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JAK2 — SRC

Pathways - manually collected, often from reviews:

• OpenBEL Selventa BEL large corpus: JAK2 → SRC (increases, SRC Activity, JAK2 Activity) Gharavi et al., J Biol Chem 2007*
  Evidence: Treatment of human aortic EC with Ox-PAPC and 1-palmitoyl-2-epoxyisoprostane-sn-glycero-3-phosphorylcholine induced a rapid yet sustained activation of JAK2; activation of JAK2 by Ox-PAPC was dependent on c-Src kinase activity.
• NCI Pathway Database CXCR4-mediated signaling events: SDF1/CXCR4/JAK2 complex (CXCL12-CXCR4-JAK2) → Src Family Kinases-active (FGR/LYN/LCK/YES1/BLK/HCK/SRC/FYN) (modification, activates)
  Wang et al., Blood 2000, Zhang et al., Blood 2001, Okabe et al., J Hematother Stem Cell Res 2002, Le et al., J Immunol 2005
  Evidence: mutant phenotype, assay, physical interaction
• NCI Pathway Database ErbB2/ErbB3 signaling events: Src (SRC) → JAK2 (JAK2) (modification, activates) Ren et al., J Biol Chem 2002
  Evidence: mutant phenotype, assay
• Reactome Reaction: JAK2 → SRC (reaction) Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997
• Reactome Reaction: JAK2 → SRC (indirect_complex) Brizzi et al., J Biol Chem 1999, Ning et al., Oncogene 2001, Argetsinger et al., Mol Cell Biol 2004, Argetsinger et al., Mol Endocrinol 2010, Weiler et al., Blood 1996, Feng et al., Mol Cell Biol 1997, Deberry et al., Biochem J 1997

Protein-Protein interactions - manually collected from original source literature:

Studies that report less than 10 interactions are marked with *

• IRef Biogrid Interaction: SRC — JAK2 (physical association, affinity chromatography technology) Liang et al., Cancer Cell 2010*
• IRef Intact Interaction: Complex of ERBB2-SRC-SRC-JAK2-ERBB2-JAK2 (association, anti bait coimmunoprecipitation) Liang et al., Cancer Cell 2010*

Text-mined interactions from Literome

Iwamoto et al., Oncogene 2000 (Acute-Phase Reaction) : The JAK-inhibitor, JAB/SOCS-1 selectively inhibits cytokine induced, but not v-Src induced JAK-STAT activation ... In this report, we investigated the effect of ectopic expression of JAB on v-Src induced JAK-STAT activation ... Furthermore, in vitro kinase assay indicated that JAB suppressed hyperactivation of JAK1/JAK2 and JAK1 induced by IFNgamma and IL-6 plus sIL-6R respectively, but not v-Src induced basal JAK1/JAK2 activity
Liang et al., Cancer Cell 2010 (Breast Neoplasms) : Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2 mediated Src activation and PTEN inactivation ... We identified Jak2 mediated activation of Src and inactivation of PTEN as underlying mechanisms through which rHuEPO antagonizes trastuzumab induced therapeutic effects
Murakami et al., J Cell Physiol 1998 (Gallbladder Neoplasms) : These results raise the possibility that Jak-2 and Tyk-2 are both activated by v-Src , thereby contributing to the constitutive activation of STAT3 in the v-Src transformed cells