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Gencode Genes

ASAP1-IT2 (ENST00000626977.1) at chr8:130082738-130084768 - Homo sapiens ASAP1 intronic transcript 2 (ASAP1-IT2), long non-coding RNA. (from RefSeq NR_045385)
ASAP1 (ENST00000518721.6) at chr8:130052104-130443674 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1), transcript variant 1, mRNA. (from RefSeq NM_018482)
ASAP1 (ENST00000524367.5) at chr8:130152764-130340937 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000524299.1) at chr8:130214618-130443537 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RHA9)
ASAP1 (ENST00000524124.5) at chr8:130052104-130180862 - Contains 1 Arf-GAP domain. (from UniProt H0YBF7)
ASAP1 (ENST00000524018.1) at chr8:130152605-130160063 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000521426.5) at chr8:130214645-130386877 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RHD7)
ASAP1 (ENST00000521075.5) at chr8:130052842-130401968 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RHA9)
ASAP1 (ENST00000521057.1) at chr8:130115577-130118779 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000520927.5) at chr8:130180867-130427802 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RHA9)
ASAP1 (ENST00000520625.1) at chr8:130360689-130401915 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000520342.5) at chr8:130179335-130247042 - The sequence shown here is derived from an Ensembl  automatic analysis pipeline and should be considered as  preliminary data. (from UniProt E5RFD9)
ASAP1 (ENST00000520189.1) at chr8:130076397-130112414 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000519483.5) at chr8:130054741-130118522 - Contains 1 SH3 domain. (from UniProt H0YBM4)
ASAP1 (ENST00000519169.5) at chr8:130179118-130236996 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000518957.1) at chr8:130195113-130214624 - ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (from HGNC ASAP1)
ASAP1 (ENST00000357668.2) at chr8:130052107-130443660 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1 (ASAP1), transcript variant 2, mRNA. (from RefSeq NM_001247996)
REPS2 (ENST00000357277.8) at chrX:16946658-17153272 - Homo sapiens RALBP1 associated Eps domain containing 2 (REPS2), transcript variant 1, mRNA. (from RefSeq NM_004726)
REPS2 (ENST00000303843.7) at chrX:16946862-17153272 - Homo sapiens RALBP1 associated Eps domain containing 2 (REPS2), transcript variant 2, mRNA. (from RefSeq NM_001080975)
CTTN (ENST00000376561.7) at chr11:70398541-70436579 - Homo sapiens cortactin (CTTN), transcript variant 3, mRNA. (from RefSeq NM_001184740)
CTTN (ENST00000346329.7) at chr11:70398404-70436584 - Homo sapiens cortactin (CTTN), transcript variant 2, mRNA. (from RefSeq NM_138565)
CTTN (ENST00000301843.13) at chr11:70398529-70436575 - Homo sapiens cortactin (CTTN), transcript variant 1, mRNA. (from RefSeq NM_005231)
RAB11FIP3 (ENST00000610934.1) at chr16_KI270854v1_alt:75156-125146 - Homo sapiens RAB11 family interacting protein 3 (RAB11FIP3), transcript variant 2, mRNA. (from RefSeq NM_001142272)
RAB11FIP3 (ENST00000611004.4) at chr16_KI270854v1_alt:24765-125679 - Homo sapiens RAB11 family interacting protein 3 (RAB11FIP3), transcript variant 1, mRNA. (from RefSeq NM_014700)
RAB11FIP3 (ENST00000450428.5) at chr16:474850-522478 - Homo sapiens RAB11 family interacting protein 3 (RAB11FIP3), transcript variant 2, mRNA. (from RefSeq NM_001142272)
RAB11FIP3 (ENST00000262305.9) at chr16:425649-523011 - Homo sapiens RAB11 family interacting protein 3 (RAB11FIP3), transcript variant 1, mRNA. (from RefSeq NM_014700)
PTK2B (ENST00000517339.5) at chr8:27397452-27459386 - Non-receptor protein-tyrosine kinase that regulates  reorganization of the actin cytoskeleton, cell polarization, cell  migration, adhesion, spreading and bone remodeling. Plays a role  in the regulation of the humoral immune response, and is required  for normal levels of marginal B-cells in the spleen and normal  migration of splenic B-cells. Required for normal macrophage  polarization and migration towards sites of inflammation.  Regulates cytoskeleton rearrangement and cell spreading in T-  cells, and contributes to the regulation of T-cell responses.  Promotes osteoclastic bone resorption; this requires both  PTK2B/PYK2 and SRC. May inhibit differentiation and activity of  osteoprogenitor cells. Functions in signaling downstream of  integrin and collagen receptors, immune receptors, G-protein  coupled receptors (GPCR), cytokine, chemokine and growth factor  receptors, and mediates responses to cellular stress. Forms  multisubunit signaling complexes with SRC and SRC family members  upon activation; this leads to the phosphorylation of additional  tyrosine residues, creating binding sites for scaffold proteins,  effectors and substrates. Regulates numerous signaling pathways.  