Gene interactions and pathways from curated databases and text-mining
IL6: top 25 interacting genes (chr7:22766765-22771621)
Mouse over or click genes or lines for details. Dashed lines indicate interactions without text mining support. Click any gene to make it the new center. Click any line to show details about the interaction. Only IL6-interacting genes and only the most-mentioned/most-curated interactions are shown in the graph. See the Help Page for details.
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Less-frequently mentioned interactions with IL6, not among the Top 25
Other genes interacting with IL6. Mouse-over to show number of abstracts or databases. Sorted by article count (sort alphabetically).
Like above, interactions are colored by support. Grey:only text mining, light-blue:interaction database, blue:pathway database

MAPK9 ▸ TLR4 ▸ IL17A ▸ IL3 ▸ TLR2 ▸ EPHB2 ▸ CSF2 ▸
IL13 ▸ TGFB1 ▸ CRP ▸ IL5 ▸ VEGFA ▸ IL21 ▸ IL18 ▸
TLR3 ▸ ICAM1 ▸ IL33 ▸ PTGS2 ▸ IL22 ▸ IL7 ▸ TLR9 ▸
FGB ▸ CD40 ▸ IL32 ▸ INS ▸ IL11 ▸ CCL2 ▸ IL15 ▸
IL19 ▸ JAK2 ▸ IL31 ▸ IL24 ▸ IL25 ▸ IL20 ▸ JUN ▸
IL16 ▸ IL34 ▸ IL6ST ▸ IL26 ▸ IL9 ▸ IL27 ▸ NOS2 ▸
SOCS3 ▸ IL37 ▸ TLR5 ▸ TLR7 ▸ TLR1 ▸ STAT1 ▸ TLR8 ▸
TLR6 ▸ TLR10 ▸ PTH ▸ IL12B ▸ SOAT1 ▸ SAA1 ▸ CSRP1 ▸
IL1RN ▸ FOS ▸ AKT1 ▸ AKT3 ▸ AKT2 ▸ JAK1 ▸ CD79A ▸
LEP ▸ IL12A ▸ LRPPRC ▸ PIK3CA ▸ VIP ▸ PIK3R1 ▸ RNF19A ▸
LTA ▸ CRK ▸ PTX3 ▸ MMP1 ▸ ADCYAP1 ▸ LIF ▸ CD40LG ▸
PAF1 ▸ WDR61 ▸ CTR9 ▸ LEO1 ▸ CDC73 ▸ PRKAB2 ▸ PRKAA1 ▸
