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NR4A1 — VEGFA
Pathways - manually collected, often from reviews:
Text-mined interactions from Literome
Liu et al., Arterioscler Thromb Vasc Biol 2003
:
VEGF increased protein expression of Nurr1 and
Nur77 and decreased Nur77 phosphorylation at the negative regulatory site serine 351
Ha et al., J Biol Chem 2008
:
Specifically, inhibition of PKD by overexpression of the PKD kinase negative mutant prevents
VEGF induced HDAC5 phosphorylation and nuclear export as well as
NR4A1 induction ... Moreover, a mutant of HDAC5 specifically deficient in PKD dependent phosphorylation inhibited
VEGF mediated
NR4A1 expression, endothelial cell migration, and in vitro angiogenesis
Wu et al., FASEB J 2011
(Colonic Neoplasms) :
DCA induced
Nur77 expression
resulted in up-regulation of antiapoptotic BRE and angiogenic
VEGF , and it enhanced the growth, colony formation, and migration of colon cancer cells
Su et al., Mol Cell Biol 2013
:
Small interfering RNA ( siRNA ) knockdown of FLNB or ubiquitin ( Ub ) in human primary endothelial cells blocks VEGF mediated cytoplasmic accumulation of HDAC7, reduces
VEGF induced expression of the HDAC7 target genes Mmp-10 and
Nur77 , and inhibits VEGF induced vascular permeability