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IL10 — VIP
Text-mined interactions from Literome
Wang et al., Regul Pept 1999
:
Previous reports indicate that
VIP and the structurally related peptide PACAP,
inhibit IL-2 and
IL-10 production in antigen stimulated T lymphocytes ... The antagonists based on the neurotensin-VIP hybrid molecule did not affect the inhibitory
effect of
VIP/PACAP on IL-2 and
IL-10 production, confirming that astrocytes and T lymphocytes express different receptors
Delgado et al., J Biol Chem 1999
:
We showed previously that
VIP and PACAP
inhibit the production of macrophage derived tumor necrosis factor-alpha,
interleukin (IL)-6 , nitric oxide, and IL-12
Leceta et al., Ann N Y Acad Sci 2000
(Inflammation) :
VIP/PACAP inhibit the production of TNF alpha, IL-6, IL-12, and nitric oxide ( NO ), and
stimulate IL-10 in peritoneal macrophages and Raw 264.7 cells ...
VIP/PACAP inhibit iNOS expression through reduction in NFkB and IRF-1 binding, and
augment IL-10 by increasing CREB binding
Ganea et al., Crit Rev Oral Biol Med 2002
(Shock, Septic) :
In activated macrophages,
VIP and PACAP inhibit the production of pro-inflammatory agents ( cytokines, chemokines, and nitric oxide ), and
stimulate the production of the anti-inflammatory cytokine
IL-10
Kodali et al., J Immunol 2004
(Hypersensitivity, Delayed) :
VIP augmented the production of the
IL-10 in LPS stimulated XS106 cells while down regulating IL-12 and IL-1beta production
Larocca et al., Int Immunopharmacol 2007
:
The inhibitory effect of
VIP induced
IL-10 on nitrites was mediated by COX metabolites mostly in NOD cells as indomethacine inhibited both the increase in IL-10 and the reduction of nitrites exerted by VIP ... We conclude that both PGE2 and
VIP inhibit nitric oxide production and
increase IL-10 induced by LPS in NOD macrophages and VIP effect is mediated through an increase of COX metabolites and IL-10
Gutiérrez-Cañas et al., Brain Behav Immun 2008
(Arthritis, Rheumatoid) :
VIP increases the levels of
IL-10 and IL-4 in the supernatant of human CD4 ( + ) CD45RA ( + ) cells cultured in a non conditioned or a Th2 conditioned situation
Calafat et al., Neuroimmunomodulation 2007
(Disease Models, Animal...) :
VIP was not effective to prevent nitrite accumulation and modestly
increased IL-10 levels in macrophages coincubated with acinar cells
Fraccaroli et al., Br J Pharmacol 2009
:
Also, during the trophoblast-maternal PBMCs interaction,
VIP reduced pro-inflammatory mediators [interleukin (IL)-6, monocyte chemoattractant protein 1, nitric oxide ], while increasing
IL-10
Temerozo et al., PloS one 2013
:
VIP and PACAP
up-regulated macrophage secretion of the ß-chemokines CCL3 and CCL5 and the cytokine
IL-10 , whose neutralization reversed the neuropeptide induced inhibition of HIV-1 replication
Martinez et al., J Immunol 1996
:
In this study, we investigated the
effects of
VIP and of the structurally related neuropeptide PACAP-38 on the expression of
IL-10 in murine lymphocyte cultures ... The fact that
VIP , PACAP-38, and forskolin, all known cAMP inducers, also
inhibit IL-10 production, suggests the participation of cAMP in signal transduction
Ganea et al., Adv Neuroimmunol 1996
:
In contrast, the inhibitory
effect of
VIP and PACAP on
IL-10 production proceeds through a direct transcriptional event
Hernanz et al., J Neuroimmunol 1996
:
Differential
effects of gastrin releasing peptide, neuropeptide Y, somatostatin and
vasoactive intestinal peptide on interleukin-1 beta,
interleukin-6 and tumor necrosis factor-alpha production by whole blood cells from healthy young and old subjects
Tang et al., Ann N Y Acad Sci 1996
:
VIP has been previously shown to
inhibit IL-2, IL-4, and
IL-10 production in murine lymphocytes stimulated through the TCR associated CD3 complex
Jiang et al., Ann N Y Acad Sci 1998
:
These results indicate that both subsets of peripheral T lymphocytes express VIP1 and VIP2, but not PVR1 receptors, and that the inhibitory effect of VIP/PACAP on IL-2 and
IL-10 production is
mediated by both
VIP1 and VIP2 receptors
Delgado et al., J Immunol 1999
:
Although
VIP/PACAP do not
induce IL-10 by themselves, they enhance IL-10 production in LPS stimulated macrophages