FGF2 ▸ PRKAG1 ▸ PRKAG2 ▸ PRKAB1 ▸ PRKAA2 ▸ IL6R ▸ HGF ▸
GP2 ▸ PTX4 ▸ GP5 ▸ GP6 ▸ GP9 ▸ IGF1 ▸ MMP3 ▸
EDN1 ▸ MYLIP ▸ MMP9 ▸ GRAP2 ▸ JAK3 ▸ MMP2 ▸ TCF3 ▸
CRH ▸ TCF24 ▸ TCF7 ▸ TCF4 ▸ TCF21 ▸ TCF15 ▸ TCF20 ▸
TCF25 ▸ CD4 ▸ TCF12 ▸ MYD88 ▸ CISH ▸ TCF23 ▸ TCF19 ▸
TGFB3 ▸ IFNB1 ▸ MMP13 ▸ CA2 ▸ NOS3 ▸ TGFB2 ▸ PLG ▸
MCL1 ▸ A2M ▸ OSM ▸ PAM ▸ AHSA1 ▸ TIMP1 ▸ HP ▸
CD14 ▸ NOS1 ▸ PTBP1 ▸ HNRNPH1 ▸ HMGB1 ▸ PGF ▸ HNRNPF ▸
CEBPB ▸ CD46 ▸ PTBP2 ▸ NA ▸ CASP3 ▸ NFKBIA ▸ APOB ▸
MT3 ▸ AR ▸ CSF1 ▸ STAT5A ▸ NOX4 ▸ ALB ▸ TNFSF11 ▸
PRG3 ▸ PRG4 ▸ PRG2 ▸ TAT ▸ S100A12 ▸ PI3 ▸ CASP2 ▸
CASP8 ▸ PRKAR1B ▸ CASP4 ▸ CASP7 ▸ PRKAR1A ▸ CASP12 ▸ CASP9 ▸
PRKACB ▸ CASP5 ▸ PRKAR2A ▸ NGF ▸ CASP14 ▸ CASP1 ▸ CASP10 ▸
NOX5 ▸ PRKAR2B ▸ CASP16 ▸ NOX1 ▸ PRKACG ▸ CASP6 ▸ NOX3 ▸
CSF3 ▸ ANGPT2 ▸ POLDIP2 ▸ PRL ▸ MT4 ▸ SOCS1 ▸ PDGFB ▸
ITIH4 ▸ LPA ▸ VCAM1 ▸ FAS ▸ FOXP3 ▸ GPI ▸ CD8A ▸
SPP1 ▸ MMP7 ▸ CALM3 ▸ SOD1 ▸ SYT1 ▸ MMP10 ▸ CYP19A1 ▸
SELE ▸ FASLG ▸ SAA2 ▸ MMP14 ▸ SOD3 ▸ MMP11 ▸ ANG ▸
NUP43 ▸ IKBKB ▸ IRF1 ▸ PLA2G1B ▸ CEBPA ▸ LBP ▸ BCL2 ▸
PTPN11 ▸ TNFRSF11B ▸ IFI44 ▸ APP ▸ MMP8 ▸ MMP12 ▸ SOD2 ▸
HMOX1 ▸ MMP17 ▸ HDAC1 ▸ LPL ▸ ADIPOQ ▸ FCER2 ▸ SETBP1 ▸
MMP21 ▸ MMP27 ▸ CCL3 ▸ MMP19 ▸ NAALADL1 ▸ CD28 ▸ CTSB ▸
MMP25 ▸ SERPINE1 ▸ MMP20 ▸ MMP24 ▸ CPOX ▸ EGF ▸ F2RL1 ▸
MMP26 ▸ MMP15 ▸ MMP28 ▸ CALML3 ▸ ALG1 ▸ MMP16 ▸ FGF1 ▸
SAA4 ▸ MSH6 ▸ FGF4 ▸ PPARG ▸ FGF23 ▸ IRAK4 ▸ MAP3K7 ▸
APC ▸ CSK ▸ PTHLH ▸ FGF7 ▸ NPS ▸ ERVK-6 ▸ IL23A ▸
GFAP ▸ AGTR2 ▸ MSH3 ▸ LTF ▸ AGT ▸ PTPRC ▸ SERPINA3 ▸
GH1 ▸ BCL6 ▸ HES1 ▸ BCL3 ▸ TYR ▸ HDAC2 ▸ MIF ▸
