Wurm et al., Cytokine 2008
:
Insulin induces monocytic CXCL8 secretion by the mitogenic signalling pathway ... Inhibition of the phosphatidylinositol 3-kinase by wortmannin or the mammalian target of rapamycin by rapamycin did not influence insulin mediated CXCL8 induction ... In contrast, blockage of the ERK-specific MAP kinase MEK with PD98059, that prevents phosphorylation of ERK1/ERK2, abrogated insulin induced CXCL8 release in primary monocytes
Tariq et al., Journal of translational medicine 2013
:
SDF-1alpha also enhances the glucose responsive insulin secretion in IPCs in vitro