bcl-  xL/BCL2L1, BRCA2, CALD1, CASP8, CDC7, CDC20, CDC25A, CDC25C,  CC2D1A, CSNK2 proteins/CKII, FZR1/CDH1, CDK7, CEBPB, CHAMP1,  DMD/dystrophin, EEF1 proteins/EF-1, EZH2, KIF11/EG5, EGFR, FANCG,  FOS, GFAP, GOLGA2/GM130, GRASP1, UBE2A/hHR6A, HIST1H1  proteins/histone H1, HMGA1, HIVEP3/KRC, LMNA, LMNB, LMNC, LBR,  LATS1, MAP1B, MAP4, MARCKS, MCM2, MCM4, MKLP1, MYB, NEFH, NFIC,  NPC/nuclear pore complex, PITPNM1/NIR2, NPM1, NCL, NUCKS1,  NPM1/numatrin, ORC1, PRKAR2A, EEF1E1/p18, EIF3F/p47, p53/TP53,  NONO/p54NRB, PAPOLA, PLEC/plectin, RB1, UL40/R2, RAB4A, RAP1GAP,  RCC1, RPS6KB1/S6K1, KHDRBS1/SAM68, ESPL1, SKI, BIRC5/survivin,  STIP1, TEX14, beta-tubulins, MAPT/TAU, NEDD1, VIM/vimentin, TK1,  FOXO1, RUNX1/AML1 and RUNX2. CDK1/CDC2-cyclin-B controls  pronuclear union in interphase fertilized eggs. Essential for  early stages of embryonic development. During G2 and early  mitosis, CDC25A/B/C-mediated dephosphorylation activates  CDK1/cyclin complexes which phosphorylate several substrates that  trigger at least centrosome separation, Golgi dynamics, nuclear  envelope breakdown and chromosome condensation. Once chromosomes  are condensed and aligned at the metaphase plate, CDK1 activity is  switched off by WEE1- and PKMYT1-mediated phosphorylation to allow  sister chromatid separation, chromosome decondensation,  reformation of the nuclear envelope and cytokinesis. Inactivated  by PKR/EIF2AK2- and WEE1-mediated phosphorylation upon DNA damage  to stop cell cycle and genome replication at the G2 checkpoint  thus facilitating DNA repair. Reactivated after successful DNA  repair through WIP1-dependent signaling leading to CDC25A/B/C-  mediated dephosphorylation and restoring cell cycle progression.  In proliferating cells, CDK1-mediated FOXO1 phosphorylation at the  G2-M phase represses FOXO1 interaction with 14-3-3 proteins and  thereby promotes FOXO1 nuclear accumulation and transcription  factor activity, leading to cell death of postmitotic neurons. The  phosphorylation of beta-tubulins regulates microtubule dynamics  during mitosis. NEDD1 phosphorylation promotes PLK1-mediated NEDD1  phosphorylation and subsequent targeting of the gamma-tubulin ring  complex (gTuRC) to the centrosome, an important step for spindle  formation. In addition, CC2D1A phosphorylation regulates CC2D1A  spindle pole localization and association with SCC1/RAD21 and  centriole cohesion during mitosis. The phosphorylation of Bcl-  xL/BCL2L1 after prolongated G2 arrest upon DNA damage triggers  apoptosis. In contrast, CASP8 phosphorylation during mitosis  prevents its activation by proteolysis and subsequent apoptosis.  This phosphorylation occurs in cancer cell lines, as well as in  primary breast tissues and lymphocytes. EZH2 phosphorylation  promotes H3K27me3 maintenance and epigenetic gene silencing. CALD1  phosphorylation promotes Schwann cell migration during peripheral  nerve regeneration. (from UniProt P06493)
CHEK1 (ENST00000524737.6) at chr11:125626558-125676041 - Serine/threonine-protein kinase which is required for  checkpoint-mediated cell cycle arrest and activation of DNA repair  in response to the presence of DNA damage or unreplicated DNA. May  also negatively regulate cell cycle progression during unperturbed  cell cycles. This regulation is achieved by a number of mechanisms  that together help to preserve the integrity of the genome.  Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to  and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of  CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at  'Ser-216' creates binding sites for 14-3-3 proteins which inhibit  CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-  124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of  CDC25A. Phosphorylation of CDC25A at 'Ser-76' primes the protein  for subsequent phosphorylation at 'Ser-79', 'Ser-82' and 'Ser-88'  by NEK11, which is required for polyubiquitination and degradation  of CDCD25A. Inhibition of CDC25 leads to increased inhibitory  tyrosine phosphorylation of CDK-cyclin complexes and blocks cell  cycle progression. Also phosphorylates NEK6. Binds to and  phosphorylates RAD51 at 'Thr-309', which promotes the release of  RAD51 from BRCA2 and enhances the association of RAD51 with  chromatin, thereby promoting DNA repair by homologous  recombination. Phosphorylates multiple sites within the C-terminus  of TP53, which promotes activation of TP53 by acetylation and  promotes cell cycle arrest and suppression of cellular  proliferation. Also promotes repair of DNA cross-links through  phosphorylation of FANCE. Binds to and phosphorylates TLK1 at  'Ser-743', which prevents the TLK1-dependent phosphorylation of  the chromatin assembly factor ASF1A. This may enhance chromatin  assembly both in the presence or absence of DNA damage. May also  play a role in replication fork maintenance through regulation of  PCNA. May regulate the transcription of genes that regulate cell-  cycle progression through the phosphorylation of histones.  Phosphorylates histone H3.1 (to form H3T11ph), which leads to  epigenetic inhibition of a subset of genes. May also phosphorylate  RB1 to promote its interaction with the E2F family of  transcription factors and subsequent cell cycle arrest. (from UniProt O14757)
MARK3 (ENST00000303622.13) at chr14:103385541-103503831 - Homo sapiens microtubule affinity regulating kinase 3 (MARK3), transcript variant 3, mRNA. (from RefSeq NM_002376)