PLA2G4A ▸ PRDX2 ▸ MSH4 ▸ IL1R1 ▸ MSH2 ▸ PDLIM7 ▸ FGF18 ▸
IFNA2 ▸ FGF8 ▸ MSH5 ▸ FGF22 ▸ FGF20 ▸ TP53 ▸ CREB5 ▸
CEACAM5 ▸ LTB ▸ FGF19 ▸ FGF13 ▸ ABCC1 ▸ SMAD3 ▸ FGF21 ▸
FGF9 ▸ FGF12 ▸ FGF6 ▸ IGF2 ▸ IL2RA ▸ PPARA ▸ MTX1 ▸
FGF16 ▸ FGF17 ▸ CREB1 ▸ F2R ▸ SKP1 ▸ FGF3 ▸ FGF14 ▸
FGF11 ▸ CUL1 ▸ FGF10 ▸ FGF5 ▸ KITLG ▸ CREB3 ▸ CHUK ▸
HES2 ▸ IFNA10 ▸ TRAF6 ▸ MRXS5 ▸ IFNA7 ▸ MPO ▸ PTK2 ▸
CXCL12 ▸ HES5 ▸ HES4 ▸ MTOR ▸ PTK6 ▸ PTK7 ▸ HSPD1 ▸
IFNA21 ▸ CD44 ▸ HES7 ▸ UCN ▸ CDKN1A ▸ CD8B ▸ EPO ▸
IFNA14 ▸ RHO ▸ TXN ▸ ESR1 ▸ CCL5 ▸ HES3 ▸ MAP2K1 ▸
IFNA5 ▸ EGFR ▸ IFNA16 ▸ HES6 ▸ SST ▸ IFNA1 ▸ SMAD2 ▸
CEBPD ▸ IFNA6 ▸ IFNA17 ▸ IFNA4 ▸ IFNA8 ▸ ANXA1 ▸ BMP2 ▸
IFNA13 ▸ IKBKG ▸ HSPB1 ▸ RBBP4 ▸ STAT4 ▸ FCGR1A ▸ NPY ▸
RENBP ▸ CAV1 ▸ CNTN2 ▸ MAP2K4 ▸ CAV3 ▸ SMAD4 ▸ AVP ▸
C4BPA ▸ RBBP7 ▸ ANPEP ▸ HAMP ▸ NAMPT ▸ MUC1 ▸ CXCL10 ▸
IDO1 ▸ P2RX7 ▸ PAEP ▸ CNTF ▸ BAX ▸ PRKCA ▸ SMAD7 ▸
CXCL1 ▸ SP1 ▸ KLK3 ▸ WNK1 ▸ TFPI ▸ CAV2 ▸ CAT ▸
CD86 ▸ ARID4B ▸ SMAD5 ▸ GCG ▸ IFI27 ▸ S100B ▸ IRS1 ▸
IL17RA ▸ AGTR1 ▸ GZMB ▸ NPEPPS ▸ IRF3 ▸ DUSP1 ▸ MBP ▸
SMAD9 ▸ ADCY4 ▸ SMAD6 ▸ ADCY5 ▸ ADCY9 ▸ REL ▸ CD5 ▸
JUND ▸ TAB1 ▸ ADCY10 ▸ NPPA ▸ WNT5A ▸ BMP7 ▸ RAG2 ▸
HLA-DRB1 ▸ BMP6 ▸ NM ▸ SMAD1 ▸ MUC4 ▸ NOD1 ▸ SIN3A ▸
RAG1 ▸ CHAT ▸ CLEC7A ▸ GIF ▸ PDCD11 ▸ NOD2 ▸ HDC ▸
BCL10 ▸ SELP ▸ DDIT3 ▸ IRAK1 ▸ ADCY3 ▸ ADCY6 ▸ CYP3A4 ▸
SHC1 ▸ TGFA ▸ ADM ▸ ACE ▸ MET ▸ ADCY8 ▸ SAP130 ▸
SAP30 ▸ SYK ▸ ADCY1 ▸ TNFRSF1B ▸ CSE ▸ SELL ▸ SRC ▸
ACP2 ▸ STS ▸ SUDS3 ▸ ADCY7 ▸ HLA-DRA ▸ HIF1A ▸ TNFRSF1A ▸