Promotes activation of phosphatidylinositol 3-kinase and of the  AKT1 signaling cascade. Promotes activation of NOS3. Regulates  production of the cellular messenger cGMP. Promotes activation of  the MAP kinase signaling cascade, including activation of  MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho  family GTPases, such as RHOA and RAC1. Recruits the ubiquitin  ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates  P53/TP53 activity, P53/TP53 ubiquitination and proteasomal  degradation. Acts as a scaffold, binding to both PDPK1 and SRC,  thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373',  and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC  family members, and thereby contributes to the regulation of NMDA  receptor ion channel activity and intracellular Ca(2+) levels. May  also regulate potassium ion transport by phosphorylation of  potassium channel subunits. Phosphorylates SRC; this increases SRC  kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1.  Promotes phosphorylation of ASAP2, RHOU and PXN; this requires  both SRC and PTK2/PYK2. (from UniProt Q14289)
NCK1 (ENST00000288986.6) at chr3:136862208-136949126 - Adapter protein which associates with tyrosine-  phosphorylated growth factor receptors, such as KDR and PDGFRB, or  their cellular substrates. Maintains low levels of EIF2S1  phosphorylation by promoting its dephosphorylation by PP1. Plays a  role in the DNA damage response, not in the detection of the  damage by ATM/ATR, but for efficient activation of downstream  effectors, such as that of CHEK2. Plays a role in ELK1-dependent  transcriptional activation in response to activated Ras signaling. (from UniProt P16333)
NCK1 (ENST00000481752.6) at chr3:136862208-136951606 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 1, mRNA. (from RefSeq NM_006153)
NCK1 (ENST00000469404.1) at chr3:136930470-136949823 - Homo sapiens NCK adaptor protein 1 (NCK1), transcript variant 2, mRNA. (from RefSeq NM_001190796)
CRK (ENST00000398970.5) at chr17:1420689-1456223 - Homo sapiens CRK proto-oncogene, adaptor protein (CRK), transcript variant I, mRNA. (from RefSeq NM_005206)
CRK (ENST00000300574.3) at chr17:1420693-1456232 - Homo sapiens CRK proto-oncogene, adaptor protein (CRK), transcript variant II, mRNA. (from RefSeq NM_016823)
SH3KBP1 (ENST00000379716.5) at chrX:19534007-19670998 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 10, mRNA. (from RefSeq NM_001353897)
SH3KBP1 (ENST00000379698.8) at chrX:19535693-19799751 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 2, mRNA. (from RefSeq NM_001024666)
SH3KBP1 (ENST00000397821.8) at chrX:19533977-19887600 - Homo sapiens SH3 domain containing kinase binding protein 1 (SH3KBP1), transcript variant 1, mRNA. (from RefSeq NM_031892)
APC (ENST00000508376.6) at chr5:112737895-112846056 - Homo sapiens APC regulator of WNT signaling pathway (APC), transcript variant 13, mRNA. (from RefSeq NM_001354904)
APC (ENST00000257430.9) at chr5:112737885-112846239 - Homo sapiens APC regulator of WNT signaling pathway (APC), transcript variant 15, mRNA. (from RefSeq NM_001354906)
PLCG1 (ENST00000244007.7) at chr20:41136960-41175721 - Homo sapiens phospholipase C gamma 1 (PLCG1), transcript variant 1, mRNA. (from RefSeq NM_002660)
PLCG1 (ENST00000373271.5) at chr20:41137237-41177626 - Homo sapiens phospholipase C gamma 1 (PLCG1), transcript variant 2, mRNA. (from RefSeq NM_182811)
PTK2B (ENST00000420218.3) at chr8:27325564-27459391 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 4, mRNA. (from RefSeq NM_173175)
PTK2B (ENST00000397501.5) at chr8:27311482-27459390 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 1, mRNA. (from RefSeq NM_173174)
PTK2B (ENST00000346049.10) at chr8:27325552-27459386 - Homo sapiens protein tyrosine kinase 2 beta (PTK2B), transcript variant 3, mRNA. (from RefSeq NM_173176)
GRB2 (ENST00000648046.1) at chr17:75319479-75405699 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392564.5) at chr17:75318076-75393864 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392563.5) at chr17:75318076-75393656 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
GRB2 (ENST00000392562.5) at chr17:75318076-75405486 - Adapter protein that provides a critical link between  cell surface growth factor receptors and the Ras signaling  pathway. (from UniProt P62993)
