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Gencode Genes

CASP4 (ENST00000444739.7) at chr11:104942866-104968574 - Homo sapiens caspase 4 (CASP4), transcript variant alpha, mRNA. (from RefSeq NM_001225)
CASP4 (ENST00000534356.1) at chr11:104946624-104948734 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000533730.5) at chr11:104944753-104968547 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000533252.1) at chr11:104942869-104947192 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt H0YD34)
CASP4 (ENST00000531546.1) at chr11:104951397-104968575 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000531333.5) at chr11:104949661-104968639 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000530309.1) at chr11:104942873-104947358 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000529565.1) at chr11:104942870-104950992 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000529183.5) at chr11:104948602-104968565 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000525116.5) at chr11:104942866-104948894 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000524843.5) at chr11:104949402-104968581 - caspase 4 (from HGNC CASP4)
CASP4 (ENST00000417440.2) at chr11:104951028-104969366 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E9PMT1)
CASP4 (ENST00000393150.7) at chr11:104942868-104956698 - Homo sapiens caspase 4 (CASP4), transcript variant gamma, mRNA. (from RefSeq NM_033306)
HIGD1A (ENST00000418900.6) at chr3:42784330-42804488 -   P49662:CASP4; NbExp=1; IntAct=EBI-1051940, EBI-1057327;  Q9P286:PAK7; NbExp=1; IntAct=EBI-1051940, EBI-1051061;  P14678:SNRPB; NbExp=1; IntAct=EBI-1051940, EBI-372458; (from UniProt Q9Y241)
HIGD1A (ENST00000452906.3) at chr3:42785252-42804433 - Homo sapiens HIG1 hypoxia inducible domain family member 1A (HIGD1A), transcript variant 1, mRNA. (from RefSeq NM_001099668)
HIGD1A (ENST00000321331.11) at chr3:42784298-42804531 - Homo sapiens HIG1 hypoxia inducible domain family member 1A (HIGD1A), transcript variant 3, mRNA. (from RefSeq NM_014056)
UFL1 (ENST00000369278.5) at chr6:96521806-96555276 - Homo sapiens UFM1 specific ligase 1 (UFL1), mRNA. (from RefSeq NM_015323)
CASP8 (ENST00000264274.13) at chr2:201233443-201287711 - Most upstream protease of the activation cascade of  caspases responsible for the TNFRSF6/FAS mediated and TNFRSF1A  induced cell death. Binding to the adapter molecule FADD recruits  it to either receptor. The resulting aggregate called death-  inducing signaling complex (DISC) performs CASP8 proteolytic  activation. The active dimeric enzyme is then liberated from the  DISC and free to activate downstream apoptotic proteases.  Proteolytic fragments of the N-terminal propeptide (termed CAP3,  CAP5 and CAP6) are likely retained in the DISC. Cleaves and  activates CASP3, CASP4, CASP6, CASP7, CASP9 and CASP10. May  participate in the GZMB apoptotic pathways. Cleaves ADPRT.  Hydrolyzes the small-molecule substrate, Ac-Asp-Glu-Val-Asp-|-AMC.  Likely target for the cowpox virus CRMA death inhibitory protein.  Isoform 5, isoform 6, isoform 7 and isoform 8 lack the catalytic  site and may interfere with the pro-apoptotic activity of the  complex. (from UniProt Q14790)
CARD16 (ENST00000375706.7) at chr11:105041326-105045324 - Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 1, mRNA. (from RefSeq NM_001017534)
CARD16 (ENST00000375704.8) at chr11:105041326-105045324 - Homo sapiens caspase recruitment domain family member 16 (CARD16), transcript variant 2, mRNA. (from RefSeq NM_052889)
APBB1 (ENST00000299402.10) at chr11:6395125-6419070 - Transcription coregulator that can have both coactivator  and corepressor functions. Adapter protein that forms a  transcriptionally active complex with the gamma-secretase-derived  amyloid precursor protein (APP) intracellular domain. Plays a  central role in the response to DNA damage by translocating to the  nucleus and inducing apoptosis. May act by specifically  recognizing and binding histone H2AX phosphorylated on 'Tyr-142'  (H2AXY142ph) at double-strand breaks (DSBs), recruiting other pro-  apoptosis factors such as MAPK8/JNK1. Required for histone H4  acetylation at double-strand breaks (DSBs). Its ability to  specifically bind modified histones and chromatin modifying  enzymes such as KAT5/TIP60, probably explains its trancription  activation activity. Function in association with TSHZ3, SET and  HDAC factors as a transcriptional repressor, that inhibits the  expression of CASP4. Associates with chromatin in a region  surrounding the CASP4 transcriptional start site(s). (from UniProt O00213)