CCR5 ▸ ADCY2 ▸ CORT ▸ IBD9 ▸ HSPG2 ▸ EDN3 ▸ ICAM4 ▸
PPP2CA ▸ S100A9 ▸ MUC7 ▸ CTGF ▸ IRAK3 ▸ MPG ▸ BMP1 ▸
ADORA1 ▸ TF ▸ PGP ▸ ABCB1 ▸ CYP1A1 ▸ PIGA ▸ MUC13 ▸
ZFP36 ▸ ST2 ▸ POMC ▸ PTGS1 ▸ ATP8A2 ▸ MUC8 ▸ MUC20 ▸
IL17D ▸ MUC22 ▸ ICAM5 ▸ MUC6 ▸ TYK2 ▸ UTP18 ▸ MAP2K2 ▸
MAP2K5 ▸ HSF1 ▸ BTRC ▸ CCL20 ▸ CXCL17 ▸ MUC12 ▸ ICOSLG ▸
EDN2 ▸ BCL9 ▸ SFTPC ▸ OPRM1 ▸ NCAM1 ▸ APOE ▸ IBD5 ▸
IBD6 ▸ UTP6 ▸ EIF2AK2 ▸ IBD8 ▸ MUC17 ▸ HSP90AB1 ▸ GRB2 ▸
NLRP3 ▸ LGALS1 ▸ IBD7 ▸ PLD1 ▸ SETD2 ▸ HMGCR ▸ SEA ▸
FGFR3 ▸ TPO ▸ HRAS ▸ IGFBP1 ▸ CCND1 ▸ IRF4 ▸ PLD2 ▸
IBD4 ▸ ARSA ▸ ATF3 ▸ ANXA6 ▸ MAP2K6 ▸ MAP2K7 ▸ TNFSF13B ▸
UTP23 ▸ MUC16 ▸ UTP15 ▸ RETN ▸ IL17F ▸ S100A8 ▸ CYP3A ▸
UTP3 ▸ INA ▸ VAV1 ▸ MUC2 ▸ PDGFA ▸ AHR ▸ CR2 ▸
ITGB1 ▸ CTF1 ▸ ICAM2 ▸ TNFRSF8 ▸ ICAM3 ▸ MAP2K3 ▸ CTSL ▸
BCL5 ▸ MUC21 ▸ UTP20 ▸ MOG ▸ MUC19 ▸ IBD3 ▸ IBD2 ▸
MUC15 ▸ PTPN4 ▸ REG1A ▸ NTF3 ▸ ACHE ▸ PITX2 ▸ TGM2 ▸
HCK ▸ CXCL6 ▸ GPX3 ▸ EPS15 ▸ CD80 ▸ PARP14 ▸ FXR2 ▸
C5AR1 ▸ GPX2 ▸ UCN2 ▸ GNA13 ▸ ETS1 ▸ OAS3 ▸ GPX8 ▸
PDCD4 ▸ TRPV1 ▸ HCL3 ▸ GPX4 ▸ OAS1 ▸ CD163 ▸ BMP4 ▸
FOXO3 ▸ BMP10 ▸ IDS ▸ CRYGEP ▸ NEUROD2 ▸ PARP8 ▸ HCL2 ▸
CSH2 ▸ HSPB3 ▸ PARP6 ▸ LYN ▸ FUT4 ▸ PON1 ▸ ESR2 ▸
C1QA ▸ PARP3 ▸ GPX6 ▸ TRAF2 ▸ HSP90AA1 ▸ PARP16 ▸ GAL ▸
PARK2 ▸ CX3CR1 ▸ EBP ▸ LCN2 ▸ NNMT ▸ BGLAP ▸ NEUROD6 ▸
GYS1 ▸ PARP2 ▸ NDP ▸ WNT4 ▸ BCR ▸ CTSS ▸ PPP2R2B ▸
IL1R2 ▸ TIMP2 ▸ HPD ▸ BTK ▸ SLPI ▸ TEC ▸ CD2 ▸
CXCR4 ▸ SERPINF1 ▸ ANGPT1 ▸ PARP4 ▸ GHRH ▸ PIM1 ▸ PCK1 ▸
PLD5 ▸ RPL17 ▸ CPB1 ▸ GPX7 ▸ TRNAI1 ▸ ADORA3 ▸ PPP2R1A ▸
MPL ▸ PARP10 ▸ IRF5 ▸ BMP15 ▸ GYS2 ▸ SCARB1 ▸ IGFBP3 ▸