FYN (ENST00000368682.7) at chr6:111660332-111873067 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 2, mRNA. (from RefSeq NM_153047)
FYN (ENST00000354650.7) at chr6:111660332-111873452 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 1, mRNA. (from RefSeq NM_002037)
FYN (ENST00000229471.8) at chr6:111661282-111759131 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 3, mRNA. (from RefSeq NM_153048)
GRB2 (ENST00000316615.9) at chr17:75318076-75405709 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 2, mRNA. (from RefSeq NM_203506)
GRB2 (ENST00000316804.10) at chr17:75318076-75405678 - Homo sapiens growth factor receptor bound protein 2 (GRB2), transcript variant 1, mRNA. (from RefSeq NM_002086)
FYN (ENST00000368667.6) at chr6:111661282-111793886 - Homo sapiens FYN proto-oncogene, Src family tyrosine kinase (FYN), transcript variant 4, mRNA. (from RefSeq NM_001370529)
FYN (ENST00000368678.8) at chr6:111661286-111873430 - Non-receptor tyrosine-protein kinase that plays a role  in many biological processes including regulation of cell growth  and survival, cell adhesion, integrin-mediated signaling,  cytoskeletal remodeling, cell motility, immune response and axon  guidance. Inactive FYN is phosphorylated on its C-terminal tail  within the catalytic domain. Following activation by PKA, the  protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1  phosphorylation, activation and targeting to focal adhesions.  Involved in the regulation of cell adhesion and motility through  phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-  catenin). Regulates cytoskeletal remodeling by phosphorylating  several proteins including the actin regulator WAS and the  microtubule-associated proteins MAP2 and MAPT. Promotes cell  survival by phosphorylating AGAP2/PIKE-A and preventing its  apoptotic cleavage. Participates in signal transduction pathways  that regulate the integrity of the glomerular slit diaphragm (an  essential part of the glomerular filter of the kidney) by  phosphorylating several slit diaphragm components including NPHS1,  KIRREL and TRPC6. Plays a role in neural processes by  phosphorylating DPYSL2, a multifunctional adapter protein within  the central nervous system, ARHGAP32, a regulator for Rho family  GTPases implicated in various neural functions, and SNCA, a small  pre-synaptic protein. Participates in the downstream signaling  pathways that lead to T-cell differentiation and proliferation  following T-cell receptor (TCR) stimulation. Also participates in  negative feedback regulation of TCR signaling through  phosphorylation of PAG1, thereby promoting interaction between  PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains  LCK and FYN in an inactive form. Promotes CD28-induced  phosphorylation of VAV1. (from UniProt P06241)
FYN (ENST00000538466.5) at chr6:111660332-111720062 - Non-receptor tyrosine-protein kinase that plays a role  in many biological processes including regulation of cell growth  and survival, cell adhesion, integrin-mediated signaling,  cytoskeletal remodeling, cell motility, immune response and axon  guidance. Inactive FYN is phosphorylated on its C-terminal tail  within the catalytic domain. Following activation by PKA, the  protein subsequently associates with PTK2/FAK1, allowing PTK2/FAK1  phosphorylation, activation and targeting to focal adhesions.  Involved in the regulation of cell adhesion and motility through  phosphorylation of CTNNB1 (beta-catenin) and CTNND1 (delta-  catenin). Regulates cytoskeletal remodeling by phosphorylating  several proteins including the actin regulator WAS and the  microtubule-associated proteins MAP2 and MAPT. Promotes cell  survival by phosphorylating AGAP2/PIKE-A and preventing its  apoptotic cleavage. Participates in signal transduction pathways  that regulate the integrity of the glomerular slit diaphragm (an  essential part of the glomerular filter of the kidney) by  phosphorylating several slit diaphragm components including NPHS1,  KIRREL and TRPC6. Plays a role in neural processes by  phosphorylating DPYSL2, a multifunctional adapter protein within  the central nervous system, ARHGAP32, a regulator for Rho family  GTPases implicated in various neural functions, and SNCA, a small  pre-synaptic protein. Participates in the downstream signaling  pathways that lead to T-cell differentiation and proliferation  following T-cell receptor (TCR) stimulation. Also participates in  negative feedback regulation of TCR signaling through  phosphorylation of PAG1, thereby promoting interaction between  PAG1 and CSK and recruitment of CSK to lipid rafts. CSK maintains  LCK and FYN in an inactive form. Promotes CD28-induced  phosphorylation of VAV1. (from UniProt P06241)
