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JUN — MMP1
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Westermarck et al., FASEB J 1999
(Neoplasm Invasiveness...) :
This review will summarize the current view on the role of MMPs in tumor growth, invasion, and survival, and focus on the
role of mitogen activated protein kinases and
AP-1 and ETS transcription factors in the regulation of
MMP gene expression during invasion process
Wenk et al., J Biol Chem 1999
:
Collectively, we have found that enhanced Mn-SOD activity, via an unbalanced H ( 2 ) O ( 2 ) overproduction and detoxification, induces
MMP-1 mRNA levels, and this effect is at least partly
mediated by the DNA recognition sequence
AP-1
Barchowsky et al., Cytokine 2000
(MAP Kinase Signaling System) :
We have reported previously that NF-kappaB and
AP-1 cooperate to
mediate IL-1 induced
MMP-1 transcription
Sato et al., Cancer Res 2002
(Fibrosarcoma...) :
These results suggest that nobiletin inhibits tumor cell invasive activity not only by suppressing the expression of MMPs but also augmenting TIMP-1 production in tumor cells, and that the nobiletin mediated inhibition of
activator protein-1 binding activity is at least partly
involved in the suppression of
MMP expression
Fahmi et al., Osteoarthritis Cartilage 2002
:
Peroxisome proliferator activated receptor gamma activators
inhibit MMP-1 production in human synovial fibroblasts likely by reducing the binding of the
activator protein 1
Bianchi et al., J Biol Chem 2003
:
As a functional consequence of this interaction, expression of huCOP1 in mammalian cells down-regulates
c-Jun dependent transcription and the expression of the AP-1 target genes, urokinase and
matrix metalloproteinase 1
Maldonado et al., Immunology 2003
:
Up-regulation of
matrix metalloproteinase-1 expression in U937 cells by low-density lipoprotein containing immune complexes
requires the
activator protein-1 and the Ets motifs in the distal and the proximal promoter regions ... The mutation study further indicated that the
activator protein-1 (AP-1) ( -3471 ) or Ets ( -3836 ) motifs in this distal region were
essential for the LDL-IC stimulated
MMP-1 expression ... In conclusion, the present study shows that both the distal and proximal
AP-1 and Ets motifs are
required for LDL-IC stimulated
MMP-1 expression in U937 histiocytes
Sugioka et al., Int J Cancer 2004
(Carcinoma, Hepatocellular...) :
The purpose of present study is to determine the
involvement of
c-Jun in
matrix metalloproteinase-1 (MMP-1) expression, which is previously reported by us to be expressed only in the early stage of human HCC showing stromal invasion
Game et al., Atherosclerosis 2005
:
In an attempt to explore the signaling mechanism by which pioglitazone inhibits the oxLDL upregulated MMP-1 expression, we found that extracellular signal regulated kinase ( ERK ) and
c-Jun-N-terminal kinase (JNK) pathways were
required for the oxLDL stimulated
MMP-1 expression, but pioglitazone failed to antagonize the activation of ERK and JNK by oxLDL ... Taken together, the present study indicates that pioglitazone
inhibits oxLDL stimulated
MMP-1 expression in VSMCs by inhibiting
c-Jun transcriptional activity through a mitogen activated protein kinase ( MAPK ) -independent mechanism
Kim et al., J Lipid Res 2005
:
We found that UV radiation increases
MMP-1 expression and that this is
mediated by p44 and p42 MAP kinase ( ERK ) and
Jun-N-terminal kinase (JNK) activation but not by p38 activation
Ray et al., Biochim Biophys Acta 2005
(Inflammation...) :
These results show that induction and activation of
AP-1 and SAF-1 transcription factors are
involved in the regulation of
