Gene interactions and pathways from curated databases and text-mining

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ITGB1 — RHOA

Pathways - manually collected, often from reviews:

  • OpenBEL Selventa BEL large corpus: RHOA → ITGB1 (increases, ITGB1 Activity, RHOA Activity)
    Evidence: RhoA-SRF activation of the skeletal a-actin promoter occurs through an integrin-dependent pathway (68). Overexpression of either b1D- or b1Asubunits can enhance RhoA activation of skeletal a-actin and, conversely, a dominant negative mutant of b1-integrin inhibits RhoA activation (68).
  • OpenBEL Selventa BEL large corpus: RHOA → ITGB1 (increases, ITGB1 Activity, RHOA Activity)
    Evidence: These early stages paralleled collagen I activation of Src kinase and GTPase Rho through beta1 integrins.
  • OpenBEL Selventa BEL large corpus: ITGB1 → RHOA (increases, RHOA Activity, ITGB1 Activity)
    Evidence: GTPases of the RHOA subfamily have an important role in the regulation of integrin- mediated adhesion. Transgenic expression of constitutively active V14RHOA results in increased adhesion of both thymocytes and T cells through beta1 and beta2 integrins, whereas expression of C3 transferase, which inhibits RHOA, RHOB and RHOC, causes decreased adhesion105.
  • BioCarta ucalpain and friends in cell spread: Integrin-alpha/Integrin-beta/ECM complex (ITGA1-ITGB1) → RhoA (RHOA) (modification, collaborate)

Text-mined interactions from Literome

Zhou et al., J Biol Chem 2005 (Carcinoma, Squamous Cell) : Our results indicate that in squamous epithelial cells, collagen-alpha2beta1 integrin binding activates RhoA, slowing cell locomotion, whereas laminin-5-alpha3beta1 integrin interaction inhibits RhoA and activates PAK1, stimulating cell migration ... Our results indicate that in squamous epithelial cells, collagen-alpha2beta1 integrin binding activates RhoA , slowing cell locomotion, whereas laminin-5-alpha3beta1 integrin interaction inhibits RhoA and activates PAK1, stimulating cell migration
Benoit et al., Biol Cell 2009 : Integrin alpha8beta1 regulates adhesion, migration and proliferation of human intestinal crypt cells via a predominant RhoA/ROCK dependent mechanism