SRC (ENST00000373578.6) at chr20:37346154-37406050 - Homo sapiens SRC proto-oncogene, non-receptor tyrosine kinase (SRC), transcript variant 2, mRNA. (from RefSeq NM_198291)
SRC (ENST00000373567.6) at chr20:37383668-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000373558.2) at chr20:37384150-37406050 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)
SRC (ENST00000358208.8) at chr20:37382604-37405432 - Non-receptor protein tyrosine kinase which is activated  following engagement of many different classes of cellular  receptors including immune response receptors, integrins and other  adhesion receptors, receptor protein tyrosine kinases, G protein-  coupled receptors as well as cytokine receptors. Participates in  signaling pathways that control a diverse spectrum of biological  activities including gene transcription, immune response, cell  adhesion, cell cycle progression, apoptosis, migration, and  transformation. Due to functional redundancy between members of  the SRC kinase family, identification of the specific role of each  SRC kinase is very difficult. SRC appears to be one of the primary  kinases activated following engagement of receptors and plays a  role in the activation of other protein tyrosine kinase (PTK)  families. Receptor clustering or dimerization leads to recruitment  of SRC to the receptor complexes where it phosphorylates the  tyrosine residues within the receptor cytoplasmic domains. Plays  an important role in the regulation of cytoskeletal organization  through phosphorylation of specific substrates such as AFAP1.  Phosphorylation of AFAP1 allows the SRC SH2 domain to bind AFAP1  and to localize to actin filaments. Cytoskeletal reorganization is  also controlled through the phosphorylation of cortactin (CTTN).  When cells adhere via focal adhesions to the extracellular matrix,  signals are transmitted by integrins into the cell resulting in  tyrosine phosphorylation of a number of focal adhesion proteins,  including PTK2/FAK1 and paxillin (PXN). In addition to  phosphorylating focal adhesion proteins, SRC is also active at the  sites of cell-cell contact adherens junctions and phosphorylates  substrates such as beta-catenin (CTNNB1), delta-catenin (CTNND1),  and plakoglobin (JUP). Another type of cell-cell junction, the gap  junction, is also a target for SRC, which phosphorylates connexin-  43 (GJA1). SRC is implicated in regulation of pre-mRNA-processing  and phosphorylates RNA-binding proteins such as KHDRBS1. Also  plays a role in PDGF-mediated tyrosine phosphorylation of both  STAT1 and STAT3, leading to increased DNA binding activity of  these transcription factors. Involved in the RAS pathway through  phosphorylation of RASA1 and RASGRF1. Plays a role in EGF-mediated  calcium-activated chloride channel activation. Required for  epidermal growth factor receptor (EGFR) internalization through  phosphorylation of clathrin heavy chain (CLTC and CLTCL1) at 'Tyr-  1477'. Involved in beta-arrestin (ARRB1 and ARRB2) desensitization  through phosphorylation and activation of ADRBK1, leading to beta-  arrestin phosphorylation and internalization. Has a critical role  in the stimulation of the CDK20/MAPK3 mitogen-activated protein  kinase cascade by epidermal growth factor. Might be involved not  only in mediating the transduction of mitogenic signals at the  level of the plasma membrane but also in controlling progression  through the cell cycle via interaction with regulatory proteins in  the nucleus. Plays an important role in osteoclastic bone  resorption in conjunction with PTK2B/PYK2. Both the formation of a  SRC-PTK2B/PYK2 complex and SRC kinase activity are necessary for  this function. Recruited to activated integrins by PTK2B/PYK2,  thereby phosphorylating CBL, which in turn induces the activation  and recruitment of phosphatidylinositol 3-kinase to the cell  membrane in a signaling pathway that is critical for osteoclast  function. Promotes energy production in osteoclasts by activating  mitochondrial cytochrome C oxidase. Phosphorylates DDR2 on  tyrosine residues, thereby promoting its subsequent  autophosphorylation. Phosphorylates RUNX3 and COX2 on tyrosine  residues, TNK2 on 'Tyr-284' and CBL on 'Tyr-731'. Enhances  DDX58/RIG-I-elicited antiviral signaling. Phosphorylates PDPK1 at  'Tyr-9', 'Tyr-373' and 'Tyr-376'. (from UniProt P12931)