MMP-1 expression in the chondrocytes which could be used as therapeutic targets to combat pathogenesis of OA
Kroczynska et al., Proc Natl Acad Sci U S A 2006
(Mesothelioma) :
Ap-1 activity
caused the expression and activation of
matrix metalloprotease (MMP)-1 and MMP-9, which in turn led to cell invasion
Kajanne et al., J Cell Physiol 2007
:
Here we provide genetic and biochemical evidence that EGF-R- and
AP-1 mediated signals are
required for
MMP expression and collagen contraction in fibroblasts
Hammaker et al., Arthritis Res Ther 2007
(Arthritis, Rheumatoid) :
c-Jun N-terminal kinase (JNK) contributes to metalloproteinase (
MMP ) gene expression and joint destruction in inflammatory arthritis
Oliver et al., J Rheumatol 2007
(Arthritis, Experimental...) :
We evaluated whether a vanadium
AP-1 inhibitor could
reduce MMP expression and subsequent joint damage in CIA
Cortez et al., Am J Physiol Heart Circ Physiol 2007
:
Inhibition of
AP-1 , NF-kappaB, or C/EBP activation
attenuated IL-17 stimulated
MMP-1 expression
Fréchet et al., Oncogene 2008
(Xeroderma Pigmentosum) :
Deletion analysis revealed the essential
role of
AP-1 activation in constitutive
MMP1 overexpression in XP-C primary fibroblasts
Li et al., J Cell Biochem 2010
(MAP Kinase Signaling System) :
The
role of
c-Jun in
MMP-1 expression was confirmed by the finding that suppression of c-Jun expression by RNA interference significantly inhibited MMP-1 expression
Green et al., J Immunol 2010
(Tuberculosis, Central Nervous System) :
Chemical inhibition and promoter-reporter analyses showed that NF-kappaB and AP-1
c-Jun/FosB heterodimers
regulate CoMTb induced
MMP-1/-3 secretion
Speidl et al., FASEB J 2011
(Plaque, Atherosclerotic) :
In addition, blocking experiments revealed that
MMP-1 expression was
mediated by activation of the transcription factor
AP-1 , and MMP-9 expression was induced by activation of NF-?B and AP-1
Pradeepkumar Singh et al., J Pineal Res 2011
(Diabetes Mellitus, Experimental...) :
Moreover, increased expression of both
MMP-1 and -13 was
mediated by
activator protein-1 activation via extracellular signal regulated kinase 1/2 which were parallel to upregulation of tumor necrosis factor-a, interleukin-1ß, and heat shock protein-70 during ulceration
Chen et al., Regul Toxicol Pharmacol 2011
:
Taken together, CDP
inhibits UVB induced
MMP-1 expression in skin fibroblasts by suppressing expression of
AP-1 and CYR61 and MCP-1 production
Chan et al., International journal of molecular sciences 2011
:
In the current study, pretreatment with nitric oxide ( NO ) scavengers inhibited PDT induced mitochondrial
membrane potential ( MMP ) changes,
activation of caspase-9, caspase-3, p21 activated protein kinase 2 (PAK2) and
c-Jun N-terminal kinase (JNK) , and gene expression of p53 and p21 involved in apoptotic signaling
Zhan et al., Exp Cell Res 2012
(Neoplasm Invasiveness...) :
MMP-1 , -2, -9 and-12 expression, and MLK3 induced activation of MMP-2 and MMP-9
requires both extracellular signal regulated kinase ( ERK ) and
c-Jun N-terminal kinase (JNK) activities ... In addition, inhibition of
activator protein-1 (AP-1) reduced
MMP-1 , MMP-9 and MMP-12 gene expression
Lee et al., J Dermatol Sci 2013
:
In UVB irradiated HaCaT cells, 8-oxo-dG inhibited ROS production, subsequent
activation of mitogen activated protein kinase ( MAPK ), ATF-2, and
c-Jun , and
MMP expression
Westermarck et al., Oncogene 1997
:
Interestingly, PU.1 abolished
induction of
MMP-1 promoter by both
c-Jun and JunB ... These results show that three structurally distinct ETS transcription factors differently modulate
AP-1 dependent upregulation of
MMP-1 gene expression