TSHZ3 (ENST00000240587.5) at chr19:31274945-31349436 - Homo sapiens teashirt zinc finger homeobox 3 (TSHZ3), transcript variant 1, mRNA. (from RefSeq NM_020856)
DDIT3 (ENST00000552740.5) at chr12:57516809-57520511 - Multifunctional transcription factor in ER stress  response. Plays an essential role in the response to a wide  variety of cell stresses and induces cell cycle arrest and  apoptosis in response to ER stress. Plays a dual role both as an  inhibitor of CCAAT/enhancer-binding protein (C/EBP) function and  as an activator of other genes. Acts as a dominant-negative  regulator of C/EBP-induced transcription: dimerizes with members  of the C/EBP family, impairs their association with C/EBP binding  sites in the promoter regions, and inhibits the expression of  C/EBP regulated genes. Positively regulates the transcription of  TRIB3, IL6, IL8, IL23, TNFRSF10B/DR5, PPP1R15A/GADD34, BBC3/PUMA,  BCL2L11/BIM and ERO1L. Negatively regulates; expression of BCL2  and MYOD1, ATF4-dependent transcriptional activation of asparagine  synthetase (ASNS), CEBPA-dependent transcriptional activation of  hepcidin (HAMP) and CEBPB-mediated expression of peroxisome  proliferator-activated receptor gamma (PPARG). Inhibits the  canonical Wnt signaling pathway by binding to TCF7L2/TCF4,  impairing its DNA-binding properties and repressing its  transcriptional activity. Plays a regulatory role in the  inflammatory response through the induction of caspase-11  (CASP4/CASP11) which induces the activation of caspase-1 (CASP1)  and both these caspases increase the activation of pro-IL1B to  mature IL1B which is involved in the inflammatory response. (from UniProt P35638)
MTHFD1L (ENST00000367321.7) at chr6:150865549-151101887 - Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like (MTHFD1L), transcript variant 14, non-coding RNA. (from RefSeq NR_146720)
MTHFD1L (ENST00000367307.8) at chr6:150865716-150899021 - Homo sapiens methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like (MTHFD1L), transcript variant 8, mRNA. (from RefSeq NM_001350489)
APBB1 (ENST00000609331.5) at chr11:6395430-6404664 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 7, mRNA. (from RefSeq NM_001257325)
APBB1 (ENST00000608704.5) at chr11:6395125-6405660 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 6, mRNA. (from RefSeq NM_001257320)
APBB1 (ENST00000608655.5) at chr11:6395125-6404843 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 9, mRNA. (from RefSeq NM_001257319)
APBB1 (ENST00000608645.5) at chr11:6395304-6405415 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 5, mRNA. (from RefSeq NM_001257326)
APBB1 (ENST00000608394.5) at chr11:6395143-6405417 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 4, mRNA. (from RefSeq NM_001257321)
APBB1 (ENST00000609360.6) at chr11:6395125-6419094 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 1, mRNA. (from RefSeq NM_001164)
APBB1 (ENST00000311051.7) at chr11:6395125-6419414 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 2, mRNA. (from RefSeq NM_145689)
APBB1 (ENST00000530885.5) at chr11:6395468-6404898 - Homo sapiens amyloid beta precursor protein binding family B member 1 (APBB1), transcript variant 8, mRNA. (from RefSeq NM_001257323)
CASP8 (ENST00000432109.6) at chr2:201233463-201286594 - Homo sapiens caspase 8 (CASP8), transcript variant B, mRNA. (from RefSeq NM_033355)
CASP8 (ENST00000392258.7) at chr2:201233506-201281915 - Homo sapiens caspase 8 (CASP8), transcript variant E, mRNA. (from RefSeq NM_033358)
CASP8 (ENST00000323492.11) at chr2:201260500-201287709 - Homo sapiens caspase 8 (CASP8), transcript variant C, mRNA. (from RefSeq NM_033356)
CASP8 (ENST00000264275.9) at chr2:201233466-201286729 - Homo sapiens caspase 8 (CASP8), transcript variant A, mRNA. (from RefSeq NM_001228)
CASP8 (ENST00000392263.6) at chr2:201233443-201286594 - Homo sapiens caspase 8 (CASP8), transcript variant F, mRNA. (from RefSeq NM_001080124)
CASP8 (ENST00000358485.8) at chr2:201258036-201287711 - Homo sapiens caspase 8 (CASP8), transcript variant H, non-coding RNA. (from RefSeq NR_111983)
DDIT3 (ENST00000551116.5) at chr12:57516589-57520517 - Homo sapiens DNA damage inducible transcript 3 (DDIT3), transcript variant 4, mRNA. (from RefSeq NM_001195056)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_033306.2 at chr11:104942867-104968532
NM_001225.3 at chr11:104942867-104968598