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

NM_001247996.1 at chr8:130052104-130443660
NM_018482.3 at chr8:130052104-130443660
NR_002765.2 at chr8:130295355-130296533
NR_045385.1 at chr8:130082738-130084768

NCBI RefSeq genes, predicted subset (XM_* or XR_*)

XM_017013467.2 at chr8:130052104-130357933
XM_006716565.3 at chr8:130052104-130358107
XM_011517053.1 at chr8:130052104-130386877
XM_011517052.2 at chr8:130052104-130409060
XM_006716563.3 at chr8:130052104-130427753
XM_006716564.1 at chr8:130052104-130443536
XM_005250925.1 at chr8:130052104-130443660
XM_006716566.1 at chr8:130052104-130443660
XM_017013469.1 at chr8:130052104-130443660
XM_017013468.1 at chr8:130052104-130443848

NCBI RefSeq and Ensembl transcripts from the MANE Project (v0.6)

ASAP1 at chr8:130052104-130443674

RefSeq Genes

ASAP1 at chr8:130052105-130443674 - (NM_001362926) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 5
ASAP1 at chr8:130052105-130443674 - (NM_018482) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 1
ASAP1 at chr8:130052105-130443674 - (NM_001362925) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 4
ASAP1 at chr8:130052105-130443660 - (NM_001362924) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 3
ASAP1 at chr8:130052105-130443660 - (NM_001247996) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform 2
ASAP1-IT1 at chr8:130295355-130296533 - (NR_002765) 
ASAP1-IT2 at chr8:130082738-130084768 - (NR_045385) 

NCBI RefSeq genes, curated subset (NM_*, NR_*, NP_* or YP_*)

ASAP1 intronic transcript 1 at chr8:130295355-130296533 - (NR_002765.2)
ASAP1 intronic transcript 2 at chr8:130082738-130084768 - (NR_045385.1)