TNPO1 ▸ CD19 ▸ BMP3 ▸ IRF8 ▸ MS4A1 ▸ PTS ▸ PGD ▸
CA1 ▸ EPS8 ▸ C1orf228 ▸ PLD4 ▸ PLD6 ▸ CD1D ▸ ITGAM ▸
GTF2B ▸ GPX1 ▸ IRF9 ▸ ROR1 ▸ NFATC2 ▸ CHGA ▸ BPI ▸
C1QB ▸ MAF ▸ CIB1 ▸ PARP11 ▸ ATP5O ▸ MAPKAPK2 ▸ CLU ▸
ATP7A ▸ KNG1 ▸ GPX5 ▸ NEUROD1 ▸ PARP9 ▸ THBD ▸ PARP15 ▸
FXR1 ▸ AHSG ▸ HDAC6 ▸ GNRH1 ▸ OAS2 ▸ TSLP ▸ HDAC3 ▸
CYP1A2 ▸ WNT10B ▸ DNMT1 ▸ PLD3 ▸ ABL1 ▸ PARP1 ▸ HCL1 ▸
CPB2 ▸ CCL1 ▸ XRCC1 ▸ NEUROD4 ▸ EPX ▸ ETS2 ▸ FXYD1 ▸
BMP5 ▸ OPN1LW ▸ HSPA5 ▸ XBP1 ▸ PARP12 ▸ HDAC4 ▸ CREBBP ▸
GAST ▸ SMC3 ▸ RAF1 ▸ FMR1 ▸ IL1RAP ▸ CXCL2 ▸ NPY4R ▸
PDCD7 ▸ RLN2 ▸ SMC6 ▸ SOS1 ▸ MSC ▸ COQ7 ▸ TSN ▸
CRAT ▸ PC ▸ NTF4 ▸ HDAC9 ▸ ROR2 ▸ ADH6 ▸ TNC ▸
PDCD1 ▸ MAL ▸ GSTM1 ▸ VWF ▸ MTA3 ▸ STK40 ▸ RBP4 ▸
RLN3 ▸ CXCL9 ▸ ADH7 ▸ PPP5C ▸ C5 ▸ PRNP ▸ ADIPOR1 ▸
STK10 ▸ CCR1 ▸ CXCL16 ▸ CXCR3 ▸ KRT10 ▸ CD274 ▸ SMC5 ▸
ARG2 ▸ IRF7 ▸ TNFAIP6 ▸ STK19 ▸ NLRC5 ▸ HDAC8 ▸ IGF1R ▸
SARS ▸ COQ2 ▸ MAP3K3 ▸ TTR ▸ CCL4 ▸ RORC ▸ AMELX ▸
WNT3 ▸ CDKN1B ▸ CX3CL1 ▸ STK4 ▸ KLRB1 ▸ DEFB4B ▸ LRG1 ▸
LCAT ▸ CHP2 ▸ STK36 ▸ CXCL5 ▸ CXCL3 ▸ EREG ▸ IGFBP7 ▸
QRICH1 ▸ AZU1 ▸ REN ▸ ACE2 ▸ RAC1 ▸ OXA1L ▸ CALM1 ▸
MCS ▸ STEAP4 ▸ PTPN22 ▸ ACR ▸ IGFBP4 ▸ IGFBP2 ▸ ASIP ▸
TRD ▸ NOTCH2 ▸ ADH5 ▸ PDCD6 ▸ RAB7A ▸ ATF1 ▸ UCN3 ▸
HDAC7 ▸ KDR ▸ LDLR ▸ HDAC11 ▸ ECM1 ▸ GSTM4 ▸ PIAS3 ▸
TBP ▸ ICOS ▸ MICE ▸ FYN ▸ NOTCH1 ▸ WAS ▸ FGL1 ▸
COQ5 ▸ P2RX1 ▸ RAB7B ▸ TGM4 ▸ COQ6 ▸ C3AR1 ▸ CXCL13 ▸
TAC3 ▸ SLC39A14 ▸ MIA ▸ WNT16 ▸ OXTR ▸ CD59 ▸ RUNX2 ▸
QRICH2 ▸ NR4A1 ▸ STK25 ▸ COQ3 ▸ TRAF3IP2 ▸ PLAT ▸ KRT38 ▸