MARK3 (ENST00000553942.5) at chr14:103385985-103503245 - Homo sapiens microtubule affinity regulating kinase 3 (MARK3), transcript variant 2, mRNA. (from RefSeq NM_001128919)
MARK3 (ENST00000440884.7) at chr14:103385392-103503252 - Homo sapiens microtubule affinity regulating kinase 3 (MARK3), transcript variant 5, mRNA. (from RefSeq NM_001128921)
MARK3 (ENST00000216288.11) at chr14:103385860-103503826 - Homo sapiens microtubule affinity regulating kinase 3 (MARK3), transcript variant 4, mRNA. (from RefSeq NM_001128920)
MARK3 (ENST00000429436.7) at chr14:103385415-103503831 - Homo sapiens microtubule affinity regulating kinase 3 (MARK3), transcript variant 1, mRNA. (from RefSeq NM_001128918)
LZTS1 (ENST00000616228.1) at chr8:20249895-20255181 - Involved in the regulation of cell growth. May stabilize  the active CDC2-cyclin B1 complex and thereby contribute to the  regulation of the cell cycle and the prevention of uncontrolled  cell proliferation. May act as a tumor suppressor. (from UniProt Q9Y250)
LZTS1 (ENST00000522290.5) at chr8:20249722-20255181 - Involved in the regulation of cell growth. May stabilize  the active CDC2-cyclin B1 complex and thereby contribute to the  regulation of the cell cycle and the prevention of uncontrolled  cell proliferation. May act as a tumor suppressor. (from UniProt Q9Y250)
CHEK2 (ENST00000649563.1) at chr22:28687751-28741806 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 4, mRNA. (from RefSeq NM_001257387)
CHEK2 (ENST00000348295.7) at chr22:28687743-28741834 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 2, mRNA. (from RefSeq NM_145862)
CHEK2 (ENST00000404276.6) at chr22:28687743-28741820 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 1, mRNA. (from RefSeq NM_007194)
CHEK2 (ENST00000382580.6) at chr22:28687763-28741838 - Homo sapiens checkpoint kinase 2 (CHEK2), transcript variant 3, mRNA. (from RefSeq NM_001005735)
ZHX2 (ENST00000314393.6) at chr8:122781655-122974510 - Homo sapiens zinc fingers and homeoboxes 2 (ZHX2), transcript variant 2, mRNA. (from RefSeq NM_014943)
MAPKAPK2 (ENST00000294981.8) at chr1:206684944-206732863 - Homo sapiens MAPK activated protein kinase 2 (MAPKAPK2), transcript variant 1, mRNA. (from RefSeq NM_004759)
MAPKAPK2 (ENST00000367103.3) at chr1:206685037-206734283 - Homo sapiens MAPK activated protein kinase 2 (MAPKAPK2), transcript variant 2, mRNA. (from RefSeq NM_032960)
PLK4 (ENST00000514379.5) at chr4:127881232-127898579 - Homo sapiens polo like kinase 4 (PLK4), transcript variant 3, mRNA. (from RefSeq NM_001190801)
PLK4 (ENST00000513090.5) at chr4:127880927-127898639 - Homo sapiens polo like kinase 4 (PLK4), transcript variant 2, mRNA. (from RefSeq NM_001190799)
LZTS1 (ENST00000265801.6) at chr8:20246165-20255292 - Homo sapiens leucine zipper tumor suppressor 1 (LZTS1), transcript variant 2, mRNA. (from RefSeq NM_001362884)
CDK1 (ENST00000395284.8) at chr10:60778478-60794852 - Homo sapiens cyclin dependent kinase 1 (CDK1), transcript variant 1, mRNA. (from RefSeq NM_001786)
CDK1 (ENST00000316629.8) at chr10:60778454-60794843 - Homo sapiens cyclin dependent kinase 1 (CDK1), transcript variant 2, mRNA. (from RefSeq NM_033379)
PLK4 (ENST00000270861.10) at chr4:127880893-127899224 - Homo sapiens polo like kinase 4 (PLK4), transcript variant 1, mRNA. (from RefSeq NM_014264)
LZTS1 (ENST00000381569.5) at chr8:20246165-20303963 - Homo sapiens leucine zipper tumor suppressor 1 (LZTS1), transcript variant 1, mRNA. (from RefSeq NM_021020)
CHEK1 (ENST00000428830.6) at chr11:125625974-125676255 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 2, mRNA. (from RefSeq NM_001114121)
CHEK1 (ENST00000534070.5) at chr11:125626341-125657147 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 3, mRNA. (from RefSeq NM_001274)
CHEK1 (ENST00000532449.6) at chr11:125626229-125656845 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 6, non-coding RNA. (from RefSeq NR_045205)
PLK3 (ENST00000372201.5) at chr1:44800377-44805990 - Homo sapiens polo like kinase 3 (PLK3), mRNA. (from RefSeq NM_004073)
PLK1 (ENST00000300093.9) at chr16:23678889-23690367 - Homo sapiens polo like kinase 1 (PLK1), mRNA. (from RefSeq NM_005030)
CHEK1 (ENST00000438015.6) at chr11:125625976-125657147 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 1, mRNA. (from RefSeq NM_001114122)
CHEK1 (ENST00000544373.5) at chr11:125625977-125655710 - Homo sapiens checkpoint kinase 1 (CHEK1), transcript variant 8, mRNA. (from RefSeq NM_001330428)
PIM1 (ENST00000373509.6) at chr6:37170152-37175428 - Homo sapiens Pim-1 proto-oncogene, serine/threonine kinase (PIM1), transcript variant 1, mRNA. (from RefSeq NM_002648)
MAPK14 (ENST00000229794.8) at chr6:36027770-36110755 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 2, mRNA. (from RefSeq NM_139012)
MAPK14 (ENST00000310795.8) at chr6:36028158-36108509 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 4, mRNA. (from RefSeq NM_139014)
MAPK14 (ENST00000229795.7) at chr6:36027711-36111236 - Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1, mRNA. (from RefSeq NM_001315)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_022809.3 at chr5:138285265-138331877
NM_001364027.1 at chr5:138285265-138331877
NM_001364028.1 at chr5:138285265-138331877
NM_001364026.1 at chr5:138285265-138338355
NM_001790.5 at chr5:138285269-138331804
NM_001287582.2 at chr5:138285269-138331804
NM_001318098.2 at chr5:138285269-138338341
NM_001287583.2 at chr5:138285269-138338341

