◀ Back to EGFR
EGFR — SOS1
Pathways - manually collected, often from reviews:
-
BioCarta role of egf receptor transactivation by gpcrs in cardiac hypertrophy:
EGF/EGF R complex (EGF-EGFR)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta egf signaling pathway:
EGF/EGF-R complex (EGF-EGFR)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta trefoil factors initiate mucosal healing:
TFFs/ErbB1/ERBB2 complex (EGFR-ERBB2-TFF3_TFF2_TFF1)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta angiotensin ii mediated activation of jnk pathway via pyk2 dependent signaling:
EGF-R (EGFR)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta keratinocyte differentiation:
EGF/EGF-R complex (EGF-EGFR)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
BioCarta role of erbb2 in signal transduction and oncology:
ERBB ligand/ERBB2/ERBB 1/3/4 complex (ERBB2-ERBB4_ERBB3_EGFR)
→
SHC/GRB2/SOS-1 complex (SOS1-GRB2-SHC1)
(modification, activates)
-
KEGG Regulation of actin cytoskeleton:
EGFR/FGFR1/FGFR2/FGFR3/FGFR4/INSRR/PDGFRA/PDGFRB
→
SOS1/SOS2
(protein-protein, activation)
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1)
→
mTOR (MTOR)
(modification, activates)
Iwasaki et al., Endocrinology 1999
Evidence: mutant phenotype, other species
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
GRB2/SOS1 complex (GRB2-SOS1)
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003
Evidence: assay
-
NCI Pathway Database ErbB1 downstream signaling:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
SOS1 (SOS1)
(modification, activates)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database ErbB1 downstream signaling:
EGFR/EGFR/EGF/EGF complex (EGFR-EGF)
→
Eps8/ABI1/SOS1 complex (EPS8-ABI1-SOS1)
(modification, activates)
Scita et al., Nature 1999, Lanzetti et al., Nature 2000, Sini et al., Nat Cell Biol 2004
Evidence: mutant phenotype, physical interaction
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1)
→
EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1)
(modification, collaborate)
Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
Evidence: physical interaction, other species
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
Evidence: physical interaction, other species
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
EGF/EGFR dimer/SHC complex (EGF-EGFR-SHC1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
Evidence: physical interaction, other species
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
None
→
EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1)
(modification, collaborate)
Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database EGFR-dependent Endothelin signaling events:
HRAS/GDP complex (HRAS)
→
EGF/EGFR dimer/SHC/GRB2/SOS1 complex (EGF-EGFR-SHC1-GRB2-SOS1)
(modification, collaborate)
Iwasaki et al., Endocrinology 1999, Daub et al., Nature 1996
Evidence: mutant phenotype, other species
-
NCI Pathway Database Internalization of ErbB1:
GRB2 (GRB2)
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(modification, collaborate)
Burke et al., Mol Biol Cell 2001
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
→
EGF (EGF)
(modification, collaborate)
Burke et al., Mol Biol Cell 2001
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
→
EGFR (EGFR)
(modification, collaborate)
Burke et al., Mol Biol Cell 2001
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
→
SOS1 (SOS1)
(modification, collaborate)
Burke et al., Mol Biol Cell 2001
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR (EGFR)
→
SOS1 (SOS1)
(modification, collaborate)
Burke et al., Mol Biol Cell 2001
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
None
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
→
None
(modification, activates)
Haugh et al., J Biol Chem 1999, Pennock et al., Mol Cell Biol 2003, Wiley et al., J Biol Chem 1991, Di Guglielmo et al., EMBO J 1994, Herbst et al., J Biol Chem 1994
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
None
→
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
→
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
→
RAS family/GTP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
