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FAS — RAF1
Pathways - manually collected, often from reviews:
-
OpenBEL Selventa BEL large corpus:
Complex of CFLAR-KRT18-KRT8-RAF1
→
FAS
(increases)
Gilbert et al., Mol Cell Biol 2004*
Evidence: c-Flip, along with Raf-1, is part of a K8/K18-immunoisolated complex from wild-type hepatocytes, and Fas stimulation leads to further c-Flip and Raf-1 recruitment in the complex.
Text-mined interactions from Literome
Gilbert et al., Mol Cell Biol 2004
(MAP Kinase Signaling System) :
c-Flip, along with Raf-1, is part of a K8/K18 immunoisolated complex from wild-type hepatocytes, and
Fas stimulation
leads to further c-Flip and
Raf-1 recruitment in the complex
Shin et al., Int J Hematol 2010
:
To distinguish between the activation signalling and the death inducing pathway downstream of Fas, we generated a novel T cell line expressing a chimeric hCD8-FasC protein and found that stimulation with the anti-CD8 antibodies induced tyrosine phosphorylation of TCR-proximal proteins,
activation of
Raf-1/ERK , p38 and JNK, and increased expression of CD69,
Fas , and Fas ligand