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_011543763.1 at chr5:138285271-138331005
XM_011543764.1 at chr5:138285271-138331087
XM_011543762.1 at chr5:138285271-138331794
XM_011543759.3 at chr5:138285271-138338055
XM_006714739.3 at chr5:138285271-138338181
XM_005272145.3 at chr5:138285271-138338355
XM_011543760.2 at chr5:138285271-138338355
XM_011543761.2 at chr5:138285271-138338355

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

CDC25C at chr5:138285269-138331804

RefSeq Genes

CDC25C at chr5:138285269-138338341 - (NM_001287583) M-phase inducer phosphatase 3 isoform c
CDC25C at chr5:138285265-138338355 - (NM_001364026) M-phase inducer phosphatase 3 isoform f
CDC25C at chr5:138285265-138331877 - (NM_022809) M-phase inducer phosphatase 3 isoform b
CDC25C at chr5:138285265-138331877 - (NM_001364027) M-phase inducer phosphatase 3 isoform g
CDC25C at chr5:138285269-138331804 - (NM_001790) M-phase inducer phosphatase 3 isoform a
CDC25C at chr5:138285269-138331804 - (NM_001287582) M-phase inducer phosphatase 3 isoform a
CDC25C at chr5:138285265-138331877 - (NM_001364028) M-phase inducer phosphatase 3 isoform h
CDC25C at chr5:138285269-138338341 - (NM_001318098) M-phase inducer phosphatase 3 isoform e

