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ADRA2B — GRK1

Text-mined interactions from Literome

Desai et al., J Pharmacol Exp Ther 2006 : In this study, using NG108 cells ( endogenous alpha2B-AR ), we provide strong evidence for a critical role of both GRK3 and GRK2 in down-regulation of the alpha2B-AR ... To more directly establish a role for GRK3 and GRK2 in alpha2B-AR down-regulation, NG108 cells were transfected to express GRK3ct, which binds to liberated Gbetagamma subunits, preventing GRK3 and GRK2 translocation to the membrane ... Overexpression of GRK3ct prevented not only the translocation of GRK3 and GRK2 but also the down-regulation of the alpha2B-AR caused by 24-h pretreatment with 20 microM EPI ... Taken together, these data provide direct evidence for a role of GRK3 and GRK2 in the down-regulation of the alpha2B-AR and contribute significantly to the increasing evidence in the literature for a pivotal role of GRKs in modulating the agonist induced down-regulation of the alpha2-AR
Salim et al., J Pharmacol Exp Ther 2007 : Relatively small changes in G-protein coupled receptor kinase ( GRK ) 3 expression ( approximately 2-fold ) profoundly affect alpha2-adrenergic receptor ( AR ) function and preferentially regulate neuronal alpha2A- and alpha2B-AR signaling