Non-Human RefSeq Genes

asap1 at chr8:130054740-130358166 - (NM_001097266) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
ASAP1 at chr8:130052105-130443503 - (NM_175821) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Asap1 at chr8:130052090-130443742 - (NM_001276467) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform e
Asap1 at chr8:130052090-130358215 - (NM_001276462) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform c
Asap1 at chr8:130052090-130443742 - (NM_001276461) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform b
Asap1 at chr8:130052090-130358215 - (NM_001276463) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform d
Asap1 at chr8:130054731-130401943 - (NM_001044245) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1
Asap1 at chr8:130052090-130443742 - (NM_010026) arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 1 isoform a
asap1a at chr8:130054728-130358145 - (NM_001130663) ArfGAP with SH3 domain, ankyrin repeat and PH domain 1a

Basic Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

ASAP1 at chr8:130052104-130443674
ASAP1 at chr8:130052107-130443660

Comprehensive Gene Annotation Set from GENCODE Version 31 (Ensembl 97)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052104-130443674
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 29 (Ensembl 94)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 28 (Ensembl 92)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 27 (Ensembl 90)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 26 (Ensembl 88)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 25 (Ensembl 85)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 24 (Ensembl 83)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 23 (Ensembl 81)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 22 (Ensembl 79)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Basic Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130443660

Comprehensive Gene Annotation Set from GENCODE Version 20 (Ensembl 76)

ASAP1 at chr8:130052104-130180862
ASAP1 at chr8:130052107-130443660
ASAP1 at chr8:130052842-130401968
ASAP1 at chr8:130052842-130443660
ASAP1 at chr8:130054741-130118522
ASAP1 at chr8:130076397-130112414
ASAP1 at chr8:130115577-130118779
ASAP1 at chr8:130152605-130160063
ASAP1 at chr8:130152764-130340937
ASAP1 at chr8:130179118-130236996
ASAP1 at chr8:130179335-130247042
ASAP1 at chr8:130180867-130427802
ASAP1 at chr8:130195113-130214624
ASAP1 at chr8:130214618-130443537
ASAP1 at chr8:130214645-130386877
ASAP1 at chr8:130360689-130401915

Retroposed Genes V9, Including Pseudogenes

ASAP1 at chr2:9206867-9207231 - (NM_018482.3-3)
ASAP1 at chr2:9206867-9207231 - (NM_018482.3-3)

International Knockout Mouse Consortium Genes Mapped to Human Genome

Asap1_45742 at chr8:130052107-130401971

Human Aligned mRNA Search Results

BC020631 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1, mRNA (cDNA clone IMAGE:4733268), complete cds.
BC137135 - Homo sapiens ArfGAP with SH3 domain, ankyrin repeat and PH domain 1, mRNA (cDNA clone MGC:168755 IMAGE:9021132), complete cds.

Human Unaligned mRNA Search Results

NR_002765 - Homo sapiens ASAP1 intronic transcript 1 (ASAP1-IT1), long non-coding RNA.
NR_045385 - Homo sapiens ASAP1 intronic transcript 2 (ASAP1-IT2), long non-coding RNA.

Non-Human Aligned mRNA Search Results

KF601564 - Xenopus laevis Asap1 mRNA, complete cds.
DQ238624 - Rattus norvegicus ASAP1 splice variant c (Ddef1) mRNA, complete cds, alternatively spliced.
DQ238623 - Rattus norvegicus ASAP1 splice variant b (Ddef1) mRNA, complete cds, alternatively spliced.
DQ238622 - Rattus norvegicus ASAP1 splice variant a (Ddef1) mRNA, complete cds, alternatively spliced.
BC002201 - Mus musculus ArfGAP with SH# domain, ankyrin repeat and PH domain1, mRNA (cDNA clone IMAGE:3489486), partial cds.
BC048818 - Mus musculus ArfGAP with SH# domain, ankyrin repeat and PH domain1, mRNA (cDNA clone IMAGE:3668778), partial cds.
BC094581 - Mus musculus ArfGAP with SH# domain, ankyrin repeat and PH domain1, mRNA (cDNA clone MGC:106491 IMAGE:30549241), complete cds.
JU327451 - TSA: Macaca mulatta Mamu_502503 mRNA sequence.
JV043390 - TSA: Macaca mulatta Mamu_405327 mRNA sequence.