CHP1 ▸ STK24 ▸ DEFB114 ▸ GSTM3 ▸ STK39 ▸ PINK1 ▸ WNT6 ▸
STK16 ▸ IFIT1 ▸ SERPING1 ▸ APOA4 ▸ SP3 ▸ CALM2 ▸ MYO10 ▸
TNFSF10 ▸ SMN1 ▸ BAI1 ▸ ARG1 ▸ CD38 ▸ CCK ▸ SMC4 ▸
ITGA4 ▸ PTK2B ▸ CDK9 ▸ SCG5 ▸ NMU ▸ SAA3P ▸ CDKN2A ▸
DYNLRB1 ▸ CD69 ▸ TAC4 ▸ SFTPA1 ▸ CNR2 ▸ MEPE ▸ COQ9 ▸
SCG3 ▸ GCLC ▸ CDH1 ▸ CD33 ▸ THBS1 ▸ ACAN ▸ BLVRB ▸
KRT37 ▸ MYO19 ▸ BSG ▸ ACSM3 ▸ AREG ▸ DERL1 ▸ IL2RB ▸
WNT1 ▸ LGALS3 ▸ ANGPT4 ▸ PARK7 ▸ TRAF5 ▸ RB1 ▸ SDC1 ▸
CPA1 ▸ MKL1 ▸ PDCD10 ▸ COQ4 ▸ CP ▸ TRAF1 ▸ PLA2G2D ▸
VIMP ▸ CEACAM1 ▸ SERPINA1 ▸ XIAP ▸ CD1C ▸ GSTM5 ▸ SCG2 ▸
TSC22D3 ▸ RPS6KA3 ▸ FLT3LG ▸ NTN1 ▸ ADH4 ▸ CXCL11 ▸ SERPINA6 ▸
NANOG ▸ JUNB ▸ VCP ▸ KRT13 ▸ E2F1 ▸ CALCA ▸ STK11 ▸
HDAC5 ▸ HBD ▸ PSMB9 ▸ APCS ▸ IRAK2 ▸ GIP ▸ CD34 ▸
ABCG2 ▸ SPN ▸ POU5F1 ▸ ADAM17 ▸ IL2RG ▸ SLC25A3 ▸ ITGA2B ▸
PDAP1 ▸ MYO6 ▸ BAI3 ▸ NTS ▸ PHB ▸ NR0B1 ▸ IGFBP5 ▸
ACD ▸ COL1A1 ▸ CCR2 ▸ HPX ▸ SERPINB5 ▸ NT5E ▸ RABEPK ▸
STK38 ▸ CCR6 ▸ MUC5AC ▸ BDNF ▸ EEF1A2 ▸ ITGA5 ▸ P2RY6 ▸
VHLL ▸ MCC ▸ CEBPZ ▸ SLC33A1 ▸ GAS6 ▸ PCK2 ▸ WNT11 ▸
AIF1 ▸ AD5 ▸ CXCL14 ▸ HDAC10 ▸ FLOT2 ▸ ECM2 ▸ CDK4 ▸
STK31 ▸ STK33 ▸ STK3 ▸ RASIP1 ▸ TBCC ▸ HCFC1 ▸ ATF4 ▸
TGM7 ▸ PDCD2 ▸ BAI2 ▸ TAC1 ▸ WNT2 ▸ LYZ ▸ MYC ▸
SMC2 ▸ ABCA4 ▸ GSTM2 ▸ IRG1 ▸ PDCD5 ▸ RNASE3 ▸ TFAP2A ▸
HSPB8 ▸ SERPINE2 ▸ MIP ▸ RLN1 ▸ IRF2 ▸ EDNRA ▸ EGR1 ▸
TIRAP ▸ FGFR2 ▸ STK35 ▸ TIMP3 ▸ MTA1 ▸ MTA2 ▸ MYO16 ▸
F12 ▸ SH3GL2 ▸ ERBB3 ▸ PIK3C3 ▸ NFKB2 ▸ FOXO1 ▸ MEOX2 ▸
ZBTB16 ▸ KAT2B ▸ PTGER4 ▸ GCSAM ▸ HNRNPA1 ▸ CBL ▸ PRKD1 ▸
PTPRE ▸ PIAS1 ▸
Data information
Please see the Gene Interactions Track Manual.