(modification, activates)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
→
None
(modification, activates)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1)
→
GRB2/SOS1 complex (GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p46 SHC complex (EGFR-EGF-SHC1)
→
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Internalization of ErbB1:
GRB2/SOS1 complex (GRB2-SOS1)
→
EGFR/EGFR/EGF/EGF/p46 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Internalization of ErbB1:
None
→
EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
RAS family/GDP complex (HRAS_KRAS_HRAS_KRAS_NRAS)
→
EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
→
None
(modification, activates)
Haugh et al., J Biol Chem 1999
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
Vps24 (CHMP3)
→
EGFR/EGFR/EGF/EGF/GRB2/SOS1 complex (EGFR-EGF-GRB2-SOS1)
(translocation, activates)
Burke et al., Mol Biol Cell 2001, Ravid et al., J Biol Chem 2004, Mosesson et al., Dev Cell 2009, Levkowitz et al., Genes Dev 1998
Evidence: assay
-
NCI Pathway Database Internalization of ErbB1:
GRB2/SOS1 complex (GRB2-SOS1)
→
EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Internalization of ErbB1:
GRB2/SOS1 complex (GRB2-SOS1)
→
EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
NCI Pathway Database Internalization of ErbB1:
EGFR/EGFR/EGF/EGF/p52 SHC complex (EGFR-EGF-SHC1)
→
EGFR/EGFR/EGF/EGF/p52 SHC/GRB2/SOS1 complex (EGFR-EGF-SHC1-GRB2-SOS1)
(modification, collaborate)
Haugh et al., J Biol Chem 1999, Balbis et al., Endocrinology 2007, Di Guglielmo et al., EMBO J 1994
Evidence: assay, physical interaction
-
Reactome Reaction:
EGFR
→
SOS1
(reaction)
Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995
-
Reactome Reaction:
EGFR
→
SOS1
(indirect_complex)
Lynch et al., N Engl J Med 2004, Sordella et al., Science 2004, Pao et al., Proc Natl Acad Sci U S A 2004, Greulich et al., PLoS Med 2005, Yang et al., Cancer Res 2006, Choi et al., Oncogene 2007, Lee et al., PLoS Med 2006, Huang et al., Proc Natl Acad Sci U S A 2007, Xu et al., Br J Cancer 2007, Batzer et al., Mol Cell Biol 1994*, Okutani et al., J Biol Chem 1994*, Chardin et al., Science 1993, Xie et al., J Biol Chem 1995
-
WikiPathways ESC Pluripotency Pathways:
EGFR
→
SOS1/GRB2
(activation)
Protein-Protein interactions - manually collected from original source literature:
Studies that report less than 10 interactions are marked with *
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Kurada et al., J Biol Chem 2009*
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Tong et al., J Proteome Res 2008
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Foerster et al., Proteomics 2013
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Qian et al., Mol Cell Biol 1998*
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Qian et al., EMBO J 2000*
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(direct interaction, pull down)
Buday et al., J Biol Chem 1994*
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(direct interaction, pull down)
Tong et al., Mol Cell Proteomics 2009
-
IRef Biogrid Interaction:
SOS1
—
EGFR
(physical association, affinity chromatography technology)
Tong et al., Mol Cell Proteomics 2009
-
IRef Hprd Interaction:
SOS1
—
EGFR
(in vivo)
Qian et al., Mol Cell Biol 1998*
-
IRef Intact Interaction:
Complex of 228 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
-
IRef Intact Interaction:
Complex of 38 proteins
(association, pull down)
Blagoev et al., Nat Biotechnol 2003
-
IRef Ophid Interaction:
SOS1
—
EGFR
(aggregation, interologs mapping)
Brown et al., Bioinformatics 2005
Text-mined interactions from Literome
Oh-hora et al., J Exp Med 2003
:
The BCR requires RasGRP3 ; in contrast,
epidermal growth factor receptor is
dependent on
Sos1 and Sos2
Wakasaki et al., Neoplasia (New York, N.Y.) 2010
(Carcinoma, Squamous Cell...) :
Little is known, however, about a
role of
CIN85 in
EGFR signaling as well as its relevance to tumor development and progression of HNSCC
Schroeder et al., Mol Biol Cell 2012
:
In this study we show that
EGFR activation
leads to a pronounced src mediated tyrosine phosphorylation of
CIN85 that subsequently influences EGFR ubiquitination