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017018397.1 at chr11:104942866-104956618
XM_011543019.1 at chr11:104942866-104968596

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

CASP4 at chr11:104942866-104968574

RefSeq Genes

CASP4 at chr11:104942866-104968574 - (NM_033306) caspase-4 isoform gamma precursor
CASP4 at chr11:104942866-104968574 - (NM_001225) caspase-4 isoform alpha precursor

Non-Human RefSeq Genes

CASP4 at chr11:104942872-104968563 - (NM_001260956) caspase-4
Casp4 at chr11:104995740-105002201 - (NM_053736) caspase 4
Casp4 at chr11:104944749-104955002 - (NM_053736) caspase 4
CASP4 at chr11:104942861-104951988 - (NM_176638) caspase-4
CASP4 at chr11:104886714-105044660 - (NM_001009365) caspase-1
CASP4 at chr11:104944753-105044660 - (NM_001003125) caspase-1
CASP4 at chr11:104901456-104952005 - (NM_001309343) caspase 4, apoptosis-related cysteine peptidase
Casp4 at chr11:104995744-105002201 - (NM_007609) caspase-4 precursor
Casp4 at chr11:104944749-104951098 - (NM_007609) caspase-4 precursor

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CASP4 at chr11:104942866-104968574
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104968574
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

CASP4 at chr11:104942866-104948894
CASP4 at chr11:104942866-104969436
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942868-104956698
CASP4 at chr11:104942869-104947192
CASP4 at chr11:104942870-104950992
CASP4 at chr11:104942873-104947358
CASP4 at chr11:104944753-104968547
CASP4 at chr11:104946624-104948734
CASP4 at chr11:104948602-104968565
CASP4 at chr11:104949402-104968581
CASP4 at chr11:104949661-104968639
CASP4 at chr11:104951028-104969366
CASP4 at chr11:104951397-104968575

International Knockout Mouse Consortium Genes Mapped to Human Genome

Casp4_47499 at chr11:104942867-104968598
Casp4_75743 at chr11:104942867-104968598

BC017839 Alignments in Human Aligned mRNAs

This aligns in multiple positions. Click on a hyperlink to go to tracks display at a particular alignment.
 SIZE IDENTITY CHROMOSOME STRAND  START     END       cDNA   START  END  TOTAL
------------------------------------------------------------------------------
 1273  100.0%         11     - 104942877 104968562  BC017839     3  1275  1306

Non-Human Aligned mRNA Search Results

BC112708 - Bos taurus caspase 4, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:137679 IMAGE:8170234), complete cds.
BT020999 - Bos taurus caspase 4, apoptosis-related cysteine protease (CASP4), mRNA, complete cds.
JU473387 - TSA: Macaca mulatta Mamu_387057 mRNA sequence.
EU836041 - Mustela putorius furo caspase 4 (Casp4) mRNA, partial cds.
BC061255 - Mus musculus caspase 4, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:74411 IMAGE:30251263), complete cds.
BC104720 - Rattus norvegicus caspase 4, apoptosis-related cysteine peptidase, mRNA (cDNA clone MGC:124949 IMAGE:7382967), complete cds.