Non-Human RefSeq Genes

CDC25C at chr5:138285268-138338341 - (NM_001280334) M-phase inducer phosphatase 3
Cdc25c at chr5:138285689-138329648 - (NM_001107396) M-phase inducer phosphatase 3
CDC25C at chr5:138285146-138331194 - (NM_001097996) M-phase inducer phosphatase 3
CDC25C at chr5:138285692-138331150 - (NM_001123095) M-phase inducer phosphatase 3
Cdc25c at chr5:138285689-138331179 - (NM_009860) M-phase inducer phosphatase 3

Basic Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285269-138331804
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 33 (Ensembl 99)

CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285269-138331804
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285577-138331869
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285269-138331804
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285269-138331804
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285577-138331869
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285577-138331869
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CDC25C at chr5:138285265-138331835
CDC25C at chr5:138285265-138331877
CDC25C at chr5:138285573-138331794
CDC25C at chr5:138285580-138338355
CDC25C at chr5:138285692-138331180
CDC25C at chr5:138285744-138292114
CDC25C at chr5:138291985-138331872
CDC25C at chr5:138325815-138338325
CDC25C at chr5:138325918-138328882

International Knockout Mouse Consortium Genes Mapped to Human Genome

Cdc25c_101640 at chr5:138285270-138331827
Cdc25c_114798 at chr5:138285270-138331827
Cdc25c_115775 at chr5:138285270-138331827
Cdc25c_115867 at chr5:138285270-138331827
Cdc25c_119640 at chr5:138285270-138331827
Cdc25c_119707 at chr5:138285270-138331827
Cdc25c_31244 at chr5:138285270-138331827
Cdc25c_89050 at chr5:138285270-138331827

Human Aligned mRNA Search Results

U64205 - Homo sapiens Cdc25C associated protein kinase C-TAK1 mRNA, complete cds.
AJ304504 - Homo sapiens mRNA for M-phase inducer phosphatase 3 isoform cdc25Cdm, (CDC25C gene).
AF312681 - Homo sapiens CDC25C splicing variant 2 mRNA, partial cds.
AF277723 - Homo sapiens cell division cycle 25C splice variant 2 (CDC25C) mRNA, partial cds.
AF277724 - Homo sapiens cell division cycle 25C splice variant 3 (CDC25C) mRNA, partial cds.
AF277725 - Homo sapiens cell division cycle 25C splice variant 4 (CDC25C) mRNA, partial cds.
AF277726 - Homo sapiens cell division cycle 25C splice variant 5 (CDC25C) mRNA, partial cds.
BC019089 - Homo sapiens cell division cycle 25 homolog C (S. pombe), mRNA (cDNA clone MGC:29447 IMAGE:4858949), complete cds.

Non-Human Aligned mRNA Search Results

BC140630 - Bos taurus cell division cycle 25 homolog C (S. pombe), mRNA (cDNA clone MGC:148425 IMAGE:8188700), complete cds.
BC169346 - Xenopus laevis tyrosine phosphatase, mRNA (cDNA clone MGC:196073 IMAGE:9040980), complete cds.
BC004669 - Mus musculus cell division cycle 25 homolog C (S. pombe), mRNA (cDNA clone MGC:6032 IMAGE:3498846), complete cds.
AY890492 - Synthetic construct Homo sapiens clone FLH134988.01X cell division cycle 25C (CDC25C) mRNA, complete cds.
AY892885 - Synthetic construct Homo sapiens clone FLH031205.01L cell division cycle 25C (CDC25C) mRNA, partial cds.
AY893494 - Synthetic construct Homo sapiens clone FLH127833.01X cell division cycle 25C (CDC25C) mRNA, complete cds.
AB169213 - Macaca fascicularis testis cDNA, clone: QtsA-18052, similar to human cell division cycle 25C (CDC25C), transcript variant 2,mRNA, RefSeq: NM_022809.1.